{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002503","ANALYSIS_ID":"AN004112","VERSION":"1","CREATED_ON":"March 9, 2023, 5:33 pm"},

"PROJECT":{"PROJECT_TITLE":"Endothelial Cell CD36 Regulates Membrane Ceramide Formation, Exosome Fatty Acid Delivery to Tissues and Circulating Fatty Acid Levels","PROJECT_TYPE":"MS quantitative analysis","PROJECT_SUMMARY":"Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we visualized FA transfer by ECs using click chemistry. Apical FA interaction with EC CD36 induces actin reorganization, caveolin-1 tyrosine 14 (Cav-1Y14) phosphorylation, and ceramide generation in caveolae, culminating in caveolae internalization into FA/CD36/ceramide vesicles that are secreted basolaterally as small extracellular vesicles, sEVs (exosomes). In transwells, ECs expressing fluorescent CD63 (exosomal marker) transfer FAs to underlying myotubes in CD63-labeled sEVs. In vivo FA-CD63-CD36 transfer from ECs to muscle is shown using a mouse with EC-specific expression of emGFP-CD63. CD36 depletion, actin-binding latrunculin-B, Src inhibition, Cav-1Y14 mutation, and membrane neutral sphingomyelinase inhibition by GW4869 helped map the FA-sEV pathway. Injecting GW4869 to mice reduced muscle FA uptake, raised plasma FAs and lowered glucose, mimicking prominent Cd36-/- phenotypes. The FA-sEV pathway we describe contributes to crosstalk between ECs and underlying cells and links regulation of membrane ceramide to blood FAs.","INSTITUTE":"Washington University in St. Louis","DEPARTMENT":"IM-Nutitrional Science","LABORATORY":"Abumrad Lab","LAST_NAME":"Palacios","FIRST_NAME":"Hector","ADDRESS":"West Building 00201, St. Louis, Missouri, 63110, USA","EMAIL":"hectorp@wustl.edu","PHONE":"314-362-5397"},

"STUDY":{"STUDY_TITLE":"Endothelial Cell CD36 Regulates Membrane Ceramide Formation, Exosome Fatty Acid Delivery to Tissues and Circulating Fatty Acid Levels","STUDY_TYPE":"Membrane ceramide and Fatty Acid Uptake","STUDY_SUMMARY":"Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we visualized FA transfer by ECs using click chemistry. Apical FA interaction with EC CD36 induces actin reorganization, caveolin-1 tyrosine 14 (Cav-1Y14) phosphorylation, and ceramide generation in caveolae, culminating in caveolae internalization into FA/CD36/ceramide vesicles that are secreted basolaterally as small extracellular vesicles, sEVs (exosomes). In transwells, ECs expressing fluorescent CD63 (exosomal marker) transfer FAs to underlying myotubes in CD63-labeled sEVs. In vivo FA-CD63-CD36 transfer from ECs to muscle is shown using a mouse with EC-specific expression of emGFP-CD63. CD36 depletion, actin-binding latrunculin-B, Src inhibition, Cav-1Y14 mutation, and membrane neutral sphingomyelinase inhibition by GW4869 helped map the FA-sEV pathway. Injecting GW4869 to mice reduced muscle FA uptake, raised plasma FAs and lowered glucose, mimicking prominent Cd36-/- phenotypes. The FA-sEV pathway we describe contributes to crosstalk between ECs and underlying cells and links regulation of membrane ceramide to blood FAs.","INSTITUTE":"Washington University in St. Louis","DEPARTMENT":"IM-Nutitrional Science","LABORATORY":"Abumrad Lab","LAST_NAME":"Palacios","FIRST_NAME":"Hector","ADDRESS":"West Building 00201, St. Louis, Missouri, 63110, USA","EMAIL":"hectorp@wustl.edu","PHONE":"314-362-5397"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"5",
"Sample ID":"KO1n_05",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO1n_05.mzML"}
},
{
"Subject ID":"13",
"Sample ID":"KO1n_13",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO1n_13.mzML"}
},
{
"Subject ID":"21",
"Sample ID":"KO1n_21",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO1n_21.mzML"}
