#METABOLOMICS WORKBENCH hjyoo2_20231007_033452 DATATRACK_ID:4380 STUDY_ID:ST002924 ANALYSIS_ID:AN004794 PROJECT_ID:PR001816 VERSION 1 CREATED_ON October 11, 2023, 8:59 pm #PROJECT PR:PROJECT_TITLE Gut sphingolipid metabolites in infants with atopic dermatitis associated with PR:PROJECT_TITLE food allergy PR:PROJECT_SUMMARY This study determines S1P, ceradmides, sphingomyelins and diacylglycerols from PR:PROJECT_SUMMARY infant feces to explore differential sphingolipid metabolism associated with PR:PROJECT_SUMMARY food allergy in atopic dermatitis. PR:INSTITUTE Asan Medical Center PR:LAST_NAME Yoo PR:FIRST_NAME Hyun Ju PR:ADDRESS 88, Olympic-ro, 43-gil, Songpa-gu, Seoul, Seoul, 05505, Korea, South PR:EMAIL yoohyunju@amc.seoul.kr PR:PHONE 02-3010-4029 #STUDY ST:STUDY_TITLE Gut sphingolipid metabolites in infants with atopic dermatitis associated with ST:STUDY_TITLE food allergy - Part 2 ST:STUDY_SUMMARY This study determines sphingolipids and diacylglycerols from infant feces to ST:STUDY_SUMMARY explore the lipid changes with food allergy in atopic dermatitis. Food allergy ST:STUDY_SUMMARY (FA) may be present in the range of 20–80% in atopic dermatitis (AD). Food ST:STUDY_SUMMARY sensitization through the skin can cause FA due to damage to the skin barrier, ST:STUDY_SUMMARY and failure to acquire tolerance to food allergens in the gut can equally cause ST:STUDY_SUMMARY the development of FA. Gut metabolites can influence the physical gut barrier ST:STUDY_SUMMARY and intestinal homeostasis. Therefore, it is possible that gut metabolites ST:STUDY_SUMMARY related to gut immunity play an important role in the development of FA. ST:STUDY_SUMMARY Sphingolipids are key factors in cell inflammatory response and affect gut ST:STUDY_SUMMARY epithelial cells and skin barrier integrity and function. FA is associated with ST:STUDY_SUMMARY a marked decrease in serum sphingolipid levels. However, there are no reports of ST:STUDY_SUMMARY FA-associated gut sphingolipid metabolites in infants by targeted metabolomics. ST:STUDY_SUMMARY In our previous study, we showed that when FA is present in various phenotypes ST:STUDY_SUMMARY of AD in early life, it might be associated with the later development of ST:STUDY_SUMMARY asthma. The discovery of a biomarker that can distinguish the phenotypes that ST:STUDY_SUMMARY accompany AD and FA from other AD phenotypes is therefore expedient. ST:STUDY_SUMMARY Consequently, we aimed to investigate whether FA in AD infants. can be ST:STUDY_SUMMARY classified as gut sphingolipid metabolites using targeted metabolomics. ST:INSTITUTE Asan Medical Center ST:LAST_NAME Yoo ST:FIRST_NAME Hyun Ju ST:ADDRESS 88, Olympic-ro, 43-gil, Songpa-gu, Seoul, Seoul, 05505, Korea, South ST:EMAIL yoohyunju@amc.seoul.kr ST:PHONE 02-3010-4029 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER Not applicable SU:HUMAN_RACE Pacific asian #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 1_AD_human feces_child_1_2_dilu s_AD_1 Factor:AD Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 4_AD_human feces_child_1_2_dilu s_AD_2 Factor:AD Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 10_AD_human feces_child_1_2_dilu s_AD_3 Factor:AD Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 13_AD_child_1_2_dilu s_AD_4 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 24_AD_child_1_2_dilu s_AD_5 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 25_AD_child_1_2_dilu s_AD_6 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 33_AD_child_1_2_dilu s_AD_7 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 39_AD_child_1_2_dilu s_AD_8 Factor:AD Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 41_AD_child_1_2_dilu s_AD_9 Factor:AD Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 46_AD_child_1_2_dilu s_AD_10 Factor:AD Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 51_AD_child_1_2_dilu s_AD_12 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 53_AD_child_1_2_dilu s_AD_13 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 55_AD_child_1_2_dilu s_AD_14 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 56_AD_child_1_2_dilu s_AD_15 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 57_AD_child_1_2_dilu s_AD_16 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 62_AD_child_1_2_dilu s_AD_11 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 64_AD_child_1_2_dilu s_AD_17 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 66_AD_child_1_2_dilu s_AD_18 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 68_AD_child_1_2_dilu s_AD_19 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 11_mild AD_1/3 dilu s_AD_20 Factor:AD Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 12_moderate AD_1/3 dilu s_AD_21 Factor:AD Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 17_severe AD_1/3 dilu s_AD_22 Factor:AD Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 25_mild AD_1/3 dilu s_AD_23 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 33_mild_AD_1/3 dilu s_AD_24 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 34_mild AD_1/3 dilu s_AD_25 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 36_mild AD_1/3 dilu s_AD_26 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 47_moderate AD_1/3 dilu s_AD_27 Factor:AD Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 53_mild_AD_1/3 dilu s_AD_28 Factor:AD Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 66_mild AD_1/3 dilu s_AD_29 Factor:AD Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 78_moderate AD_1/3 dilu s_AD_30 Factor:AD Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 3_AD_human feces_child_1_2_dilu s_AD_FA_1 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 7_AD_human feces_child_1_2_dilu s_AD_FA_2 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 1_Disease_1/30 s_AD_FA_45 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 2_Disease_1/30 s_AD_FA_46 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 3_Disease_1/30 s_AD_FA_47 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 4_Disease_1/30 s_AD_FA_48 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 5_Disease_1/30 s_AD_FA_49 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 6_Disease_1/30 s_AD_FA_50 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 7_Disease_1/30 s_AD_FA_51 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 8_Disease_1/30 s_AD_FA_52 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 9_Disease_1/30 s_AD_FA_53 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 10_Disease_1/30 s_AD_FA_54 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 11_Disease_1/30 s_AD_FA_55 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 12_Disease_1/30 s_AD_FA_56 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 13_Disease_1/30 s_AD_FA_57 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 14_Disease_1/30 s_AD_FA_58 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 15_Disease_1/30 s_AD_FA_59 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 16_Disease_1/30 s_AD_FA_60 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 17_Disease_1/30 s_AD_FA_61 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 18_Disease_1/30 s_AD_FA_62 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 19_Disease_1/30 s_AD_FA_63 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 20_Disease_1/30 s_AD_FA_64 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 21_Disease_1/30 s_AD_FA_65 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 22_Disease_1/30 