Metabolite_name RefMet_name Sample_n_003 Sample_n_007 Sample_n_011 Sample_n_015 Sample_n_019 Sample_n_004 Sample_n_008 Sample_n_012 Sample_n_016 Sample_n_020 Sample_n_QC1 Sample_n_QC2 Sample_n_QC3 Sample_n_QC4 Sample_n_QC5 Sample_n_001 Sample_n_005 Sample_n_009 Sample_n_013 Sample_n_017 Sample_n_002 Sample_n_006 Sample_n_010 Sample_n_014 Sample_n_018 Factors - group:KO_Retina group:KO_Retina group:KO_Retina group:KO_Retina group:KO_Retina group:KO_RPE group:KO_RPE group:KO_RPE group:KO_RPE group:KO_RPE group:QC group:QC group:QC group:QC group:QC group:WT_Retina group:WT_Retina group:WT_Retina group:WT_Retina group:WT_Retina group:WT_RPE group:WT_RPE group:WT_RPE group:WT_RPE group:WT_RPE 2-Aminoadipic acid alpha-Aminoadipic acid 1102876 1036842 1471432 2142228 1798433 113461 284165 209179 230394 307506 917528 817578 373199 628 1826496 1224390 1406693 2222557 512360 224132 255092 250656 471723 339312 2-Hydroxybenzaldehyde 2-Hydroxybenzaldehyde 473151 439949 1596317 1853176 550196 341274 234202 277652 287448 169433 454206 460662 217753 33661 12666 483686 423976 371061 323596 506527 231728 182086 182331 272575 143353 2-Hydroxyisobutyric acid 2-Hydroxyisobutyric acid 21310526 16646993 10918745 24230472 21370106 4725664 2347900 2450766 2988916 3282046 13477321 12211728 7095486 2557682 935965 28054902 29115336 28776350 38369176 24444560 5367830 4321766 5186115 4511692 6260148 2-METHYLMALEATE (IORA) Citraconic acid 223945 275398 324560 374278 261801 21057 27801 33219 26503 18001 151671 136541 68448 8369 20492 283162 291903 197322 281734 273615 15380 26886 30637 34813 26376 3-HYDROXYBENZOATE (IORA) 3-Hydroxybenzoic acid 9662 11100 36629 37847 8180 40456 6818 13154 20135 8237 11693 8945 3778 1228 3059 4427 10039 4879 10175 10564 5391 5794 10832 6193 11794 4-HYDROXYBENZALDEHYDE 4-Hydroxybenzaldehyde 1277003 834028 1206164 1664997 984373 309507 149676 391835 310574 97757 538817 565034 221446 28013 67150 1481196 939657 1083833 981628 1151903 170063 153866 214536 175564 144796 4-Nitrophenol 4-Nitrophenol 312608 493649 555238 698902 407792 585468 413527 477132 569289 462976 500898 516065 277412 110677 57885 478010 412980 233779 311055 457495 418352 312777 347020 481852 357039 ADENINE Adenine 3143200 3544886 2741309 4371718 4003549 51384 71647 78545 44003 74924 1294870 1286713 668875 18040 14584 4068211 3629959 1792144 2316671 2562328 81497 32209 41782 62687 67665 Aspartate Aspartic acid 15266297 10879916 10624924 18992072 14186870 749800 762505 505111 1099832 881158 8616846 7548002 5835738 33527 4201 15931509 15270450 12851909 14196294 9208255 1184787 606937 534310 1368395 572464 Azelaic acid Azelaic acid 1270796 1785391 1186346 1354673 955648 1074932 1490505 904765 972910 946234 1639191 1534919 989387 607664 681201 1471306 4048572 1137760 1038364 1115518 1054474 1057291 1010755 1444416 1056824 Creatine Creatine 5345718 4989568 4777441 5120202 5328636 1977689 1822685 1442916 1524408 1530250 4356360 3962616 2327574 19052 1036 5825492 5430068 4930047 5588368 5158930 2149128 1564029 1476094 1952685 1548121 DIHYDROOROTATE (IORA) 4,5-Dihydroorotic acid 185698 259062 236529 261660 300411 185276 280355 231600 241468 218328 221228 201127 125975 167943 201208 160033 325077 135297 239408 206662 180641 305708 170174 DL-3-Aminoisobutyric acid 3-Aminoisobutanoic acid 2367069 1839553 2157506 2540755 2276299 155176 210879 127623 