Metabolite_name RefMet_name Inj02_Kid Met_5 Inj04_Kid Met_1 Inj07_Kid Met_2 Inj09_Kid Met_3 Inj19_Kid Met_4 Inj06_Liv Met_2 Inj11_Liv Met_5 Inj13_Liv Met_3 Inj18_Liv Met_1 Inj20_Liv Met_4 Inj01_Kid Sal_1 Inj03_Kid Sal_5 Inj12_Kid Sal_2 Inj15_Kid Sal_4 Inj17_Kid Sal_3 Inj05_Liv Sal_3 Inj08_Liv Sal_4 Inj10_Liv Sal_1 Inj14_Liv Sal_5 Inj16_Liv Sal_2 Factors - Treatment:Metformin | Organ:Kidney Treatment:Metformin | Organ:Kidney Treatment:Metformin | Organ:Kidney Treatment:Metformin | Organ:Kidney Treatment:Metformin | Organ:Kidney Treatment:Metformin | Organ:Liver Treatment:Metformin | Organ:Liver Treatment:Metformin | Organ:Liver Treatment:Metformin | Organ:Liver Treatment:Metformin | Organ:Liver Treatment:Saline | Organ:Kidney Treatment:Saline | Organ:Kidney Treatment:Saline | Organ:Kidney Treatment:Saline | Organ:Kidney Treatment:Saline | Organ:Kidney Treatment:Saline | Organ:Liver Treatment:Saline | Organ:Liver Treatment:Saline | Organ:Liver Treatment:Saline | Organ:Liver Treatment:Saline | Organ:Liver 2-Aminobenzoic acid 2-Aminobenzoic acid 177267 234805 307789 302382 239810 235019 110489 192091 214790 243019 206130 227503 215351 215865 115704 92622 105065 114865 223748 208407 Acylcarnitine (C2:0) CAR 2:0 2963201 2256979 5689386 6128560 6142862 40176 46488 76505 91186 58760 3057598 4190516 2257984 4965413 1843135 212636 99855 79301 203705 214671 Acylcarnitine (C3:0) CAR 3:0 1073042 1861374 1464259 1208306 1149839 65158 39191 122185 224925 76878 310450 1726932 282886 1462412 189193 448984 98188 143177 160975 236758 Acylcarnitine (C4:0) CAR 4:0 53872 95599 57920 42193 144810 13532 12359 14547 26117 11940 66810 107863 94730 36010 50247 26948 12544 20571 39842 25348 Arginine Arginine 539775 296549 348304 369495 389957 4931 4128 6296 4529 5832 484067 438399 449902 372706 200642 7177 5663 8080 4819 5384 Creatine Creatine 2575708 2723559 2348455 2227557 2292174 1310417 1124783 1239875 1747526 1404825 2209961 2769658 2446914 2253373 1991563 1375101 1034059 1180325 1427944 1491500 gamma-Butyrobetaine 3-Dehydroxycarnitine 34148 56426 54662 45840 65119 38563 26279 35237 37014 26818 47076 37787 37520 40585 32818 23610 23715 22267 23531 25795 Glutamic acid Glutamic acid 1185431 959948 1202142 1127508 1019410 175283 149092 111940 335944 230674 1120746 1253484 1209036 1378184 721225 167054 156556 160055 177385 156421 Hypoxanthine Hypoxanthine 1887206 1774943 1592810 1523331 1723034 556519 497578 543375 896939 633953 2147330 2222660 2307587 1508313 1263009 461200 460379 481882 615663 510631 LPC(16:1) LPC 16:1 32450 28486 23802 26084 28103 149622 154373 163856 329026 233469 48697 36149 39924 47163 35201 283229 190205 299679 312060 228312 LPC(20:3) LPC 20:3 110646 35543 100111 88064 103064 215057 268034 283385 290172 311576 43902 58877 95900 110811 78117 239021 146621 336896 219442 209351 LPC(20:4) LPC 20:4 448417 403128 342086 260879 375974 1009483 1240347 1130553 1539297 1424419 463660 595284 406621 423715 297591 1028235 651354 1345394 1140261 991306 LPC(22:5) LPC 22:5 116578 89071 81161 80759 70525 145975 171241 164713 144472 207126 33466 