s_AD_FA_66 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 23_Disease_1/30 s_AD_FA_67 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 24_Disease_1/30 s_AD_FA_68 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 25_Disease_1/30 s_AD_FA_69 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 26_Disease_1/30 s_AD_FA_70 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 27_Disease_1/30 s_AD_FA_71 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 28_Disease_1/30 s_AD_FA_72 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 30_Disease_1/30 s_AD_FA_73 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 31_Disease_1/30 s_AD_FA_74 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 32_Disease_1/30 s_AD_FA_75 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 33_Disease_1/30 s_AD_FA_76 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 34_Disease_1/30 s_AD_FA_77 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 35_Disease_1/30 s_AD_FA_78 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 36_Disease_1/30 s_AD_FA_79 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 37_Disease_1/30 s_AD_FA_80 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 38_Disease_1/30 s_AD_FA_81 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 39_Disease_1/30 s_AD_FA_82 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 61_Disease_1/30 s_AD_FA_83 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 16_AD_child_1_2_dilu s_AD_FA_3 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 35_AD_child_1_2_dilu s_AD_FA_4 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 38_AD_child_1_2_dilu s_AD_FA_5 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 42_AD_child_1_2_dilu s_AD_FA_6 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 45_AD_child_1_2_dilu s_AD_FA_7 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 54_AD_child_1_2_dilu s_AD_FA_8 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 63_AD_child_1_2_dilu s_AD_FA_9 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 67_AD_child_1_2_dilu s_AD_FA_10 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 5_moderate AD_1/3 dilu s_AD_FA_11 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 6_moderate AD_1/3 dilu s_AD_FA_12 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 13_moderate AD_1/3 dilu s_AD_FA_13 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 14_mild AD_1/3 dilu s_AD_FA_14 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 19_severe AD_1/3 dilu s_AD_FA_15 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 28_mild AD_1/3 dilu s_AD_FA_16 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 30_mild AD_1/3 dilu s_AD_FA_17 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 31_moderate AD_1/3 dilu s_AD_FA_18 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 35_moderate AD_1/3 dilu s_AD_FA_19 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 37_moderate AD_1/3 dilu s_AD_FA_20 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 38_mild AD_1/3 dilu s_AD_FA_21 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 39_moderate AD_1/3 dilu s_AD_FA_22 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 40_mild AD_1/3 dilu s_AD_FA_23 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 46_mild AD_1/3 dilu s_AD_FA_24 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 48_severe AD_1/3 dilu s_AD_FA_25 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 49_moderate AD_1/3 dilu s_AD_FA_26 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 51_severe AD_1/3 dilu s_AD_FA_27 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 54_severe AD_1/3 dilu s_AD_FA_28 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 55_mild AD_1/3 dilu s_AD_FA_29 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 56_moderate AD_1/3 dilu s_AD_FA_30 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 57_severe AD_1/3 dilu s_AD_FA_31 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 58_severe AD_1/3 dilu s_AD_FA_32 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 60_moderate AD_1/3 dilu s_AD_FA_33 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 65_moderate AD_1/3 dilu s_AD_FA_34 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 68_moderate AD_1/3 dilu s_AD_FA_35 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 69_severe AD_1/3 dilu s_AD_FA_36 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 70_moderate AD_1/3 dilu s_AD_FA_37 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 71_mild AD_1/3 dilu s_AD_FA_38 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 73_mild_AD_1/3 dilu s_AD_FA_39 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 75_moderate AD_1/3 dilu s_AD_FA_40 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 76_moderate AD_1/3 dilu s_AD_FA_41 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 77_mild AD_1/3 dilu s_AD_FA_42 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 79_severe AD_1/3 dilu s_AD_FA_43 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 80_mild AD_1/3 dilu s_AD_FA_44 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 5_control_human feces_child_1_2_dilu s_Con_1 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 9_control_human feces_child_1_2_dilu s_Con_2 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 11_control_human feces_child_1_2_dilu s_Con_3 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 14_control_human feces_child_1_2_dilu s_Con_4 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 15_control_human feces_child_1_2_dilu s_Con_5 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 41_Control_1/30 s_Con_27 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 43_Control_1/30 s_Con_28 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 44_Control_1/30 s_Con_29 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 45_Control_1/30 s_Con_30 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 48_Control_1/30 s_Con_31 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 49_Control_1/30 s_Con_32 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 50_Control_1/30 s_Con_33 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 51_Control_1/30 s_Con_34 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 52_Control_1/30 s_Con_35 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 53_Control_1/30 s_Con_36 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 54_Control_1/30 s_Con_37 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 55_Control_1/30 s_Con_38 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 56_Control_1/30 s_Con_39 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 57_Control_1/30 s_Con_40 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 58_Control_1/30 s_Con_41 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 59_Control_1/30 s_Con_42 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 60_Control_1/30 s_Con_43 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 62_Control_1/30 s_Con_44 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 63_Control_1/30 s_Con_45 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 64_Control_1/30 s_Con_46 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 18_control_child_1_2_dilu s_Con_6 Factor:Con Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 22_control_child_1_2_dilu s_Con_7 Factor:Con Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 23_control_child_1_2_dilu s_Con_8 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 