#METABOLOMICS WORKBENCH riverup_20230405_193420 DATATRACK_ID:3845 STUDY_ID:ST002541 ANALYSIS_ID:AN004186 PROJECT_ID:PR001637
VERSION                          	1
CREATED_ON                       	10-30-2024
#PROJECT
PR:PROJECT_TITLE                 	The metabolomics analysis of Methionine restriction
PR:PROJECT_TYPE                  	targeted metabolomics data
PR:PROJECT_SUMMARY               	Methionine restriction (MR) provides metabolic benefits in many organisms.
PR:PROJECT_SUMMARY               	However, mechanisms underlying the MR-induced effect remain incompletely
PR:PROJECT_SUMMARY               	understood. Here, we show in the budding yeast S. cerevisiae that MR relays a
PR:PROJECT_SUMMARY               	signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic
PR:PROJECT_SUMMARY               	mitochondria to nitrogenic anabolism.In particular, decreases in cellular SAM
PR:PROJECT_SUMMARY               	constrain lipoate metabolism and protein lipoylation required for the operation
PR:PROJECT_SUMMARY               	of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete
PR:PROJECT_SUMMARY               	glucose oxidation with an exit of acetyl-CoA and alpha-ketoglutarate from the
PR:PROJECT_SUMMARY               	TCA cycle to the syntheses of amino acids, such as arginine and leucine. This
PR:PROJECT_SUMMARY               	mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness
PR:PROJECT_SUMMARY               	through the coordination of mitochondrial fuel metabolism with the nitrogenic
PR:PROJECT_SUMMARY               	synthesis of amino acids.
PR:INSTITUTE                     	Zhejiang University
PR:DEPARTMENT                    	Life Sciences Institute
PR:LAST_NAME                     	Cunqi
PR:FIRST_NAME                    	Ye
PR:ADDRESS                       	866 Yuhangtang Rd, Hangzhou 310058, P.R. China
PR:EMAIL                         	yecunqi@zju.edu.cn
PR:PHONE                         	15267181160
PR:DOI                           	http://dx.doi.org/10.21228/M83M7P
#STUDY
ST:STUDY_TITLE                   	Methionine restriction constrains lipoylation and activates mitochondria for
ST:STUDY_TITLE                   	nitrogenic synthesis of amino acids (Part 1)
ST:STUDY_SUMMARY                 	Methionine restriction (MR) provides metabolic benefits in many organisms.
ST:STUDY_SUMMARY                 	However, mechanisms underlying the MR-induced effect remain incompletely
ST:STUDY_SUMMARY                 	understood. Here, we show in the budding yeast S. cerevisiae that MR relays a
ST:STUDY_SUMMARY                 	signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic
ST:STUDY_SUMMARY                 	mitochondria to nitrogenic anabolism. In particular, decreases in cellular SAM
ST:STUDY_SUMMARY                 	constrain lipoate metabolism and protein lipoylation required for the operation
ST:STUDY_SUMMARY                 	of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete
ST:STUDY_SUMMARY                 	glucose oxidation with an exit of acetyl-CoA and alpha-ketoglutarate from the
ST:STUDY_SUMMARY                 	TCA cycle to the syntheses of amino acids, such as arginine and leucine. This
ST:STUDY_SUMMARY                 	mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness
ST:STUDY_SUMMARY                 	through the coordination of mitochondrial fuel metabolism with the nitrogenic
ST:STUDY_SUMMARY                 	synthesis of amino acids.
ST:INSTITUTE                     	ZheJiang University
ST:DEPARTMENT                    	Life Sciences Institute
ST:LAST_NAME                     	Cunqi
ST:FIRST_NAME                    	Ye
ST:ADDRESS                       	866 Yuhangtang Rd, Hangzhou 310058, P.R. China
ST:EMAIL                         	yecunqi@zju.edu.cn
ST:PHONE                         	15267181160
ST:SUBMIT_DATE                   	2023-04-05
#SUBJECT
SU:SUBJECT_TYPE                  	Yeast
SU:SUBJECT_SPECIES               	Saccharomyces cerevisiae
SU:TAXONOMY_ID                   	4932
SU:GENOTYPE_STRAIN               	CEN.P.K
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	-	met6KO_0h_1	Sample Type:0h	RAW_FILE_NAME=met6KO_0h_1.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_0h_2	Sample Type:0h	RAW_FILE_NAME=met6KO_0h_2.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_0h_3	Sample Type:0h	RAW_FILE_NAME=met6KO_0h_3.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_15h_1	Sample Type:15h	RAW_FILE_NAME=met6KO_15h_1.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_15h_2	Sample Type:15h	RAW_FILE_NAME=met6KO_15h_2.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_15h_3	Sample Type:15h	RAW_FILE_NAME=met6KO_15h_3.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_2h_1	Sample Type:2h	RAW_FILE_NAME=met6KO_2h_1.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_2h_2	Sample Type:2h	RAW_FILE_NAME=met6KO_2h_2.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_2h_3	Sample Type:2h	RAW_FILE_NAME=met6KO_2h_3.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_4h_1	Sample Type:4h	RAW_FILE_NAME=met6KO_4h_1.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_4h_2	Sample Type:4h	RAW_FILE_NAME=met6KO_4h_2.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_4h_3	Sample Type:4h	RAW_FILE_NAME=met6KO_4h_3.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_6h_1	Sample Type:6h	RAW_FILE_NAME=met6KO_6h_1.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_6h_2	Sample Type:6h	RAW_FILE_NAME=met6KO_6h_2.wiff
