metabolite_name L_K9D1 L_K10D1 L_K11D1 L_K7D7 L_K8D7 L_K9D7 L_K10D7 L_K11D7 L_K7D14 L_K8D14 L_K9D14 L_K10D14 L_K11D14 L_K7D21 L_K8D21 L_K9D21 L_K10D21 L_K11D21 L_K7D28 L_K8D28 L_K9D28 L_K10D28 L_K11D28 L_K7D56 L_K8D56 L_K9D56 L_K10D56 L_K11D56 Alanine 41.22905028 20.72100313 25.16260163 21.41680395 11.15207373 17.10709318 20.06269592 24.83221477 18.47206385 13.16003249 24.64539007 10.08196721 9.233791749 5.989583333 2.587672689 8.517520216 9.54738331 10.30927835 5.677059097 8.909853249 4.98960499 9.037328094 7.196749855 7.528556594 6.049495875 5.951859956 9.315589354 0 Arginine 0 0.118181818 0 0.01029654 0.045529954 0.00364395 0.040909091 0.003400447 0.022348917 0.00170593 0 0 0.007989522 0.006927083 1.726886291 0 0 0.015738832 0 0 0.004823285 0 0 0 0 0 0 0.920840065 Asparagine 2.675977654 3 2.670731707 1.128500824 1.474654378 2.155771905 2.617554859 1.85458613 1.023945268 1.104792851 1.712765957 1.590163934 1.388343157 1.520833333 0.807651435 0.819407008 1.421499293 1.573883162 0.46998604 0.990566038 0.449064449 0.94302554 0.963435868 0.856697819 0.719523373 0.778993435 1.159695817 1.168551427 Aspartate 25.75418994 14.4200627 16.50406504 8.220757825 5.778801843 11.59944367 10.95611285 8.478747204 5.929304447 4.04549147 7.074468085 3.221311475 2.57367387 1.135416667 1.912858661 2.150943396 1.647807638 2.261168385 1.498371336 1.383647799 1.072765073 1.656843484 1.404526988 1.199376947 0.811182401 1.041575492 1.628643853 0 Citrulline 2.502793296 0.65830721 1.524390244 0.504118616 0.217511521 0.278164117 0.44200627 0.293064877 0.343215507 0.14378554 0.333333333 0.07647541 0.08513425 0.039427083 0.03554729 0.046037736 0.045120226 0.067560137 0.01279665 0.015828092 0.026777547 0.030451866 0.02159025 0.021754933 0.012832264 0.008665208 0.014638783 0.264943457 Glutamine 38.77094972 23.26018809 34.18699187 8.616144975 5.078341014 8.859527121 8.119122257 10.35794183 3.124287343 0.90170593 5.514184397 2.950819672 2.861820563 0.111458333 0 1.498652291 4.391796322 0.027697595 0.805025593 3.380503145 1.937629938 3.575638507 2.031340685 2.699896158 2.401466544 3.234135667 4.27756654 0 Glutamate 50.83798883 27.77429467 34.18699187 19.93410214 10.04608295 14.60361613 16.30094044 24.83221477 14.82326112 9.666937449 18.26241135 8.172131148 5.913555992 5.364583333 0.520722635 5.498652291 5.813295615 3.567010309 6.375058167 5.167714885 5.322245322 7.465618861 6.094022055 4.018691589 1.883593034 3.04595186 4.461343473 0.176090468 Glycine 84.3575419 43.57366771 63.00813008 20.42833608 10.59907834 19.33240612 15.830721 34.67561521 15.16533637 9.504467912 16.02836879 7.524590164 6.195153897 4.302083333 1.323060574 4.274932615 5.176803395 5.580756014 2.954862727 4.365828092 3.538461538 5.507531107 3.813116657 4.589823468 2.818515124 2.853391685 4.524714829 1.152396338 Histidine 6.759776536 3.793103448 6.341463415 3.459637562 1.852534562 3.268428373 2.89968652 3.467561521 2.930444698 1.697806661 3.120567376 1.672131148 1.296660118 0.932291667 0.297024442 0.862533693 1.265912306 1.04467354 0.744532341 0.964360587 0.61954262 1.309757695 0.76610563 0.820353063 0.545371219 0.665207877 1.134347275 0.22724825 Isoleucine 6.703910615 3.699059561 5.162601626 2.471169687 1.456221198 2.64255911 2.288401254 2.818791946 2.75940707 1.762794476 2.624113475 1.680327869 1.349050426 0.734375 0.547290117 