{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002933","ANALYSIS_ID":"AN004811","VERSION":"1","CREATED_ON":"October 16, 2023, 3:29 pm"},

"PROJECT":{"PROJECT_TITLE":"Coral endosymbiont growth is enhanced by metabolic interactions with bacteria","PROJECT_SUMMARY":"Bacteria are key contributors to microalgae resource acquisition, competitive performance, and functional diversity, but their potential metabolic interactions with coral microalgal endosymbionts (Symbiodiniaceae) have been largely overlooked. Here, we show that altering the bacterial composition of two widespread Symbiodiniaceae species, during their free-living stage, results in a significant shift in their cellular metabolism. Indeed, the abundance of monosaccharides and the key phytohormone indole-3-acetic acid (IAA) were correlated with the presence of specific bacteria, including members of the Labrenzia (Roseibium) and Marinobacter genera. Single-cell stable isotope tracking revealed that these two bacterial genera are involved in reciprocal exchanges of carbon and nitrogen with Symbiodiniaceae. We identified the provision of IAA by Labrenzia and Marinobacter, and this metabolite caused a significant growth enhancement of Symbiodiniaceae. By unravelling these interkingdom interactions, our work demonstrates how specific bacterial associates fundamentally govern Symbiodiniaceae fitness.","INSTITUTE":"University of Technology Sydney","LAST_NAME":"Matthews","FIRST_NAME":"Jennifer","ADDRESS":"15 Broadway, Sydney, NSW, 2007, Australia","EMAIL":"jennifer.matthews@uts.edu.au","PHONE":"0432404274","FUNDING_SOURCE":"HFSP"},

"STUDY":{"STUDY_TITLE":"Coral endosymbiont growth is enhanced by metabolic interactions with bacteria","STUDY_SUMMARY":"Bacteria are key contributors to microalgae resource acquisition, competitive performance, and functional diversity, but their potential metabolic interactions with coral microalgal endosymbionts (Symbiodiniaceae) have been largely overlooked. Here, we show that altering the bacterial composition of two widespread Symbiodiniaceae species, during their free-living stage, results in a significant shift in their cellular metabolism. Indeed, the abundance of monosaccharides and the key phytohormone indole-3-acetic acid (IAA) were correlated with the presence of specific bacteria, including members of the Labrenzia (Roseibium) and Marinobacter genera. Single-cell stable isotope tracking revealed that these two bacterial genera are involved in reciprocal exchanges of carbon and nitrogen with Symbiodiniaceae. We identified the provision of IAA by Labrenzia and Marinobacter, and this metabolite caused a significant growth enhancement of Symbiodiniaceae. By unravelling these interkingdom interactions, our work demonstrates how specific bacterial associates fundamentally govern Symbiodiniaceae fitness.","INSTITUTE":"University of Technology Sydney","LAST_NAME":"Matthews","FIRST_NAME":"Jennifer","ADDRESS":"15 Broadway, Sydney, NSW, 2007, Australia","EMAIL":"jennifer.matthews@uts.edu.au","PHONE":"0432404274"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Symbiodiniaceae"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Sample 4",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 4_UNK-0017_14102020_17   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 23",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 23_UNK-0039_14102020_39   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 16",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 16_UNK-0037_14102020_37   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 7",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 7_UNK-0028_14102020_28   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 28",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 28_UNK-0035_14102020_35   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 26",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 26_UNK-0029_14102020_29   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 15",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 15_UNK-0034_14102020_34   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 29",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 29_UNK-0011_14102020_11   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 8",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 8_UNK-0013_14102020_13   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 17",
