metabolite_name Control 1 Control 2 Control 3 FOXO1-ER1 FOXO1-ER2 FOXO1-ER3 Pyruvic acid 0.02 0.01 0.01 0.01 0.01 0.01 Lactic acid 1.30 0.58 0.50 1.90 1.80 1.20 3-Hydroxybutyric acid 0.00 0.00 0.00 0.00 0.00 Glyceric acid 0.00 0.00 0.00 0.00 0.00 XA0002 0.02 0.02 0.02 0.03 0.03 0.03 Fumaric acid 0.01 0.01 0.01 0.01 0.01 0.01 2-Oxoisovaleric acid 0.01 0.00 0.00 0.00 0.00 0.00 Hexanoic acid 0.00 0.00 0.00 Succinic acid 0.01 0.01 0.01 0.01 0.01 0.01 Isethionic acid 0.00 0.00 0.00 0.00 0.00 0.00 5-Oxoproline 0.34 0.14 0.13 0.30 0.30 0.23 4-Methyl-2-oxovaleric acid 0.05 0.02 0.02 0.03 0.02 0.01 3-Methyl-2-oxovaleric acid 0.05 0.02 0.02 0.03 0.02 0.01 N-Acetyl-β-alanine 0.00 0.00 0.00 0.00 0.00 0.00 Malic acid 0.08 0.06 0.07 0.11 0.13 0.11 Threonic acid 0.03 0.02 0.03 0.03 0.02 0.03 Ethanolamine phosphate 0.01 0.01 0.01 0.01 0.01 0.01 Octanoic acid 0.00 0.00 XA0004 0.00 0.00 0.00 0.00 0.00 2-Oxoglutaric acid 0.03 0.02 0.03 0.03 0.03 0.04 2-Hydroxyglutaric acid 0.00 0.00 0.00 0.00 0.00 0.00 Pelargonic acid 0.00 0.00 0.00 0.00 0.00 0.00 3-Hydroxy-3-methylglutaric acid 0.00 0.00 0.00 0.00 0.00 0.00 N-Acetylcysteine 0.00 0.00 0.00 Terephthalic acid 0.00 0.00 0.00 0.00 0.00 0.00 XA0012 0.00 0.00 0.00 0.01 0.00 0.00 Phosphoenolpyruvic acid 0.00 0.00 0.00 0.00 0.01 0.01 Uric acid 0.00 0.00 0.00 0.00 0.00 0.00 Glyceraldehyde 3-phosphate 0.00 0.00 0.00 0.01 0.00 0.01 Dihydroxyacetone phosphate 0.01 0.01 0.00 0.06 0.04 0.04 Glycerol 3-phosphate 0.01 0.01 0.01 0.02 0.02 0.02 Decanoic acid 0.00 0.00 0.00 0.00 0.00 cis-Aconitic acid 0.02 0.02 0.02 0.02 0.01 0.01 N-Carbamoylaspartic acid 0.00 0.00 0.00 O-Phosphoserine 0.00 0.00 0.00 0.00 0.00 0.00 3-Phosphoglyceric acid 0.00 0.00 0.00 0.01 0.01 0.01 2-Phosphoglyceric acid 0.00 0.00 0.00 0.00 N-Acetylglutamine 0.00 0.00 0.00 N-Acetylglutamic acid 0.00 0.00 0.00 0.00 0.00 0.00 Isocitric acid 0.01 0.01 0.01 0.02 0.01 0.01 Citric acid 0.27 0.23 0.23 0.33 0.24 0.21 Quinic acid 0.00 Glucuronic acid-1 0.00 0.00 0.00 0.00 0.00 0.00 Galacturonic acid-1 0.00 0.00 0.00 0.00 0.00 0.00 Glucuronic acid-2 0.00 0.00 0.00 0.00 0.00 0.00 Galacturonic acid-2 0.00 0.00 0.00 0.00 0.00 0.00 Gluconic acid 0.04 0.03 0.04 0.09 0.06 0.07 Lauric acid 0.02 0.01 0.02 0.01 0.01 0.01 Phosphocreatine 0.70 0.66 0.72 0.55 0.59 0.56 O-Succinylhomoserine 0.00 0.00 0.00 0.00 0.00 0.00 Pantothenic acid 0.04 0.03 0.03 0.01 0.01 0.01 XA0027 0.00 0.00 0.00 0.00 0.00 0.00 Ribose 5-phosphate 0.00 0.00 0.00 0.01 0.01 0.01 Ribulose 5-phosphate 0.01 0.01 0.01 0.03 0.02 0.02 XA0033 0.17 0.15 0.15 0.13 0.12 0.12 Glucose 1-phosphate 0.03 0.03 0.03 0.06 0.05 0.05 Glucose 6-phosphate 0.01 0.01 0.01 0.03 0.03 0.04 Fructose 