0.765498652 1.237623762 0.914089347 0.618892508 0.906708595 0.51975052 1.165684348 0.742890308 0.820353063 0.600366636 0.700218818 1.210392902 0.322563274 Leucine 12.29050279 6.865203762 10.20325203 4.217462932 2.774193548 5.479833102 4.090909091 4.966442953 6.248574686 3.679935012 5.638297872 3.426229508 2.743942371 1.416666667 11.26461211 1.563342318 2.75106082 2.041237113 1.228478362 1.897274633 1.143451143 2.383759005 1.642484039 1.640706127 1.232813932 1.509846827 3.067173638 4.846526656 Lysine 18.43575419 8.495297806 17.23577236 5.28830313 3.069124424 5.9527121 5.282131661 6.398210291 5.450399088 2.83509342 4.946808511 3.303278689 2.180746562 1.557291667 0.417640808 1.428571429 2.149929279 2.233676976 1.00511866 1.598532495 1.139293139 2.691552063 1.31746953 1.495327103 1.067827681 1.067833698 1.945500634 3.855681206 Methionine 5.413407821 2.639498433 3.581300813 1.894563427 1.087557604 1.933240612 1.630094044 2.214765101 2.326111745 1.299756296 2.145390071 1.18852459 0.975769483 0.519270833 0.012539851 0.598382749 0.891089109 0.728522337 0.422987436 0.592243187 0.38004158 0.746561886 0.56645386 0.516095535 0.356095325 0.442013129 0.830164766 0.021486268 Ornithine 11.56424581 6.081504702 8.089430894 3.805601318 2.350230415 4.353268428 4.07523511 4.071588367 3.534777651 2.022745735 3.546099291 2.483606557 1.584806811 1.109375 0.850159405 1.099730458 1.654879774 1.457044674 0.614239181 1.022012579 0.781704782 1.565160445 1.033081834 0.976116303 0.673693859 0.67833698 1.248415716 1.12008616 Phenylalanine 7.430167598 4.294670846 5.040650407 2.355848435 1.520737327 2.726008345 2.115987461 2.729306488 3.033067275 1.900893582 3.120567376 1.581967213 1.335952849 0.765625 0.011317747 0.889487871 1.272984441 1.305841924 0.684039088 0.922431866 0.598752599 1.15913556 0.870574579 0.903426791 0.664527956 0.774617068 1.362484157 0.05815832 Proline 19.21787709 8.965517241 14.3495935 6.408566722 4.055299539 5.9527121 5.940438871 7.919463087 6.431014823 4.248578392 6.755319149 3.352459016 2.730844794 1.432291667 0.209883103 1.525606469 2.036775106 2.487972509 1.130758492 1.44129979 0.906444906 1.689587426 1.247823564 1.246105919 0.884509624 0.984682713 1.787072243 1.168551427 Serine 23.18435754 12.13166144 12.60162602 8.088962109 4.304147465 8.789986092 7.711598746 8.903803132 7.571265678 3.826157595 7.464539007 3.786885246 2.940406025 2.052083333 1.918172157 1.811320755 2.644978784 2.852233677 1.382038157 1.823899371 1.20997921 2.351015062 1.723737667 1.723779855 1.076993584 1.361050328 2.57287706 0.065158858 Threonine 12.17877095 7.335423197 9.715447154 4.876441516 3.105990783 4.589707928 4.952978056 5.436241611 4.25313569 2.696994314 5.141843972 2.401639344 2.167648985 1.072916667 0.026514346 1.277628032 1.739745403 1.972508591 1.000465333 1.498951782 0.765072765 1.427635887 1.300058038 1.298026999 0.976168653 1.190371991 1.844106464 0.056004308 Tryptophan 2.519553073 1.413793103 1.723577236 0.574958814 0.346543779 0.593880389 0.476489028 0.693512304 0.597491448 0.355808286 0.613475177 0.322131148 0.271119843 0.165104167 0.392667375 0.172506739 0.257425743 0.263917526 0.126105165 0.183438155 0.117255717 0.236411264 0.16540917 0.161474559 0.115490376 0.132603939 0.25095057 0.237479806 Tyrosine 6.983240223 3.260188088 5.447154472 2.009884679 1.705069124 2.698191933 