Metabolite_name RefMet_name 1020 1022 517 520 521 836 516 518 560 823 825 1030 1035 519 563 828 829 1019 1031 1032 1033 515 564 565 567 Factors - Sex:F | Genotype:DJ-1 Knockout Sex:F | Genotype:DJ-1 Knockout Sex:F | Genotype:DJ-1 Knockout Sex:F | Genotype:DJ-1 Knockout Sex:F | Genotype:DJ-1 Knockout Sex:F | Genotype:DJ-1 Knockout Sex:F | Genotype:WT Sex:F | Genotype:WT Sex:F | Genotype:WT Sex:F | Genotype:WT Sex:F | Genotype:WT Sex:M | Genotype:DJ-1 Knockout Sex:M | Genotype:DJ-1 Knockout Sex:M | Genotype:DJ-1 Knockout Sex:M | Genotype:DJ-1 Knockout Sex:M | Genotype:DJ-1 Knockout Sex:M | Genotype:DJ-1 Knockout Sex:M | Genotype:WT Sex:M | Genotype:WT Sex:M | Genotype:WT Sex:M | Genotype:WT Sex:M | Genotype:WT Sex:M | Genotype:WT Sex:M | Genotype:WT Sex:M | Genotype:WT 1-methylimidazoleacetate Methylimidazoleacetic acid 155546 98034 174569 152993 144318 148082 120732 138409 152420 151275 154091 140801 135656 158879 159138 158382 147310 114713 107317 117491 134438 117363 136637 106610 137258 1-oleoylglycerophosphocholine (18:1) LPC 18:1 19332 44573 37423 45111 90207 40904 24086 28543 91502 123456 56726 51656 29574 36962 19810 39245 34311 38750 71038 63485 73530 47550 76687 70166 42406 1-palmitoylglycerophosphocholine (16:0) LPC 16:0 65125 147811 112261 147766 320635 122601 86118 114092 268688 315904 193544 151869 87581 118767 63177 141072 131739 136079 251636 212966 180185 111788 194981 247697 149505 1-stearoylglycerophosphocholine (18:0) LPC 18:0 15398 31511 36941 96505 23471 15809 29277 57599 146743 36909 24512 28057 19793 48843 38421 34527 45916 39446 61855 18156 60375 56000 32389 2-arachidonoylglycerophosphocholine* LPC 20:4 16119 21028 26964 19615 65239 31499 20402 35304 43202 32302 29087 30183 15640 19892 24046 21157 27229 39129 29845 25372 22404 47806 21927 2-docosahexaenoylglycerophosphocholine* LPC 22:6 26758 42719 17370 18485 28619 38386 32459 21192 21408 29230 27987 19525 48170 25356 19396 27900 34460 25757 2-methylbutyrylcarnitine (C5) CAR 4:0;2Me 55232 30454 35700 69525 53626 59173 54868 56838 77493 70374 64126 59431 70553 68097 50844 61842 54176 67533 48526 74856 55147 60433 64069 63592 56203 2-oleoylglycerophosphocholine* LPC 18:1 17885 48170 48835 47906 152739 49354 29995 41684 92045 141985 80507 53733 37958 44596 28726 49082 51807 61565 96863 101588 112244 59562 75218 103758 51209 2-palmitoylglycerophosphocholine* LPC 0:0/16:0 13869 27053 20337 25533 80998 26185 20934 21255 43342 90660 47873 42831 32457 28335 21485 45156 38312 25644 42112 60029 21729 47074 54123 27488 3-dehydrocarnitine* 3-Dehydrocarnitine 1172286 1004476 821476 1002364 842243 788046 910249 1049630 1251505 964168 928074 736960 767978 788315 748530 850706 780616 709990 702810 766593 626456 668991 729743 686165 730089 4-guanidinobutanoate 4-Guanidinobutanoic acid 137274 125869 171005 230632 173376 130494 145780 170509 186277 152862 136074 186507 126399 119467 113297 161314 192732 132821 161747 194971 143900 113610 158667 119522 195390 5-aminovalerate 5-Aminopentanoic acid 167216 102210 184337 160472 135214 117329 143098 186191 138145 191494 235997 162429 196542 202187 87335 172688 105794 80447 104586 74523 161941 132268 124988 157256 134626 5-hydroxyindoleacetate 5-Hydroxyindoleacetic acid 21008 22760 19966 27404 18307 25549 21660 22215 23939 22671 19825 26845 20473 29996 24202 13667 16263 14044 17533 15664 17972 5-methylthioadenosine (MTA) 5'-Methylthioadenosine 76098 82627 86482 79397 72772 73052 78425 69851 79809 62131 82807 87531 83781 70723 62654 67289 74935 81019 80871 78808 75594 