26_control_child_1_2_dilu s_Con_9 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 29_control_child_1_2_dilu s_Con_10 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 30_control_child_1_2_dilu s_Con_11 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 31_control_child_1_2_dilu s_Con_12 Factor:Con Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 34_control_child_1_2_dilu s_Con_13 Factor:Con Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 43_control_child_1_2_dilu s_Con_14 Factor:Con Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 58_control_child_1_2_dilu s_Con_15 Factor:Con Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 59_control_child_1_2_dilu s_Con_16 Factor:Con Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 60_control_child_1_2_dilu s_Con_17 Factor:Con Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 1_control_1/3 dilu s_Con_19 Factor:Con Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 3_control_1/3 dilu s_Con_20 Factor:Con Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 4_control_1/3 dilu s_Con_21 Factor:Con Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 32_mild AD_1/3 dilu s_Con_18 Factor:Con Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 42_control_1/3 dilu s_Con_22 Factor:Con Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 43_control_1/3 dilu s_Con_23 Factor:Con Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 44_control_1/3 dilu s_Con_24 Factor:Con Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 61_control_1/3 dilu s_Con_25 Factor:Con Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 64_control_1/3 dilu s_Con_26 Factor:Con Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 1_AD_child d_AD_1 Factor:AD Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 4_AD_child d_AD_2 Factor:AD Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 10_AD_child d_AD_3 Factor:AD Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 13_AD_child d_AD_4 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 24_AD_child d_AD_5 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 25_AD_child d_AD_6 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 33_AD_child d_AD_7 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 39_AD_child d_AD_8 Factor:AD Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 41_AD_child d_AD_9 Factor:AD Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 46_AD_child d_AD_10 Factor:AD Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 51_AD_child d_AD_12 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 53_AD_child d_AD_13 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 55_AD_child d_AD_14 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 56_AD_child d_AD_15 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 57_AD_child d_AD_16 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 62_AD_child d_AD_11 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 64_AD_child d_AD_17 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 66_AD_child d_AD_18 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 68_AD_child d_AD_19 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 11_mild AD d_AD_20 Factor:AD Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 12_moderate AD d_AD_21 Factor:AD Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 17_severe AD d_AD_22 Factor:AD Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 25_mild AD d_AD_23 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 33_mild AD d_AD_24 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 34_mild AD d_AD_25 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 36_mild AD d_AD_26 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 47_moderate AD d_AD_27 Factor:AD Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 53_mild_AD d_AD_28 Factor:AD Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 66_mild AD d_AD_29 Factor:AD Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 78_moderate AD d_AD_30 Factor:AD Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 3_AD_child d_AD_FA_1 Factor:AD_FA Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 7_AD_child d_AD_FA_2 Factor:AD_FA Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 1_Disease d_AD_FA_45 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 2_Disease d_AD_FA_46 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 3_Disease d_AD_FA_47 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 4_Disease d_AD_FA_48 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 5_Disease d_AD_FA_49 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 6_Disease d_AD_FA_50 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 7_Disease d_AD_FA_51 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 8_Disease d_AD_FA_52 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 9_Disease d_AD_FA_53 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 10_Disease d_AD_FA_54 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 11_Disease d_AD_FA_55 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 12_Disease d_AD_FA_56 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 13_Disease d_AD_FA_57 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 14_Disease d_AD_FA_58 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 15_Disease d_AD_FA_59 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 16_Disease d_AD_FA_60 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 17_Disease d_AD_FA_61 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 18_Disease d_AD_FA_62 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 19_Disease d_AD_FA_63 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 20_Disease d_AD_FA_64 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 21_Disease d_AD_FA_65 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 22_Disease d_AD_FA_66 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 23_Disease d_AD_FA_67 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 24_Disease d_AD_FA_68 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 25_Disease d_AD_FA_69 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 26_Disease d_AD_FA_70 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 27_Disease d_AD_FA_71 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 28_Disease d_AD_FA_72 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 30_Disease d_AD_FA_73 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 31_Disease d_AD_FA_74 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 32_Disease d_AD_FA_75 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 33_Disease d_AD_FA_76 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 34_Disease d_AD_FA_77 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 35_Disease d_AD_FA_78 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 36_Disease d_AD_FA_79 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 37_Disease d_AD_FA_80 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 38_Disease d_AD_FA_81 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 39_Disease d_AD_FA_82 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 61_Disease d_AD_FA_83 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 16_AD_child d_AD_FA_3 Factor:AD_FA Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 35_AD_child d_AD_FA_4 Factor:AD_FA Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 38_AD_child d_AD_FA_5 Factor:AD_FA Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 42_AD_child d_AD_FA_6 Factor:AD_FA Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 