metabolite_name WT_1 WT_2 WT_3 WT_4 ClpC_1 ClpC_2 ClpC_3 ClpC_4 SrrAB_1 SrrAB_2 SrrAB_3 SrrAB_4 ClpC-SrrAB_1 ClpC-SrrAB_2 ClpC-SrrAB_3 ClpC-SrrAB_4 ADP 67.3 87.5 65.4 69.2 139.5 139.7 129.4 139.9 127.4 132 134.8 109.5 117.6 105.3 137.1 104.7 AMP 498.8 464 444.5 424 503.7 462.5 456.3 467.2 504.3 543.1 640 552.9 294 317.7 456.6 388.8 Acetate 1244.9 1317.9 1774.4 1605.9 2306.8 2406.2 2211.4 2455.2 2033.5 2135.1 2376.3 1614.2 2563.2 2707.2 2366.7 2269.8 Asparagine 10666.1 10999.3 10826.1 10963.5 13310.6 13739.8 12333.8 13152.9 18197.8 19128.3 16820.9 13053.5 12881 14657.4 17763.3 12881.1 Aspartate 5642.4 5511.8 3270.4 3160.2 4210 4880.7 3271.2 3117.2 3785.7 3785.9 6748.9 5683.7 4114.8 4666.2 7078.2 6468.6 Betaine 7077.9 7164.5 8023.8 7880.2 9240.6 9691.3 10984.5 10976.4 5446.2 4980.9 10506.2 9073.8 6321 7438.2 9760.5 9024.6 Citrulline 179.5 193.6 176.2 131.5 186.1 199.5 299.8 187.9 208.6 267.7 230.8 244.9 109.8 112.5 109.2 114.9 Dimethylamine 1598.1 1584 3024.2 2827.3 1285.1 1301.6 1598 1722.1 4015.4 4053.5 3585.8 2985.5 1598.7 1820.7 1169.1 1080.6 Formate 140.7 151.8 134.8 144.7 196.4 191.7 198.9 210.7 152.6 164.1 198.8 164 155.7 180.9 179.4 177.9 GTP 63.3 70.6 65.6 68.2 56.1 45.5 63.3 55.2 98.1 92.9 98.2 90.8 31.5 35.4 30.6 29.4 Glutamate 1635.3 1691.1 1713.9 1647.8 1847.4 1736.4 2182.8 1607.1 823.3 823.4 1580.9 1442.5 802.8 760.2 945 885 Glutarate 713.2 703.8 1621.9 1603.5 569.8 626.2 591 586 3412.3 3412.2 2360.3 1961.8 1092.6 1226.7 855 794.7 Glycine 69.9 78.4 49.9 43.3 149.8 149.9 150 162.1 55.6 55.7 55.8 68.9 105.2 105.3 133.8 132.6 Histamine 109.2 109.2 115.3 119.1 167.1 207.3 216.9 202.3 95.6 75.4 95.7 81.2 152.1 160.5 218.7 203.4 Histidine 90.4 93.4 113.6 108.2 63.3 86.6 141.5 128.1 100.6 113.2 140.6 120.6 124.2 144.6 143.1 136.2 Isoleucine 283.1 226.8 250.4 243.8 269.6 230.3 297.7 305.1 357.8 320 330.5 284.6 346.5 238.5 246.9 235.5 Lactate 187.2 187 169.4 156.2 247.8 231.6 229.4 231.9 242.2 256.3 320.3 249.5 153.6 208.2 246.3 219.6 Leucine 631.1 674.6 810.6 761.2 635.4 682.6 635.6 838.8 1041.5 989.2 1100.6 927.7 913.5 703.5 743.4 694.2 Lysine 10400.7 8755.8 10425.9 10263.3 13124.2 11183.4 13124.4 11431.8 14144.9 12574.5 14728.6 11981.2 11912.4 12479.1 12071.1 11647.8 Methionine 306.8 341 340.9 342.6 645.5 694.4 590.6 611.5 402.2 396 561.5 511.7 469.2 569.1 