82262 71161 74962 76392 acetylcarnitine CAR 2:0 2440178 2686300 2614991 2983765 2666766 2788362 2659527 2541435 2907830 2822530 2433567 2395747 2496054 2401788 2262734 2557130 2230532 2307443 2375817 2473363 2467888 2277056 2301550 2362502 2564626 acetylcholine Acetylcholine 344652 370283 514833 380405 451648 315153 340435 332405 433729 364509 332738 391726 345299 252239 355434 399141 397737 328599 371653 424457 290876 260886 319785 299988 358036 adenosine Adenosine 31300666 32384406 34012520 30758792 35312136 34842472 33807528 32920632 37550036 31851838 33641348 34297604 34514408 35293596 34208216 32512828 34881552 33661340 37530936 38366244 34209768 35033308 31500184 33502540 34192060 adenosine 5^-monophosphate (AMP) AMP 1707828 1704759 2687117 1827612 2020298 1653128 2306526 1813441 2090801 1892682 1692109 1570175 1954343 1409005 1678742 1842154 1645486 1669711 1968661 2326410 3138971 1577305 1716091 1683878 1683262 arginine Arginine 457999 538423 369802 498975 383704 430377 481449 422469 472903 408490 466106 463707 419648 426284 472692 453952 441054 428489 471905 420155 395304 412386 574750 379719 502334 beta-hydroxyisovaleroylcarnitine CAR 4:0;OH,Me 165681 139601 135836 138820 126510 134932 129520 132284 140621 135650 154147 131756 143412 104143 117526 109609 101072 154878 135530 142654 147057 121463 106444 137921 124291 betaine Betaine 634874 485148 599372 671100 538893 568387 623002 534269 574981 608500 509759 540372 548810 653846 562880 523044 489891 476971 529688 590681 458550 504356 493173 448173 504624 butyrylcarnitine CAR 4:0 138828 110346 107576 172823 120577 143292 134270 164484 151268 156336 155126 111358 105600 121386 89051 117570 86245 151310 121906 136993 184089 131490 141856 148143 143099 carnitine Carnitine 1596618 1490202 1401586 1734048 1493376 1333276 1409872 1484948 1818491 1536477 1476577 1418175 1298206 1288987 1387564 1196560 1484113 1562301 1793300 1519967 1323051 1438200 1432188 1375087 1504987 C-glycosyltryptophan* C-Glycosyltryptophan 142009 130507 162102 148857 160165 166177 159285 158674 164980 156161 152544 172408 158950 154907 146806 155430 148812 151038 154658 161068 144359 147736 147859 132819 150611 choline Choline 2793467 3306781 2748980 2794920 3460643 2990480 3229312 2298193 3476209 2807638 4077182 3155734 2583985 3268994 2633812 3165604 2933466 3416223 2855652 3169744 2456251 2096603 3503040 2382115 3046722 choline phosphate Choline phosphate 2478687 2343812 1968585 2224616 2271858 2373146 2161257 2033803 2218908 2103524 2313588 2273473 2096927 2284551 2188006 2217391 2355826 2201672 2133676 2132765 2007132 2176580 1998621 2077899 2112494 citrulline Citrulline 61888 64367 48969 57342 59440 57461 55202 57312 66674 43980 55042 58764 59372 55808 70032 55676 49458 62636 60639 48122 48374 52340 54893 58473 48410 creatine Creatine 95098576 116162584 111515088 129166472 132156760 103887344 121007376 118650992 119903472 108667024 110717224 132114472 105160992 127219016 117500600 126707968 107901160 117821688 121717056 121445032 111661896 135706320 122116560 108062112 122411592 creatinine Creatinine 390287 377190 367885 425907 317222 366223 322019 352415 429298 336965 375214 365605 349281 352811 337523 356395 346297 438021 382007 347838 433222 338838 311530 380393 404688 cysteine-glutathione disulfide S-Glutathionyl-cysteine 148770 163106 147261 167381 151658 168469 147977 151919 169390 187858 195174 141974 141271 186164 140050 136693 153400 154277 140944 128466 99216 127897 152329 131449 179149 cytidine Cytidine 368457 362690 317363 