},
{
"Subject ID":"7",
"Sample ID":"KO1p_07",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO1p_07.mzML"}
},
{
"Subject ID":"15",
"Sample ID":"KO1p_15",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO1p_15.mzML"}
},
{
"Subject ID":"23",
"Sample ID":"KO1p_23",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO1p_23.mzML"}
},
{
"Subject ID":"6",
"Sample ID":"KO3n_06",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO3n_06.mzML"}
},
{
"Subject ID":"14",
"Sample ID":"KO3n_14",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO3n_14.mzML"}
},
{
"Subject ID":"22",
"Sample ID":"KO3n_22",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO3n_22.mzML"}
},
{
"Subject ID":"8",
"Sample ID":"KO3p_08",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO3p_08.mzML"}
},
{
"Subject ID":"16",
"Sample ID":"KO3p_16",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO3p_16.mzML"}
},
{
"Subject ID":"24",
"Sample ID":"KO3p_24",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_KO3p_24.mzML"}
},
{
"Subject ID":"1",
"Sample ID":"WT1n_01",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT1n_01.mzML"}
},
{
"Subject ID":"9",
"Sample ID":"WT1n_09",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT1n_09.mzML"}
},
{
"Subject ID":"17",
"Sample ID":"WT1n_17",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT1n_17.mzML"}
},
{
"Subject ID":"3",
"Sample ID":"WT1p_03",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT1p_03.mzML"}
},
{
"Subject ID":"11",
"Sample ID":"WT1p_11",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT1p_11.mzML"}
},
{
"Subject ID":"19",
"Sample ID":"WT1p_19",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT1p_19.mzML"}
},
{
"Subject ID":"2",
"Sample ID":"WT3n_02",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT3n_02.mzML"}
},
{
"Subject ID":"10",
"Sample ID":"WT3n_10",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT3n_10.mzML"}
},
{
"Subject ID":"18",
"Sample ID":"WT3n_18",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT3n_18.mzML"}
},
{
"Subject ID":"4",
"Sample ID":"WT3p_04",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT3p_04.mzML"}
},
{
"Subject ID":"12",
"Sample ID":"WT3p_12",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT3p_12.mzML"}
},
{
"Subject ID":"20",
"Sample ID":"WT3p_20",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1a","RAW_FILE_NAME":"HSS_Nada_Exo_Pos_IPA_WT3p_20.mzML"}
},
{
"Subject ID":"1",
"Sample ID":"WT1n_01_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_01.mzML"}
},
{
"Subject ID":"2",
"Sample ID":"WT3n_02_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_02.mzML"}
},
{
"Subject ID":"3",
"Sample ID":"WT1p_03_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_03.mzML"}
},
{
"Subject ID":"4",
"Sample ID":"WT3p_04_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_04.mzML"}
},
{
"Subject ID":"5",
"Sample ID":"KO1n_05_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_05.mzML"}
},
{
"Subject ID":"6",
"Sample ID":"KO3n_06_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_06.mzML"}
},
{
"Subject ID":"7",
"Sample ID":"KO1p_07_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_07.mzML"}
},
{
"Subject ID":"8",
"Sample ID":"KO3p_08_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_08.mzML"}
},
{
"Subject ID":"9",
"Sample ID":"WT1n_09_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_09.mzML"}
},
{
"Subject ID":"10",
"Sample ID":"WT3n_10_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_10.mzML"}
},
{
"Subject ID":"11",
"Sample ID":"WT1p_11_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_11.mzML"}
},
{
"Subject ID":"12",
"Sample ID":"WT3p_12_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_12.mzML"}
