Metabolite_name RefMet_name S4 S5 S6 S7 S8 S9 S1 S2 S3 Factors - Genotype:KO Genotype:KO Genotype:KO Genotype:KO Genotype:KO Genotype:KO Genotype:WT Genotype:WT Genotype:WT 1-Octadecanol Stearyl alcohol 22.9166 25.8391 25.5528 23.0856 20.4968 27.5347 26.6461 25.7712 19.0643 2-Hydroxybutyrate 2-Hydroxybutyric acid 21.8029 25.4257 25.8109 21.6376 20.4232 25.0888 22.8016 20.9278 21.5342 2-Hydroxyglutarate 2-Hydroxyglutaric acid 18.1113 17.3124 25.5762 18.1199 21.6366 26.1545 45.4186 36.9407 19.4643 3-Phosphoglycerate 3-Phosphoglyceric acid 17.0103 27.3342 25.8584 18.9370 35.9687 20.9061 31.4036 21.5174 17.1590 6-Phosphogluconate 6-Phosphogluconic acid 19.6860 27.4654 23.9742 33.5341 24.9338 32.6062 21.0831 20.0689 24.2255 Aconitate trans-Aconitic acid 17.4402 29.8780 21.5430 36.1074 25.8110 40.6928 20.4988 22.6089 19.4843 Adenine Adenine 24.6211 26.5992 25.5338 25.7168 21.9753 24.0578 26.3067 26.1880 24.3995 Adonitol Ribitol 33.7004 31.7217 46.7179 49.8333 44.1709 30.5212 27.3750 41.9881 40.4189 Alanine Alanine 27.5878 24.7694 21.4880 22.3730 25.3280 27.9086 23.1264 22.5994 29.6783 alpha-Keto-beta-Methylvalerate (KMV) 3-Methyl-2-oxovaleric acid 33.1309 12.6206 23.7757 12.5121 21.2587 21.3985 26.2978 20.7222 28.9363 alpha-Ketoglutarate 2-Oxoglutaric acid 21.1834 18.1167 19.8528 26.5367 18.2608 39.8420 34.6376 25.8762 25.4677 alpha-Ketoisocaproate (KIC) Ketoleucine 27.3385 26.3594 30.1034 28.7876 20.1030 29.0145 18.7481 20.7459 26.4313 alpha-Ketoisovalerate (KIV) Ketoisovaleric acid 23.7740 23.7882 22.9965 21.0837 20.8479 22.8760 22.3327 21.3644 22.9569 Aminoadipate Aminoadipic acid 20.7381 14.9965 30.7643 19.1134 26.8241 18.1138 27.1147 17.9803 31.4674 Arachidic acid (Eicosanoic acid) Arachidic acid 29.7021 33.8373 22.4316 22.8851 22.5590 16.7822 27.6603 23.9604 26.0966 Arachidonate Arachidonic acid 24.8692 24.1814 25.4780 27.5788 22.4140 28.4691 28.0119 25.1150 21.9226 Asparagine Asparagine 27.3919 19.7678 32.1859 25.0661 25.2582 29.4259 24.8179 26.8948 22.1843 Aspartate Aspartic acid 21.0909 21.6268 24.6514 16.6750 25.9389 29.2265 18.9788 20.9257 34.1754 beta-Alanine beta-Alanine 26.9919 30.4145 30.0653 27.4688 17.1214 25.2199 18.6178 29.5736 28.1197 beta-Hydroxy beta-Methylbutyric acid (HMB) 3-Hydroxyisovaleric acid 23.4866 23.0033 29.3711 29.9860 23.3225 36.5096 17.7445 32.5342 26.5553 beta-Hydroxybutyrate (3-Hydroxybutyrate) 3-Hydroxybutyric acid 24.4501 13.6027 29.6390 36.0391 15.4684 25.3642 23.8049 31.0635 36.2525 Cholesterol Cholesterol 22.6049 24.5532 25.2951 28.2047 25.4708 27.7717 25.8639 24.3508 21.6765 Citraconate Citraconic acid 27.6426 20.8386 15.8567 19.7968 39.3408 18.8110 34.9678 26.2301 22.0407 Citrate Citric acid 21.4077 18.8161 25.8096 24.6205 22.7807 30.7287 36.8885 23.9656 21.6912 Citrulline Citrulline 36.2632 28.5961 23.8116 29.3514 46.6284 26.2584 50.7307 35.4456 24.7535 Cysteine Cysteine 26.1008 24.4878 28.8953 30.0135 25.6359 23.2873 26.6502 27.1502 24.1522 Dihydroxyacetone phosphate (DHAP) Dihydroxyacetone phosphate 14.4387 21.7030 18.4121 17.3349 37.7834 16.6703 28.4426 18.5816 13.9825 