"Factors":{"Genotype":"Symbiodinium microadriaticum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 17_UNK-0026_14102020_26   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 9",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 9_UNK-0027_14102020_27   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 3",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 3_UNK-0041_14102020_41   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 24",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 24_UNK-0031_14102020_31   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 2",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 2_UNK-0043_14102020_43   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 10",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 10_UNK-0022_14102020_22   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 1",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 1_UNK-0042_14102020_42   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 6",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 6_UNK-0016_14102020_16   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 22",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 22_UNK-0015_14102020_15   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 20",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Untreated"},
"Additional sample data":{"RAW_FILE_NAME":"JM 20_UNK-0044_14102020_44   Area"}
},
{
"Subject ID":"-",
"Sample ID":"Sample 19",
"Factors":{"Genotype":"Breviolum minutum","Treatment":"Ab+Tx"},
"Additional sample data":{"RAW_FILE_NAME":"JM 19_UNK-0030_14102020_30   Area"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Sampled from Symbiodiniaceae cultures in F/2 media","SAMPLE_TYPE":"Cultured cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Symbiodiniaceae cultures Two Symbiodiniaceae cultures were targeted from existing stocks at the University of Technology Sydney, Symbiodinium microadriaticum (ITS2: A1, culture ID: RT61), and Breviolum minutum (ITS2: B1, culture ID: RT2, CCMP2463) as preliminary trials allowed these cultures to be maintained for extended periods in an extracellular bacteria-free state. Each Symbiodiniaceae species was sub-cultured (n = 10 per Symbiodiniaceae species) by adding 10 mL of original cultures in 90 mL of autoclaved and filter sterilised (0.22 µm) artificial seawater (ASW) and F/2 media. Cultures were grown for one month (to achieve a minimum cell density of 106 cells/mL) at 26˚C with an irradiance of 85 ± 15 µmol photons m-2 s-1 (Philips TLD 18W/54 fluorescent tubes, 10 000 K on a 12h:12h light:dark cycle). Before use, cells were centrifuged at 700 × g for 10 mins at 26˚C and rinsed twice with ASW to remove residual media solution. Cells were resuspended in 100 mL ASW + F/2 media in sterile culture flasks. Untreated cultures Untreated Symbiodiniaceae cultures (n = 5) were maintained as above alongside the Ab+Tx treatments (below). Antibiotic treatment (AbTx) Each antibiotic treatment subculture (n = 5 per Symbiodiniaceae species) was provided with TritonX-100 detergent added to a final concentration of 20 µg/mL and placed on a shaker at mid speed for 30 s. All cultures (Ab+Tx treatment and untreated) were immediately centrifuged at 700 × g for 10 mins at 26˚C, and the supernatant discarded. Cells were rinsed in 20 mL ASW and centrifuged at 700 x g for 10 mins at 26˚C. Cells were transferred to sterile culture flasks and resuspended in 9 ml ASW+F/2. An aliquot of 1 mL custom antibiotic mix (Penicillin at 31.25 µg mL-1, Streptomycin and Kanamycin at 50 µg mL-1, and Neomycin, Ciprofloxacin and Ampicillin all at 100 µg mL-1; Ab+Tx) was added to each antibiotic treatment flask (and 1 mL ASW added to each untreated flask), and flasks were replaced in the incubator. After 48 hours, 90 mL ASW + F/2 was added to all cultures. Cultures were allowed to recover for 5 days prior to metabolism quenching."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Seven days after the antibiotic treatment process, 3 × 1 mL aliquots were collected from each culture flask for flow cytometry cell counting of both bacteria and Symbiodiniaceae cells, bacteria community analysis via 16S rRNA amplicon sequencing analysis, and Symbiodiniaceae photophysiological measurements (methods described in more detail below). The remaining Symbiodiniaceae cells were concentrated by centrifugation at 700 × g for 10 mins at 26˚C, the media discarded, and Symbiodiniaceae pellets snap frozen in liquid nitrogen for metabolite profiling."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Shimadzu GC-2010","COLUMN_NAME":"Agilent DB5-MS (15m x 0.25mm, 0.25um)","SOLVENT_A":"helium","SOLVENT_B":"helium","FLOW_GRADIENT":"10°C min-1","FLOW_RATE":"1 mL/min","COLUMN_TEMPERATURE":"100-320"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Shimazdu 2030","INSTRUMENT_TYPE":"GC-TOF","MS_TYPE":"EI","ION_MODE":"POSITIVE","MS_COMMENTS":"Approximately 520 quantifying MRM targets were collected using Shimadzu Smart Database along with qualifier for each target which covers about 350 endogenous metabolites and multiple 13C labelled internal standards. Both chromatograms and MRMs were evaluated using the Shimadzu GCMS browser and LabSolutions Insight software."},

