{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003039","ANALYSIS_ID":"AN004986","VERSION":"1","CREATED_ON":"January 9, 2024, 12:14 pm"},

"PROJECT":{"PROJECT_TITLE":"A Non-Targeted Metabolomics Comparative Study on Plasma of Pfizer and Sinopharm COVID- 19 Vaccinated individuals, Assessed by (TIMS-QTOF) Mass Spectrometry.","PROJECT_SUMMARY":"COVID-19 is a contagious globally threatening infectious disease that accounted for an ongoing pandemic that manifested in multi-organs diseases and failures. The current study aimed to investigate the effectiveness of the Pfizer and Sinopharm vaccines in relation to metabolomic alterations and their association with immune pathways. The study employed a cross-sectional design and utilized an untargeted metabolomics-based approach. Plasma samples were collected from three groups: non- vaccinated participants, Sinopharm vaccinated participants, and Pfizer vaccinated participants. Comparative metabolomic analysis was performed using TIMS-QTOF, and a one-way ANOVA test was conducted using MetaboAnalyst Software. Out of the 105 detected metabolites, 72 showed statistically significant alterations (p<0.05) among the different groups. Several metabolites, including neopterin, pyridoxal, and syringic acid, were highly altered in individuals vaccinated with Pfizer. On the other hand, sphinganine, neopterin, and sphingosine were impacted in individuals vaccinated with Sinopharm. These metabolites could potentially serve as biomarkers for vaccine efficacy. Furthermore, both Pfizer and Sinopharm vaccinations were found to affect sphingolipid metabolism pathways and histidine metabolism pathways when compared to the control group. The Sinopharm group exhibited altered lysine degradation compared to the control group. When comparing the enriched pathways of the Pfizer and Sinopharm groups, purine metabolism was found to be affected. Additionally, perturbations in tryptophan metabolism and vitamin B6 metabolism were observed when comparing the Pfizer group with both the control and Sinopharm groups. These findings highlight the importance of metabolomics in assessing vaccine effectiveness and identifying potential biomarkers.","INSTITUTE":"Sharjah Institute for Medical Research","LAST_NAME":"Facility","FIRST_NAME":"Core","ADDRESS":"M32, SIMR, College of Pharmacy, Health Sciences, University of Sharjah, Sharjah, UAE, Sharjah, 000, United Arab Emirates","EMAIL":"tims-tof@sharjah.ac.ae","PHONE":"+971 6 5057656"},

"STUDY":{"STUDY_TITLE":"A Non-Targeted Metabolomics Comparative Study on Plasma of Pfizer and Sinopharm COVID- 19 Vaccinated individuals, Assessed by (TIMS-QTOF) Mass Spectrometry.","STUDY_SUMMARY":"COVID-19 is a contagious globally threatening infectious disease that accounted for an ongoing pandemic that manifested in multi-organs diseases and failures. The current study aimed to investigate the effectiveness of the Pfizer and Sinopharm vaccines in relation to metabolomic alterations and their association with immune pathways. The study employed a cross-sectional design and utilized an untargeted metabolomics-based approach. Plasma samples were collected from three groups: non- vaccinated participants, Sinopharm vaccinated participants, and Pfizer vaccinated participants. Comparative metabolomic analysis was performed using TIMS-QTOF, and a one-way ANOVA test was conducted using MetaboAnalyst Software. Out of the 105 detected metabolites, 72 showed statistically significant alterations (p<0.05) among the different groups. Several metabolites, including neopterin, pyridoxal, and syringic acid, were highly altered in individuals vaccinated with Pfizer. On the other hand, sphinganine, neopterin, and sphingosine were impacted in individuals vaccinated with Sinopharm. These metabolites could potentially serve as biomarkers for vaccine efficacy. Furthermore, both Pfizer and Sinopharm vaccinations were found to affect sphingolipid metabolism pathways and histidine metabolism pathways when compared to the control group. The Sinopharm group exhibited altered lysine degradation compared to the control group. When comparing the enriched pathways of the Pfizer and Sinopharm groups, purine metabolism was found to be affected. Additionally, perturbations in tryptophan metabolism and vitamin B6 metabolism were observed when comparing the Pfizer group with both the control and Sinopharm groups. These findings highlight the importance of metabolomics in assessing vaccine effectiveness and identifying potential biomarkers.","INSTITUTE":"Sharjah Institute for Medical Research","LAST_NAME":"Facility","FIRST_NAME":"Core","ADDRESS":"M32, SIMR, College of Pharmacy, Health Sciences, University of Sharjah, Sharjah, UAE, Sharjah, 000, United Arab Emirates","EMAIL":"tims-tof@sharjah.ac.ae","PHONE":"+971 6 5057656"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","GENDER":"Male"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Dual 123-8783",
"Factors":{"Treatment":"Dual"},
"Additional sample data":{"RAW_FILE_NAME":"Dual 123-8783.d"}
},
{
"Subject ID":"-",
"Sample ID":"Dual 372-8784",
"Factors":{"Treatment":"Dual"},
"Additional sample data":{"RAW_FILE_NAME":"Dual 372-8784.d"}
},
{
"Subject ID":"-",
"Sample ID":"Dual 414-8785",
"Factors":{"Treatment":"Dual"},
"Additional sample data":{"RAW_FILE_NAME":"Dual 414-8785.d"}
},
{
"Subject ID":"-",
"Sample ID":"Dual 517-8786",
"Factors":{"Treatment":"Dual"},
"Additional sample data":{"RAW_FILE_NAME":"Dual 517-8786.d"}
},
{
"Subject ID":"-",
"Sample ID":"Dual 573-8787",
"Factors":{"Treatment":"Dual"},
"Additional sample data":{"RAW_FILE_NAME":"Dual 573-8787.d"}
},
{
"Subject ID":"-",
"Sample ID":"Dual 59-8782",
"Factors":{"Treatment":"Dual"},
"Additional sample data":{"RAW_FILE_NAME":"Dual 59-8782.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-01-8417",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-01-8417.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-08-8418",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-08-8418.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-09-8419",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-09-8419.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-101-8439",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-101-8439.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-102-8440",
"Factors":{"Treatment":"Pfizer"},
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{
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"Sample ID":"Pfizer-103-8441",
"Factors":{"Treatment":"Pfizer"},
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{
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"Sample ID":"Pfizer-104-8442",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-104-8442.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-106-8443",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-106-8443.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-107-8444",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-107-8444.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-108-8445",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-108-8445.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-113-8446",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-113-8446.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-117-8447",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-117-8447.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-118-8449",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-118-8449.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-12-8420",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-12-8420.d"}