Fructose Fructose 19.8562 27.0658 43.8457 32.8206 38.6055 21.7195 31.0844 26.4947 22.4503 Fructose 6-phosphate Fructose 6-phosphate 10.3689 46.4009 54.3205 22.5939 28.4335 20.7321 21.3154 15.4704 14.3954 Fumarate Fumaric acid 22.7496 23.4465 26.8240 19.6429 29.6475 28.9338 31.0118 21.9649 28.2777 Gamma-aminobutyric acid (GABA) gamma-Aminobutyric acid 22.1804 23.4301 28.2191 29.3717 22.6869 31.0477 28.2686 31.7145 16.0801 Glucose Glucose 22.5579 26.6644 20.6518 20.3743 39.7056 24.6867 33.0924 16.4198 30.4575 Glucose 6-phosphate Glucose 6-phosphate 10.8640 43.4350 57.2779 24.5957 29.3981 21.9621 20.7927 14.9161 13.3459 Glutamate Glutamic acid 22.2428 13.9973 28.4877 23.4030 26.0098 19.8032 30.5104 26.0209 30.2454 Glutamine Glutamine 24.6910 19.0829 26.6134 27.8858 22.8653 22.8564 24.1792 30.1206 29.2560 Glycerate Glyceric acid 22.3110 30.1826 28.5542 23.4293 29.5366 22.5291 32.0803 22.9275 22.7136 Glycine Glycine 26.1360 26.4614 27.0225 32.2180 19.0590 28.1979 20.0396 28.5878 22.2632 Guanine Guanine 23.6589 44.2628 23.2792 26.4387 19.3254 27.0558 25.5172 20.3934 23.9065 Heneicosylic acid (Heneicosanoic acid) Heneicosylic acid 38.2967 30.2898 22.2882 18.7755 17.3408 18.1766 23.7825 41.7249 22.2759 Heptadecanoic acid Margaric acid 23.7671 28.2625 25.7187 27.8110 20.3858 29.7779 25.7434 26.5731 23.5805 Histamine Histamine 22.1924 25.0206 33.3119 17.2403 20.1727 24.7982 22.2906 20.7615 23.6867 Histidine Histidine 26.3471 18.7411 33.8476 18.8685 16.4984 19.7355 23.8727 19.4637 25.7605 Homoserine Homoserine 25.4536 18.5076 23.8045 20.6482 25.3770 21.0512 31.8094 24.0103 23.1091 Hypotaurine Hypotaurine 21.3841 18.3850 26.0915 21.6067 23.8617 40.5356 29.7294 20.5456 15.0988 Hypoxanthine Hypoxanthine 24.4938 27.5067 29.5709 26.8935 24.3601 25.6548 24.4527 24.4523 26.2690 Inosine Inosine 25.6180 26.4265 27.3114 30.8621 22.7760 29.7217 20.3719 26.6999 26.5406 Inotisol 20.9371 20.7301 27.9403 27.9078 30.4992 21.8942 28.0303 17.8746 24.4884 Isocitrate Isocitric acid 19.0161 20.4234 23.7399 24.4791 25.5379 30.3643 33.8348 22.6988 22.7546 Isoleucine Isoleucine 27.5091 18.1244 30.2861 31.0859 22.0852 20.3646 18.1768 28.7146 33.1173 Lactate Lactic acid 16.7383 47.1889 38.3524 14.1085 26.8481 24.6549 26.9735 14.5156 25.2320 Lauric acid Lauric acid 31.2788 20.4844 21.4258 24.8554 36.9622 22.5827 32.6749 32.2873 26.6336 Leucine Leucine 26.8611 16.9663 30.4901 30.6139 21.3799 19.7581 16.5462 25.6124 32.7664 Linoleate Linoleic acid 23.1948 25.6022 26.9811 28.2115 29.3903 26.9833 33.0211 26.1572 25.6509 Linolenic acid Octadecatrienoic acid 25.9350 24.7065 25.3370 22.9296 16.4268 27.1532 21.1697 20.5228 21.0838 Lysine Lysine 21.4640 17.2468 23.6182 26.0082 30.9373 22.4014 42.9051 18.6506 23.6864 Malate Malic acid 22.4640 21.3267 27.6063 17.8198 31.0173 30.4390 32.0935 20.6529 28.9877 Mannose Mannose 33.6304 27.3140 25.3508 25.8916 33.6900 23.7475 29.3193 23.8976 26.8777 Methionine Methionine 25.7791 18.9092 22.3073 21.1696 27.7635 26.3838 29.0244 21.1554 22.1881 Myristic acid Myristic acid 29.6985 35.4624 33.1972 34.4682 15.4561 28.6744 18.0663 