45_AD_child d_AD_FA_7 Factor:AD_FA Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 54_AD_child d_AD_FA_8 Factor:AD_FA Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 63_AD_child d_AD_FA_9 Factor:AD_FA Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 67_AD_child d_AD_FA_10 Factor:AD_FA Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 5_moderate AD d_AD_FA_11 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 6_moderate AD d_AD_FA_12 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 13_moderate AD d_AD_FA_13 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 14_mild AD d_AD_FA_14 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 19_severe AD d_AD_FA_15 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 28_mild AD d_AD_FA_16 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 30_mild AD d_AD_FA_17 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 31_moderate AD d_AD_FA_18 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 35_moderate AD d_AD_FA_19 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 37_moderate AD d_AD_FA_20 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 38_mild AD d_AD_FA_21 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 39_moderate AD d_AD_FA_22 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 40_mild AD d_AD_FA_23 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 46_mild AD d_AD_FA_24 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 48_severe AD d_AD_FA_25 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 49_moderate AD d_AD_FA_26 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 51_severe AD d_AD_FA_27 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 54_severe AD d_AD_FA_28 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 55_mild AD d_AD_FA_29 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 56_moderate AD d_AD_FA_30 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 57_severe AD d_AD_FA_31 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 58_severe AD d_AD_FA_32 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 60_moderate AD d_AD_FA_33 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 65_moderate AD d_AD_FA_34 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 68_moderate AD d_AD_FA_35 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 69_severe AD d_AD_FA_36 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 70_moderate AD d_AD_FA_37 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 71_mild AD d_AD_FA_38 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 73_mild_AD d_AD_FA_39 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 75_moderate AD d_AD_FA_40 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 76_moderate AD d_AD_FA_41 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 77_mild AD d_AD_FA_42 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 79_severe AD d_AD_FA_43 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 80_mild AD d_AD_FA_44 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 5_control_child d_Con_1 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 9_control_child d_Con_2 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 11_control_child d_Con_3 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 14_control_child d_Con_4 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 15_control_child d_Con_5 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 41_Control d_Con_27 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 43_Control d_Con_28 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 44_Control d_Con_29 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 45_Control d_Con_30 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 48_Control d_Con_31 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 49_Control d_Con_32 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 50_Control d_Con_33 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 51_Control d_Con_34 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 52_Control d_Con_35 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 53_Control d_Con_36 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 54_Control d_Con_37 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 55_Control d_Con_38 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 56_Control d_Con_39 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 57_Control d_Con_40 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 58_Control d_Con_41 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 59_Control d_Con_42 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 60_Control d_Con_43 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 62_Control d_Con_44 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 63_Control d_Con_45 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 64_Control d_Con_46 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 18_control_child d_Con_6 Factor:Con Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 22_control_child d_Con_7 Factor:Con Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 23_control_child d_Con_8 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 26_control_child d_Con_9 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 29_control_child d_Con_10 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 30_control_child d_Con_11 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 31_control_child d_Con_12 Factor:Con Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 34_control_child d_Con_13 Factor:Con Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 43_control_child d_Con_14 Factor:Con Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 58_control_child d_Con_15 Factor:Con Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 59_control_child d_Con_16 Factor:Con Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 60_control_child d_Con_17 Factor:Con Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 1_control d_Con_19 Factor:Con Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 3_control d_Con_20 Factor:Con Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 4_control d_Con_21 Factor:Con Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 32_mild AD d_Con_18 Factor:Con Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 42_control d_Con_22 Factor:Con Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 43_control d_Con_23 Factor:Con Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 44_control d_Con_24 Factor:Con Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 61_control d_Con_25 Factor:Con Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 64_control d_Con_26 Factor:Con Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb #COLLECTION CO:COLLECTION_SUMMARY The study population consisted of 158 six-month-old infants (46 healthy infants, CO:COLLECTION_SUMMARY 30 only AD group, and 82 with combined AD and FA) involved in the Cohort for CO:COLLECTION_SUMMARY Childhood Origin of Asthma and Allergic Diseases (COCOA) (reference: BMC Pulm CO:COLLECTION_SUMMARY Med 2014, 14:109.) CO:SAMPLE_TYPE Feces #TREATMENT TR:TREATMENT_SUMMARY no treatment #SAMPLEPREP SP:SAMPLEPREP_SUMMARY ~40 mg of feces was used and lipids were extracted by Bligh and Dyer method SP:SAMPLEPREP_SUMMARY after adding internal standard solutions (50 μl of 100 nM C18 ceramide-d7 and SP:SAMPLEPREP_SUMMARY C18:1 Sphingomyelin-d9 and 200 μl of 1 μM 1,3-19:0-d5). Organic solutions SP:SAMPLEPREP_SUMMARY containing the lipids were dried using a vacuum centrifuge and stored at SP:SAMPLEPREP_SUMMARY –20°C until LC-MS/MS analysis. The dried matter was reconstituted with SP:SAMPLEPREP_SUMMARY methanol and injected into the LC-MS/MS system. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Ceramides, sphingomyelines, sphinganine, sphingosine CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity CH:COLUMN_NAME Agilent Pursuit 5 C18 (150 x 2.0 mm, 5um) CH:SOLVENT_A 5 mM ammonium formate/MeOH/tetrahydrofuran (500/200/300, v/v/v) CH:SOLVENT_B 5 mM ammonium formate/MeOH/ tetrahydrofuran (100/200/700, v/v/v) CH:FLOW_GRADIENT 50 % of B at 0 min, 50 % of B for 5 min, 50-70 % of B for 3 min, 70 % of B for 7 CH:FLOW_GRADIENT min, 70-90 % of B for 7 min, 90 % of B for 3 min, 90-50 % of B for 0.1 min, 50 % CH:FLOW_GRADIENT of B for 4.9 min CH:FLOW_RATE 200 uL/min CH:COLUMN_TEMPERATURE 35 #ANALYSIS AN:ANALYSIS_TYPE MS AN:ACQUISITION_PARAMETERS_FILE MS_metadata.docx #MS MS:INSTRUMENT_NAME ABI Sciex 5500 QTrap MS:INSTRUMENT_TYPE QTRAP MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Multiple reaction monitoring (MRM) was performed in the positive ion mode and MS:MS_COMMENTS the extracted ion chromatogram corresponding to the specific transition for each MS:MS_COMMENTS lipid was used for quantification. The calibration range for each lipid was MS:MS_COMMENTS 0.1-1000 nM (r2 ≥ 0.99). Data analysis was performed by using Analyst 1.5.2 MS:MS_COMMENTS software. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS pmol/mg MS_METABOLITE_DATA_START Samples s_AD_1 s_AD_2 s_AD_3 s_AD_4 s_AD_5 s_AD_6 s_AD_7 s_AD_8 s_AD_9 s_AD_10 s_AD_11 s_AD_12 s_AD_13 s_AD_14 s_AD_15 s_AD_16 s_AD_17 s_AD_18 s_AD_19 s_AD_20 s_AD_21 s_AD_22 s_AD_23 s_AD_24 s_AD_25 s_AD_26 s_AD_27 s_AD_28 s_AD_29 s_AD_30 s_AD_FA_1 s_AD_FA_2 s_AD_FA_3 s_AD_FA_4 s_AD_FA_5 s_AD_FA_6 s_AD_FA_7 s_AD_FA_8 s_AD_FA_9 s_AD_FA_10 s_AD_FA_11 s_AD_FA_12 s_AD_FA_13 s_AD_FA_14 s_AD_FA_15 s_AD_FA_16 s_AD_FA_17 s_AD_FA_18 s_AD_FA_19 s_AD_FA_20 s_AD_FA_21 s_AD_FA_22 s_AD_FA_23 s_AD_FA_24 s_AD_FA_25 s_AD_FA_26 s_AD_FA_27 s_AD_FA_28 s_AD_FA_29 s_AD_FA_30 s_AD_FA_31 s_AD_FA_32 s_AD_FA_33 s_AD_FA_34 s_AD_FA_35 s_AD_FA_36 s_AD_FA_37 s_AD_FA_38 s_AD_FA_39 s_AD_FA_40 s_AD_FA_41 s_AD_FA_42 s_AD_FA_43 s_AD_FA_44 s_AD_FA_45 s_AD_FA_46 s_AD_FA_47 s_AD_FA_48 s_AD_FA_49 s_AD_FA_50 s_AD_FA_51 s_AD_FA_52 s_AD_FA_53 s_AD_FA_54 s_AD_FA_55 s_AD_FA_56 s_AD_FA_57 s_AD_FA_58 s_AD_FA_59 s_AD_FA_60 s_AD_FA_61 s_AD_FA_62 s_AD_FA_63 s_AD_FA_64 s_AD_FA_65 s_AD_FA_66 s_AD_FA_67 s_AD_FA_68 s_AD_FA_69 s_AD_FA_70 s_AD_FA_71 s_AD_FA_72 s_AD_FA_73 s_AD_FA_74 s_AD_FA_75 s_AD_FA_76 s_AD_FA_77 s_AD_FA_78 s_AD_FA_79 s_AD_FA_80 s_AD_FA_81 s_AD_FA_82 s_AD_FA_83 s_Con_1 s_Con_2 s_Con_3 s_Con_4 s_Con_5 s_Con_6 s_Con_7 s_Con_8 s_Con_9 s_Con_10 s_Con_11 s_Con_12 s_Con_13 s_Con_14 s_Con_15 s_Con_16 s_Con_17 s_Con_18 s_Con_19 s_Con_20 s_Con_21 s_Con_22 s_Con_23 s_Con_24 s_Con_25 s_Con_26 s_Con_27 s_Con_28 s_Con_29 s_Con_30 s_Con_31 s_Con_32 s_Con_33 s_Con_34 s_Con_35 s_Con_36 s_Con_37 s_Con_38 s_Con_39 s_Con_40 s_Con_41 s_Con_42 s_Con_43 s_Con_44 s_Con_45 s_Con_46 Factors Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con C14_Ceramide 8.139130435 7.261538462 11.68 3.04157377 8.334857143 7.049309091 4.669935484 6.25434986 8.714883561 4.021650914 18.33494354 13.14487982 21.04502529 10.2230837 14.90942628 13.18291273 8.168467211 4.580503576 4.045883994 1.628408269 2.427177254 13.18547643 3.098642923 2.002532248 0.126185517 3.392252671 3.745125439 9.717170084 5.643994869 11.09886116 1.477894737 9.476923077 7.994434783 2.172708571 13.91855316 9.346614625 9.489922612 12.60235839 3.161963051 7.604624277 11.53952822 3.704939193 2.449043716 3.32506884 1.153952822 1.097752535 0.630656587 5.41411236 2.8710554 1.15825858 2.529180131 3.30294905 1.820693295 4.662376689 7.860394108 0.728647199 1.190870206 2.892849323 1.782977617 1.143758708 2.161161143 7.219527663 0.375942974 1.40602165 3.82238806 9.237437811 1.386781034 2.550249534 0.158919938 1.07250516 0.843771832 3.702938433 1.525968983 9.861538962 6.350518629 2.481420561 7.615084112 11.96260486 27.29562617 10.4051838 10.101 6.957131691 46.95279252 15.28738148 15.89926217 2.407802969 16.95921299 7.160556594 5.26106716 10.3746963 13.68566852 19.25185459 18.7441992 8.364598891 19.14972274 7.886621811 23.64187705 10.14169316 37.99304991 27.08536784 3.814160533 7.256246243 38.2578537 5.019455192 12.38480854 3.063704053 19.82883986 10.53156062 10.92229466 3.66655516 11.69168399 27.60700356 6.513527402 12.49811321 11.23404255 8.15483871 7.560784314 8.444444444 8.193391304 5.872941176 8.980119147 11.4738073 10.26778512 7.0378891 4.639369348 12.14381642 5.411453744 9.011594696 12.4752953 8.432335433 15.44865523 2.774853996 5.133864932 2.920048792 7.676882962 4.404267516 9.236727707 2.022499364 1.638959997 15.51252336 15.84109414 6.687558621 20.202 25.24575701 25.62858487 4.689244833 6.650115888 11.18900891 13.47239317 8.493781885 4.906065552 40.77145433 43.80311231 9.140985623 20.27000712 16.17380006 50.21273836 17.78288968 20.33073905 C16_Ceramide 18.29463556 29.7230341 15.69890977 9.266984852 17.27064497 18.79739164 11.75325983 26.52025378 31.29982105 20.45135558 41.63040674 29.82543641 49.27680798 13.9680798 23.55777224 20.71195324 14.64120832 9.410841855 6.658934169 14.29189301 18.94268281 32.4419591 16.31358025 11.26218327 4.922770866 10.93781544 20.84614013 28.69930186 16.79220084 23.76111601 11.29018789 42.09881698 28.38392955 15.60313442 44.03969416 33.91932145 39.5977343 30.98465956 10.47078269 23.17176681 32.65050822 26.45609155 19.45143653 18.20182635 20.11537539 8.160562343 6.991643007 22.88478192 18.53287189 9.045775885 14.6244654 16.28088771 21.26436879 24.13655571 26.53924012 10.98819209 21.45406777 18.5081212 10.47870613 14.13489425 16.19626369 29.20327631 7.80933384 14.29715713 18.30036113 23.99560626 12.32400749 20.95229399 2.453015894 16.53958453 6.460775206 15.57150197 15.12209045 23.02139481 62.26623794 47.27151125 58.37459807 85.92740836 80.53311897 102.7887103 64.12866559 63.23662087 139.5272026 95.42098802 50.70250804 46.85665217 83.33376206 40.86839586 105.8806667 68.28688372 86.944 88.92 96.70776471 78.92376471 123.272 92.34506667 117.7950968 116.5333333 166.1866667 160.3382857 47.54375758 54.38295652 89.68037614 47.4976149 58.53184855 31.55760769 113.5429844 63.25547142 91.53853007 45.05412027 92.13434298 118.6656214 66.65699332 22.9094681 30.72002843 17.18858733 18.36145565 15.6607129 19.39387268 14.14114338 29.26956239 31.79416789 40.78822936 41.5677959 25.28678304 28.81440467 24.87531172 13.08847837 21.12324829 12.91821882 24.85210257 21.44358179 17.47233853 14.59021606 26.50175532 20.69161094 30.7750228 11.0696573 11.21410275 88.7113583 67.03925967 73.15516133 84.22620579 107.6951768 117.072005 45.26836364 47.50991304 87.30327273 85.43294118 55.22118919 41.73697561 175.5955457 128.6468419 75.33151596 82.92705712 106.5335655 205.732081 105.906844 77.54574403 C18_Ceramide 4.250931677 15.62959707 6.810285714 1.98121766 8.997935103 19.49262537 1.996422114 6.475273011 8.319456989 2.826058422 20.21661806 8.709155975 14.19739819 4.400275545 5.921457042 24.03106201 3.755126024 4.997309417 1.37943405 5.526755395 2.320281325 7.12877095 6.491961195 7.796385454 0.716382766 2.258479223 4.486667308 13.78488601 6.512129934 11.41173246 3.868270677 28.37186813 26.65404643 4.483303835 25.0849714 47.27871322 46.70240628 8.052866978 5.171124593 21.22312447 4.68242128 6.814427982 9.915114836 2.412069367 12.40985272 