SUBJECT_SAMPLE_FACTORS           	-	met6KO_6h_3	Sample Type:6h	RAW_FILE_NAME=met6KO_6h_3.wiff
#COLLECTION
CO:COLLECTION_SUMMARY            	Care was taken to quench cells quickly in -40℃ and maintain metabolites in
CO:COLLECTION_SUMMARY            	acid to minimize oxidation
CO:SAMPLE_TYPE                   	Yeast cells
#TREATMENT
TR:TREATMENT_SUMMARY             	Mutant MET6KO cells were cultured in SD medium with the supplements of Met and
TR:TREATMENT_SUMMARY             	growed to log phase, then cells were washed with normal SD medium and
TR:TREATMENT_SUMMARY             	re-cultured in SD medium
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Briefly, equal OD units of cells were rapidly quenched to stop metabolism by
SP:SAMPLEPREP_SUMMARY            	addition into 4 volumes of quenching buffer containing 60% methanol and 10 mM
SP:SAMPLEPREP_SUMMARY            	Tricine, pH 7.4 that was pre-cooled to -40°C. 5 min after holding at -40°C,
SP:SAMPLEPREP_SUMMARY            	cells were spun at 5,000 g for 3 min at 0°C, washed with the same buffer, and
SP:SAMPLEPREP_SUMMARY            	then resuspended in 1 mL extraction buffer containing 75% ethanol and 0.5 mM
SP:SAMPLEPREP_SUMMARY            	Tricine, pH 7.4. Intracellular metabolites were extracted by incubating at 75°C
SP:SAMPLEPREP_SUMMARY            	for 3 min, followed by chilling on ice for 5 min. Samples were spun at 20,000 g
SP:SAMPLEPREP_SUMMARY            	for 1 min to pellet cell debris, and 0.9 mL of the supernatant was transferred
SP:SAMPLEPREP_SUMMARY            	to a new tube. After a second spin at 20,000 g for 10 min, 0.8 mL of the
SP:SAMPLEPREP_SUMMARY            	supernatant was transferred to a new tube. Metabolites in the extraction buffer
SP:SAMPLEPREP_SUMMARY            	were dried using a vacuum concentrator system (Labconco) and stored at -80°C
SP:SAMPLEPREP_SUMMARY            	until analysis. Dried metabolite extracts were resuspended in 60% acetonitrile
SP:SAMPLEPREP_SUMMARY            	for injection.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Low pH polar
CH:INSTRUMENT_NAME               	Shimadzu 20AD
CH:COLUMN_NAME                   	Merck SeQuant ZIC-pHILIC (150 x 2.1mm,5um)
CH:COLUMN_TEMPERATURE            	45
CH:FLOW_GRADIENT                 	0.01 min 80% B, 20 min 20% B, 20.5 min 80% B, 34 min 80% B.
CH:FLOW_RATE                     	0.15ml/min
CH:SOLVENT_A                     	20 mM ammonium carbonate and 0.1% (v/v) ammonium hydroxide
CH:SOLVENT_B                     	acetonitrile
CH:CHROMATOGRAPHY_TYPE           	HILIC
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 6500+ QTrap
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:MS_COMMENTS                   	SCIEX OS
MS:ION_MODE                      	POSITIVE
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	Peak intensity
MS_METABOLITE_DATA_START
Samples	met6KO_0h_1	met6KO_0h_2	met6KO_0h_3	met6KO_15h_1	met6KO_15h_2	met6KO_15h_3	met6KO_2h_1	met6KO_2h_2	met6KO_2h_3	met6KO_4h_1	met6KO_4h_2	met6KO_4h_3	met6KO_6h_1	met6KO_6h_2	met6KO_6h_3
Factors	Sample Type:0h	Sample Type:0h	Sample Type:0h	Sample Type:15h	Sample Type:15h	Sample Type:15h	Sample Type:2h	Sample Type:2h	Sample Type:2h	Sample Type:4h	Sample Type:4h	Sample Type:4h	Sample Type:6h	Sample Type:6h	Sample Type:6h	
13C-Alanine-1															
13C-Arginine-1	8217.6638	3168.5500	10322.8665	11415.1079	4431.6277	4814.9774	16726.5874	5632.7042	4497.4041	14974.3943	8982.0850	3431.2020	2012.3118	9882.6390	3148.0270
13C-Aspartate-1	1196.6255	7776.9072	16435.0347	8705.4092	17033.0535	13009.4854	17239.3896	7490.3519	27055.5770	6190.4703	23028.2398	8254.8300	8120.1559	16859.3234	8747.9308
13C-Cystine-1	1521.2358	2762.2583	5910.7358	2226.2541	2649.4369	5288.7380	2413.4279	4440.7933	4126.4383	7457.0156	25164.3584	13922.0007	11204.9648	21723.5776	4736.7494
13C-Glutamic acid-1	9567.4354	10761.3592	24157.0545	23918.5330	23524.1404	8419.9137	9089.1643	21774.6763	36868.9952	13394.3835	11959.2692	12914.6697	10762.4908	12196.8993	22003.6618
13C-Glycine-1															
13C-Histidine-1	98663.8956	77968.8973	81518.9693	160933.9168	192038.7926	170124.1692	85289.6681	118886.5056	137901.1601	110720.7161	175309.7753	294164.7121	151628.1848	222354.9946	163115.7145
13C-Iso Leucine-1															
13C lysine			2152.6844												2630.9068
13C-Lysine-1	613699.7233	809391.9851	621335.7505	556737.3633	838729.0737	1132690.3270	1176893.6690	1431330.3380	951610.0267	478475.6465	777473.0998	212835.4890	265772.4796	434213.1758	1269860.9620