191890 184676 1347002 1263151 757808 2400 2293999 2257667 1951209 2307892 1647226 228080 167721 148536 262913 132351 DOPA DOPA 11206 2511 1396 28930 31945 7188 10510 13551 13751 21051 20169 14502 8333 11455 2330 13697 19937 6844 14377 8313 7340 12681 866 D-PANTOTHENIC ACID Pantothenic acid 588286 552775 473439 674288 539646 307697 331629 213965 167052 210594 300769 305981 103672 235856 150996 234350 492071 485059 108624 72509 139755 190785 225042 FUMARATE (IORA) Fumaric acid 2044056 1619283 1610532 2272390 2097338 315670 300546 202522 135813 175264 846018 859660 222333 729 2594814 2469493 1370783 2138498 1830172 327027 346585 294286 206868 315298 Gluconate Gluconic acid 252941 258829 246095 452193 293555 192744 197270 152521 176202 170118 237549 225783 70689 357923 358107 236767 355201 228325 257432 210120 157446 227968 174174 Glucose Glucose 160829 158277 191829 169386 192349 1294342 1370554 958804 1012541 1173018 192764 209791 187679 895 155633 162658 214371 131275 587795 1465057 1243684 925254 1312588 827804 Glutamine Glutamine 2323807 2157496 2362051 2822474 2171442 1245855 1666742 1265750 1677586 1307336 2360248 2174120 1352699 34306 10553 2408114 2781816 2363819 2358605 4037836 2024545 1511588 1243132 2072146 1242336 GLYCERATE Glyceric acid 72950 51069 165351 245309 98228 140694 100703 102824 172165 114737 157863 149118 73013 5706 1080 188583 75064 94737 115556 55035 126060 83395 67761 233190 102826 Glycerophosphate(2) sn-Glycero-3-phosphate 1066755 783497 773198 828031 880476 131244 125817 52639 102096 112659 577540 603144 368311 718 543618 868503 626649 909883 368126 103841 131667 96949 131894 157656 HydroxyButyric acid Hydroxybutyric acid 1763079 1404963 1863661 1573717 1980940 2788452 1829909 1100401 1833402 1898118 2508451 2560404 1798362 602048 897941 2041878 1394911 1770148 2008144 1473956 963594 2812691 1403000 1173612 1842224 HYPOXANTHINE (IORA) Hypoxanthine 1783153 1738416 1581440 2777110 2464489 1995084 2131960 1632509 1800069 1940719 2172608 1934119 765280 25037 949 2098616 2388155 1331365 2275390 2524977 2504366 2246398 1769065 2419788 2810524 Itaconic acid (Not validated) Itaconic acid 1825179 1082830 1791371 3186632 2541307 943683 884065 867963 657312 814448 2464715 2097823 1064817 8011 5217 2770723 1461225 2479725 3018289 980052 1252094 845224 708187 654512 582687 L-5-Oxoproline Pyroglutamic acid 3787062 4600534 4302158 10912424 6233930 658979 562254 473026 680849 510249 2506166 2364130 867285 14335 3093 4625214 11088073 2449547 3359396 4686730 512512 588186 436161 527727 825533 Lactic acid Lactic acid 158785936 170303216 131934936 220114816 175064896 12857257 10275928 6703748 7344698 9630021 91001472 94471208 35337296 8392391 2145718 223979376 240881872 159591680 224487424 161706384 14129601 10425335 9272425 11079046 9659015 L-Glutamic acid Glutamic acid 32654146 25355038 28197920 31887186 28177908 2828860 3611895 2250917 3317498 3086484 19674724 17436700 11292401 82117 30168 32477736 30618988 27094230 29221648 22179142 4131217 3030941 2573174 4280912 2271678 MALEATE (IORA) Maleic acid 20972 18200 11223 28993 14038 5780 20077 11132 29613 13051 12492 18631 16293 685 13715 16922 12108 13834 13134 14181 15238 10826 31120 7547 Meglutol 3-Hydroxymethylglutaric acid 259195 261147 237153 307395 212923 125272 108090 96263 74058 47697 166790 164098 53907 1623 823 255428 261316 163686 