1.870303106 0.373269795 9.64519949 3.163303351 1.846760829 7.772688234 7.97583804 8.634442799 14.21220663 10.20259434 2.406469663 5.812926536 10.18302869 2.081073113 2.752530464 4.06750623 17.0258337 3.472901926 6.977282072 8.467836257 8.864766082 1.782553755 14.69880757 0.398008438 3.075150476 0.950097984 2.137467105 16.00123355 16.54643513 10.09654775 7.837751351 20.53837838 24.43174054 22.42637838 25.71762162 10.17989189 28.31536118 54.3744 99.62331204 15.22753912 32.77736089 67.30196302 8.096288288 27.1254321 38.77907551 30.31019943 18.71813443 13.68868555 17.13185185 32.28695157 47.20776955 32.78999602 46.12421652 159.6044318 61.18518519 26.1304003 17.87671498 20.72154474 46.76963077 18.68001324 19.09080921 55.90879841 24.86585369 56.04003972 7.630861966 56.8173921 33.34841708 43.752572 5.597843666 25.02030395 6.112073733 6.663529412 3.970793651 8.729306143 9.994748106 8.446057421 8.698127925 22.4767653 24.3503147 22.68610166 6.79800995 14.26717694 9.053099446 6.796100604 6.412957633 1.924388966 14.03002793 2.280635171 6.801102204 35.00471698 4.909198113 19.97830189 3.518241627 2.814278611 44.02115413 17.56325379 33.10774278 16.74324324 22.04367568 22.95228596 12.01825365 7.436216855 34.2637037 29.72880174 8.581360027 10.1955411 157.7083085 33.51378113 60.87846938 23.8362597 87.1919545 60.15416951 38.58494538 20.38208078 C18_1_Ceramide 4.412041278 9.639524361 8.467763338 0.368008346 9.569064935 11.61924298 4.087917889 5.029969455 5.240526316 2.981678766 25.59219049 6.47904466 11.13590141 9.645972203 13.12475285 15.50393632 4.17344581 4.395760115 2.612787503 2.013513347 1.309683874 11.83840336 9.835310747 2.176006008 0.42160382 4.408005008 5.503286368 9.495106762 6.270293759 10.1004732 1.749231766 10.47774387 13.81386166 1.673293247 11.01758271 8.14475888 10.77597403 9.157971486 2.572559034 4.040744831 4.110556723 4.3217711 2.982852474 2.329315476 2.986098644 1.127716511 2.078442817 7.768470083 1.381982154 0.759851767 2.336989296 4.739479454 3.091584604 8.012943755 8.469635231 1.206437094 1.765685811 5.06405694 1.251627709 3.378675489 4.586315719 8.302698005 1.954409475 2.152600848 2.853467016 10.82717391 0.898578683 2.877134792 0.225140982 1.251122444 0.717480422 2.688125937 8.070378092 8.567843259 4.780468643 2.207585386 18.62520251 25.77262397 47.08268267 29.61924565 15.82414666 10.89997647 37.91559081 16.50870222 20.86145215 5.289694462 51.7094438 5.917382046 8.286196904 9.755551588 10.79595847 19.85234675 9.626611109 8.925940047 27.68705216 10.72026724 26.56260701 14.60707788 54.04618814 34.47649783 5.979244357 10.67298188 45.15340113 13.71785146 16.01370621 2.247425382 19.68898305 12.49594124 11.81338983 6.571198093 22.53631291 66.62751864 16.83408051 8.481041737 9.998442821 5.602213053 6.276374024 6.05380757 4.388164032 5.999048128 8.169442026 5.942382519 9.769224701 9.990560021 4.645745849 6.299669507 9.065935049 6.192089767 6.964637829 2.474335676 2.95960084 4.30487395 1.153555444 4.447852745 9.836930605 6.152829181 11.81191281 2.836496524 1.420531667 55.49806963 10.39150018 9.766189158 17.67939144 22.2005762 11.94115806 5.626139375 5.021255189 45.19743766 33.05339574 7.166440566 4.610460168 93.58829944 45.55243119 14.59609944 25.92560147 31.64556549 50.12986293 14.94234173 19.12120773 C20_Ceramide 1.194466768 6.050675387 1.320619224 0.812519225 2.219643973 6.296732724 1.03268159 2.141047222 4.424109162 1.345909579 5.341624158 8.055559016 9.956844181 0.786166591 2.490293782 13.28459044 1.960135539 1.108850789 1.461191947 2.339709868 1.076330817 2.8225 2.555886009 0.532445694 0.09004069 0.546068875 1.895292956 7.397681452 2.285082459 12.88003654 1.46724195 11.92338973 8.531396138 1.268687071 17.46059259 22.37854406 18.6826936 6.86356464 2.127847671 4.05030464 1.567186345 3.741383881 4.20697832 0.920276507 3.624607354 0.432534555 0.165380859 2.616024503 0.561525709 0.750574669 2.031821987 4.28486772 5.069282863 3.96090766 8.244017595 1.986510264 1.215152555 3.326370051 0.880385231 1.184663673 1.325901898 10.0480461 0.479038673 0.888643178 3.949525237 11.87678661 0.548048232 4.157580585 0.149027117 1.698956107 2.468753389 2.38918066 2.113701274 8.591201492 3.044001992 3.147176763 3.589910788 16.40271137 16.12538589 9.209560166 3.708059751 17.71408223 56.83614274 60.94173067 5.544869535 13.98541567 35.35858834 4.879451176 11.33458967 26.47264181 20.35660872 17.99913381 13.73542803 5.408324787 47.59854098 23.93398334 13.89715162 21.10501345 97.891339 33.85783009 13.33793307 10.10151153 9.950308017 23.52451093 5.06757173 5.152851497 18.61556962 5.360227848 32.34620253 2.807188291 8.715702045 20.26720633 17.15503956 2.038493356 10.41072089 2.388122354 1.880280526 1.745830766 3.738858865 4.997141492 10.47472904 5.388833333 5.729850638 9.734666667 5.218789577 2.510480393 6.052913063 6.657123427 6.515707464 2.468121819 1.032621951 2.845447154 1.608795069 5.872708068 32.18146628 2.18516129 10.08153959 1.661878152 1.839284718 5.058052888 7.575720352 17.90097811 13.34628859 18.07289627 23.50079615 6.341709555 10.05075016 8.570594922 9.614799621 4.827817339 2.876064625 71.00761603 18.65359291 26.00018565 11.95935272 43.01624856 50.38774904 19.93225453 5.080825434 C24_Ceramide 4.394554238 16.77990158 3.502401796 2.300089419 6.511428571 10.48436364 3.120938416 6.392615385 9.283368421 3.832870027 27.6640435 18.88971391 21.51863532 2.598404086 6.716342724 20.92501707 4.985171536 5.251770389 2.529788541 4.52743152 2.63159009 6.844924893 2.445470832 2.856994121 0.360566775 0.78146672 4.315885373 16.22199445 4.417417752 16.25335204 5.049229133 24.55488215 17.99905138 5.572571429 38.09476923 41.38779841 27.67365967 14.0746888 5.026313426 12.92323774 3.036742831 5.809421067 8.90777897 1.902181968 8.444276117 0.697959471 0.309813802 4.108132218 2.022395652 1.44518667 4.066542578 8.119221943 6.745156493 6.110341917 11.46542355 4.385608593 4.03373923 5.360311209 1.923556654 1.890215005 3.7900115 19.78788079 1.142592652 3.462806289 5.590404387 15.77292666 1.453602534 7.26253427 0.248703549 5.989718986 1.382733 3.354242632 4.60459647 11.24813507 9.171364103 15.21230769 14.56 31.1808 25.55076923 21.82564103 9.291692308 33.08307692 72.66461538 105.6402797 11.86202429 43.42153846 47.88340081 13.4017094 39.73194389 46.34379084 40.55549869 35.21154309 26.87049393 17.80170223 36.01679667 53.29314629 34.81245847 48.31521505 150.8020348 65.74634068 33.22170158 24.20534983 13.09339918 35.65597306 9.336375309 10.2697626 38.81955556 11.71370667 78.14162963 9.134844444 28.95279772 41.94773333 37.59466667 7.24040404 20.21737947 5.065710872 5.105803129 3.658910089 6.519209486 14.1484492 30.9445614 10.48584615 22.58481715 22.4933687 9.728819975 8.635656516 14.6701564 10.05262685 14.5039053 4.66333979 2.98879426 4.383564914 1.87786988 10.6601509 29.38579029 4.920201446 14.67032541 2.664744299 3.865458183 15.64740125 14.42341463 53.61740053 25.58769231 34.70769231 40.42004963 18.09025469 12.78538991 34.77896885 25.19108806 13.08665677 9.539844567 75.48246914 31.44760889 40.68724938 26.38222222 74.03011448 69.51142029 47.34539339 17.30182946 C24_1_Ceramide 2.505566131 8.098612421 1.521970811 1.278720553 1.421940874 5.634419257 2.991093789 5.027542373 3.998513232 4.145314631 9.002524967 7.138286518 5.532677596 1.443461398 3.013044451 15.84904275 4.301569645 1.858689023 1.372591769 5.503831192 2.876324077 4.619038076 5.15329658 4.210214924 0.526633663 0.535466094 6.32423756 29.37476592 6.186576355 15.70905172 1.816915845 15.30211505 10.82132558 2.556298201 