"MS_METABOLITE_DATA":{
"Units":"relative abundance",

"Data":[{"Metabolite":"2-Hydroxybutyric acid","Sample 4":"0.001307549","Sample 23":"0.00249848","Sample 16":"0.001894168","Sample 7":"0.002587739","Sample 28":"0.002309704","Sample 26":"0.003440907","Sample 15":"0.004031323","Sample 29":"0.002095001","Sample 8":"0.004346371","Sample 17":"0.002655532","Sample 9":"0.001639743","Sample 3":"0.001460268","Sample 24":"0.002453371","Sample 2":"0.001618794","Sample 10":"0.001808709","Sample 1":"0.001225124","Sample 6":"0.002261151","Sample 22":"0.001586089","Sample 20":"0.002099723","Sample 19":"0.001449947"},{"Metabolite":"3-Hydroxybutyric acid","Sample 4":"0.032161937","Sample 23":"0.030299173","Sample 16":"0.042045913","Sample 7":"0.033905105","Sample 28":"0.030873966","Sample 26":"0.028099893","Sample 15":"0.029888829","Sample 29":"0.038268747","Sample 8":"0.034676568","Sample 17":"0.03264323","Sample 9":"0.037586917","Sample 3":"0.035377596","Sample 24":"0.031684234","Sample 2":"0.029999586","Sample 10":"0.032071463","Sample 1":"0.033868019","Sample 6":"0.047781001","Sample 22":"0.031885673","Sample 20":"0.032543122","Sample 19":"0.032759953"},{"Metabolite":"Acetoacetic acid","Sample 4":"0.000781907","Sample 23":"0.000658062","Sample 16":"0.000804078","Sample 7":"0.000745849","Sample 28":"0.000557864","Sample 26":"0.000810873","Sample 15":"0.000787032","Sample 29":"0.000615181","Sample 8":"0.000847018","Sample 17":"0.000707491","Sample 9":"0.000953401","Sample 3":"0.000823945","Sample 24":"0.000828352","Sample 2":"0.000527545","Sample 10":"0.000982036","Sample 1":"0.000539988","Sample 6":"0.000940376","Sample 22":"0.000676039","Sample 20":"0.000919277","Sample 19":"0.000544895"},{"Metabolite":"Adipic acid","Sample 4":"0.003306642","Sample 23":"0.005082855","Sample 16":"0.005194674","Sample 7":"0.004864003","Sample 28":"0.005035844","Sample 26":"0.005421459","Sample 15":"0.005377462","Sample 29":"0.003681471","Sample 8":"0.004514188","Sample 17":"0.004762447","Sample 9":"0.004621127","Sample 3":"0.006463696","Sample 24":"0.003787476","Sample 2":"0.003718643","Sample 10":"0.004180309","Sample 1":"0.004657785","Sample 6":"0.004346759","Sample 22":"0.004769151","Sample 20":"0.004061091","Sample 19":"0.004884256"},{"Metabolite":"Arachidonic acid","Sample 4":"0.002567066","Sample 23":"0.003472258","Sample 16":"0.002500451","Sample 7":"0.003743283","Sample 28":"0.003547869","Sample 26":"0.00417813","Sample 15":"0.005990561","Sample 29":"0.003014873","Sample 8":"0.004401244","Sample 17":"0.003602136","Sample 9":"0.003191114","Sample 3":"0.002892939","Sample 24":"0.002493018","Sample 2":"0.001414007","Sample 10":"0.002440974","Sample 1":"0.00248975","Sample 6":"0.002949098","Sample 22":"0.002597098","Sample 20":"0.002445919","Sample 19":"0.002295344"},{"Metabolite":"Beta-Alanine","Sample 4":"0.000504263","Sample 23":"0.000968698","Sample 16":"0.000618628","Sample 7":"0.001218349","Sample 28":"0.001569388","Sample 26":"0.001026447","Sample 15":"0.000664728","Sample 29":"0.001753539","Sample 8":"0.000637886","Sample 17":"0.001241758","Sample 9":"0.006514522","Sample 3":"0.020367908","Sample 24":"0.007321313","Sample 2":"0.040034939","Sample 10":"0.007255969","Sample 1":"0.021987369","Sample 6":"0.005981929","Sample 22":"0.023235044","Sample 20":"0.005495089","Sample 19":"0.026363608"},{"Metabolite":"Capric acid","Sample 4":"0.009434049","Sample 23":"0.020290474","Sample 16":"0.010616825","Sample 7":"0.015913809","Sample 28":"0.008899869","Sample 26":"0.008509661","Sample 15":"0.015416292","Sample 29":"0.017076448","Sample 8":"0.009476188","Sample 17":"0.015447598","Sample 9":"0.007936774","Sample 3":"0.01418892","Sample 24":"0.007736081","Sample 2":"0.010141663","Sample 10":"0.007449408","Sample 1":"0.011340111","Sample 6":"0.009261571","Sample 22":"0.011551964","Sample 20":"0.01110903","Sample 19":"0.011795668"},{"Metabolite":"Caprylic acid","Sample 4":"0.006341911","Sample 23":"0.019871316","Sample 16":"0.00895291","Sample 7":"0.018217474","Sample 28":"0.009071559","Sample 26":"0.015082204","Sample 15":"0.013626389","Sample 29":"0.020266171","Sample 8":"0.011484882","Sample 17":"0.018359291","Sample 9":"0.009648309","Sample 3":"0.015400416","Sample 24":"0.012349367","Sample 2":"0.013433071","Sample 