6-phosphate 0.00 0.00 0.00 0.01 0.01 0.01 myo-Inositol 1-phosphate 0.01 0.02 0.02 0.02 0.03 0.02 myo-Inositol 3-phosphate 0.01 0.02 0.02 0.02 0.03 0.02 myo-Inositol 2-phosphate 0.00 0.00 0.00 0.00 0.00 0.00 Sulfotyrosine 0.00 0.00 0.00 0.00 0.00 0.00 Sorbitol 6-phosphate 0.00 0.00 0.00 0.00 0.00 0.00 2,3-Diphosphoglyceric acid 0.00 0.00 0.00 0.00 0.00 0.00 6-Phosphogluconic acid 0.00 0.00 0.00 0.00 0.00 0.00 Rhein 0.00 0.00 0.00 0.00 0.00 0.00 Sedoheptulose 7-phosphate 0.01 0.00 0.01 0.02 0.01 0.02 N-Acetylglucosamine 1-phosphate 0.00 0.00 0.00 0.00 0.00 0.00 N-Acetylglucosamine 6-phosphate 0.00 0.00 0.00 0.00 0.00 0.00 N-Acetylneuraminic acid 0.00 0.00 0.00 0.00 0.00 0.00 Ribulose 1,5-diphosphate 0.00 0.00 0.00 0.00 0.00 0.00 3'-CMP 0.00 0.00 0.00 0.00 0.00 2'-CMP 0.00 0.00 0.00 0.00 0.00 CMP 0.00 0.00 0.00 0.00 0.00 0.00 UMP 0.00 0.00 0.00 0.00 0.00 0.00 N-Glycolylneuraminic acid 0.00 0.00 0.00 0.00 0.00 0.00 cAMP 0.00 0.00 0.00 0.00 Phytic acid_divalent 0.01 0.01 0.01 0.01 0.01 0.00 5-Aminoimidazole-4-carboxamide ribotide 0.00 0.00 Fructose 1,6-diphosphate 0.03 0.03 0.01 0.37 0.19 0.21 AMP 0.01 0.01 0.01 0.01 0.01 0.01 IMP 0.00 0.00 0.00 0.00 0.00 0.00 GMP 0.00 0.00 0.00 0.00 0.00 0.00 XA0055 0.00 0.00 0.00 0.02 0.01 0.01 NADPH_divalent 0.01 0.01 0.01 0.01 0.01 0.01 CoA_divalent 0.01 0.01 0.01 0.01 0.01 0.01 PRPP 0.00 0.00 0.00 0.00 0.00 0.00 FAD_divalent 0.00 0.00 0.00 0.00 0.00 0.00 CDP 0.00 0.00 0.00 0.00 0.00 0.00 UDP 0.01 0.01 0.01 0.01 0.01 0.01 Acetyl CoA_divalent 0.00 0.00 0.00 0.00 0.00 0.00 Thiamine diphosphate 0.00 0.00 0.00 0.00 0.00 0.00 Adenosine 5'-phosphosulfate 0.00 0.00 0.00 0.00 0.00 ADP 0.07 0.07 0.07 0.06 0.05 0.06 GDP 0.01 0.01 0.01 0.01 0.01 0.01 XA0065 0.00 0.00 0.00 0.00 0.00 0.00 HMG CoA_divalent 0.00 0.00 0.00 0.00 0.00 0.00 dCTP 0.00 0.00 0.00 dTTP 0.00 0.00 0.00 CTP 0.10 0.09 0.09 0.08 0.08 0.08 UTP 0.42 0.40 0.40 0.42 0.38 0.39 ATP 1.50 1.40 1.40 1.40 1.30 1.30 GTP 0.22 0.21 0.21 0.24 0.21 0.22 dTDP-glucose 0.00 0.00 0.00 0.00 0.00 0.00 UDP-glucose 0.21 0.20 0.20 0.28 0.22 0.24 UDP-galactose 0.21 0.20 0.20 0.28 0.22 0.24 UDP-glucuronic acid 0.06 0.06 0.05 0.06 0.06 0.06 ADP-glucose 0.00 0.00 0.00 0.00 0.00 0.00 GDP-fucose 0.00 0.00 0.00 0.00 0.00 0.00 GDP-glucose 0.00 0.00 0.00 0.00 0.00 0.00 GDP-mannose 0.00 0.00 0.00 0.00 0.00 0.00 GDP-galactose 0.00 0.00 0.00 0.00 0.00 0.00 UDP-N-acetylgalactosamine 0.15 0.13 0.14 0.09 0.09 0.09 UDP-N-acetylglucosamine 0.15 0.13 0.14 0.09 0.09 0.09 CMP-N-acetylneuraminate 0.01 0.01 0.01 0.01 0.01 0.01 NAD+ 0.07 0.06 0.07 0.05 0.05 0.05 NADH 0.01 0.00 0.00 0.01 0.01 0.01 NADP+ 0.01 0.00 0.00 0.01 0.00 0.00 metabolite_name KEGG ID