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{
"Subject ID":"-",
"Sample ID":"Pfizer-122-8450",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-122-8450.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-124-8451",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-124-8451.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-126-8452",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-126-8452.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-127-8453",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-127-8453.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-13-8421",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-13-8421.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-14-8422",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-14-8422.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-154-8454",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-154-8454.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-155-8455",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-155-8455.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-18-8423",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-18-8423.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-20-8424",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-20-8424.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-200-8456",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-200-8456.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-201-8457",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-201-8457.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-202-8458",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-202-8458.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-203-8459",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-203-8459.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-205-8460",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-205-8460.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-209-8461",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-209-8461.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-211-8462",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-211-8462.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-212-8463",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-212-8463.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-213-8465",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-213-8465.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-216-8466",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-216-8466.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-219-8467",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-219-8467.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-22-8425",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-22-8425.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-220-8468",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-220-8468.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-221-8469",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-221-8469.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-222-8470",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-222-8470.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-223-8471",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-223-8471.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-224-8472",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-224-8472.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-226-8473",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-226-8473.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-227-8474",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-227-8474.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-23-8426",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-23-8426.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-232-8475",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-232-8475.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-234-8476",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-234-8476.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-237-8477",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-237-8477.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-238-8478",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-238-8478.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-240-8479",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-240-8479.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-243-8481",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-243-8481.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-248-8482",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-248-8482.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-253-8483",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-253-8483.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-254-8484",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-254-8484.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-255-8485",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-255-8485.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-27-8427",
"Factors":{"Treatment":"Pfizer"},
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},
{
"Subject ID":"-",
"Sample ID":"Pfizer-28-8428",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-28-8428.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-302-8486",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-302-8486.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-309-8487",
"Factors":{"Treatment":"Pfizer"},
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{
"Subject ID":"-",
"Sample ID":"Pfizer-310-8488",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-310-8488.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-311-8489",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-311-8489.d"}
},
{
"Subject ID":"-",
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"Factors":{"Treatment":"Pfizer"},
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},
{
"Subject ID":"-",
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},
{
"Subject ID":"-",
"Sample ID":"Pfizer-315-8492",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-315-8492.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-316-8493",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-316-8493.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-318-8494",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-318-8494.d"}
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{
"Subject ID":"-",
"Sample ID":"Pfizer-320-8495",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-320-8495.d"}
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{
"Subject ID":"-",
"Sample ID":"Pfizer-322-8497",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-322-8497.d"}
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{
"Subject ID":"-",
"Sample ID":"Pfizer-324-8498",
"Factors":{"Treatment":"Pfizer"},
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{
"Subject ID":"-",
"Sample ID":"Pfizer-329-8499",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-329-8499.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-332-8500",
"Factors":{"Treatment":"Pfizer"},
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},
{
"Subject ID":"-",
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"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-334-8501.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-338-8502",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-338-8502.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-343-8503",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-343-8503.d"}