10":"0.009313776","Sample 1":"0.013303469","Sample 6":"0.01562109","Sample 22":"0.014797649","Sample 20":"0.011995089","Sample 19":"0.01414536"},{"Metabolite":"Cholesterol","Sample 4":"9.79E-05","Sample 23":"0.00016517","Sample 16":"4.66E-05","Sample 7":"0.000197677","Sample 28":"6.99E-05","Sample 26":"0.000206568","Sample 15":"9.45E-05","Sample 29":"0.00026014","Sample 8":"0.000264517","Sample 17":"0.000207389","Sample 9":"9.79E-05","Sample 3":"0.000296422","Sample 24":"0.000100304","Sample 2":"8.93E-05","Sample 10":"4.63E-05","Sample 1":"6.04E-05","Sample 6":"0.000109362","Sample 22":"0.000142929","Sample 20":"0.000112605","Sample 19":"0.000129695"},{"Metabolite":"cis-Aconitic acid","Sample 4":"0.001832478","Sample 23":"0.002244338","Sample 16":"0.001652403","Sample 7":"0.001740168","Sample 28":"0.00161383","Sample 26":"0.001940023","Sample 15":"0.001541879","Sample 29":"0.001136986","Sample 8":"0.001512276","Sample 17":"0.001765378","Sample 9":"0.001022723","Sample 3":"0.001080856","Sample 24":"0.000947123","Sample 2":"0.000693174","Sample 10":"0.000950415","Sample 1":"0.00075771","Sample 6":"0.001198773","Sample 22":"0.000906004","Sample 20":"0.000819471","Sample 19":"0.000808656"},{"Metabolite":"Citramalic acid","Sample 4":"0.000995413","Sample 23":"0.001109546","Sample 16":"0.000622235","Sample 7":"0.001145429","Sample 28":"0.000757662","Sample 26":"0.001237663","Sample 15":"0.001075913","Sample 29":"0.001110743","Sample 8":"0.00138475","Sample 17":"0.001150845","Sample 9":"0.00524732","Sample 3":"0.003613443","Sample 24":"0.004937578","Sample 2":"0.002869005","Sample 10":"0.007211764","Sample 1":"0.002881466","Sample 6":"0.004281107","Sample 22":"0.003333831","Sample 20":"0.007967521","Sample 19":"0.003100178"},{"Metabolite":"Citric acid","Sample 4":"1.814943981","Sample 23":"1.416797249","Sample 16":"1.604656964","Sample 7":"1.800176843","Sample 28":"1.655119437","Sample 26":"1.512623867","Sample 15":"1.418957979","Sample 29":"1.622587682","Sample 8":"1.768402787","Sample 17":"1.58804641","Sample 9":"3.547344903","Sample 3":"4.087997437","Sample 24":"3.249034756","Sample 2":"3.014947108","Sample 10":"3.630691971","Sample 1":"3.289038004","Sample 6":"3.246247595","Sample 22":"3.381507003","Sample 20":"3.612697945","Sample 19":"3.44333836"},{"Metabolite":"D-Galactose","Sample 4":"2.8464811","Sample 23":"2.583111302","Sample 16":"3.057890663","Sample 7":"2.376437773","Sample 28":"2.712274286","Sample 26":"1.978138772","Sample 15":"3.128235572","Sample 29":"2.089167954","Sample 8":"2.747231322","Sample 17":"2.297743955","Sample 9":"2.406969059","Sample 3":"2.790477838","Sample 24":"1.763946865","Sample 2":"2.208178721","Sample 10":"2.144313306","Sample 1":"2.754646144","Sample 6":"2.636512861","Sample 22":"2.590647615","Sample 20":"2.727670638","Sample 19":"2.585954608"},{"Metabolite":"D-Glucose","Sample 4":"4.188429501","Sample 23":"4.619073691","Sample 16":"4.464811161","Sample 7":"4.184552074","Sample 28":"4.004885511","Sample 26":"3.951381221","Sample 15":"4.414119831","Sample 29":"4.269555343","Sample 8":"3.940656961","Sample 17":"4.256140582","Sample 9":"4.497684272","Sample 3":"5.624919171","Sample 24":"4.366338637","Sample 2":"4.603021918","Sample 10":"4.33547331","Sample 1":"5.204780888","Sample 6":"4.650622156","Sample 22":"4.967379552","Sample 20":"4.540678614","Sample 19":"5.099942693"},{"Metabolite":"D-Glucuronic acid","Sample 4":"0.000226619","Sample 23":"0.000131151","Sample 16":"0.000195437","Sample 7":"0.000137593","Sample 28":"4.24E-05","Sample 26":"0.000251019","Sample 15":"0.000168678","Sample 29":"5.14E-05","Sample 8":"0.000213225","Sample 17":"0.000142795","Sample 9":"0.000211847","Sample 3":"0.000372066","Sample 24":"2.44E-05","Sample 2":"0.000207119","Sample 10":"0.000132455","Sample 1":"0.000268248","Sample 6":"0.000330896","Sample 22":"0.000251887","Sample 20":"0.000318158","Sample 19":"0.000190255"},{"Metabolite":"D-Maltose","Sample 4":"2.90993413","Sample 23":"3.333996456","Sample 16":"2.690234363","Sample 7":"3.168908851","Sample 28":"2.250527169","Sample 26":"3.510051882","Sample 15":"1.865445472","Sample 29":"3.101388047","Sample 8":"2.912976409","Sample 17":"3.278586309","Sample 9":"1.675933538","Sample 3":"1.752890889","Sample 24":"1.112549967","Sample 2":"1.586099599","Sample 10":"1.229166787","Sample 1":"1.721773541","Sample 6":"1.576152482","Sample 22":"1.696130733","Sample 20":"1.563128704","Sample 19":"1.689209926"},{"Metabolite":"D-Mannose","Sample 4":"0.003029711","Sample 23":"0.017041727","Sample 16":"0.016026355","Sample 7":"0.008054183","Sample 28":"0.010523196","Sample 26":"0.003556829","Sample 15":"0.009650766","Sample 