22.64256121 26.81355932 18.41739428 5.675884528 3.846876098 10.97270173 9.07118783 9.320467021 8.264261857 3.380385772 8.748178175 1.544454494 1.316584158 14.03026553 5.171079899 1.927051599 4.040311174 8.943463096 14.88312527 11.55330227 12.30696629 3.524212382 6.404972508 5.810393258 1.936797753 3.16343633 3.858978164 40.25450745 1.475655431 5.307112069 14.39490969 16.9180624 2.968136489 14.08355911 0.325942386 11.49046222 1.24196101 3.435369458 5.749876847 22.54588154 8.990772277 6.390653465 10.1420297 21.18313663 12.39363861 49.15686469 7.904615718 22.22774077 21.70942574 79.14271827 3.375867639 12.77025044 45.58863992 7.370484048 22.44984668 20.5325938 49.45641725 15.8469506 12.69087724 15.18111234 13.93138514 32.29759455 17.08841677 40.86539641 130.0262613 62.9997138 16.18995818 10.43339604 6.472369209 21.3337817 5.311354232 5.943839743 13.48915361 7.442838871 42.84789969 7.810815047 18.4789197 20.30811912 20.56847962 4.976585269 15.11438685 4.611671657 2.498952646 2.042018551 4.561931374 5.550037804 7.699098028 6.11684322 10.27120496 18.02980713 12.57794395 3.633750116 10.32943814 6.320662028 6.212622721 4.553126839 7.01738477 7.556272545 2.379036334 10.44908062 46.48314607 4.471235955 33.24651685 3.215696373 3.825352274 11.2014236 9.787693794 22.79829976 10.58745668 15.74168317 14.74882785 6.956193898 4.763928005 13.45961778 18.24396833 8.516971131 6.084787302 94.53979101 8.64813442 25.45747126 8.73685402 54.53369051 23.00228431 24.7694315 5.967704892 18_0_SM 0.536059204 4.055501 0.429659574 0.955912331 0.673156056 1.769881423 0.138226508 0.941176326 0.118386103 0.289077976 0.562384506 0.776505648 1.148215525 0.04189235 0.173869743 20.49407145 0.068441036 0.394201561 0.099495779 17.21015478 0.787723214 0.94872089 6.002636916 5.112582739 0.287251408 0.124978532 1.00963189 14.34343361 3.109433741 0.544150905 10.74968272 9.100927441 21.20311909 1.057962733 0.149725737 21.41318339 4.641686015 0.92282939 8.349250671 23.51310979 0.933888543 10.41070764 36.25684932 0.941041488 13.25297712 1.671552372 0.050372811 3.398318254 2.622636048 1.99403836 4.891037487 7.812955985 7.959328084 10.80942273 2.345795561 4.850192413 3.100769288 5.153329439 2.422064836 1.846609716 2.321915227 18.0726065 4.895662967 4.042263863 9.507957393 1.290760495 0.803902382 19.77599859 0.046506313 0.730386138 0.047898511 0.629349389 7.213886278 16.60292993 0.682769607 5.831606987 1.908212227 0.74589359 0.707384279 1.782071616 0.141908188 8.25647638 10.1035179 26.11623025 0.808542956 44.61493964 12.13661963 4.258363901 43.44586207 5.198717562 8.672870027 1.921508046 0.528830264 4.248593915 2.327980902 42.04711724 1.320808899 23.27980902 19.69328382 10.97197241 24.584 2.852776012 0.280585387 6.887095855 3.251643733 21.12545093 6.349696 4.337273173 45.346944 0.52658928 6.535561846 7.38700032 26.771976 0.361868058 17.11748906 0.226982384 0.813166458 0.145987392 0.757254253 3.068883205 0.048661772 0.252274067 2.392308931 15.2925818 19.07503004 0.298442535 7.475489989 2.121601172 0.976998737 3.040673809 1.083928724 22.02603596 0.443358212 19.87786081 3.883549065 0.409380491 8.904953271 2.060706543 4.367669719 0.395351805 2.771296794 9.728467399 0.507850153 1.463077729 1.78276422 11.90667085 0.856938531 1.468104075 2.573092089 0.572557465 3.858178638 3.9924416 1.614283776 26.64250027 0.867482984 43.19632291 0.609512181 10.90732281 0.544461276 18_1_SM 0.035002211 0.386840504 0.042471186 0.06166742 0.039354136 0.100588679 0.015566553 0.059465567 NA 0.030300926 0.052480944 0.065927978 0.143078363 NA 0.002129474 0.799608877 0.012267215 0.036244516 0.006574143 0.406264403 0.07596539 0.100928041 0.524667946 0.45239943 0.020668615 0.014175018 0.106423584 1.337488252 0.389782483 0.047083817 0.507118644 0.575384615 0.693860037 0.118550943 NA 1.153524904 0.163074074 0.068515152 0.615075075 1.801853746 0.082045923 0.748863738 2.169402062 0.081034794 0.387118088 0.171677697 0.005430761 0.27962072 0.263779825 0.15705045 0.233205009 0.448848878 0.551171654 0.683995049 0.191903008 0.252216939 0.076433771 0.146785714 0.181726333 0.095603853 0.150867144 1.013306522 0.212935855 0.239591067 0.727911833 0.19961949 0.044656216 0.543549884 0.004197897 0.063911241 0.003134694 0.035473782 0.319335557 1.792982787 0.098813843 0.359580723 0.149756731 0.038522039 0.098329282 0.301646749 0.009575791 0.499189104 1.072982294 0.991396543 0.100039922 1.626317444 1.054966447 0.363512066 1.881856651 0.248838607 0.414261061 0.11703717 0.036552447 0.135511509 0.494315263 1.212471399 0.097584392 1.266877167 0.584473392 0.724018635 0.9176204 0.185165469 0.044591839 0.351675717 0.317697387 0.352110805 0.734174634 0.531987389 1.294817081 0.033988948 0.826588224 0.274714799 1.568046845 0.037794691 1.186873422 0.020652816 0.087254237 0.011175392 0.071203256 0.103560716 NA 0.03124783 0.313937462 1.418919221 0.652686981 0.022929527 0.385425101 0.091567568 0.081865909 0.112882255 0.122982216 0.940639175 0.051950695 1.364371853 0.390295489 0.046353383 2.846097744 0.338093229 0.315019425 0.014259581 0.210727108 0.436161514 0.031031323 0.10038638 0.159790061 0.505655686 0.083027933 0.106229028 0.140860648 0.054561213 0.289810237 0.3589669 0.153616031 1.663239261 0.047351558 2.31052645 0.039488729 0.48260708 0.062452961 16_0_SM 3.687994809 11.87416762 3.859104478 8.615036744 7.684729064 7.087147335 3.350389321 6.273381295 1.809415625 5.509302903 2.944724653 8.426080126 13.04199005 1.02458783 1.972788688 38.32639302 2.099243061 3.721648064 2.278665545 21.02872319 8.607262303 12.41167224 14.77750602 6.074351882 2.01160872 1.767059228 9.117795918 72.4353125 14.76586607 7.479441964 15.23330715 20.05970149 35.83808096 9.174384236 1.493333333 22.54527413 8.999345978 7.641791045 25.50613741 41.34475939 11.3312652 24.42778464 34.47686734 7.123406145 21.25895979 6.48145377 1.428881103 14.67582593 19.69913753 6.940317753 11.71741958 18.03126881 44.09084365 13.79685366 11.99799 12.15129412 7.397648936 8.59465625 8.761840909 8.407 9.075481132 55.72081395 6.2301875 8.06921875 25.39257143 12.12438095 6.025923345 27.85891071 0.483943323 12.18339666 0.651606383 7.206 11.35588393 47.28189369 0.73662359 4.879331868 2.006892308 0.439532308 0.824123077 5.358495726 0.276996923 9.489902098 6.122057143 26.58282517 0.804845344 20.73773756 8.41794332 3.561025641 47.02772093 3.117315738 12.90487299 2.450009302 0.45873554 2.660079891 4.618922361 29.81536744 0.972502326 18.27125581 16.48246154 10.46444651 20.38528541 2.166552073 0.249941851 7.103973514 1.378262822 6.772578112 3.181023369 2.174873445 39.77633991 1.002875873 4.814679584 5.849397997 18.70612443 5.666460152 25.60812956 1.691670679 11.50763828 2.610945274 9.877061469 11.61866126 0.558980184 3.928057554 16.15284821 43.34408335 24.33307148 2.09825449 14.54879449 4.820659971 12.89501591 21.74493387 15.36396321 28.98065217 6.483513887 33.17399311 9.62001 3.491307 50.8023 7.808449675 10.9526412 0.097013888 4.55612758 8.525411141 0.552276923 1.49127033 1.352861538 8.210739958 0.677047523 1.392994503 2.007883995 0.307738228 1.956766421 2.712269499 1.429347059 15.72989863 0.579465024 41.72722307 0.388904316 8.550492392 0.820429544 24_0_SM 0.278040965 3.100578035 0.282927746 0.513989182 0.431908256 0.549331248 0.071980018 0.351415094 0.040443562 0.199700716 0.184735317 0.685147218 1.377438706 0.041133158 0.097677398 11.83655577 0.012727603 0.235011519 0.073570932 7.474463152 0.744958655 0.609369673 2.296101054 2.111604045 0.211411379 0.185324718 0.947660099 8.384159483 2.295900152 