metabolite_name OPC-0uM-1 OPC-0uM-5 OPC-1uM-2 OPC-1uM-6 OPC-3uM-3 OPC-3uM-7 OPC-10uM-4 OPC-10uM-8 Adenine 23.6 17.7 20.7 20.5 25.6 18.3 15.6 15.7 Adenosine 9.20 10.30 10.04 9.61 11.38 9.37 10.07 10.59 Alanine 12432 11711 9414 10703 9154 7941 4284 4301 Arginine 890 919 870 952 1059 948 1052 1105 Argininosuccinic acid 32.4 27.9 29.5 27.3 30.8 27.9 20.4 17.9 Asparagine 455 398 394 393 422 332 400 338 Aspartic acid 11047 12559 9616 11342 9440 9449 4934 5886 Beta-Alanine 390 370 333 376 402 362 362 340 Betaine 484 635 528 645 646 632 594 652 Betaine aldehyde 0.352 N.D. 0.537 0.006 0.712 N.D. N.D. N.D. Carnitine 599 635 593 647 586 597 548 574 Carnosine 9.46 9.97 8.61 9.08 9.15 9.90 9.32 9.86 Choline 159 197 147 191 193 157 177 204 cis-3-hydroxyproline 81.8 92.7 84.8 86.5 88.7 94.3 90.2 91.1 Citrulline 10.03 10.57 9.77 10.28 12.35 10.82 10.88 11.14 Creatine 4167 4497 4223 4705 5555 5035 5805 6347 Creatinine 5.25 5.50 4.89 7.15 7.48 6.07 6.83 6.22 Cystathionine 1791 2156 1840 2177 2063 2111 1941 2063 Cysteine 602 378 359 321 817 325 662 509 Gamma-Aminobutyric acid 8.14 7.77 8.84 7.50 9.47 6.84 9.76 7.86 Glutamic acid 55195 63135 53295 60239 61228 59639 58612 62625 Glutamine 54299 57601 51123 57098 60057 53072 48176 50866 Glutathione 18710 22947 14342 20757 22146 18541 22934 23263 Glycine 25088 24691 23745 25504 28075 24249 24921 25217 Guanosine 3.95 N.D. N.D. N.D. N.D. N.D. 4.17 N.D. Histidine 3697 3656 3350 4132 4099 3821 3985 4135 Homocysteine N.D. N.D. N.D. N.D. N.D. N.D. N.D. 2.97 Homoserine 13.6 12.9 13.2 15.2 N.D. 16.2 N.D. 12.7 Inosine N.D. N.D. N.D. N.D. N.D. 0.903 N.D. N.D. Isoleucine 6087 6197 5737 6492 7031 6292 6299 6688 Leucine 7514 8021 6994 8279 8565 7729 7793 8586 Lysine 2393 2603 2391 2713 2762 2422 2835 2929 Methionine 4961 5371 4642 5444 5333 5415 5387 5789 Ornithine 76.7 93.7 74.3 91.9 65.1 70.4 47.8 38.6 Oxidized glutathione 5703 5305 6472 5842 5502 5830 3560 3635 Phenylalanine 4984 5168 4691 5254 5549 5007 5165 5413 Proline 8283 8465 7272 7747 7335 6720 4165 4201 Putrescine 4.63 4.79 4.57 3.82 4.07 3.43 3.29 N.D. S-Adenosylhomocysteine 41.4 76.5 57.8 57.0 43.9 49.1 68.8 60.8 S-Adenosylmethionine 976 1008 870 1136 1084 1105 915 1097 Sarcosine N.D. 16.35 8.72 N.D. 17.85 3.07 13.53 14.62 Serine 20596 21174 18361 20581 21268 19113 16595 16974 Spermidine 8.07 8.56 8.03 8.71 8.85 9.14 5.47 7.54 Spermine 40.62 35.73 33.65 47.92 37.86 37.10 9.83 28.58 Threonine 31255 31006 28471 31658 33751 29901 27489 28305 Tryptophan 580.3 613.4 541.2 635.1 711.4 573.3 645.8 652.4 Tyrosine 5081 5351 4771 5518 5665 5200 5548 5557 Valine 8177 8421 7804 8862 9626 8897 9303 9781 metabolite_name KEGG ID HMDB ID Adenine C00147 HMDB00034 Adenosine C00212 HMDB00050 Alanine C00041,C00133,C01401 HMDB00161,HMDB01310 Arginine C00062,C00792 HMDB00517,HMDB03416 Argininosuccinic acid C03406 HMDB00052 Asparagine C00152,C01905,C16438 HMDB00168 Aspartic acid C00049,C00402,C16433 HMDB00191,HMDB06483 Beta-Alanine C00099 HMDB00056 Betaine C00719 HMDB00043 Betaine aldehyde C00576 HMDB01252 Carnitine C00318,C00487,C15025 HMDB00062 Carnosine C00386 HMDB00033 Choline C00114 HMDB00097 cis-3-hydroxyproline C01015,C01157 HMDB06055,HMDB00725 Citrulline C00327 HMDB00904 Creatine C00300 HMDB00064 Creatinine C00791 HMDB00562 Cystathionine C00542,C02291 HMDB00099 Cysteine C00097,C00736,C00793 HMDB00574,HMDB03417 Gamma-Aminobutyric acid C00334 HMDB00112 Glutamic acid C00025,C00217,C00302 HMDB00148,HMDB03339 Glutamine C00064,C00303,C00819 HMDB00641,HMDB03423 Glutathione C00051 HMDB00125 Glycine C00037 HMDB00123 Guanosine C00387 HMDB00133 Histidine C00135,C00768,C06419 HMDB00177 Homocysteine C00155,C05330 HMDB00742 Homoserine C00263 HMDB00719 Inosine C00294 HMDB00195 Isoleucine C00407,C06418,C16434 HMDB00172 Leucine C00123,C01570,C16439 HMDB00687 Lysine C00047,C00739,C16440 HMDB00182,HMDB03405 Methionine C00073,C00855,C01733 HMDB00696 Ornithine C00077,C00515,C01602 HMDB00214,HMDB03374 Oxidized glutathione C00127 HMDB03337 Phenylalanine C00079,C02057,C02265 HMDB00159 Proline C00148,C00763,C16435 HMDB00162,HMDB03411 Putrescine C00134 HMDB01414 S-Adenosylhomocysteine C00021 HMDB00939 S-Adenosylmethionine C00019 HMDB01185 Sarcosine C00213 HMDB00271 Serine C00065,C00716,C00740 HMDB00187,HMDB03406 Spermidine C00315 HMDB01257 Spermine C00750 HMDB01256 Threonine C00188,C00820 HMDB00167 Tryptophan C00078,C00525,C00806 HMDB00929 Tyrosine C00082,C01536,C06420 HMDB00158 Valine C00183,C06417,C16436 HMDB00883