258547 248674 100648 117166 111883 107845 127019 METHIONINE SULFOXIMINE (IORA) Methionine sulfoximine 283757 347335 332473 239755 238602 1294342 1370554 958804 1012541 1173018 468761 388271 116841 996 352649 388769 304786 251813 587795 1465057 1243684 925254 1312588 827804 N-ACETYLALANINE (IORA) N-Acetylalanine 518058 599079 557592 899185 707782 16250 6260 13075 9397 12708 277245 244285 140717 765 634 812388 667919 582800 880790 746945 21136 11909 18601 20253 18829 N-Acetylaspartate N-Acetylaspartic acid 27733098 23426362 20718786 33534344 25289856 1250915 861322 848270 777101 655873 13803025 12414599 4983057 12418 33875632 35621064 22942100 32050596 25869846 1159076 1065426 969167 1039721 1220530 O-Phosphoethanolamine Phosphoethanolamine 966754 865837 803645 776248 734026 1021653 1050731 921730 1282084 1012739 1050809 1420538 1316294 19297 5171 861319 726560 867347 845835 773299 1491692 982792 804834 1357619 760659 OROTATE (IORA) Orotic acid 22311 12254 18975 18384 20598 51455 54614 52665 63216 55914 32424 38825 34051 726 750 22374 21638 36425 23399 18182 71129 46938 46574 65544 38106 OXOPROLINE (IORA) Pyroglutamic acid 2973829 2237132 2564179 3030642 2693902 218356 290164 201644 289946 247002 1774725 1562956 965935 9394 5353 2813364 2727592 2453741 2710727 1983898 320952 249732 221822 378074 201059 Phenylphosphoric acid Phenyl phosphate 3947435 2677719 2640880 4383684 4198484 554276 550278 504481 450990 217723 2909271 2446858 1110150 1014 1436 5495745 3682807 4103378 5343583 1962496 793560 486930 445621 455409 199236 Phosphoric acid Phosphoric acid 7006856 16905086 8273816 21729812 13324464 3727045 9918485 3138585 9514229 5445334 3547407 7051249 8144062 896333 1643433 18124160 19712202 17437012 9766460 17046168 1711928 2263301 4685478 5639184 6383538 Salicylic acid Salicylic acid 1196457 1564544 1586058 1535572 1292750 774393 1009466 1080878 896919 576230 914384 967734 504667 41788 58624 922211 1463956 691961 2012682 1301705 672570 957681 847146 1150685 987442 SUCCINIC ACID Succinic acid 14844274 7404718 14719687 15824038 9836488 952629 922438 781369 919744 867042 5186544 5005670 1811924 5791 5979 9852003 11314920 13633024 17347996 15863357 974518 776669 688717 915946 814940 Taurine Taurine 283512864 242573056 232903744 303919744 245952720 39386604 40701632 32034578 47278704 36757748 205765808 191963888 162744128 2973150 963296 314238784 286551392 271037056 265546896 191954592 65528336 38783576 33966048 61975084 24244152 Threonine Threonine 296429 413159 359310 412979 311142 235383 331588 239072 392834 281930 360161 320796 143201 1809 1403 426011 480946 262137 338260 363799 411110 284544 212360 485731 235775 TRYPTOPHAN Tryptophan 102462 95310 64353 140783 85274 159294 265077 113432 89628 105987 133499 114444 38930 124031 133261 76674 81996 105408 152576 161201 144658 123109 261354 UREIDOPROPIONATE (IORA) Ureidopropionic acid 25127 21813 23373 38500 38502 39320 46640 68853 30160 72515 28036 35077 21950 42417 20491 19962 21332 45629 89221 82607 66632 91468 45859 UROCANATE (IORA) Urocanic acid 6347 6425 1335 31360 2531 1872 836 913 906 1373 1450 1963 4609 39373 1233 1740 2469 2298 3528 1024 675 1112 Xanthine Xanthine 2756605 2684192 2347618 3545681 3532138 1618622 1632800 1171368 1311433 1781660 2265527 2139910 725133 1471 3260069 3972349 1688121 2651126 3042642 1666078 1823502 1271058 1942100 2560268