HMDB ID quantified m/z MT/RT Pyruvic acid C00022 HMDB00243 87.009 12.42 Lactic acid C00186,C00256,C01432 HMDB00190,HMDB01311 89.025 10.41 3-Hydroxybutyric acid C01089,C03197 HMDB00011,HMDB00357,HMDB00442 103.04 9.2 Glyceric acid C00258 HMDB00139,HMDB06372 105.019 9.99 XA0002 110.985 15.13 Fumaric acid C00122 HMDB00134 115.004 24.64 2-Oxoisovaleric acid C00141 HMDB00019 115.041 9.81 Hexanoic acid C01585 HMDB00535 115.077 8.62 Succinic acid C00042 HMDB00254 117.02 20.3 Isethionic acid C05123 HMDB03903 124.992 11.18 5-Oxoproline C01879 HMDB00267 128.036 9.15 4-Methyl-2-oxovaleric acid C00233 HMDB00695 129.057 9.23 3-Methyl-2-oxovaleric acid C00671,C03465 HMDB00491 129.057 9.23 N-Acetyl-β-alanine C01073 130.052 8.58 Malic acid C00149,C00497,C00711 HMDB00156,HMDB00744 133.015 20.68 Threonic acid C01620 HMDB00943 135.031 8.92 Ethanolamine phosphate C00346 HMDB00224 140.013 7.72 Octanoic acid C06423 HMDB00482 143.107 8.04 XA0004 144.031 8.98 2-Oxoglutaric acid C00026 HMDB00208 145.015 20.72 2-Hydroxyglutaric acid C02630,C01087,C03196 HMDB00606,HMDB00694 147.03 16.43 Pelargonic acid C01601 HMDB00847 157.123 7.84 3-Hydroxy-3-methylglutaric acid C03761 161.046 14.94 N-Acetylcysteine C06809 HMDB01890 162.023 8.58 Terephthalic acid C06337 HMDB02428 165.02 16.08 XA0012 166.019 9.06 Phosphoenolpyruvic acid C00074 HMDB00263 166.975 20.44 Uric acid C00366 HMDB00289 167.022 8.6 Glyceraldehyde 3-phosphate C00118,C00661 HMDB01112 168.991 11.23 Dihydroxyacetone phosphate C00111 HMDB01473 168.992 12.21 Glycerol 3-phosphate C00093 HMDB00126 171.007 11.69 Decanoic acid C01571 HMDB00511 171.14 7.67 cis-Aconitic acid C00417 HMDB00072 173.01 27.21 N-Carbamoylaspartic acid C00438 HMDB00828 175.036 14.94 O-Phosphoserine C01005 HMDB00272 184.003 11.88 3-Phosphoglyceric acid C00197 HMDB00807 184.986 19.01 2-Phosphoglyceric acid C00631 HMDB03391 184.986 18.51 N-Acetylglutamine HMDB06029 187.073 7.8 N-Acetylglutamic acid C00624 HMDB01138 188.057 12.74 Isocitric acid C00311 HMDB00193 191.019 27.9 Citric acid C00158 HMDB00094 191.02 25.46 Quinic acid C00296 HMDB03072 191.058 7.81 Glucuronic acid-1 193.036 7.94 Galacturonic acid-1 193.036 7.94 Glucuronic acid-2 193.036 7.8 Galacturonic acid-2 193.036 7.8 Gluconic acid C00257 HMDB00625 195.052 7.9 Lauric acid C02679 HMDB00638 199.171 7.4 Phosphocreatine C02305 HMDB01511 210.029 11.86 O-Succinylhomoserine C01118 218.068 11.77 Pantothenic acid C00864 HMDB00210 218.105 7.4 XA0027 227.202 7.18 Ribose 5-phosphate C00117 HMDB01548 229.012 10.16 Ribulose 5-phosphate C00199,C01101 HMDB00618 229.012 10.53 XA0033 242.081 7.37 Glucose 1-phosphate C00103 HMDB01586 259.024 9.75 Glucose 6-phosphate