311637 411097 336120 366429 332566 368399 333618 357993 425912 355432 354985 296539 337304 330577 350295 357173 371174 317531 309977 334802 335436 362243 cytidine-5^-diphosphoethanolamine CDP-Ethanolamine 105448 93293 98220 81502 75250 91111 102479 89960 82473 97852 103036 90442 99463 83084 90028 78871 89904 77483 75013 93922 75644 87311 93462 77854 101208 cytidine 5^-monophosphate (5^-CMP) CMP 123179 81888 142999 103361 129459 104498 150177 129402 124870 114483 99457 126942 113767 98451 111696 112266 88890 115396 113598 133309 134371 119143 114356 122327 104238 ergothioneine Ergothioneine 183938 177217 169658 167760 181064 178402 162621 165077 234585 227545 192662 174627 207301 161174 193627 199335 192262 196214 201097 209764 232887 146004 191555 203415 207012 gamma-glutamylglutamate gamma-Glutamylglutamic acid 1183161 1147451 1056484 1127912 1181747 1051578 1039473 936978 1144176 1077136 1211806 1267553 1036185 1145103 1013923 958168 1199840 1004090 1031293 1009527 745984 846629 1045576 922329 1022999 gamma-glutamylglutamine gamma-Glutamylglutamine 289467 327292 338858 324601 334641 292730 302881 317651 357179 325482 328831 300007 315022 314778 310059 311594 305730 307497 310638 331646 294498 243245 320668 324129 333534 gamma-glutamylleucine gamma-Glutamylleucine 19097 16289 22242 26931 19867 23635 23735 20901 20704 24530 26096 23521 15730 23028 21880 17034 27681 17791 19278 21371 19316 19267 glutamate Glutamic acid 15797459 14795468 14675310 14605950 15919563 15129082 15370374 14120694 15621727 13746282 13793159 14726848 14204983 14380675 14711857 15568413 14540250 13746604 15465014 14461797 13916527 13897703 13313735 13952296 13966792 glutamate_ gamma-methyl ester Glutamic acid, gamma-methyl ester 61349 89817 73296 95241 80539 58451 64834 67094 122066 75442 85739 115036 94470 84021 54857 85407 104376 75254 92411 98086 112539 74861 89029 61086 69567 glutamine Glutamine 16484486 17192802 17072074 16947116 17758436 16458691 17148616 17206332 19632198 16345949 17151180 16793634 16703608 16132605 17215472 16609231 18046640 17610402 18732030 16950976 18111206 16426924 16078866 16864634 16172067 glutarylcarnitine (C5) CAR 5:0 151811 157541 147777 143922 164540 77348 156939 124787 133871 158251 157342 125158 90831 105841 98543 116383 82348 134434 112015 122747 101834 86446 101172 71630 91214 glutathione_ oxidized (GSSG) Oxidized glutathione 2157263 1686512 2157155 2666363 2371873 2641122 2442975 2143355 2342754 2125830 2053186 2652166 2412792 2859486 2173303 2630453 2653716 2550690 2621522 2326262 2323272 2372901 2020873 2279771 2369174 glutathione_ reduced (GSH) Glutathione 5296767 6167525 5642378 3357189 5091950 3334854 4265441 4310262 5048487 5111107 5365820 4404558 4356688 3075920 5272800 3989999 3621528 3370613 4794887 4756097 4464309 4390600 4767303 4259264 3943854 glycerophosphorylcholine (GPC) sn-Glycero-3-phosphocholine 4774610 4545046 4884743 5140748 4962932 4759798 4371426 4588906 5025784 4392823 4270432 4303354 4599258 4284696 4787969 5100186 5045615 4176003 5010367 4385968 4903269 4848931 4474929 4918389 4845044 glycylleucine Gly-Leu 50725 32047 37105 46486 37438 38841 46351 40968 32766 44451 62475 43078 43490 43299 74040 30716 26793 45137 27559 45435 47648 30798 26275 38449 46060 guanosine Guanosine 870950 891472 894038 1046041 1045164 1103930 992948 1075150 1031381 984595 905059 989423 1039556 1023495 994889 1052048 920237 1018571 1086839 980599 935259 936527 983506 1039617 1092971 guanosine 5^- monophosphate (5^-GMP) GMP 98704 103194 155984 124854 111602 