29":"0.008721619","Sample 8":"0.004692111","Sample 17":"0.009343589","Sample 9":"0.014813253","Sample 3":"0.03349662","Sample 24":"0.016745781","Sample 2":"0.036775857","Sample 10":"0.018321664","Sample 1":"0.038439266","Sample 6":"0.020007697","Sample 22":"0.031707974","Sample 20":"0.036921761","Sample 19":"0.035086317"},{"Metabolite":"D-Xylose","Sample 4":"0.128953328","Sample 23":"0.105857154","Sample 16":"0.118957491","Sample 7":"0.10794825","Sample 28":"0.096404511","Sample 26":"0.110337383","Sample 15":"0.117920429","Sample 29":"0.09028156","Sample 8":"0.108860342","Sample 17":"0.103606087","Sample 9":"0.063219724","Sample 3":"0.097039815","Sample 24":"0.036516595","Sample 2":"0.098190702","Sample 10":"0.042055096","Sample 1":"0.102920862","Sample 6":"0.066516548","Sample 22":"0.092413503","Sample 20":"0.057451052","Sample 19":"0.097606814"},{"Metabolite":"Dodecanoic acid","Sample 4":"0.018556817","Sample 23":"0.03308012","Sample 16":"0.022076705","Sample 7":"0.029522354","Sample 28":"0.029188979","Sample 26":"0.026897094","Sample 15":"0.032934621","Sample 29":"0.025323407","Sample 8":"0.021638735","Sample 17":"0.028705744","Sample 9":"0.015156689","Sample 3":"0.032842229","Sample 24":"0.012342421","Sample 2":"0.018374265","Sample 10":"0.012805676","Sample 1":"0.022707598","Sample 6":"0.012872461","Sample 22":"0.022849822","Sample 20":"0.015458871","Sample 19":"0.024116099"},{"Metabolite":"Eicosapentaenoic acid","Sample 4":"0.002344865","Sample 23":"0.002756933","Sample 16":"0.002517373","Sample 7":"0.003205536","Sample 28":"0.004085728","Sample 26":"0.003368565","Sample 15":"0.005293123","Sample 29":"0.003096806","Sample 8":"0.004055632","Sample 17":"0.00310696","Sample 9":"0.002677812","Sample 3":"0.002837347","Sample 24":"0.002527751","Sample 2":"0.002117345","Sample 10":"0.002438231","Sample 1":"0.003208692","Sample 6":"0.003796086","Sample 22":"0.002967257","Sample 20":"0.00304658","Sample 19":"0.002740144"},{"Metabolite":"Elaidic acid","Sample 4":"0.000971041","Sample 23":"0.001332133","Sample 16":"0.001286913","Sample 7":"0.001140774","Sample 28":"0.001128136","Sample 26":"0.000761773","Sample 15":"0.001418655","Sample 29":"0.001161092","Sample 8":"0.000732667","Sample 17":"0.001098943","Sample 9":"0.001064175","Sample 3":"0.002625107","Sample 24":"0.001171451","Sample 2":"0.001166065","Sample 10":"0.000397848","Sample 1":"0.00177981","Sample 6":"0.000781335","Sample 22":"0.001621333","Sample 20":"0.001181361","Sample 19":"0.001719575"},{"Metabolite":"Fructose 1-phosphate","Sample 4":"0.006202519","Sample 23":"0.011150417","Sample 16":"0.006013039","Sample 7":"0.009520923","Sample 28":"0.005931769","Sample 26":"0.009769259","Sample 15":"0.004667806","Sample 29":"0.006091996","Sample 8":"0.008819884","Sample 17":"0.009133149","Sample 9":"0.015499243","Sample 3":"0.005287738","Sample 24":"0.002347476","Sample 2":"0.002241983","Sample 10":"0.007836769","Sample 1":"0.002076169","Sample 6":"0.010215815","Sample 22":"0.006997649","Sample 20":"0.010834451","Sample 19":"0.004118208"},{"Metabolite":"Fumaric acid","Sample 4":"0.00628319","Sample 23":"0.008812489","Sample 16":"0.006658714","Sample 7":"0.009799924","Sample 28":"0.006054712","Sample 26":"0.013156999","Sample 15":"0.010148393","Sample 29":"0.007625523","Sample 8":"0.013562519","Sample 17":"0.009848734","Sample 9":"0.010105871","Sample 3":"0.009344325","Sample 24":"0.01542523","Sample 2":"0.010109337","Sample 10":"0.012051443","Sample 1":"0.006648152","Sample 6":"0.014046833","Sample 22":"0.009604557","Sample 20":"0.01159282","Sample 19":"0.008847471"},{"Metabolite":"Galactitol","Sample 4":"0.005826103","Sample 23":"0.006745327","Sample 16":"0.006033567","Sample 7":"0.005811807","Sample 28":"0.006506473","Sample 26":"0.005007742","Sample 15":"0.005484133","Sample 29":"0.005734819","Sample 8":"0.005086968","Sample 17":"0.005824924","Sample 9":"0.005516142","Sample 3":"0.007332113","Sample 24":"0.00488946","Sample 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29":"0.016521534","Sample 8":"0.011412741","Sample 17":"0.017096788","Sample 9":"0.024196621","Sample 3":"0.031403007","Sample 24":"0.017847934","Sample 2":"0.030675597","Sample 10":"0.018628359","Sample 1":"0.026903481","Sample 6":"0.016317639","Sample 22":"0.027701538","Sample 20":"0.024608819","Sample 19":"0.029121656"},{"Metabolite":"L-Alanine","Sample 4":"0.728528439","Sample 23":"0.814348511","Sample 16":"0.759358927","Sample 7":"0.778866144","Sample 28":"0.907123723","Sample 26":"0.667681958","Sample 15":"0.568637744","Sample 29":"1.033285908","Sample 8":"0.573133829","Sample 17":"0.82354563","Sample 9":"2.123922837","Sample 