C00668,C01172,C00092 HMDB01401 259.024 9.47 Fructose 6-phosphate C05345,C00085 HMDB00124 259.024 9.58 myo-Inositol 1-phosphate C01177 HMDB00213 259.024 9.89 myo-Inositol 3-phosphate C04006 HMDB06814 259.024 9.89 myo-Inositol 2-phosphate 259.024 10.08 Sulfotyrosine 260.024 8.04 Sorbitol 6-phosphate C01096 HMDB05831 261.038 9.58 2,3-Diphosphoglyceric acid C01159 HMDB01294 264.953 17.91 6-Phosphogluconic acid C00345 HMDB01316 275.018 14.14 Rhein C10401 283.024 8.32 Sedoheptulose 7-phosphate C05382 HMDB01068 289.035 9.33 N-Acetylglucosamine 1-phosphate C04256 HMDB01367 300.05 9.2 N-Acetylglucosamine 6-phosphate C00357 HMDB01062 300.05 8.83 N-Acetylneuraminic acid C00270 HMDB00230 308.101 6.94 Ribulose 1,5-diphosphate C01182 308.979 15.12 3'-CMP C05822 322.045 9.42 2'-CMP C03104 HMDB11692 322.045 9.42 CMP C00055 HMDB00095 322.046 9.22 UMP C00105 HMDB00288 323.03 9.41 N-Glycolylneuraminic acid C03410 HMDB00833 324.095 6.92 cAMP C00575 HMDB00058 328.045 7.24 Phytic acid_divalent C01204 HMDB03502 328.924 15.91 5-Aminoimidazole-4-carboxamide ribotide C04677 HMDB01517 337.054 9.1 Fructose 1,6-diphosphate C00354 HMDB01058 338.99 14.06 AMP C00020 HMDB00045 346.058 8.93 IMP C00130 HMDB00175 347.04 9.18 GMP C00144 HMDB01397 362.052 8.8 XA0055 369 13.79 NADPH_divalent C00005 HMDB00221 371.54 10.87 CoA_divalent C00010 HMDB01423 382.551 10.22 PRPP C00119 HMDB00280 388.945 16.29 FAD_divalent C00016 HMDB01248 391.572 7.6 CDP C00112 HMDB01546 402.012 11.04 UDP C00015 HMDB00295 402.997 11.22 Acetyl CoA_divalent C00024 HMDB01206 403.558 9.87 Thiamine diphosphate C00068 HMDB01372 423.031 7.66 Adenosine 5'-phosphosulfate C00224 HMDB01003 426.015 9.77 ADP C00008 HMDB01341 426.023 10.45 GDP C00035 HMDB01201 442.018 10.25 XA0065 445.055 6.7 HMG CoA_divalent C00356 HMDB01375 454.572 10.97 dCTP C00458 HMDB00998 465.985 11.98 dTTP C00459 HMDB01342 480.983 11.67 CTP C00063 HMDB00082 481.978 11.91 UTP C00075 HMDB00285 482.963 12.11 ATP C00002 HMDB00538 505.989 11.38 GTP C00044 HMDB01273 521.986 11.03 dTDP-glucose C00842 HMDB01328 563.07 8.13 UDP-glucose C00029 HMDB00286 565.05 8.32 UDP-galactose C00052 HMDB00302 565.05 8.32 UDP-glucuronic acid C00167 HMDB00935 579.029 10.61 ADP-glucose C00498 HMDB06557 588.078 8.01 GDP-fucose C00325 HMDB01095 588.078 8.01 GDP-glucose C00394 HMDB03351 604.07 7.98 GDP-mannose C00096 HMDB01163 604.07 7.98 GDP-galactose C02280 604.07 7.98 UDP-N-acetylgalactosamine C00203 HMDB00304 606.076 8.13 UDP-N-acetylglucosamine C00043 HMDB00290 606.076 8.13 CMP-N-acetylneuraminate C00128 HMDB01176 613.141 7.87 NAD+ C00003 HMDB00902 662.104 6.33 NADH C00004 HMDB01487 664.12 7.88 NADP+ C00006 HMDB00217 742.07 9.02