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{
"Subject ID":"-",
"Sample ID":"Pfizer-345-8504",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-345-8504.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-348-8505",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-348-8505.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-350-8506",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-350-8506.d"}
},
{
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"Sample ID":"Pfizer-356-8507",
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"Additional sample data":{"RAW_FILE_NAME":"Pfizer-356-8507.d"}
},
{
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"Sample ID":"Pfizer-357-8508",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-357-8508.d"}
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},
{
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},
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},
{
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},
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},
{
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"Sample ID":"Pfizer-374-8514",
"Factors":{"Treatment":"Pfizer"},
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},
{
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"Factors":{"Treatment":"Pfizer"},
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},
{
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},
{
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{
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},
{
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"Factors":{"Treatment":"Pfizer"},
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},
{
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"Factors":{"Treatment":"Pfizer"},
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},
{
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"Sample ID":"Pfizer-412-8522",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-412-8522.d"}
},
{
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"Sample ID":"Pfizer-415-8523",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-415-8523.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-421-8524",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-421-8524.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-424-8582",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-424-8582.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-426-8525",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-426-8525.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-429-8526",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-429-8526.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-432-8528",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-432-8528.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-436-8529",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-436-8529.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-437-8530",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-437-8530.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-438-8531",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-438-8531.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-441-8532",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-441-8532.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-445-8533",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-445-8533.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-446-8534",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-446-8534.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-450-8535",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-450-8535.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-451-8536",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-451-8536.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-452-8537",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-452-8537.d"}
},
{
"Subject ID":"-",
"Sample ID":"Pfizer-455-8538",
"Factors":{"Treatment":"Pfizer"},
"Additional sample data":{"RAW_FILE_NAME":"Pfizer-455-8538.d"}
},
{
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{
"Subject ID":"-",
"Sample ID":"Sin 503-8686",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 503-8686.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 506-8687",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 506-8687.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 507-8688",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 507-8688.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 508-8689",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 508-8689.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 514-8690",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 514-8690.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 518-8692",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 518-8692.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 52-8588",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 52-8588.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 523-8693",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 523-8693.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 528-8694",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 528-8694.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 529-8695",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 529-8695.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 532-8696",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 532-8696.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 541-8697",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 541-8697.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 557-8698",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 557-8698.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 558-8699",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 558-8699.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 559-8700",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 559-8700.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 570-8701",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 570-8701.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 576-8702",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 576-8702.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 60-8599",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 60-8599.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 62-8600",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 62-8600.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 70-8601",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 70-8601.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 71-8602",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 71-8602.d"}
},
{
"Subject ID":"-",
"Sample ID":"Sin 73-8603",
"Factors":{"Treatment":"Sinopharm"},