814.8 777.3 NAD+ 316.9 350.1 373.4 347.5 610 702.5 741.2 640.5 489.8 480 432.9 424.3 521.1 618 744.9 722.4 NADP+ 21.2 26.4 36.5 36.9 30.5 33.7 48 30.9 30.8 33.2 32.6 33.8 25.2 30.3 33.6 26.1 Niacinamide 25.9 25.8 23.8 26 39.6 55.5 35.8 44.9 28.3 43.1 26.8 28.3 27.6 37.8 52.5 40.8 Nicotinamide N-oxide 68.9 74.6 100 97.2 77.6 110.6 127.8 109.4 169.5 153.8 101.8 111.1 100.5 113.4 99 84.6 N-alpha-Acetyllysine 1437.9 1349.9 3033.9 2894.8 3469.1 3416.1 3899.2 4030.1 3424 3421.2 1859.1 1561.8 3491.7 3954 2452.8 2278.2 O-Phosphocholine 63.3 58.4 100 86.6 81 94.8 93.5 106.9 125.8 126.5 133.2 89.5 118.5 130.8 117.9 115.8 Phenylalanine 269.4 288.5 319.3 313.6 356.8 357 442.9 405.5 404.1 393.2 404 332.3 442.5 390 399.6 343.8 Succinate 238.1 246.4 222.8 214.8 225.7 238.1 199.8 199.5 320.9 318.2 684 610.5 184.8 239.1 368.7 346.8 Tartrate 244.2 244.3 244.6 244.7 280 281.1 281.4 281.5 277.2 277.3 277.6 277.5 239.3 239.4 239.5 239.8 Theophylline 15.8 9.2 14.6 12.7 98.5 98.6 98.8 98.9 12 15.4 30.8 12.9 91.1 91.2 91.3 91.4 Threonine 247.5 218.4 201.4 192 314.8 280.8 283.9 269.6 300.7 300.8 382.2 300.9 199.8 249.6 296.1 260.7 Trigonelline 137.6 147.3 71.3 71.5 196.1 235.9 203.2 179.5 50.1 50.2 190.8 169.8 117 136.2 206.1 195.6 Trimethylamine N-oxide 3502.1 3584.9 3949.2 3582.6 4225.9 4013.3 4353.7 4562.5 1662.2 1986.5 5197.5 4246.8 2391 2692.5 4089.3 3806.7 Tryptophan 191.3 198.4 236.5 235.5 265.6 274.6 335.7 277.4 265.8 240.2 299.7 240 288 283.5 282.3 284.7 Tyrosine 468.1 468.2 468.3 472.2 649.9 612.2 675.1 668.3 514.5 499.7 684.6 612 487.5 570.6 693 659.1 UMP 106.1 100 94.8 90.8 108.8 108.2 109.7 97.6 130.8 133.8 178.5 139.1 67.5 72.9 102.3 92.4 Valine 557.6 544 603.5 608.2 540.2 467.2 546.1 587.5 759.4 689.8 747.7 648.3 666 511.8 530.1 503.1 sn-Glycero-3-phosphocholine 140.9 135.1 160.9 163.8 212.9 217.6 278 234.7 201.5 194.5 172.9 187.1 157.5 185.1 168.9 163.2 metabolite_name ADP AMP Acetate Asparagine Aspartate Betaine Citrulline Dimethylamine Formate GTP Glutamate Glutarate Glycine Histamine Histidine Isoleucine Lactate Leucine Lysine Methionine NAD+ NADP+ Niacinamide Nicotinamide N-oxide N-alpha-Acetyllysine O-Phosphocholine Phenylalanine Succinate Tartrate Theophylline Threonine Trigonelline Trimethylamine N-oxide Tryptophan Tyrosine UMP Valine sn-Glycero-3-phosphocholine