},
{
"Subject ID":"13",
"Sample ID":"KO1n_13_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_13.mzML"}
},
{
"Subject ID":"14",
"Sample ID":"KO3n_14_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_14.mzML"}
},
{
"Subject ID":"15",
"Sample ID":"KO1p_15_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_15.mzML"}
},
{
"Subject ID":"16",
"Sample ID":"KO3p_16_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_16.mzML"}
},
{
"Subject ID":"17",
"Sample ID":"WT1n_17_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_17.mzML"}
},
{
"Subject ID":"18",
"Sample ID":"WT3n_18_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_18.mzML"}
},
{
"Subject ID":"19",
"Sample ID":"WT1p_19_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_19.mzML"}
},
{
"Subject ID":"20",
"Sample ID":"WT3p_20_FA",
"Factors":{"Genotype":"Wild-type","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_20.mzML"}
},
{
"Subject ID":"21",
"Sample ID":"KO1n_21_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_21.mzML"}
},
{
"Subject ID":"22",
"Sample ID":"KO3n_22_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Neg"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_22.mzML"}
},
{
"Subject ID":"23",
"Sample ID":"KO1p_23_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_23.mzML"}
},
{
"Subject ID":"24",
"Sample ID":"KO3p_24_FA",
"Factors":{"Genotype":"Knock-out","Treatment":"Pos"},
"Additional sample data":{"Batch":"1b","RAW_FILE_NAME":"Nada_iHILIC_Exosomes_221_PNS_24.mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Samples were collected and aliquots representing the same EV counts were dried under nitrogen, and resuspended in 2:2:1 acetonitrile:methanol:H2O (v/v) (for polar metabolites, eg. fatty acids, phospholipids) or in 100% isopropanol (for less-polar metabolites, eg. ceramides). The samples were mixed on an orbital shaker (360 rpm) for 1 min at room temperature before the LC/MS analysis.","SAMPLE_TYPE":"Cultured cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Myotube Treatment with hMEC Generated FA-sEV: hMECs grown to confluence were serum-starved and treated with OA:BSA (100µM:50µM) or BSA (50µM controls). The sEVs were isolated from media collected over 48h and particle number and protein content determined."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Samples were collected and aliquots representing the same EV counts were dried under nitrogen, and resuspended in 2:2:1 acetonitrile:methanol:H2O (v/v) (for polar metabolites, eg. fatty acids, phospholipids) or in 100% isopropanol (for less-polar metabolites, eg. ceramides). The samples were mixed on an orbital shaker (360 rpm) for 1 min at room temperature before the LC/MS analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1290 Infinity II","COLUMN_NAME":"Waters CORTECS UPLC C18 (150 x 2.1mm,1.6um)","SOLVENT_A":"A: 60% acetonitrile, 40% water, 0.1% formic acid, 10 mM ammonium formate, 2.5 mM medronic acid","SOLVENT_B":"90% 2-propanol, 10% acetonitrile, 0.1% formic acid, 10 mM ammonium formate","FLOW_GRADIENT":"0-2 min, 30% B; 17 min, 75% B; 20 min, 85% B; 23-26 min, 100% B; 26 min, 30% B followed by a re-equilibration phase of 5 min.","FLOW_RATE":".25ml/min","COLUMN_TEMPERATURE":"60","METHODS_FILENAME":"LC_Method.pdf"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","ANALYSIS_PROTOCOL_FILE":"MS_Method.pdf"},

"MS":{"INSTRUMENT_NAME":"Agilent 6545 QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"-"},

"MS_METABOLITE_DATA":{
"Units":"Peak Area",