33.4407 26.3865 N-Acetylglycine N-Acetylglycine 31.4192 14.1137 17.3507 10.7919 19.3313 12.7609 30.6294 25.6309 32.8596 N-Acetylmethionine N-Acetylmethionine 14.4762 27.1470 20.6277 29.5248 13.3719 32.6291 13.4797 16.1647 18.7347 N-Acetylserine N-Acetylserine 29.8492 16.9912 27.6179 22.3128 27.0466 21.3065 34.1325 30.1137 23.7458 Oleic acid Oleic acid 20.8497 22.5178 24.0339 25.8078 27.1265 26.5502 26.9020 23.5269 22.1963 O-Phosphoethanolamine Phosphoethanolamine 22.3583 23.1232 26.7006 28.2150 26.0390 26.9885 27.8247 22.5898 23.2293 O-Phosphoserine Phosphoserine 24.2498 25.4473 23.8926 24.0799 20.7923 37.7203 23.4658 24.6529 23.2863 Ornithine Ornithine 26.6115 22.6569 29.9769 26.2302 24.0803 30.1863 30.3454 27.1349 23.6197 Orotate Orotic acid 17.5737 19.0538 24.7459 23.0925 21.4780 10.4967 19.9003 19.1160 17.1308 Palmitate Palmitic acid 26.1317 26.4344 27.8361 30.6410 20.2817 28.2888 20.5271 28.5154 26.4744 Phenylalanine Phenylalanine 25.3284 20.0364 28.8100 27.2225 20.5454 24.3523 22.2381 25.0578 25.2499 Phosphoenolpyruvate Phosphoenolpyruvic acid 25.1081 27.3193 24.9066 26.2995 27.4215 26.1683 28.6907 26.4108 24.4330 Proline Proline 28.5186 12.3294 29.3720 23.3450 25.3930 20.6706 26.6343 31.1998 26.9149 Pterin Pterin 18.6551 18.2287 39.1870 24.2849 28.7987 22.0069 29.3968 19.2171 23.1084 Pyruvate Pyruvic acid 14.8646 45.9766 35.6212 15.4074 23.0460 24.9519 18.2492 15.8149 23.3337 Ribose Ribose 22.0356 28.2369 25.0911 27.9903 22.1983 21.2635 24.8093 27.6510 22.4746 Ribose 5-phosphate Ribose 5-phosphate 19.5833 29.1270 32.1965 28.7784 27.6389 21.0124 28.1885 26.8382 19.6743 Sedoheptulose 7-phosphate Sedoheptulose 7-phosphate 25.6703 44.2824 29.5611 37.5471 41.4718 23.6823 35.8133 36.1124 20.1075 Serine Serine 27.4501 22.6447 25.5353 23.4146 24.1353 25.4450 27.4969 24.4941 22.8593 Sphingosine Sphingosine 23.1852 25.8101 29.2501 27.9958 24.3048 26.9697 24.0535 22.6923 25.9652 Stearate Stearic acid 21.2228 23.3705 25.2210 30.4222 25.5356 30.7331 28.0956 23.3265 20.5744 Succinate Succinic acid 18.1506 39.3586 39.0529 18.5470 22.9114 21.7325 21.0040 25.7884 22.0452 Taurine Taurine 25.5639 21.7391 19.8537 20.4787 20.1899 18.6609 24.5673 22.1690 25.4682 Threonine Threonine 25.8103 20.4655 23.1420 22.9710 24.7523 24.5376 31.9257 23.8863 27.7105 Thymidine Thymidine 24.0082 25.5954 25.3557 29.9861 21.6802 30.2944 25.5915 25.1291 19.6703 Thymine Thymine 25.7335 28.6684 31.3922 34.7241 17.9139 27.3505 25.0142 29.7046 20.0786 Tryptophan Tryptophan 23.8400 21.5500 32.5158 29.2493 19.9230 26.8362 23.6709 28.9213 21.3064 Tyrosine Tyrosine 24.7204 24.4815 28.3853 28.4227 22.4891 29.7058 33.3762 21.8892 14.0965 Uracil Uracil 26.0169 22.6658 29.0357 28.1829 21.0487 23.7976 21.2184 28.0093 23.6438 Urea Urea 24.1108 27.7497 29.5122 25.2377 20.0103 25.7508 23.5876 24.9973 32.5936 Valine Valine 24.1784 16.9935 28.2653 25.9371 23.0509 22.6649 22.0712 27.9994 29.1921 Xanthine Xanthine 24.6974 27.4981 31.7949 23.9523 18.2431 23.2483 19.8600 22.7586 30.0346 Xylose Xylose 24.5265 39.8951 42.3960 50.5120 49.2992 29.9066 42.4185 35.5515 31.1756