13C-Methionine-1	375117.9879	359807.3007	485425.4832	438300.9275	436881.6091	395812.6400	405763.0857	366675.5737	493352.9059	342595.9867	351360.5594	438065.4864	341888.3115	338517.9394	457271.8623
13 C phenylalanine	2932.0478	2813.4032		3276.0809	3154.1874	4191.0321	2669.1469		5816.2848	8931.2707	3017.3428	6062.4782	8419.7234	6699.8291	4002.0867
13C-Phenylalanine-1	1174.3588	4448.0194	5367.6799	6955.7142	4224.4059	2031.9415	2615.6721	8090.8004	4446.2959	8344.7766	1421.7175		1246.5866	11197.9804	2587.2353
13C-Proline1	73448.5408	42427.6728	53461.3548	72822.5455	84102.7647	48359.7176	46385.6441	58509.7241	82041.7465	58573.4999	58698.1059	60364.5295	60447.9432	79278.1870	53872.6646
13C-Serine-1															
13C-Threonine-1	7257.9007		8842.0604	2590.9614	3861.1155	1602.3693	3716.8983	4610.1995	5318.0019	3106.7748	7104.9093	1617.2807	4364.6584	9089.5695	10771.5025
13C tyrosine	2330870.6080	2096050.7230	3007649.2780	2670988.6120	2888074.3720	2223426.1470	2276440.7150	2347165.7930	3587171.9160	2030429.8260	2192562.8520	2930854.0290	1708711.3530	1367341.3480	2862867.0240
13C-Tyrosine	160766530.8000	139860027.4000	216868714.8000	198987285.7000	206912951.3000	150302623.9000	161503972.5000	156171160.5000	252267639.7000	147963524.3000	147665122.2000	200259906.0000	125354528.4000	100530507.4000	205386411.7000
13C valine-1															
13C-Valine-1	4323.2375										2363.8724				
1-Methyladenosine	2484638.2360	4401541.7890	4187442.5080	58548072.2700	60679811.2100	46557805.1800	3946162.0010	3855902.1230	6774911.7310	16930900.2100	15898977.1700	13557081.8600	29849751.6100	21437868.7500	4516291.1730
1-Methylhistidine	58665.3360	88716.0089	150554.2696	67683.5046	36753.4561	50231.9982	5808.2878	13855.7549	34427.3391	62864.8757	61948.7696	84587.2452	51854.4819	79973.8683	102211.2561
1-Methylnicotinamide	61369.4318	163968.6353	148829.1857	8028309.0490	7084124.3640	7574598.6530	158374.4939	135426.7711	370990.1593	5050185.7180	5807749.9660	5489744.5720	8609795.0850	10927300.8900	121943.2726
3_5-Diiodothyronine	6183.3190	11567.9926	13627.9456	4087.3777	9003.5936	18926.6963	7876.8656	14565.7513	9018.4120	6200.3807	7052.5903	7879.4049	5659.3195	10763.3542	16641.9500
5-Methoxytryptophan	36869.4067	23703.1149	25306.7858	15104.5414	16483.6591	5436.3761	17950.1795	10031.7479	15997.5654	11945.1484	45992.7517	12282.2301	14047.2664	34660.0132	23340.1529
5-Methyltetrahydrofolic acid	14725.9725	23566.7879	30067.5477	28351.8412	9903.7950	22355.2489	22866.9028	25637.3106	30923.0184	17429.4102	25988.1304	18907.2360	25213.8544	12517.4143	10183.6832
5^-Methylthioadenosine	1020671812.0000	1598160726.0000	1044623842.0000	64190226.4100	66660546.8800	80008537.2900	334794835.3000	224795691.1000	225073117.4000	220198021.8000	330369711.2000	264759629.0000	299726058.8000	299029463.3000	1133395761.0000
5-Thymidylic acid	39705.4801	40345.1160	62585.3629	78050.6334	77867.2740	49092.0011	48989.2188	47815.0457	92389.2683	44334.2880	59625.5933	25287.6578	37803.9086	30242.1487	72327.5918
7-Methylguanosine	22352.7565	26402.7241	27110.4858	763065.4010	772300.0434	584834.2900	60625.1517	71836.2223	99043.7085	973404.5822	914304.6087	680217.6249	1077709.9890	1477608.8410	50972.9958
Acetoacetyl-CoA		4065.5844	4554.5851	3587.7809	2400.0260	3336.0343	8844.6129	10045.3879	5503.8816	7414.4344	9089.0214	5499.0659	2862.7889	5011.8681	7653.9339
Acetyl-CoA	5841993.1680	5284400.6060	4807952.8420	3491278.8540	2694623.8130	3447849.8390	5929647.8730	5649566.0300	5053031.2350	4313608.9860	5800134.6710	6150996.4800	4854255.8980	3561083.7680	4634409.2920
Adenine	64012974.1400	92900288.1000	80360886.3000	10179513.4600	10328506.9500	16121831.2500	25767661.0100	24589226.5200	32675487.9100	19659426.5000	33886809.0100	105668983.7000	22725999.3900	26811501.5800	86536364.2000
Adenosine	35543712.4300	29743601.1000	23951755.3100	23666112.4100	26342317.7000	55017523.1400	22081553.6400	19109177.9500	26099935.2200	31923989.0700	49019836.8900	496858924.2000	53289723.2900	41166235.4200	38355623.5900
Adenosine monophosphate	47521533.0000	81765987.7800	73687010.4100	43087373.5700	36224179.3500	41486575.5200	37508564.0700	33699281.3300	64992883.2900	65964377.1900	91372313.4600	69531916.8700	86877234.6600	82501229.1400	90019517.5800
AICAR	281322.7033	412587.2827	333641.6252	53050.8696	74862.1326	72364.0936	129575.3951	108798.8541	150989.6336	83126.5258	132312.5648	113097.5096	119574.2681	103319.4205	304079.7539
AICA-riboside	220701.0279	472663.4489	313544.4915	370795.7955	348654.1723	257110.5553	132597.3292	158913.6136	276023.5061	411818.0598	421882.1949	299659.7260	542402.3578	659976.3645	473827.8983
Argininosuccinic acid	500569.0756	863439.4470	742782.1191	1414722.8710	1242796.4210	2047732.5950	688127.9397	658451.7310	1335996.3980	1917616.8000	2121253.6990	4015963.9850	2870418.1810	2090039.0240	738426.2452