"Data":[{"Metabolite":"Cer_NS d18:1_16:0","WT1n_09":"436683","WT3n_18":"397224","WT1p_19":"340366","WT3p_12":"492913","KO1n_13":"244860","KO3n_14":"283941","KO1p_15":"213093","KO3p_16":"335666","WT1n_01":"816677","WT3n_10":"860526","WT1p_11":"601445","WT3p_20":"766225","KO1n_05":"651517","KO3n_06":"223202","KO1p_07":"346193","KO3p_08":"278528"},{"Metabolite":"Cer_NS d18:1_24:0","WT1n_09":"150433","WT3n_18":"168294","WT1p_19":"192996","WT3p_12":"141969","KO1n_13":"220404","KO3n_14":"181244","KO1p_15":"239389","KO3p_16":"168299","WT1n_01":"187799","WT3n_10":"217493","WT1p_11":"151574","WT3p_20":"161633","KO1n_05":"157679","KO3n_06":"155507","KO1p_07":"138784","KO3p_08":"167710"},{"Metabolite":"Cer_NS d18:1_24:1","WT1n_09":"247450","WT3n_18":"188562","WT1p_19":"206361","WT3p_12":"254442","KO1n_13":"118290","KO3n_14":"183673","KO1p_15":"136795","KO3p_16":"130475","WT1n_01":"576809","WT3n_10":"529388","WT1p_11":"366819","WT3p_20":"591854","KO1n_05":"159822","KO3n_06":"102759","KO1p_07":"118092","KO3p_08":"122657"},{"Metabolite":"Cer_NS d42:3","WT1n_09":"74072","WT3n_18":"72789","WT1p_19":"102351","WT3p_12":"107438","KO1n_13":"27209","KO3n_14":"34177","KO1p_15":"28912","KO3p_16":"54203","WT1n_01":"237374","WT3n_10":"162916","WT1p_11":"139817","WT3p_20":"221282","KO1n_05":"120199","KO3n_06":"31263","KO1p_07":"52395","KO3p_08":"72284"},{"Metabolite":"DG 16:0_18:1","WT1n_09":"377462","WT3n_18":"713295","WT1p_19":"627262","WT3p_12":"407668","KO1n_13":"285496","KO3n_14":"339213","KO1p_15":"415152","KO3p_16":"263691","WT1n_01":"170210","WT3n_10":"304418","WT1p_11":"541221","WT3p_20":"446983","KO1n_05":"274234","KO3n_06":"284739","KO1p_07":"123593","KO3p_08":"288215"},{"Metabolite":"HexCer_NS d18:1_16:0","WT1n_09":"993997","WT3n_18":"1115497","WT1p_19":"1269004","WT3p_12":"1385576","KO1n_13":"147880","KO3n_14":"144450","KO1p_15":"150161","KO3p_16":"173064","WT1n_01":"4380316","WT3n_10":"2006214","WT1p_11":"1688524","WT3p_20":"2326625","KO1n_05":"1077042","KO3n_06":"169173","KO1p_07":"683420","KO3p_08":"317836"},{"Metabolite":"HexCer_NS d18:1_22:0","WT1n_09":"569006","WT3n_18":"652772","WT1p_19":"767227","WT3p_12":"656451","KO1n_13":"578411","KO3n_14":"815366","KO1p_15":"585326","KO3p_16":"803997","WT1n_01":"666309","WT3n_10":"538052","WT1p_11":"609627","WT3p_20":"602512","KO1n_05":"523966","KO3n_06":"508921","KO1p_07":"479968","KO3p_08":"597695"},{"Metabolite":"LPC 0:0/16:0","WT1n_09":"465058","WT3n_18":"1670035","WT1p_19":"724748","WT3p_12":"993780","KO1n_13":"361605","KO3n_14":"564330","KO1p_15":"398972","KO3p_16":"251320","WT1n_01":"8860413","WT3n_10":"1645537","WT1p_11":"1379905","WT3p_20":"9414150","KO1n_05":"1675615","KO3n_06":"802771","KO1p_07":"1170939","KO3p_08":"996286"},{"Metabolite":"LPC 0:0/18:0","WT1n_09":"780994","WT3n_18":"1718635","WT1p_19":"638180","WT3p_12":"936839","KO1n_13":"438047","KO3n_14":"880436","KO1p_15":"603604","KO3p_16":"325806","WT1n_01":"7585071","WT3n_10":"1561666","WT1p_11":"1396212","WT3p_20":"8843053","KO1n_05":"1557168","KO3n_06":"1088114","KO1p_07":"1102683","KO3p_08":"1197586"},{"Metabolite":"LPC 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"Metabolites":[{"metabolite_name":"Cer_NS d18:1_16:0"},{"metabolite_name":"Cer_NS d18:1_24:0"},{"metabolite_name":"Cer_NS d18:1_24:1"},{"metabolite_name":"Cer_NS d42:3"},{"metabolite_name":"DG 16:0_18:1"},{"metabolite_name":"HexCer_NS d18:1_16:0"},{"metabolite_name":"HexCer_NS d18:1_22:0"},{"metabolite_name":"LPC 0:0/16:0"},{"metabolite_name":"LPC 0:0/18:0"},{"metabolite_name":"LPC 0:0/18:1"},{"metabolite_name":"LPC 0:0/18:2"},{"metabolite_name":"LPC 15:0/0:0"},{"metabolite_name":"LPC 16:0/0:0"},{"metabolite_name":"LPC 18:0/0:0"},{"metabolite_name":"LPC 18:1/0:0"},{"metabolite_name":"PC 14:0_16:0"},{"metabolite_name":"PC 15:0_16:0"},{"metabolite_name":"PC 15:0_18:2"},{"metabolite_name":"PC 15:0_20:4"},{"metabolite_name":"PC 16:0_16:0"},{"metabolite_name":"PC 16:0_16:1"},{"metabolite_name":"PC 