162370 82627 110592 54884 54781 80566 183318 58994 129110 LPC(22:6) LPC 22:6 1297363 951583 915444 924621 747718 1656482 1888318 1745436 1632929 2061253 993298 1743861 939630 1223360 645222 1458159 844297 1978820 1530543 1444271 LPE(20:4) LPE 20:4 383141 253182 239398 226317 232532 263073 242810 261085 392811 349902 308676 436097 267213 271111 177070 268065 160350 297080 305951 260380 LPE(22:6) LPE 22:6 324381 209558 196338 241198 152318 219639 197069 190705 224991 275973 191817 339022 197855 241146 119732 196834 94695 231662 222488 201291 Lysine Lysine 118317 42010 64107 70107 69791 33752 38891 24899 78633 74611 114296 76125 86921 64898 25597 60577 26883 95776 65011 30034 Methionine Methionine 416361 327727 288038 285358 253187 118208 93367 98489 153678 131138 360448 454777 440118 274783 168630 126321 84545 124895 93672 102077 N6_N6_N6-Trimethyl-L-lysine N-6-Trimethyllysine 107235 80238 107291 126036 142777 25679 27753 28487 100488 65813 142613 111857 101271 135478 38454 48951 23148 38729 104665 41420 PE(34:2) PE 34:2 117394 125040 147320 159022 119258 630894 487022 475403 392877 527293 125274 130627 140691 138629 152252 583479 515425 584296 620696 664952 PE(38:6) PE 38:6 81800 97642 71133 82162 86792 18139 16819 18163 27887 22906 78085 80943 63256 88074 65767 22622 21079 20023 22782 19594 Phenylalanine Phenylalanine 1140228 840764 719133 807453 840258 382261 291171 380000 692816 524267 894717 1124900 1081192 782634 521215 476972 304544 475007 471714 470126 SM (d34:2) SM 34:2;O2 373209 232815 359999 467642 305862 14983 15787 19782 23539 19008 284502 291370 325931 385295 329232 20210 30793 20565 17999 18379 SM (d36:1) SM 36:1;O2 2261 2720 3280 2552 13160 8581 10588 9169 12092 2874 2367 2217 4845 12489 13730 15724 12213 13101 SM (d42:2) SM 42:2;O2 28287 37434 38823 61567 24083 80595 36334 51021 33365 55467 39470 23983 47938 30603 75249 85269 76196 99949 60027 73131 SM (d42:3) SM 42:3;O2 63439 64093 76736 118592 52181 24571 14606 21293 20045 23238 69014 60660 100390 70690 106316 30385 29995 35148 22226 25358 TG(50:2) TG 50:2 18544 29349 16713 39533 16844 22010 17897 28478 47816 26175 53893 12970 13888 36529 73045 27251 23783 32854 20882 38360 TG(50:3) TG 50:3 23972 54999 17625 32702 24908 45689 38679 58694 92768 79013 97020 19078 14127 54556 166017 70302 51772 68878 50361 78829 TG(52:4) TG 52:4 80513 169021 69342 114802 80996 489634 434068 546443 614583 604007 323757 62359 43392 201849 523401 620413 352041 497055 390503 698650 TG(54:6) TG 54:6 185589 356498 156086 207729 137207 210294 251293 261308 346530 416357 284307 121301 69675 283543 509605 363357 147867 207042 231600 326117 TG(56:7) TG 56:7 195828 395285 164756 198650 128902 254061 314047 337157 384595 505332 125096 120765 73858 224989 95657 417095 167693 311571 221041 411635 TG(58:8) TG 58:8 94861 199387 80407 83809 63841 59371 102968 96048 132291 144385 63857 59219 32849 107867 49791 138123 43118 72451 64684 109236 Tryptophan Tryptophan 269945 257428 201904 219450 186166 85975 63359 76365 175787 99128 281806 283431 321766 167641 127423 122911 74615 91416 134481 109740