Asymmetric dimethylarginine	224852.7618	491565.7823	473581.4544	3168511.4820	3023742.1540	2974113.6670	204611.3488	278902.7820	621409.1378	1004382.5510	1266639.2120	1148628.9850	1321877.7190	1344762.7630	336295.6540
Betaine	41355005.8800	54431660.6900	103430682.9000	137805141.6000	202768772.8000	92261437.3900	48757033.6000	58340840.0100	41746853.5700	36455168.2500	96431439.9200	755099863.5000	66046712.6100	43602014.8100	31525979.8700
Betaine aldehyde	244152058.9000	177027005.6000	300817001.9000	317497870.5000	310113540.7000	241625319.1000	208188638.2000	217241835.9000	324799595.5000	229554858.1000	244270163.4000	229692666.3000	186263743.4000	181002595.0000	304167123.9000
Biotin	478225.2695	552346.3661	990883.7334	162573.5067	94633.1668	232564.2431	971305.1218	722120.2400	3050423.2590	1388775.6340	1462091.7380	1535028.3630	1073331.6060	960297.3735	942653.8924
Carnitine	948448.8759	2593021.2600	951548.8077	1874293.5250	1901696.3680	1983636.9990	946584.4217	1317919.1520	1259082.0190	1961167.0920	2809069.1840	9363768.9680	2254549.9360	2412254.6700	997487.5722
Choline	3317150.5670	8296350.8880	2084853.4100	12183953.4600	6458091.2950	9682907.6830	4836491.4040	3654449.3530	4344764.8200	2538602.5020	5380786.7090	42875422.6500	4628607.7780	1753462.4030	1867362.6190
Citrulline	6958796.4260	19435102.9200	19386348.9500	13086693.5300	12374622.9000	10356531.4100	12190124.8700	12412154.2600	32421165.8800	31962653.7600	41439552.7300	41770105.5100	24634712.8300	34456285.5600	27842848.1300
Coenzyme A	211492.0136	55915.3167	100961.6562	123627.1080	150794.8106	97256.3630	180288.3119	100042.5820	251896.0953	248420.5357	307566.0622	246566.1940	192166.7688	63551.6646	47553.5808
Creatine	368093.2092	1533573.7380	492587.2740	1011186.9510	714131.2376	963426.1524	608835.4536	1013698.0040	641124.3499	510481.3737	780361.6044	3366759.1580	587362.6984	484740.9793	581667.0979
Creatinine	375608.9844	1692319.7680	404931.1375	789652.6183	645298.2072	1195122.5370	712550.2096	784232.8963	653854.8255	317390.6941	829007.4337	4740648.7100	610424.1131	482183.3784	537827.9191
Cytidine	721106.9886	2161172.2620	1507619.9200	9147113.6380	8921360.0340	7516574.8630	2464861.8890	2350275.8970	7411388.9270	55415581.8900	69149573.0700	57243120.9100	54595912.5300	61016083.5000	2089722.2450
Cytidine monophosphate	510848.8079	1016480.5360	755971.3982	679204.9794	614696.8980	709805.9319	453548.2847	417115.6724	809456.1066	1650459.0610	1439300.2160	2493263.8500	1637167.7940	1726545.6170	843580.9206
Cytosine	1072944.1780	750030.4170	1123147.9330	730158.1981	1017927.6360	721616.4508	1204583.2880	837431.7861	484458.9229	999072.1394	1510442.2240	1131615.7920	2144625.4470	1212842.9860	560022.7367
dCMP	19080.6027	37003.3735	25211.3941	36684.2692	34664.4563	28262.9266	20521.0395	27008.1067	52449.8246	37546.9896	57144.5012	66689.6715	35778.1059	53425.4391	28989.6869
Deoxyadenosine	734993.4085	942757.6781	1266022.6900	4667080.9260	3855624.4200	4363969.0200	1214027.4320	1177245.6490	2668856.9740	3888140.6040	4625842.9620	5756912.4590	4676083.8530	6807124.7980	1260848.5210
Deoxyadenosine monophosphate	4992080.4870	6829090.6720	6516888.0480	7208019.5160	5197589.1090	4372231.2920	6691471.2370	5030059.7870	6489447.0420	6689264.3390	9282317.5420	4353503.5630	6996586.0160	7785883.7900	3777439.9860
Deoxyguanosine	48338.9948	140301.7998	84318.6274	305684.7766	271780.2006	239470.9724	164738.7036	168342.0210	257745.7617	1023913.7640	934944.6968	904777.1313	615457.0783	765365.3773	111918.6355
Dephospho-CoA	406198.7427	442977.9756	308099.4564	207167.5700	106789.1706	136692.0776	182548.1907	177128.2055	288346.3728	414294.5036	363012.3781	429051.7058	398736.0253	383580.8505	345508.9692
dGMP	27916.6282	16430.9204	32234.5626	49165.9725	32412.6183	16355.3787	19083.8250	34875.0966	31586.8750	60978.7328	18651.3088	39309.5269	42273.6395	51156.5478	28239.0998
Dihydrofolic acid	18409.9182	16792.4248	17930.1318	19174.5317	25570.8941	16432.3338	21894.2830	16901.5915	24090.6106	16435.2844	22901.3150	32100.6714	22256.5428	16707.8559	29566.4765
Dimethylglycine	101159.5362	95550.8156	71254.3111	736625.7380	746070.4415	604296.4442	112172.2109	90791.7581	157642.0257	142953.1286	224871.3550	166658.9512	312518.9481	325801.5117	109433.7388
DL-2-Aminooctanoic acid	3443.8612	23182.6766	4427.3959	44009.1223	31298.8942	39771.2683	6852.8646	37513.8928	9510.8541	11736.5921	23117.2846	109317.7302	21049.8631	21715.0489	9341.5520
DL-O-Phosphoserine	11421.3236	16590.7096	11215.9871	4214.2049	9517.3142	3127.4052	21638.3851	12487.3681	18838.8426	10685.7801	11087.9227	10567.3250	10267.9978	11717.5377	10565.8118
Ethanolamine	41419.8790	93641.9410	57108.7419	1808354.6390	1560356.3860	1214869.2080	41232.5448	112299.3596	111903.1814	132868.5871	260648.0610	703840.8838	421327.1959	423218.2220	82956.9688
FAD	5386346.0730	5033825.7080	4884227.4880	4394867.6160	4536532.6960	3809427.4320	5032046.0370	4386078.9140	5136774.4730	5335007.8680	5183560.6340	5276055.8830	4769155.4160	5006258.4150	4482754.7650