"Additional sample data":{"RAW_FILE_NAME":"Sin 73-8603.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 11-8707",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 11-8707.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 111-8725",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 111-8725.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 120-8726",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 120-8726.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 129-8727",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 129-8727.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 152-8728",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 152-8728.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 17-8708",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 17-8708.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 2-8703",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 2-8703.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 21-8709",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 21-8709.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 24-8710",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 24-8710.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 25-8711",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 25-8711.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 26-8712",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 26-8712.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 3-8704",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 3-8704.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 303-8729",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 303-8729.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 306-8730",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 306-8730.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 317-8731",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 317-8731.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 327-8732",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 327-8732.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 328-8733",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 328-8733.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 342-8734",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 342-8734.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 344 -8735",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 344 -8735.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 349-8736",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 349-8736.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 351-8737",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 351-8737.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 355-8738",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 355-8738.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 360-8739",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 360-8739.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 365-8740",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 365-8740.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 366 -8741",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 366 -8741.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 368-8742",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 368-8742.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 369-8743",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 369-8743.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 373-8744",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 373-8744.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 375-8745",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 375-8745.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 376-8746",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 376-8746.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 383-8747",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 383-8747.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 384-8748",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 384-8748.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 386-8749",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 386-8749.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 391-8750",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 391-8750.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 392-8751",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 392-8751.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 394-8752",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 394-8752.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 395-8754",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 395-8754.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 398-8755",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 398-8755.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 399-8756",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 399-8756.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 403-8757",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 403-8757.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 404-8758",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 404-8758.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 410-8759",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 410-8759.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 418-8760",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 418-8760.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 423-8761",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 423-8761.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 425-8762",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 425-8762.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 431-8763",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 431-8763.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 435-8764",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 435-8764.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 440-8765",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 440-8765.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 442-8766",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 442-8766.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 444-8767",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 444-8767.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 456-8768",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 456-8768.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 502-8769",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 502-8769.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 504-8770",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 504-8770.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 510-8771",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 510-8771.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 511-8772",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 511-8772.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 519-8773",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 519-8773.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 521-8774",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 521-8774.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 533-8775",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 533-8775.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 535-8776",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 535-8776.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 537-8777",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 537-8777.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 539-8778",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 539-8778.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 54-8713",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 54-8713.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 550-8779",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 550-8779.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 552-8780",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 552-8780.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 57-8714",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 57-8714.