16:0_17:0"},{"metabolite_name":"PC 16:0_17:1"},{"metabolite_name":"PC 16:0_18:0"},{"metabolite_name":"PC 16:0_18:1"},{"metabolite_name":"PC 16:0_18:2"},{"metabolite_name":"PC 16:0_18:3"},{"metabolite_name":"PC 16:0_20:3"},{"metabolite_name":"PC 16:0_20:4"},{"metabolite_name":"PC 16:0_22:4"},{"metabolite_name":"PC 16:0_22:5"},{"metabolite_name":"PC 16:0_22:6"},{"metabolite_name":"PC 16:1_18:1"},{"metabolite_name":"PC 17:0_18:1"},{"metabolite_name":"PC 17:0_20:3"},{"metabolite_name":"PC 18:0_18:1"},{"metabolite_name":"PC 18:0_18:2"},{"metabolite_name":"PC 18:0_20:2"},{"metabolite_name":"PC 18:0_20:3"},{"metabolite_name":"PC 18:0_20:4"},{"metabolite_name":"PC 18:0_20:5"},{"metabolite_name":"PC 18:0_22:4"},{"metabolite_name":"PC 18:0_22:5"},{"metabolite_name":"PC 18:0_22:6"},{"metabolite_name":"PC 18:1_18:1"},{"metabolite_name":"PC 18:1_18:2"},{"metabolite_name":"PC 18:1_20:3"},{"metabolite_name":"PC 18:1_20:4"},{"metabolite_name":"PC 18:1_22:6"},{"metabolite_name":"PC 18:2_18:2"},{"metabolite_name":"PC 18:2_20:4"},{"metabolite_name":"PC 31:0"},{"metabolite_name":"PC 33:0"},{"metabolite_name":"PC 33:1"},{"metabolite_name":"PC 34:4"},{"metabolite_name":"PC 36:4"},{"metabolite_name":"PC 37:2"},{"metabolite_name":"PC 37:4"},{"metabolite_name":"PC 38:5"},{"metabolite_name":"PC 38:6"},{"metabolite_name":"PC 40:5"},{"metabolite_name":"PE 16:0_18:1"},{"metabolite_name":"PE 16:0_20:4"},{"metabolite_name":"PE 16:0_22:6"},{"metabolite_name":"PE 18:0_18:1"},{"metabolite_name":"PE 18:0_18:2"},{"metabolite_name":"PE 18:0_20:4"},{"metabolite_name":"PE 18:0_22:4"},{"metabolite_name":"PE 18:0_22:5"},{"metabolite_name":"PE 18:0_22:6"},{"metabolite_name":"PE 18:1_18:1"},{"metabolite_name":"PE 18:1_22:6"},{"metabolite_name":"PS 18:0_20:4"},{"metabolite_name":"PS 18:0_22:6"},{"metabolite_name":"PS 36:1"},{"metabolite_name":"PS 36:2"},{"metabolite_name":"SM d16:1_16:0"},{"metabolite_name":"SM d18:1_18:0"},{"metabolite_name":"SM d32:1"},{"metabolite_name":"SM d33:1"},{"metabolite_name":"SM d34:0"},{"metabolite_name":"SM d34:1"},{"metabolite_name":"SM d34:2"},{"metabolite_name":"SM d35:1"},{"metabolite_name":"SM d36:0"},{"metabolite_name":"SM d36:2"},{"metabolite_name":"SM d37:1"},{"metabolite_name":"SM d38:0"},{"metabolite_name":"SM d38:1"},{"metabolite_name":"SM d38:2"},{"metabolite_name":"SM d39:1"},{"metabolite_name":"SM d40:1"},{"metabolite_name":"SM d40:2"},{"metabolite_name":"SM d41:1"},{"metabolite_name":"SM d41:2"},{"metabolite_name":"SM d41:3"},{"metabolite_name":"SM d42:1"},{"metabolite_name":"SM d42:2"},{"metabolite_name":"SM d42:3"},{"metabolite_name":"TG 14:0_16:0_18:1"},{"metabolite_name":"TG 15:0_16:0_18:1"},{"metabolite_name":"TG 16:0_16:0_17:0"},{"metabolite_name":"TG 16:0_16:0_18:1"},{"metabolite_name":"TG 16:0_16:1_18:1"},{"metabolite_name":"TG 16:0_16:1_18:2"},{"metabolite_name":"TG 16:0_17:0_18:0"},{"metabolite_name":"TG 16:0_17:0_18:1"},{"metabolite_name":"TG 16:0_17:1_18:1"},{"metabolite_name":"TG 16:0_18:0_18:1"},{"metabolite_name":"TG 16:0_18:0_20:0"},{"metabolite_name":"TG 16:0_18:1_18:1"},{"metabolite_name":"TG 16:0_18:1_18:2"},{"metabolite_name":"TG 16:0_18:1_20:4"},{"metabolite_name":"TG 16:0_18:2_18:2"},{"metabolite_name":"TG 17:0_18:1_18:1"},{"metabolite_name":"TG 18:0_18:0_18:1"},{"metabolite_name":"TG 18:0_18:1_18:1"},{"metabolite_name":"TG 18:0_18:1_20:4"},{"metabolite_name":"TG 18:2_18:2_18:2"},{"metabolite_name":"TG 18:2_18:2_18:3"},{"metabolite_name":"TG 46:1"},{"metabolite_name":"TG 46:2"},{"metabolite_name":"TG 47:1"},{"metabolite_name":"TG 48:1"},{"metabolite_name":"TG 48:2"},{"metabolite_name":"TG 49:1"},{"metabolite_name":"TG 49:2"},{"metabolite_name":"TG 50:2"},{"metabolite_name":"TG 54:5"},{"metabolite_name":"TG 56:3"}]
}

}