Flavone	56584.1844	96141.9098	138457.5816	99487.1668	120804.4673	77498.9493	139845.2321	110672.8676	89005.7073	102514.7411	108974.8333	117933.5052	177664.7386	177198.3584	79051.0165
Folic acid	106881.5769	182471.1882	180230.6795	155024.8076	153581.0434	126406.2424	121738.6788	196311.8826	198577.7423	98789.1230	139764.5124	200087.9766	86584.1136	154187.8779	187034.1172
Gamma-Aminobutyric acid	26171.9618	35472.4353	36895.9558	407628.2177	310022.4238	290775.8350	43807.3849	59739.5446	47242.2552	112864.7495	243160.8277	502103.9979	247847.5436	275967.3705	41308.8001
Glucosamine	1325098889.0000	1148101199.0000	1194451732.0000	1248343287.0000	1385334641.0000	1258823543.0000	1223483109.0000	1174059697.0000	1309729204.0000	1339037911.0000	1347336187.0000	1281331224.0000	1300514304.0000	1350553540.0000	1238611046.0000
Glucosamine-1P	13209.2744	6567.0751	12796.0674	9824.7801	19283.3078	21431.4908	14025.7255	7707.5028	19885.8906	5364.0921	11994.9764	17861.7090	10925.9942	24369.6102	12065.9896
Glucosamine 6-phosphate				6896.2807			3526.2977	1813.0345		4060.7175	3518.5910			13246.9960	
Glutathione	20784616.0300	61724983.5000	33085710.7600	18502580.2400	7739861.4920	12252869.0400	9404215.8160	8794992.5760	24558124.7100	26688272.8700	22694916.3700	24848646.6000	24614823.7200	12015398.7200	51139267.4700
Glycerophosphocholine	54094004.3900	106063759.9000	38401162.9000	30511723.3500	23523329.4200	25667094.5700	22849901.7200	25697218.7400	23534024.7300	27288465.0900	30434726.8900	193676092.6000	32107698.6900	23787536.7600	41059180.8100
Glycine	39244.2165	33776.8871	31571.9719	35879.3460	39225.9698	28247.8907	39102.5256	28702.3023	38939.7004	35452.4511	32281.2724	40422.0953	30138.5374	32766.6511	33261.9552
GMP	1190909.3270	1926881.9600	1564903.5100	708798.8444	838320.3833	834442.4148	710537.7777	789642.5396	1231259.2990	1633402.9690	2135936.4920	2001844.9510	1476708.6340	1466120.9520	1498567.2600
Guanine	1867898.1200	426415.8797	613646.7558	2725479.9460	2923801.8310	2404665.8110	537903.6310	530918.4135	572126.1348	7153970.2320	8348005.1910	5636790.6880	5825308.7940	6290580.2350	468959.0381
Guanosine	91528.2854	125305.2321	100731.1730	1590389.8270	1639084.0580	1521263.0480	116312.1677	130551.3046	251729.1373	4380536.8720	3995018.2450	3762577.4750	3938430.7750	4407056.5610	90152.6114
Homocysteine	4738.5106	11594.3735	20297.8767	80503.0178	62293.2575		12477.3421	19485.9705	71894.0673	125622.3417	200474.7670	320997.7415	142759.7807	230246.7515	19029.2069
Hydroxyproline	1834173.6830	1728707.8110	1576754.6370	1849094.2500	1875349.3550	1803887.1160	1734630.7100	1647637.5130	1794139.0800	1674351.8830	1769419.3350	1664147.6490	1754635.3300	1967650.1220	1591401.7150
Imidazole	83854.5841	70615.8889	87802.6440	166696.1622	118237.1282	3039198.4930	76472.9048	41146.9148	23853.8806	126038.0686	112574.2662	135466.6357	195054.4691	158544.7607	99610.5452
Imidazoleacetic acid	325985.2293	424383.4051	431591.7132	2899150.6390	3060633.0280	2245330.0610	379864.6665	419382.2293	436114.3861	1365486.7750	1864075.1630	1832870.0330	2336152.7800	3514166.2820	564762.4289
IMP	2761991.0060	4594323.5560	4273901.8010	2149373.9380	1973550.5980	2480615.5940	2256154.8810	2116654.0210	4217913.0680	3958933.1980	5115382.4610	4141782.0500	5272955.0370	4549129.8740	5108926.8470
Indole	39480.1519	74340.5101	72957.1332	893443.3281	900879.2205	889721.5660	132185.2835	143199.2753	400063.9467	740908.0804	881547.2784	1129810.5240	918372.1740	1086412.8340	65855.6972
L-Acetylcarnitine	855262.0846	1827609.6660	1758713.6480	4983954.7860	4017264.7000	4363325.0900	1411129.3500	1237820.4620	2595423.3250	3748906.9850	3824554.9350	4436059.9530	4545563.0230	5188903.8060	1976959.5130
L-Alanine	956632.1516	2174848.4560	2868374.6260	29214946.9600	21928348.6900	22258604.6900	960325.0417	1150442.7860	3903602.2890	13389626.8800	22351591.6600	30727769.2700	28299322.0500	27878207.0100	3844375.2330
L-Arginine	35704429.5000	60052457.4800	51520721.7600	314353289.0000	314458466.3000	244366635.3000	70429561.0300	78236499.7000	104736176.2000	215970282.6000	269211854.3000	274956937.4000	279105654.1000	299651481.7000	71508015.1100
L-Asparagine	224844.0830	741084.3831	795897.5207	5227856.1680	4479114.6540	3884746.8680	657592.7449	717256.7211	1893176.4470	3783422.1650	5103226.0300	6701990.6670	4732495.9150	5518298.8960	875650.3435
L-Aspartic acid	944595.0701	3057838.0080	3253083.5870	12750387.0000	13521968.1800	12032240.0200	3944409.3770	3764799.8790	10843048.1300	21000609.3500	26275357.3800	30858452.1700	23874219.0300	25067030.8800	3346322.1730
L-Cystathionine	1920656.9940	3898716.4540	3723901.5620	931190.3949	1001777.6230	925414.0020	847681.7205	764353.4138	1154396.0520	1750451.3390	2064062.2320	1966404.4270	1811584.4240	1814062.2120	3787317.3490
L-Cysteine	10632.9227	3334.8939	5875.5667	8556.7040	6529.6234	5763.7398	8967.0063	7154.9053	13169.5613	6438.3244	8269.8847	6170.9380	10241.2381	11675.7184	8747.2356
L-Cystine	2203.2838				2084.0568			2955.6686							
