Metabolite_name RefMet_name cKO1 cKO2 cKO3 cKO4 cKO5 cKO6 Ctrl1 Ctrl2 Ctrl3 Ctrl4 Ctrl5 Ctrl6 Factors - Genotype:cKO Genotype:cKO Genotype:cKO Genotype:cKO Genotype:cKO Genotype:cKO Genotype:Ctrl Genotype:Ctrl Genotype:Ctrl Genotype:Ctrl Genotype:Ctrl Genotype:Ctrl 1-Methylhistamine 1-Methylhistamine 3236 3033.7500 3032.7500 3842.1250 2425.6250 3-Nitrotyrosine Nitrotyrosine 4-Hydroxyphenylpyruvic acid 4-Hydroxyphenylpyruvic acid 12125.3750 4-Pyridoxic acid 4-Pyridoxic acid 23421 12124.1250 26453.7040 16532.9770 14604.1250 15155.8750 23285.2270 22321.1250 11847.6250 16947.3750 3167.8750 23146.8750 5-Hydroxy-L-tryptophan 5-Hydroxy-tryptophan 6267.6835 3639.6250 2829.8750 2223.5000 3842.1250 4449 5-Hydroxymethyl-2^-deoxyuridine 3638.3750 3234.7500 5-Methyltetrahydrofolic 5-Methyl-THF 2756.2500 5-Thymidylic acid dTMP 6-Gluconolactone 9185.8505 12314.2630 21680.5205 19839.0645 7900.6365 8453.5070 8083.9015 14143.6835 13958.2270 4778.2350 33990.3610 8-Hydroxy-deoxyguanosine 8-Hydroxy-deoxyguanosine 3033.7500 3438.2500 5865.2500 8-Hydroxyguanosine 8-Hydroxyguanosine 4044 3234.5000 3033 2629.2500 Acetoacetic acid Acetoacetic acid 3581.5000 5511.2500 4409.3750 Aconitic acid cis-Aconitic acid 2755 2755 Alpha-Linolenic acid alpha-Linolenic acid 85353.6912 73038.3610 70960.9880 110251.1335 57602.8970 140555.9745 80202.8615 66112.2817 59809.7035 81513.2426 187685.3155 96427.1355 Aminoadipic acid Aminoadipic acid 267781.6470 213774.7495 206845.9830 245704.3275 147814.6185 274437.2630 202493.0250 278218.2355 252150.6640 168230.1280 217151.1725 228295.4180 Azelaic acid Azelaic acid 141872.0335 294415.2050 157044.5700 182568.9630 147254.7050 122425.8955 153598.4905 204087.2925 167106.6040 106973.4030 163124.0275 184950.1175 Cadaverine Cadaverine 27703.5590 9503.2500 20625.0590 13345.5000 9503.5000 32961.4925 19109.1840 27501.0585 6269 14357.3750 9098.5000 27300.1175 cGAMP 4247.2500 cGMP 3',5' cyclic GMP Cytidine monophosphate CMP Cytidine triphosphate CTP dCMP dCMP Deoxyuridine Deoxyuridine 3842.7500 3235.1250 3033.5000 1820.2500 4246.3750 D-Glucosamine Glucosamine 7176.4335 6068.1840 11527.3680 22859.1040 25078.8605 17694.3675 19621.1700 Dihydrofolic acid Dihydrofolic acid DL-Acetylcarnitine CAR 2:0 2022.5000 1820.2500 2831.2500 DL-Homocysteine Homocysteine 1820.2500 9504.3750 4449.5000 Dopamine Dopamine 10610.6025 7440.7040 17087.0565 6615.0795 15436.1820 4410.8525 7855.6025 5511.9770 9922.9545 7305.8300 29236.4454 Folic acid Folic acid Gamma-Aminobutyric acid gamma-Aminobutyric acid Gibberellin A3 Gibberellin A3 Glyceraldehyde Glyceraldehyde Glycerol Glycerol Glycocholic acid Glycocholic acid Heptadecanoic acid Margaric acid 4684.3750 Histamine Histamine 44092.4710 Indole Indole 40246.7870 50763.8385 25886.1690 32159.4125 28920.4780 32763.1695 30538.3605 23863.9855 38627.0950 40250.3980 40953.9710 31953.1100 Indoleacetic acid Indoleacetic acid 8292.2500 6673.7500 6269.7500 8494.5000 3842.7500 11527.1250 5764.1250 4449.5000 8898 10212.3750 5966.1250 7684.3750 Isobutyric acid Isobutyric acid 12677 11574.8750 8129 5786.5000 6475.3750 15982.7500 10195.7500 9368.7500 9369.1250 Isovaleric acid Isovaleric acid L-Ascorbic acid(Vit. C) Vitamin C L-Cysteine Cysteine L-Cysteinylglycine Cys-Gly 2628 2224.5000 3640.3750 L-Cystine Cystine 4247.2500 3033.6250 2224.6250 L-Galactose L-Galactose 30861.5000 16119.8520 47124.7045 Linoleic acid Linoleic acid 53194.0550 251809.4820 240772.2340 112184.3495 132858.0600 138791.6745 216109.3710 L-Proline Proline 6007883.0250 5320591.0180 5710486.8070 5674570.3880 4100576.3100 6262856.7330 6750719.4240 6049151.9560 3726929.0850 4621220.8800 4589086.9780 6593024.8200 Melatonin Melatonin 6876.5000 4247.2500 4651.7500 Methylmalonic acid Methylmalonic acid 13230.1585 20675.7160 7303.8295 6615.2045 21226.9430 Myristic acid Myristic acid 12126.2275 8542.3520 13502.3750 4408.3750 N2_N2-Dimethylguanosine N2,N2-Dimethylguanosine 4852.5000 7483.2500 2831.5000 9304.3090 5258.5000 4247.2500 3640.5000 3236 N6-Methyladenosine N6-Methyladenosine 15774.9340 27908.2350 10312.5000 9809.9340 5862.5000 16178.3750 9099.7500 15368.6250 11727.5000 11730.6840 17189.5590 13146.1840 N-Acetylneuraminic acid N-Acetylneuraminic acid 15982.7500 8266.2500 13227.1250 18464.7045 6888.7500 19016.2045 6888.2500 NAD NAD NADP NADP NADPH NADPH Normetanephrine Normetanephrine 10110.6250 4447 2831.5000 7481.1835 5662.6250 23055.4930 4449.1250 13044.2500 5662 7076.7500 8089.4340 8090 Orotidylic acid(OMP) Orotidylic acid oxaloacetate Oxaloacetic acid 82418.6015 41206.3230 77730.8505 50578.0095 63667.2085 112470.0895 34316.2950 122944.9410 52519.4730 30316.3395 118245.0100 110249.7040 Phenylpyruvic acidPA Quinolinic acid 11573.5000 7715 10471.2500 4685 6337.5000 5786.7500 10470.7500 4685.6250 12676 Propionic acid Propionic acid Prostaglandin E2 PGE2 Putrescine Putrescine 4346.5000 8290.5000 6978.4340 6775.3090 14761 3032.5000 4045 5259.3090 4650.4335 11325.2500 15371.1840 2629.3750 Quinolinic acid Quinolinic acid Salicyluric acid Salicyluric acid 2830.1250 2426 Spermidine Spermidine 2223.3750 4650.7500 4651.7500 3032.5000 2224.7500 Taurocholic acid Taurocholic acid Tetrahydrofolic acid THF