3":"3.55327096","Sample 24":"1.434830386","Sample 2":"3.348861147","Sample 10":"1.688846254","Sample 1":"3.41811511","Sample 6":"1.62949499","Sample 22":"3.184694428","Sample 20":"2.802115431","Sample 19":"3.376175036"},{"Metabolite":"L-Aspartic acid","Sample 4":"0.027004431","Sample 23":"0.047502375","Sample 16":"0.04173646","Sample 7":"0.03603878","Sample 28":"0.045607858","Sample 26":"0.030126059","Sample 15":"0.026973356","Sample 29":"0.031395416","Sample 8":"0.016222528","Sample 17":"0.036265657","Sample 9":"0.036130975","Sample 3":"0.069530988","Sample 24":"0.035233828","Sample 2":"0.042609679","Sample 10":"0.033971809","Sample 1":"0.037760928","Sample 6":"0.02318535","Sample 22":"0.051868727","Sample 20":"0.061642423","Sample 19":"0.050408856"},{"Metabolite":"L-Cysteine","Sample 4":"0.393131915","Sample 23":"0.887088293","Sample 16":"0.430373965","Sample 7":"0.638355757","Sample 28":"0.745000645","Sample 26":"0.430195891","Sample 15":"0.583931206","Sample 29":"0.639677157","Sample 8":"0.423113561","Sample 17":"0.648829274","Sample 9":"0.21911793","Sample 3":"0.259249867","Sample 24":"0.167144869","Sample 2":"0.386779687","Sample 10":"0.19293569","Sample 1":"0.217736706","Sample 6":"0.200662754","Sample 22":"0.272581807","Sample 20":"0.182598527","Sample 19":"0.284017015"},{"Metabolite":"L-Glutamic acid","Sample 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10":"0.000331701","Sample 1":"0.000510223","Sample 6":"0.000628439","Sample 22":"0.000628094","Sample 20":"0.000434725","Sample 19":"0.000568367"},{"Metabolite":"Malonic acid","Sample 4":"0.001877232","Sample 23":"0.001409869","Sample 16":"0.001918302","Sample 7":"0.001372256","Sample 28":"0.000979871","Sample 26":"0.00155042","Sample 15":"0.00193927","Sample 29":"0.001002262","Sample 8":"0.002357247","Sample 17":"0.001333702","Sample 9":"0.001162602","Sample 3":"0.000641684","Sample 24":"0.001254811","Sample 2":"0.00027477","Sample 10":"0.001560901","Sample 1":"0.000446101","Sample 6":"0.00160603","Sample 22":"0.000632771","Sample 20":"0.001257091","Sample 19":"0.000449225"},{"Metabolite":"Mannose 6-phosphate","Sample 4":"0.006508811","Sample 23":"0.0129131","Sample 16":"0.006405992","Sample 7":"0.010591262","Sample 28":"0.006023945","Sample 26":"0.010635333","Sample 15":"0.004311008","Sample 29":"0.006514628","Sample 8":"0.009135309","Sample 17":"0.010163581","Sample 9":"0.017515584","Sample 3":"0.005286944","Sample 24":"0.002458623","Sample 2":"0.00199454","Sample 10":"0.007926148","Sample 1":"0.001795978","Sample 6":"0.000113751","Sample 22":"0.007338063","Sample 20":"0.012094132","Sample 19":"0.004022456"},{"Metabolite":"Methylsuccinic acid","Sample 4":"0.000721047","Sample 23":"0.00121576","Sample 16":"0.001333796","Sample 7":"0.001038017","Sample 28":"0.001025452","Sample 26":"0.001189145","Sample 15":"0.001199531","Sample 29":"0.00051204","Sample 8":"0.000694038","Sample 17":"0.00098874","Sample 9":"0.001347814","Sample 3":"0.001187473","Sample 24":"0.001373752","Sample 2":"0.001104412","Sample 10":"0.000814895","Sample 1":"0.001055356","Sample 6":"0.000782038","Sample 22":"0.00111913","Sample 20":"0.001406266","Sample 19":"0.001088945"},{"Metabolite":"myo-Inositol","Sample 4":"0.153228212","Sample 23":"0.254886097","Sample 16":"0.116455514","Sample 7":"0.200748174","Sample 28":"0.150204083","Sample 26":"0.177027393","Sample 15":"0.108478277","Sample 29":"0.234998208","Sample 8":"0.116754799","Sample 17":"0.210209141","Sample 9":"3.397885371","Sample 3":"4.518098051","Sample 24":"1.303912384","Sample 2":"4.257908961","Sample 10":"1.836195583","Sample 1":"4.274695023","Sample 6":"2.808253217","Sample 22":"4.081139085","Sample 20":"2.90183355","Sample 19":"4.28286951"},{"Metabolite":"Myristic acid","Sample 4":"0.028007113","Sample 23":"0.044056594","Sample 16":"0.03264859","Sample 7":"0.039540219","Sample 28":"0.042094935","Sample 26":"0.035551875","Sample 15":"0.044410236","Sample 29":"0.036167337","Sample 8":"0.040675148","Sample 17":"0.038829006","Sample 9":"0.055041293","Sample 3":"0.133841345","Sample 24":"0.048059129","Sample 2":"0.063657162","Sample 10":"0.052877985","Sample 1":"0.091265284","Sample 6":"0.053401314","Sample 22":"0.086507676","Sample 20":"0.073912244","Sample 19":"0.093771191"},{"Metabolite":"Nicotinic acid","Sample 4":"0.089962178","Sample 23":"0.130748367","Sample 16":"0.093760874","Sample 7":"0.108573917","Sample 28":"0.103196373","Sample 26":"0.092352335","Sample 15":"0.082472586","Sample 29":"0.109960777","Sample 8":"0.077894433","Sample 17":"0.110408849","Sample 9":"0.168020947","Sample 3":"0.180729743","Sample 24":"0.151227778","Sample 2":"0.116315691","Sample 10":"0.201336158","Sample 