L-Glutamic acid	17430520.0500	56946684.6200	52594282.0100	311868228.9000	292776827.8000	254400701.7000	74904994.2000	73040433.3600	180259604.7000	331025871.2000	403275401.8000	426551659.0000	383273090.3000	435509368.7000	65493311.9300
L-Glutamine	3844414.7240	10507458.4900	15353473.6500	317854105.2000	301189190.4000	267911231.4000	46472214.9600	45062429.6200	138493166.0000	219392252.8000	277275424.5000	273006947.5000	306487212.9000	340741405.9000	18454791.2900
L-Histidine	43645861.1800	80388545.0200	90649000.2500	1087542206.0000	1044870579.0000	940021545.4000	119801451.4000	138738381.0000	257839079.3000	545316651.6000	716332547.3000	672934587.7000	785958064.2000	935186276.8000	164420131.9000
L-Histidinol	133393.6503	121657.3415	100545.0231	53569.7682	100583.6522	69046.6523	105749.2171	117235.8965	156813.7709	108480.3213	221591.2032	155062.5649	137153.8386	154759.0715	280808.5158
L-Homoserine	80533.3414	155321.9047	276030.1466	310574.8862	265426.9216	220251.4212	54410.7044	49678.0650	125856.6843	197836.8176	313468.7032	278300.9337	358714.0333	395086.4386	239776.8547
L-Kynurenine	18800.3178	65848.2518	98629.1059	681546.3451	660352.7495	627771.5555	83612.2460	73468.6174	284061.1644	600596.8716	652913.4280	821520.4760	838968.9251	933088.2799	112789.3436
L-Leucine	4462792.8310	22887513.3900	8145995.9220	352506892.2000	314251582.6000	295842627.6000	14625930.3600	14597239.6500	55039869.6600	89523802.7500	121253084.4000	271314253.7000	187972768.6000	232967807.0000	9763379.1380
L-Lysine	296459.1399	590962.5956	550409.4555	6656584.2690	6247617.2230	5114118.4210	864823.8177	1039581.0490	1240729.7960	4114613.2450	5519631.5750	6361841.5860	5511057.4900	6447175.2830	717319.6311
L-Methionine	29794634.6000	50311725.9400	89319867.1000	1380820.3140	1321176.4750	1491510.5050	404878.8386	518047.2770	470543.0270	578453.2503	797698.7933	7752656.2860	1456181.0740	1002655.6870	111997571.9000
L-Phenylalanine	1338105.2420	8412312.6200	3585449.6180	89126880.4500	75043929.9900	77326931.4700	6274740.3160	6132252.8270	19713785.0400	36280208.2200	53552371.1700	116900631.2000	75726762.0900	81447257.5800	3971980.3170
L-Proline	5582870.1130	14325150.3300	11617836.3300	296254583.8000	280790796.8000	238045883.3000	10858571.9900	13122305.1300	35074727.8800	124477834.6000	158576883.4000	241977530.2000	231683793.4000	178958666.0000	14807968.7600
L-Threonine	1698833.6180	4059408.1110	4872451.9760	46808270.8600	37407059.1700	38228009.3500	3308171.0130	3377492.3780	8720692.1100	18989435.5700	24270588.1500	31075161.9100	31350617.0100	34007310.1600	5027611.6010
L-Tryptophan	248356.3470	621928.1479	540462.8911	8404984.4750	7456993.9380	7728588.9660	1039700.3580	1143336.4270	3152695.7890	7269078.1220	8063522.8070	9159599.0620	7809161.5780	9421504.5760	643061.5937
L-Tyrosine	230571.1140	934922.4146	693082.0197	18124687.7100	15811692.9500	14241915.1100	1725813.9200	1739308.0950	5295238.6500	9641234.4640	11046554.1700	14430897.8400	12945664.7600	12078256.8800	875150.0690
L-Valine	39140.7752	158515.3151	87763.6286	6580029.5670	5514710.7180	5532159.9010	316228.9939	337917.9137	1248155.0330	2972319.0250	3788638.2420	4896559.0250	5016900.2350	5517450.4580	92990.1817
Malonyl-CoA	13038.5822	26650.0451	27621.1030	1674.2542			4105.4222	4685.9332	21533.0372	5360.0409	8131.8250	6672.6247			4764.2306
Methionine sulfoxide	4915192.6210	10254624.4900	25153841.3400	641289.9859	748293.4149	1039996.3630	253992.5025	355718.3623	433258.6020	229759.9806	474842.3966	8135251.9790	560438.2803	694338.8046	11925201.1800
Methylcysteine	210687.0205	830740.3336	630154.5936	16418900.7400	13348945.7500	13729045.8700	1568345.2080	1590359.9000	4668032.4990	8206744.5790	9933953.4800	12373838.0400	11192002.2000	10554090.6200	697390.4280
N6-Acetyl-L-lysine	3101685.4960	9769550.9910	9996323.0230	76103447.3000	72940045.8200	62818362.6300	6933310.0870	6776714.1700	20620878.1000	50071461.5700	54316592.2900	53418600.0300	70974110.4800	61618141.5800	10948552.3700
N-Acetyl-D-glucosamine	82683.9685	144102.9382	135685.3512	268918.4028	294227.1274	265450.1649	131232.8530	102067.6674	211623.3700	308665.0856	334243.6070	314902.1064	365630.2773	444425.6316	137720.4981
N-Acetylglutamic acid	1393372.7240	2650341.3090	2493157.0640	3227508.5450	2452157.7020	2161066.7180	1034025.5950	1152774.0280	2007512.2660	2390361.5370	3199204.0890	2619435.8460	3143353.5720	3329359.2050	3402935.2600
N-Acetylglutamine	2163728.5550	5081285.5250	4947273.4280	14393488.0100	13535805.3100	15422826.3900	4628651.8150	4313267.3870	9369215.4540	8068053.8530	9257510.5030	11368212.5000	12228973.6900	13583934.0000	4793218.3940
N-Acetylornithine	2462632.8470	7244160.0890	6864879.4240	18087403.6300	14046476.3100	13966923.9100	3838965.5800	3489725.5530	9192083.4280	10545264.8100	13879321.4100	11601719.0700	12292791.1800	13293483.0300	7995969.9700
N-Acetylputrescine	161119.7421	931319.6233	1165350.9510	26071616.9400	25417351.8800	24635516.0100	549132.6037	915417.6710	1691432.0110	3912082.5250	8675576.6820	7477254.3320	5649224.2560	8091068.8760	1290675.5060