111982 152529 104380 106119 94469 80110 70895 98832 61585 103360 109159 77400 87010 104470 129850 199833 79675 68778 101350 84076 homostachydrine* (S)-Homostachydrine 50497 41191 45109 46890 51788 46780 26766 34689 48592 45239 45905 52486 52044 75105 42509 39480 66343 44851 56819 62250 33896 34510 61769 42481 48679 hydroxybutyrylcarnitine* CAR 4:0;OH 5900 22909 27538 18816 17579 32855 11687 26237 26781 22903 34155 25676 29471 15409 27040 11333 28697 6083 31533 32830 12231 20456 isobutyrylcarnitine CAR 3:0;2Me 52029 41336 45941 73345 43783 59874 71272 59058 89380 76443 59922 66471 46588 48579 40912 55739 53207 59305 55544 60780 50198 60119 63117 53443 75960 isoleucine Isoleucine 2519598 2192480 2118499 2383976 2461859 2488603 2283352 2417516 2600933 2342793 2413983 2649159 2583426 2962492 2213231 2356788 2333752 2615908 2546554 2304007 2321007 2262787 2482091 2295134 2566919 isovalerylcarnitine CAR 4:0;3Me 92149 76575 70044 82195 75226 71951 87872 68496 113935 105022 91529 95848 87092 62764 62631 74440 85650 116410 111275 110480 81906 91489 80639 95891 97665 leucine Leucine 4827964 4049480 3831601 4137421 4310483 3946902 4020616 3993916 4912859 4429689 4313801 4906394 4237163 5128634 3695522 4183132 3872432 4626527 4803408 3705907 4013504 4114436 4208761 4081571 4365576 lysine Lysine 501555 431545 432789 427427 360826 353748 397704 498414 472972 468366 424273 466850 439881 358901 309756 366879 393484 369163 379231 416473 364565 350973 454726 373512 399133 methionine Methionine 1361873 1440762 1263961 1539347 1336990 1530071 1392920 1514154 1474007 1507314 1586916 1502845 1292285 1370152 1169015 1339690 1371257 1455420 1413243 1364966 1299903 1386638 1386180 1260034 1382693 methyl-beta-glucopyranoside 84696 89406 56667 73429 72123 85847 60419 52192 68566 64054 51127 115140 99958 59580 68989 80084 75197 140364 113475 101033 105244 27218 71994 70317 90489 N1-methyladenosine 1-Methyladenosine 49524 25876 31791 36104 37438 29489 37163 37336 45257 37844 38005 31366 33968 34982 37768 42396 27464 40343 39291 32514 36358 47069 49397 31734 29279 N-acetylaspartate (NAA) N-Acetylaspartic acid 7450053 7308364 7844572 7985443 8175541 8313242 7610326 7732305 8694147 7758353 7539892 7720496 7976395 8121082 8276361 8164976 7542220 7821352 7567221 7723726 8111751 7579496 7323824 7957859 7559374 N-acetyl-aspartyl-glutamate (NAAG) N-Acetyl-Asp-Glu 1066373 1027410 1101483 1363442 1076676 987109 1001113 1123935 1184809 1123058 1058011 1127905 1056936 1078836 1080845 1082062 1135193 1013627 1157269 1020162 1054643 1096102 1091152 1033417 1113374 N-acetylglutamate N-Acetylglutamic acid 158996 141738 171688 169981 196417 178509 153800 167315 215527 201779 231208 179007 171847 163009 204730 182331 158322 179725 182032 197675 174555 202204 186922 204792 158228 N-acetylglutamine N-Acetylglutamine 79100 72285 90428 95951 87660 96301 100569 87609 85574 90534 89655 88918 71757 115097 72875 97145 85859 84334 76621 95140 92940 98362 104350 64635 117590 N-acetylneuraminate N-Acetylneuraminic acid 231350 237349 216061 218004 251665 202990 233509 201819 238916 231440 214054 214811 213702 233453 207980 229096 229293 199754 193554 211711 244934 233226 214226 218732 235259 N-delta-acetylornithine* N(5)-Acetyl-ornithine 93475 62396 86477 79274 99218 128695 65642 61961 85342 96534 69268 82605 95617 115781 101888 92846 64606 76375 100991 83650 120453 101101 107182 98466 99611 nicotinamide Niacinamide 8184045 9952087 9861179 9927185 9941165 7629846 9833859 9790787 10917135 9995901 9373467 8426919 7752381 