1":"0.143014633","Sample 6":"0.167817529","Sample 22":"0.165913257","Sample 20":"0.179178629","Sample 19":"0.151416117"},{"Metabolite":"Oleic acid","Sample 4":"0.004168222","Sample 23":"0.008027432","Sample 16":"0.01104404","Sample 7":"0.006648665","Sample 28":"0.00892304","Sample 26":"0.004827758","Sample 15":"0.008369655","Sample 29":"0.004422068","Sample 8":"0.003159881","Sample 17":"0.005981481","Sample 9":"0.005722521","Sample 3":"0.012958761","Sample 24":"0.004739852","Sample 2":"0.006287718","Sample 10":"0.002589401","Sample 1":"0.008717339","Sample 6":"0.002527798","Sample 22":"0.008306068","Sample 20":"0.005402293","Sample 19":"0.009051442"},{"Metabolite":"Oxalic acid","Sample 4":"0.017791158","Sample 23":"0.02310267","Sample 16":"0.021297872","Sample 7":"0.020854037","Sample 28":"0.021573361","Sample 26":"0.019205134","Sample 15":"0.022228699","Sample 29":"0.019767558","Sample 8":"0.018865654","Sample 17":"0.020732349","Sample 9":"0.017802751","Sample 3":"0.016852941","Sample 24":"0.017652749","Sample 2":"0.01697792","Sample 10":"0.018554146","Sample 1":"0.01414","Sample 6":"0.019175104","Sample 22":"0.016561875","Sample 20":"0.01526185","Sample 19":"0.016110548"},{"Metabolite":"Palmitic acid","Sample 4":"0.523501968","Sample 23":"0.868039439","Sample 16":"0.634868042","Sample 7":"0.781430548","Sample 28":"0.813885338","Sample 26":"0.742559418","Sample 15":"0.769573445","Sample 29":"0.704182775","Sample 8":"0.636328243","Sample 17":"0.774053045","Sample 9":"0.536181946","Sample 3":"1.010448998","Sample 24":"0.422008758","Sample 2":"0.564771997","Sample 10":"0.425997574","Sample 1":"0.760793725","Sample 6":"0.507855344","Sample 22":"0.752689868","Sample 20":"0.555603566","Sample 19":"0.772099495"},{"Metabolite":"Palmitoleic acid","Sample 4":"0.012989829","Sample 23":"0.014832486","Sample 16":"0.014156599","Sample 7":"0.012755294","Sample 28":"0.018983332","Sample 26":"0.007165954","Sample 15":"0.011974817","Sample 29":"0.013351493","Sample 8":"0.006461357","Sample 17":"0.012026306","Sample 9":"0.001428073","Sample 3":"0.006107315","Sample 24":"0.001026248","Sample 2":"0.001371851","Sample 10":"0.001260659","Sample 1":"0.003861124","Sample 6":"0.000695496","Sample 22":"0.003230519","Sample 20":"0.001505614","Sample 19":"0.003582971"},{"Metabolite":"Pantothenic acid","Sample 4":"0.000715346","Sample 23":"0.000898043","Sample 16":"0.000825994","Sample 7":"0.000884924","Sample 28":"0.000757409","Sample 26":"0.000816829","Sample 15":"0.00082421","Sample 29":"0.000853655","Sample 8":"0.00080225","Sample 17":"0.000863363","Sample 9":"0.002967449","Sample 3":"0.004446124","Sample 24":"0.002559435","Sample 2":"0.002781192","Sample 10":"0.002441942","Sample 1":"0.003483555","Sample 6":"0.003302463","Sample 22":"0.003631535","Sample 20":"0.002628616","Sample 19":"0.003555043"},{"Metabolite":"Phosphoric acid","Sample 4":"0.736137278","Sample 23":"0.571315841","Sample 16":"0.81870715","Sample 7":"0.591290179","Sample 28":"0.516676978","Sample 26":"0.656799237","Sample 15":"0.446442039","Sample 29":"0.430740665","Sample 8":"0.789209338","Sample 17":"0.56253648","Sample 9":"1.525829821","Sample 3":"0.937746121","Sample 24":"1.154638831","Sample 2":"0.466653611","Sample 10":"1.356976868","Sample 1":"0.572753224","Sample 6":"1.254866891","Sample 22":"0.842707304","Sample 20":"2.090230887","Sample 19":"0.704885385"},{"Metabolite":"Pyroglutamic acid","Sample 4":"1.096791699","Sample 23":"1.743294008","Sample 16":"1.258153173","Sample 7":"1.695098845","Sample 28":"1.357924372","Sample 26":"1.570075263","Sample 15":"1.023707316","Sample 29":"1.867231652","Sample 8":"1.014298003","Sample 17":"1.718924942","Sample 9":"3.012683988","Sample 3":"4.14444637","Sample 24":"3.181940485","Sample 2":"3.623243906","Sample 10":"3.454628204","Sample 1":"3.296627781","Sample 6":"3.144011154","Sample 22":"3.6648358","Sample 20":"3.385102864","Sample 19":"3.6822209"},{"Metabolite":"Stearic acid","Sample 4":"0.050318821","Sample 23":"0.116386915","Sample 16":"0.102967754","Sample 7":"0.091671836","Sample 28":"0.098362986","Sample 26":"0.093191971","Sample 15":"0.09928231","Sample 29":"0.071376507","Sample 8":"0.060253387","Sample 17":"0.093156807","Sample 9":"0.085739912","Sample 3":"0.167008983","Sample 24":"0.101443326","Sample 2":"0.108342529","Sample 10":"0.064093398","Sample 1":"0.120576203","Sample 6":"0.081547819","Sample 22":"0.12718406","Sample 20":"0.112183435","Sample 19":"0.130691125"},{"Metabolite":"Succinic acid","Sample 4":"0.078349737","Sample 23":"0.168002678","Sample 16":"0.097662671","Sample 7":"0.135910316","Sample 28":"0.124470544","Sample 