NAD	110819351.2000	119416586.6000	116312467.3000	162881238.5000	126126621.1000	119144908.9000	121779146.5000	115454851.7000	116472524.2000	143782990.2000	185571050.1000	143188067.6000	157168496.8000	158058243.7000	94986592.8300
NADH	18948080.9600	26108427.7500	24830051.6600	12260269.7300	11043328.6600	12924583.7000	14699199.4400	15241036.1200	26439671.3000	21751102.5000	23586540.5600	36276874.4800	32348573.4000	26813676.9900	26867422.2600
NADP	3070011.6330	4593596.6980	3082015.5840	3883336.3750	3535544.1320	2514129.3210	4397261.8120	4283383.1530	4962275.9580	4256898.9620	5699285.7340	4729796.2250	2888427.4260	2975643.7410	2633293.9340
NADPH	359103.5535	925606.7603	805290.3344	624933.2379	646413.1928	617608.2384	933747.2508	1042230.8180	2158032.2520	1503594.3720	2007484.7620	2322405.3940	1365133.1840	1531379.9670	628228.2294
N-Alpha-acetyllysine	2381179.7140	7398618.5620	7627138.7640	56326511.9500	54222954.8000	51415361.3100	5766832.6480	5592453.1500	15582383.1400	40567983.7300	40115378.8900	43027544.7500	50048613.1800	46841278.5000	9307786.3990
Niacinamide	1458796.8150	2490459.7750	1284490.3550	2983430.4480	3066946.7110	3907686.7440	2210428.7980	1671272.9100	1283279.4990	3652095.5420	5336531.4090	4213284.9320	8128384.2440	9636665.3330	1294767.6880
Nicotinamide ribotide	1402468.4590	2173632.2210	1580946.9740	4648029.9870	4788888.6440	4747577.0440	1477441.1300	1461436.1030	2525991.8900	4145444.4470	5982555.7480	5562759.5850	5230876.2060	5783875.1920	1996679.5700
O-Acetylserine	47428.2884	42606.8132	14703.8588	22990.9201	49032.1828	51307.3124	51547.3524	25597.8229	23825.2462	19260.9192	38529.8220	64201.9357	82364.0467	79248.4583	16480.3379
Ornithine	3148453.2360	5494366.4030	4180290.4710	47542625.9900	43754909.6400	36597546.7900	5560072.5350	6469784.2850	9153524.1810	17715748.7800	24896686.3400	24668707.2800	26709518.4400	27317727.3000	5831203.6240
Oxidized glutathione	5659249.6540	10310555.4400	11866426.0000	8228158.1840	9230999.2900	7175379.1650	4801686.9100	4660298.5750	7623701.3650	9028994.7800	12661591.3900	14385878.2100	9572088.5520	14462245.5300	8703903.6480
Phosphorylcholine	93814.0215	356305.6606	160466.4583	327168.0022	323950.3254	451366.5503	144586.3440	130981.0187	156172.7136	207826.9483	358645.5563	3797713.0470	573221.6277	438815.8969	249857.5806
Pipecolic acid	20119500.3600	56676294.8300	71480926.4700	821937982.7000	783638841.0000	697234262.0000	131411039.9000	131976702.4000	389295864.1000	633518274.1000	820119581.6000	754153338.9000	861611605.1000	912475515.6000	81915795.0800
Propionyl-CoA	118965.7204	103911.5700	94331.8650	65505.7479	48161.4643	47944.7406	38990.7986	35051.0715	42959.9807	44030.4025	45496.7221	37262.3186	68779.8004	51100.2249	119962.7375
Purine	70245.1837	194818.2319	84285.1655	1748107.5420	1590414.7350	1486375.3510	163063.3367	97494.1632	427195.3752	936155.9332	1165687.5440	2539279.7780	1626945.6090	1750412.2580	118157.3091
Putrescine	1492556.8760	1417420.9770	1322363.4710	354854.9730	458843.5017	339774.0743	1225729.0130	746659.5518	1124848.3170	888338.7791	892416.6620	734403.4772	303552.8641	756427.5667	339785.3392
Pyridoxamine	9876.1309	21573.5385	31890.5744	22664.8011	21534.9866	77276.7030	9948.0490	49533.4035	22952.2693	10513.4165	29474.5778	65149.8466	21611.0788	46796.4529	56676.5027
Pyridoxine	851750.8106	376288.9577	373889.4098	513473.9572	737227.5326	763257.0173	158507.1085	136505.3534	230581.2341	166790.1716	405247.7630	1448154.1790	393364.6788	744083.4131	425372.7851
Riboflavin	406044.0692	422369.0555	415816.9728	496365.9577	345810.6843	369976.8340	486117.0655	403367.1704	525966.2163	720059.3533	662234.5814	986634.8557	618249.0086	807656.0669	366079.1707
S-Adenosylhomocysteine	4636747.7850	9382751.2700	7915924.3730	6655172.6410	4593839.6480	5428169.3820	2547344.2640	2378539.8350	4035734.8570	7708906.0060	8486688.5950	8201557.2940	10435483.0400	10337369.5200	8217478.0260
S-Adenosylmethioninamine	476591.0577	2067407.0060	2867596.5290	600019.9145	548993.5502	577945.9105	411929.4680	514681.9078	846212.7381	1714274.8300	2006539.5680	3884126.7100	1183561.0490	1364747.7160	2128957.5930
S-Adenosylmethionine	200195119.7000	277297444.6000	201181277.4000	26242643.8300	24343509.5500	24272033.6800	75568066.1000	78496298.6700	118618720.0000	68749345.4500	100048294.2000	76064554.2400	60955671.1300	59576116.1500	253650964.8000
Sarcosine	152733.1016	381487.7890	461166.0899	3615183.7120	2584365.1360	2607115.6060	210336.8651	219708.9399	483284.1665	1573180.0230	2613424.3980	3362165.2360	3179622.1510	2910921.0520	550014.6450
Serine	952224.6015	1996194.3620	1841603.7300	6271578.1870	6849542.5450	6528440.3170	2015972.9630	2200246.2150	4465453.7470	5012648.5010	7381877.6380	11567343.1500	7349741.4070	8830275.9000	1971074.0220
Spermidine															
Spermine															
S-Ribosyl-L-homocysteine	6923.0111	5409.0630	10141.4798	10173.8670	3998.0388	15873.0066	16611.9560	14191.8119	59945.3738	6745.3747	14899.5912	5695.2898	11901.3928	9842.3251	5550.7454