0.368036799 8.077821722 5.724144064 8.781059673 0.49095026 0.056226415 22.29668185 2.77724414 0.622062567 2.450713878 5.489267909 0.304001687 4.395920825 14.42205256 0.407043457 6.769394047 0.725872117 0.103443209 1.301123931 2.659502061 1.89158496 1.917669584 5.676472051 8.144503377 2.572550463 1.494775862 7.500760649 1.105603448 2.017726293 1.392055251 0.916729526 1.401821731 20.77506014 1.791998922 3.382691172 5.830857529 2.618112762 0.579776766 9.612255233 0.064382908 1.456486057 0.10723275 0.545560432 2.140025743 8.005177991 0.364208281 8.253031579 1.866421053 0.461642779 0.748136842 0.844159064 0.216559737 5.445557895 14.52985263 16.12907177 0.956901939 38.82672446 4.054120776 2.830128655 38.57470313 2.431342151 6.597977885 2.454309375 0.425520993 2.060308456 10.72284231 27.3396375 0.958382419 10.28959615 11.91426923 7.56324 25.70757955 2.257471467 0.204976675 2.022662396 0.732325757 8.508122738 1.828817866 1.483285757 50.23259553 0.664543697 1.840489864 9.894783127 16.456366 0.511156615 4.47769647 0.309432687 1.208313499 0.12725289 0.207133867 2.8423196 0.038076134 0.152689858 2.249056604 6.747169811 3.478439721 0.143246686 2.349365756 0.746701885 1.059242824 0.147197145 0.553351385 4.153551136 0.386128181 25.19983924 3.055887931 0.316202586 4.90887931 1.360948914 6.978098551 0.145278179 2.223638511 8.795272595 0.424061842 1.712715789 2.235455348 17.28061364 2.219209239 1.515253807 2.112075 0.362477736 2.103489329 1.323031266 1.516082025 5.731893201 0.979053209 21.34467855 0.546874528 9.246613641 0.699694164 24_1_SM 0.213057862 4.756843157 0.260374573 0.554416862 0.36 0.935064935 0.189788018 0.512650177 0.054977869 0.498598757 0.161731594 0.492119488 0.755171171 0.036658628 0.083254623 12.65161731 0.029585866 0.229351353 0.133051866 14.37278144 1.181942734 1.219267241 5.599275046 4.017431071 0.258725613 0.111031662 1.91209266 19.47684602 3.316412226 0.635913995 7.290916286 10.23347179 14.31055901 0.768783673 0.109891166 15.64693554 1.848249277 0.504226044 4.037600543 9.037054188 1.510888519 9.371696964 29.90107759 0.982792295 11.94195729 1.126254181 0.222304241 2.953217638 4.747292331 2.390582792 2.604462793 9.022831788 10.61984241 4.967791109 1.490933468 5.431451613 1.716107584 1.977387853 1.819227685 1.587002268 1.517988246 35.05180983 1.548812374 3.005163182 9.530660377 2.47568205 0.917255382 10.56100204 0.056836782 1.846942235 0.049324867 0.613053289 2.749724312 18.30054522 0.73662359 4.879331868 2.006892308 0.439532308 0.824123077 5.358495726 0.276996923 9.489902098 6.122057143 26.58282517 0.804845344 20.73773756 8.41794332 3.561025641 47.02772093 3.117315738 12.90487299 2.450009302 0.45873554 2.660079891 4.618922361 29.81536744 0.972502326 18.27125581 16.48246154 10.46444651 20.38528541 2.166552073 0.249941851 7.103973514 1.378262822 6.772578112 3.181023369 2.174873445 39.77633991 1.002875873 4.814679584 5.849397997 18.70612443 0.54116767 12.67248586 0.130909091 0.837602026 0.200027341 0.838956522 2.097478992 0.023614655 0.372985866 2.051462666 12.29272572 7.231863442 0.092872194 4.833679834 1.104572148 0.560624597 1.295217488 1.825272091 17.41810345 0.709977043 25.97280049 5.580816532 0.375992238 10.4283871 1.290854185 5.331419067 0.097013888 4.55612758 8.525411141 0.552276923 1.49127033 1.352861538 8.210739958 0.677047523 1.392994503 2.007883995 0.307738228 1.956766421 2.712269499 1.429347059 15.72989863 0.579465024 41.72722307 0.388904316 8.550492392 0.820429544 SA 10.58695652 14.66666667 33.83333333 5.672131148 16.78571429 17.12727273 5.64516129 7 7.070175439 4.293103448 9.5 5.385964912 10.2 15.33846154 24.73684211 8.268292683 7 7.779661017 2.827586207 3.275259972 17.81049755 22.68815303 11.11733983 23.93640872 8.31457753 23.23285331 4.741524029 8.169942876 9.226256983 38.12238128 2.736842105 7.846153846 24.43478261 6.457142857 4.933333333 4.206896552 17.72727273 6.242424242 40.19607843 3.594594595 13.20460542 9.409716646 6.294195251 3.207618734 4.357519789 4.06947718 3.36640539 9.79301722 8.629979918 8.492821941 5.914643852 7.074670803 6.200375439 6.316384736 9.53016129 3.714104997 21.34746054 5.025285618 2.764607771 7.399193548 7.482958004 14.93604651 7.553343414 7.143942039 7.27849162 42.37243948 5.138200027 50.35998603 4.51284309 15.47524664 19.00870676 32.90698324 20.29776536 11.33613746 50.53533333 10.92675 26.105625 51.4794 54.6975 304.7722222 66.1565625 29.75 59.262 31.58909091 55.24105263 56.7 92.69473684 14.74277778 24.395 14.94418605 10.16076923 21.7175 19.845 95.55 125.7738462 19.992 47.21612903 34.14384615 64.53461538 30.192 14.71272727 11.40847826 55.59944444 18.49909091 16.26333333 7.453463415 17.51 20.23 16.15 2.8336875 12.99846154 21.063 27.3328125 14.32075472 8.829787234 1.377419355 20.78431373 10.09259259 14.26086957 7.960784314 43.33333333 15.9375 7.37704918 37.24137931 5.350877193 8.966101695 3.769230769 8.558823529 10.06521739 6.597014925 3.667579156 7.204432718 7.13622806 7.072537093 9.293387097 9.648548387 27.55459677 7.653599543 3.683350656 91.56567568 32.65243902 22.40482759 57.9009375 56.355 55.39258065 9.119727273 9.701086957 24.82772727 16.065 12.44675676 20.20097561 67.43333333 47.2668 16.50133333 24.79702703 33.10363636 24.05869565 20.64810811 21.08790698 SO 25.43478261 29.74358974 36.16666667 9.836065574 43.03571429 36.54545455 12.83870968 20.46875 9.543859649 8.275862069 55.17241379 17.71929825 35.77777778 26.46153846 24.73684211 38.53658537 19.82758621 27.11864407 9.810344828 16.73529412 40.71428571 114.3 47.38636364 5.341463415 1.786666667 43.58490566 41.63265306 26.21875 169.875 371.875 5.684210526 18.84615385 53.47826087 11.28571429 13.75 22.5862069 76.06060606 13.66666667 19.80392157 7.972972973 120.3409091 39.7826087 37 10.34375 47.04545455 17.71153846 12.97674419 63.40909091 15.1744186 11.65384615 28.39285714 33.85227273 32.60869565 55.24390244 29.79 16.47058824 17.0106383 124.375 19.09090909 13.5 138.9622642 76.74418605 19.5 8.5625 49.33333333 184.3333333 19.5 39.375 0.541304348 39.57446809 10.53191489 51.3 79.875 55.11627907 17.45333333 19.89 98.91875 127.092 177.225 156.6833333 74.52375 77.13363636 211.14 123.3272727 119.3131579 74.76 368.9 32.06388889 46.55875 50.56116279 22.33538462 66.3425 51.24 53.97 46.27269231 78.183 135.8903226 92.45384615 280.1076923 126.48 38.29636364 38.41630435 216.1833333 77.45818182 72.49083333 31.17219512 108.8 66.32266667 60.605 9.6613125 80.64538462 126.378 108.215625 33.77358491 19.14893617 2.709677419 20 28.14814815 24.7826087 21.96078431 45.78947368 24.6875 33.60655738 46.55172414 13.35087719 18.13559322 14 31.17647059 33.26086957 19.10447761 22.9125 36.9 8.608695652 44.69387755 119.1 141.9 38.7 67.15909091 16.29069767 295.2486486 89.68536585 55.64275862 82.779375 81.7275 138.1935484 34.56409091 34.76869565 146.2077273 110.25 36.85783784 49.71878049 380.8 228.48 77.588 110.9594595 148.2090909 180.0521739 96.00405405 106.2697674 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name annotation HMDB_ID C14_Ceramide Cer(d18:1/14:0) HMDB0011773 C16_Ceramide Cer(d18:1/16:0) HMDB0004949 C18_Ceramide Cer(d18:1/18:0) HMDB0004950 C18_1_Ceramide Cer(d18:1/18:1) HMDB0011774 C20_Ceramide Cer(d18:1/20:0) HMDB0004951 C24_Ceramide Cer(d18:1/24:0) HMDB0004956 C24_1_Ceramide Cer(d18:1/24:1) HMDB0004953 18_0_SM SM(d18:1/18:0) HMDB0001348 18_1_SM SM(d18:1/18:1) HMDB0012101 16_0_SM SM(d18:1/16:0) HMDB0010169 24_0_SM SM(d18:1/24:0) HMDB0011697 24_1_SM SM(d18:1/24:1) HMDB0012107 SA Sphinganine HMDB0000269 SO Sphingosine HMDB0000252 METABOLITES_END #END