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19":"4.571956735"},{"Metabolite":"Urea","Sample 4":"0.015963241","Sample 23":"0.023749956","Sample 16":"0.01647701","Sample 7":"0.024592738","Sample 28":"0.025278106","Sample 26":"0.021828195","Sample 15":"0.027499489","Sample 29":"0.029430866","Sample 8":"0.009306836","Sample 17":"0.024900439","Sample 9":"0.051645917","Sample 3":"0.050600119","Sample 24":"0.022907503","Sample 2":"0.06123272","Sample 10":"0.015471388","Sample 1":"0.033623104","Sample 6":"0.02252391","Sample 22":"0.045688789","Sample 20":"0.027113707","Sample 19":"0.047690161"},{"Metabolite":"Vitamin A","Sample 4":"0.006051867","Sample 23":"0.007874423","Sample 16":"0.006434843","Sample 7":"0.011364059","Sample 28":"0.008181331","Sample 26":"0.008357277","Sample 15":"0.008628715","Sample 29":"0.019309376","Sample 8":"0.004209763","Sample 17":"0.011726284","Sample 9":"0.001739934","Sample 3":"0.002521072","Sample 24":"0.000845125","Sample 2":"0.001165565","Sample 10":"0.001165956","Sample 1":"0.001761253","Sample 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"Metabolites":[{"Metabolite":"2-Hydroxybutyric acid","HMDB ID":"HMDB0000008"},{"Metabolite":"3-Hydroxybutyric acid","HMDB ID":"HMDB0000357"},{"Metabolite":"Acetoacetic acid","HMDB ID":"HMDB0000060"},{"Metabolite":"Adipic acid","HMDB ID":"HMDB0000448"},{"Metabolite":"Arachidonic acid","HMDB ID":"HMDB0001043"},{"Metabolite":"Beta-Alanine","HMDB ID":"HMDB0000056"},{"Metabolite":"Capric acid","HMDB ID":"HMDB0000511"},{"Metabolite":"Caprylic acid","HMDB ID":"HMDB0000482"},{"Metabolite":"Cholesterol","HMDB ID":"HMDB0000067"},{"Metabolite":"cis-Aconitic acid","HMDB ID":"HMDB0000072"},{"Metabolite":"Citramalic acid","HMDB ID":"HMDB0000426"},{"Metabolite":"Citric acid","HMDB ID":"HMDB0000094"},{"Metabolite":"D-Galactose","HMDB ID":"HMDB0000143"},{"Metabolite":"D-Glucose","HMDB ID":"HMDB0000122"},{"Metabolite":"D-Glucuronic acid","HMDB ID":"HMDB0000127"},{"Metabolite":"D-Maltose","HMDB ID":"HMDB0000163"},{"Metabolite":"D-Mannose","HMDB ID":"HMDB0000169"},{"Metabolite":"D-Xylose","HMDB ID":"HMDB0000098"},{"Metabolite":"Dodecanoic acid","HMDB ID":"HMDB0000638"},{"Metabolite":"Eicosapentaenoic acid","HMDB ID":"HMDB0001999"},{"Metabolite":"Elaidic acid","HMDB ID":"HMDB0000573"},{"Metabolite":"Fructose 1-phosphate","HMDB ID":"HMDB0001076"},{"Metabolite":"Fumaric acid","HMDB ID":"HMDB0000134"},{"Metabolite":"Galactitol","HMDB ID":"HMDB0000107"},{"Metabolite":"Galacturonic acid","HMDB ID":"HMDB0002545"},{"Metabolite":"Gamma-Aminobutyric acid","HMDB ID":"HMDB0000112"},{"Metabolite":"Gluconic acid","HMDB ID":"HMDB0000625"},{"Metabolite":"Glucose 6-phosphate","HMDB ID":"HMDB0001401"},{"Metabolite":"Glutamate, gamma-methyl ester","HMDB ID":"HMDB0061715"},{"Metabolite":"Glutaric acid","HMDB ID":"HMDB0000661"},{"Metabolite":"Glyceric acid","HMDB ID":"HMDB0000139"},{"Metabolite":"Glycerol","HMDB ID":"HMDB0000131"},{"Metabolite":"Glycine","HMDB ID":"HMDB0000123"},{"Metabolite":"Glycolic acid","HMDB ID":"HMDB0000115"},{"Metabolite":"Heptadecanoic acid","HMDB ID":"HMDB0002259"},{"Metabolite":"Indoleacetic acid","HMDB ID":"HMDB0000197"},{"Metabolite":"Itaconic acid","HMDB ID":"HMDB0002092"},{"Metabolite":"L-Alanine","HMDB ID":"HMDB0000161"},{"Metabolite":"L-Aspartic acid","HMDB ID":"HMDB0000191"},{"Metabolite":"L-Cysteine","HMDB ID":"HMDB0000574"},{"Metabolite":"L-Glutamic acid","HMDB ID":"HMDB0000148"},{"Metabolite":"L-Glutamine","HMDB ID":"HMDB0000641"},{"Metabolite":"L-Tryptophan","HMDB ID":"HMDB0000929"},{"Metabolite":"Malic acid","HMDB ID":"HMDB0000744"},{"Metabolite":"Malonic acid","HMDB ID":"HMDB0000691"},{"Metabolite":"Mannose 6-phosphate","HMDB ID":"HMDB0001078"},{"Metabolite":"Methylsuccinic acid","HMDB ID":"HMDB0001844"},{"Metabolite":"myo-Inositol","HMDB ID":"HMDB0000211"},{"Metabolite":"Myristic acid","HMDB ID":"HMDB0000806"},{"Metabolite":"Nicotinic acid","HMDB ID":"HMDB0001488"},{"Metabolite":"Oleic acid","HMDB ID":"HMDB0000207"},{"Metabolite":"Oxalic acid","HMDB ID":"HMDB0002329"},{"Metabolite":"Palmitic acid","HMDB ID":"HMDB0000220"},{"Metabolite":"Palmitoleic acid","HMDB ID":"HMDB0003229"},{"Metabolite":"Pantothenic acid","HMDB ID":"HMDB0000210"},{"Metabolite":"Phosphoric acid","HMDB ID":"HMDB0002142"},{"Metabolite":"Pyroglutamic acid","HMDB ID":"HMDB0000267"},{"Metabolite":"Stearic acid","HMDB ID":"HMDB0000827"},{"Metabolite":"Succinic acid","HMDB ID":"HMDB0000254"},{"Metabolite":"Threonic acid","HMDB ID":"HMDB0000943"},{"Metabolite":"Trehalose","HMDB ID":"HMDB0000975"},{"Metabolite":"Turanose","HMDB ID":"HMDB0011740"},{"Metabolite":"Urea","HMDB ID":"HMDB0000294"},{"Metabolite":"Vitamin A","HMDB ID":"HMDB0000305"}]
}

}