Succinyl-CoA															
Thiamine	109627471.0000	290622363.5000	297886868.4000	257388299.2000	194427995.4000	210863946.3000	132367781.2000	151953539.6000	284536197.3000	221581483.7000	314853404.6000	343723593.8000	215473686.8000	240937323.4000	253229085.5000
Thiamine monophosphate	120767.0241	138024.3360	98013.1716	207077.0941	172546.7207	168711.8434	172089.9264	171209.4925	190769.5855	192640.2213	339712.4634	222391.1370	218490.9679	220161.1894	115632.9792
Thymine	84054.9913	72622.8501	59727.8294	63315.0518	126680.5531	141347.1010	96417.7656	51867.2322	40854.2280	74655.2409	100337.5674	94351.4492	158256.6446	165394.4837	119069.3283
Urea	940986.3436	769611.7903	842261.4398	1004964.9740	859400.0124	808811.8004	718109.7533	899621.9125	863348.7546	880729.1284	887198.6118	630411.5278	635595.5685	681972.1500	793087.2237
Ureidosuccinic acid	94218.3027	184902.0286	150707.3270	83566.0631	88094.3025	89547.8614	82499.1546	78141.7022	138055.2148	193385.0488	209481.0045	379997.1000	193631.4599	172961.6663	197283.8776
Uridine 5^-monophosphate	400678.5427	620631.7081	596430.0677	865295.4697	894578.1021	1004187.7710	277313.3962	289134.6805	461228.6746	764355.6263	977952.5040	1023207.1270	1030153.2740	1166662.0530	565322.4829
Xanthylic acid	3912.9927	8860.9132	9821.8410	5979.6261	3375.6849	2134.0517	692.1959	644.5224	2301.6010	4215.4984	2037.0714		2633.9885	5022.3775	4066.1183
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	pubchem_id	inchi_key	kegg_id	other_id	other_id_type	ri	ri_type	moverz_quant	
13C-Alanine-1									
13C-Arginine-1									
13C-Aspartate-1									
13C-Cystine-1									
13C-Glutamic acid-1									
13C-Glycine-1									
13C-Histidine-1									
13C-Iso Leucine-1									
13C lysine									
13C-Lysine-1									
13C-Methionine-1									
13 C phenylalanine									
13C-Phenylalanine-1									
13C-Proline1									
13C-Serine-1									
13C-Threonine-1									
13C tyrosine									
13C-Tyrosine									
13C valine-1									
13C-Valine-1									
1-Methyladenosine									
1-Methylhistidine									
1-Methylnicotinamide									
3,5-Diiodothyronine									
5-Methoxytryptophan									
5-Methyltetrahydrofolic acid									
5'-Methylthioadenosine									
5-Thymidylic acid									
7-Methylguanosine									
Acetoacetyl-CoA									
Acetyl-CoA									
Adenine									
Adenosine									
Adenosine monophosphate									
AICAR									
AICA-riboside									
Argininosuccinic acid									
Asymmetric dimethylarginine									
Betaine									
Betaine aldehyde									
Biotin									
Carnitine									
Choline									
Citrulline									
Coenzyme A									
Creatine									
Creatinine									
Cytidine									
Cytidine monophosphate									
Cytosine									
dCMP									
Deoxyadenosine									
Deoxyadenosine monophosphate									
Deoxyguanosine									
Dephospho-CoA									
dGMP									
Dihydrofolic acid									
Dimethylglycine									
DL-2-Aminooctanoic acid									
DL-O-Phosphoserine									
Ethanolamine									
FAD									
Flavone									
Folic acid									
Gamma-Aminobutyric acid									
Glucosamine									
Glucosamine-1P									
Glucosamine 6-phosphate									
Glutathione									
Glycerophosphocholine									
Glycine									
GMP									
Guanine									
Guanosine									
Homocysteine									
Hydroxyproline									
Imidazole									
Imidazoleacetic acid									
IMP									
Indole									
L-Acetylcarnitine									
L-Alanine									
L-Arginine									
L-Asparagine									
L-Aspartic acid									
L-Cystathionine									
L-Cysteine									
L-Cystine									
L-Glutamic acid									
L-Glutamine									
L-Histidine									
L-Histidinol									
L-Homoserine									
L-Kynurenine									
L-Leucine									
L-Lysine									
L-Methionine									
L-Phenylalanine									
L-Proline									
L-Threonine									
L-Tryptophan									
L-Tyrosine									
L-Valine									
Malonyl-CoA									
Methionine sulfoxide									
Methylcysteine									
N6-Acetyl-L-lysine									
N-Acetyl-D-glucosamine									
N-Acetylglutamic acid									
N-Acetylglutamine									
N-Acetylornithine									
N-Acetylputrescine									
NAD									
NADH									
NADP									
NADPH									
N-Alpha-acetyllysine									
Niacinamide									
Nicotinamide ribotide									
O-Acetylserine									
Ornithine									
Oxidized glutathione									
Phosphorylcholine									
Pipecolic acid									
Propionyl-CoA									
Purine									
Putrescine									
Pyridoxamine									
Pyridoxine									
Riboflavin									
S-Adenosylhomocysteine									
S-Adenosylmethioninamine									
S-Adenosylmethionine									
Sarcosine									
Serine									
Spermidine									
Spermine									
S-Ribosyl-L-homocysteine									
Succinyl-CoA									
Thiamine									
Thiamine monophosphate									
Thymine									
Urea									
Ureidosuccinic acid									
Uridine 5'-monophosphate									
Xanthylic acid									
METABOLITES_END
#END