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 580-8781",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 580-8781.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 6-8705",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 6-8705.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 61-8715",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 61-8715.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 66-8716",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 66-8716.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 68-8717",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 68-8717.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 7-8706",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 7-8706.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 75-8718",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 75-8718.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 76-8719",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 76-8719.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 77-8720",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 77-8720.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 78-8721",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 78-8721.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 79-8723",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 79-8723.d"}
},
{
"Subject ID":"-",
"Sample ID":"Unvac 80-8724",
"Factors":{"Treatment":"Unvaccinated"},
"Additional sample data":{"RAW_FILE_NAME":"Unvac 80-8724.d"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"A total of 340 subjects (aged between 10-85 years) were enrolled from Al-Quds Medical Labs (AL-Zarqa, Jordan). Blood samples were collected from 77 healthy individuals (had not received any of the COVID- 19 vaccines), 107 individuals who received the Sinopharm vaccine, and 156 individuals who received the Pfizer vaccine. The samples were collected using heparinized tubes and were then subjected to centrifugation for five minutes to obtain plasma. The study received ethical approval from The Institutional Review Board at The University of Jordan (UHS-HERC-094-21032022), and all participants signed an informed consent before collecting the blood samples. Individuals who tested positive for COVID-19, had received booster doses, had received a third dose of COVID-19 vaccine, or had received a single dose of either Pfizer or Sinopharm vaccines were excluded from the study","SAMPLE_TYPE":"Blood (plasma)","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"Blood samples were collected from 77 healthy individuals (had not received any of the COVID- 19 vaccines), 107 individuals who received the Sinopharm vaccine, and 156 individuals who received the Pfizer vaccine"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"we used chloroform/methanol extraction protocol to increase the coverage of the extracted metabolites. At first, the samples (cells and buffer) were transferred into Eppendorf tubes then centrifuged at 14000 rpm for 5 min. Afterward, the buffer was discarded, and the cells were preserved. To each sample, 400 µL of the mixture containing one protease inhibitor tablet and 10 mL of lysis buffer was added. Following rest for 10 minutes, samples were transferred to 10 mL tubes, vortexed for 2–4 minutes, and sonicated with a COPLEY probe-sonicator (QSONICA SONICATOR, USA) for 30 seconds while utilizing a 30 % amplifier in an ice bath. The samples were then transferred to Eppendorf tubes and centrifuged for 5 minutes at 14000 rpm. The supernatant was then transferred to another Eppendorf, and 400 µL of methanol and 300 µL of chloroform were added. Following that, the samples were vortexed for 30 seconds and centrifuged for 5 minutes at 14000 rpm. After that, two metabolite-containing layers are obtained, after transferring the upper layer of each sample to glass vials, 400 µl of methanol was added, followed by vertexing and centrifugation. The remaining supernatant was transferred to the same glass vials used before for the drying step, with the remaining protein pellets being air-dried for proteomics. A dried metabolomics sample was resuspended in 200 µL (0.1% formic acid in water) and injected into HPLC to be analysed by Q-TOF MS.In summary, After dividing the samples into 100 µL portions in Eppendorf tubes, 300 µL of methanol from Wunstorfer Strasse, Seelze, Germany, was introduced. The tubes were subsequently vortexed and placed in an incubator at -20°C for two hours. Following incubation, the samples underwent another round of vortexing and were centrifuged for 15 minutes at 14000 rpm. The resulting supernatant was evaporated at 35 to 40 °C through speed vacuum evaporation. To assess the analysis''s repeatability, a quality control (QC) sample was created by pooling the same volume of each sample (10µl). The extracted samples were then resuspended in 100 µL of Honeywell''s LC-MS CHROMASOLV''s 0.1% formic acid in Deionized Water (Wunstorfer Strasse, Seelze, Germany). Following that, 100 µL of the prepared sample was collected in an insert inside LC glass vials after filtration through a 0.45µm hydrophilic nylon syringe filter for LC-MS/MS analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Samples were chromatographically separated by inline reversed-phase chromatography using the Elute HPG 1300 pumps and Elute Autosampler (Bruker, Darmstadt, Germany) with solvent A 0.1% FA in HPLC grade water and solvent B 0.1% FA in ACN. A Hamilton Intensity Solo 2 C18 column (100 mm x 2.1 mm, 1.8µm beads) was maintained at 35C. For metabolomics, 10 µL was injected twice for each sample and eluted using a 30-minute gradient as follows: 1% ACN was held for 2 minutes, ramping to 99% ACN over 15 minutes, held at 99% ACN for 3 minutes before re-equilibrating to 1% ACN for 10 minutes. Flow rates were 250 µL/min for elution and 350 µL/min for re-equilibration.","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Bruker Elute","COLUMN_NAME":"Hamilton Intensity Solo 2 C18 (100 x 2.1 mm, 1.8 um)","SOLVENT_A":"100% water; 0.1% formic acid","SOLVENT_B":"100% acetonitrile; 0.1% formic acid","FLOW_GRADIENT":"1%B to 99%B in 15 min","FLOW_RATE":"250 uL/min","COLUMN_TEMPERATURE":"35"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Bruker timsTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"The MS analysis was performed using a TimsTOF (Bruker, Darmstadt, Germany) with Apollo II electrospray ionization (ESI) source. The drying gas was set to flow at 10 L/min and the drying temperature to 220C and the nebulizer pressure to 2.2 bar. The capillary voltage was 4500 V and the end plate offset 500V. For metabolomics the scan range was 20-1300 m/z. The collision energy was set to 20 eV, the cycle time to 0.5 seconds with a relative minimum intensity threshold of 400 counts per thousand and target intensity of 20,000. Sodium formate was injected as an external calibrant in the first 0.3 minutes of each LC-MS/MS run. MetaboScape 4.0 software was used for metabolite processing and statistical analysis (Bruker Daltonics). The following parameters for molecular feature identification and bucketing were set in the T-ReX 2D/3D workflow: For peak detection, a minimum intensity threshold of 1,000 counts is required, as well as a minimum peak duration of 7 spectra, with feature quantification determine using peak area. The file masses were recalibrated based on the external calibrant injected between 0-0.3 min."},

"MS_METABOLITE_DATA":{
"Units":"AU",

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