8456485 9562083 10088647 9031628 7500412 9907351 7789274 10705017 8627461 8714954 9064799 9675206 nicotinamide adenine dinucleotide (NAD+) NAD 55002 43124 40356 44529 61087 41891 36990 37678 47180 42732 44618 53752 47959 54740 34869 53787 44914 44406 45467 30217 44783 45150 52947 37587 40967 ophthalmate Ophthalmic acid 40674 28585 33820 35577 26301 23505 29509 46480 36207 25044 23762 19816 19040 21671 23788 25593 16348 20677 21186 20104 21006 18248 18023 18839 16736 pantothenate Pantothenic acid 1124197 1057635 1100908 1152855 1074282 772455 1074168 1084099 1250004 1157968 1205419 781970 901878 838767 758668 697846 770741 910634 958268 864957 906639 845693 803420 859210 883840 phenylalanine Phenylalanine 4117689 4017213 3997336 4234347 4076970 4543588 4326800 4710112 4960295 4159994 4864751 4745063 4353709 4977068 4012755 4603363 4501100 4153806 4072737 4264863 3963621 4393439 4523047 4262033 4642856 pipecolate Pipecolic acid 98964 72060 131985 135783 187310 340952 146068 188519 158691 138266 127606 378593 188548 242652 168702 378445 306918 209703 270015 242699 195560 237073 201451 188499 178262 proline Proline 1936419 1718275 1670291 1869788 1831263 1927322 1919043 1927980 1855617 1927083 1871376 1949168 1752742 2135249 1628922 1899192 1888306 2054491 1755603 1954024 1734155 1739673 1692217 1709534 1718079 propionylcarnitine CAR 3:0 273728 215334 183619 346316 289525 342092 309854 393818 246265 358705 281504 266957 200294 349794 227022 230281 181623 303527 267884 285771 299435 331438 288928 249541 254939 pyridoxal Pyridoxal 65005 57606 56018 85666 77017 77703 47080 24860 40572 54796 50189 53544 49006 108340 69226 60735 43932 83860 52253 43508 50740 68092 45453 57608 54610 pyroglutamine* Pyroglutamine 601259 646620 504624 578998 627697 608365 622256 533480 675679 544433 515539 662452 683935 646623 576596 598482 598796 540955 669425 575613 596728 582268 575543 528770 609958 riboflavin (Vitamin B2) Riboflavin 17007 12504 13297 17316 14015 13933 13753 20644 13065 21755 12790 11898 32548 8202 18649 16651 17637 16301 13583 12961 14286 15670 spermidine Spermidine 603448 610442 471506 645075 581514 481199 481054 540947 698374 546925 545079 637020 601462 522676 547711 524949 604942 470181 577346 536076 519086 555746 597856 479447 538479 stachydrine Stachydrine 147835 97865 177790 224142 205859 158210 171656 139054 147876 148165 105483 158967 132631 251013 129066 131691 180956 151604 145419 112913 79576 136583 137316 160932 169611 threonine Threonine 556425 543607 524485 562954 556611 509813 588250 505021 552843 513747 534280 447998 422181 512620 386036 519187 439103 438524 477105 397170 427271 494730 480698 455443 399842 tryptophan Tryptophan 1265090 1129432 1073325 1394648 1216947 1259217 1489760 1623020 1496845 1177231 1341207 1217414 983263 1259844 1094939 1260416 1183266 1005875 964839 1011441 1025257 1138871 1113866 1006895 1149546 tyrosine Tyrosine 2113956 1964123 1393570 2437022 1565791 2597671 2599479 2150896 2018429 2565078 2787854 2228348 2278028 2500494 1680517 2579675 2491793 2115883 1991081 2535410 1922920 2172760 2232148 1888144 1923718 valine Valine 2961667 2829005 2723437 3115654 2944146 3246620 3072449 2998866 3544848 3348191 3293138 3357483 2868945 3519269 2875723 3317666 3113005 2905004 3011892 2916553 2849261 3005005 3236476 2848862 3001672 xanthine Xanthine 1435296 1422257 1133983 1361890 1431945 1372483 1303840 1395024 1427954 1393899 1511055 1534332 1295784 1571411 1357619 1391273 1707960 1471481 1508937 1313442 1004854 1349998 1481301 1357181 1474710