2.288401254 1.995525727 2.417331813 1.673436231 2.074468085 1.631147541 1.342501637 0.869791667 0.445802338 0.873315364 1.265912306 1.395189003 0.595625872 0.864779874 0.56964657 1.185330714 0.87637841 0.846313603 0.586617782 0.673960613 1.18504436 0.222940226 Valine 12.51396648 6.520376176 9.308943089 4.744645799 2.67281106 4.95132128 4.310344828 5.525727069 5.27936146 3.151909017 5.195035461 2.803278689 2.311722331 1.458333333 0.860786397 1.347708895 2.079207921 2.24742268 1.098185202 1.540880503 0.972972973 1.997380485 1.358096344 1.474558671 1.09532539 1.24726477 2.192648923 0.646203554 Acetylornithine 0.138547486 0.042319749 0.131707317 0 0 0 0 0.007941834 0.157354618 0.004061738 0 0.000868852 0.072036673 0.075520833 0.292773645 0.008086253 0.018953324 0.035876289 0.010563053 0.014046122 0.017546778 0.017681729 0.011375508 0.008047767 0.009349221 0.004420131 0.025728771 0.748519117 Asymmetric dimethylarginine 0.424022346 0.272100313 0.307723577 0.135420099 0.088940092 0.151599444 0.155799373 0.165324385 0.129988597 0.086921202 0.141134752 0.073688525 0.059528487 0.02515625 0.090860786 0.030781671 0.040876945 0.083848797 0.025221033 0.03663522 0.017837838 0.030451866 0.027278003 0.023312565 0.017048579 0.01868709 0.030671736 0.721593969 Alpha- Aminoadipic acid 16.53631285 1.021943574 6.178861789 0.401976936 0.297695853 0.534075104 0.611285266 0.67114094 0.34663626 0.202274574 0.510638298 0.300819672 0.225278324 0.1921875 0.68544102 0.241509434 0.209335219 0.632302405 0.09771987 0.094339623 0.211642412 0.330058939 0.281485781 0.23364486 0.041934005 0.115973742 0.464512041 0.608508347 cis-4-Hydroxyproline 0 0 0 0 0 0 0 0 0 0 0 0 1.96464E-05 0.000640625 0.063761955 0 0 0.000721649 0 0 0 0 0 0 0 0 0 0.090468498 Carnosine 0.043687151 0.021912226 0 0.032784185 0.022672811 0.023922114 0.027742947 0.023266219 0.021208666 0.006953696 0.026595745 0.008852459 0.008775377 0.0134375 0 0.002679245 0.003408769 0.006611684 0.001377385 0 0 0.003123772 0.013580963 0 0 0 0.020342205 0 Creatinine 0 0 0 0 0 0 0 0 0 0 0 0 0 0.382291667 13.39001063 0 0 0 0 0 0 0 0 0 0 0 0 24.07108239 Dihydroxyphenylalanine 0.02027933 0.012664577 0 0 0 0.002656467 0 0.006219239 0 0.000178716 0.007198582 0.000434426 0 0.00953125 0 0 0 0.019106529 0.000823639 0 0.001135135 0.000333988 0.000139292 0.000649013 0 0 0.002756654 0.004959612 Dopamine 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.177167474 Histamine 0.620111732 0.135736677 1.479674797 0.013739703 0.008608295 0.012336579 0.011739812 0.021387025 0.002519954 0.001015435 0.003049645 0.001393443 0.001368697 0.000802083 0.00706695 0 0 0.001408935 0 0 0 0 0 0 0 0 3.16857E-05 0.161550889 Kynurenine 0.877094972 0.045768025 0.320731707 0.030807249 0.017695853 0.031571627 0.0330721 0.04541387 0.049600912 0.034849716 0.04929078 0.019672131 0.020104781 0.0275 1.280552604 0.010242588 0.010042433 0.030721649 0.004746394 0.006079665 0.008898129 0.008840864 0.009286129 0.006074766 0.006782768 0.005601751 0.008491762 0.484652666 Methioninesulfoxide 0.170391061 0.092476489 0.111382114 0.04398682 0.022580645 0.050904033 0.048119122 0.078747204 0.064424173 0.029488221 0.051595745 0.033852459 0.019318926 0.008333333 0.026408077 0.009272237 0.018811881 0.023505155 0.006933457 0.008595388 0.006486486 0.011853307 0.011259431 0.010332295 0.006966086 0.008752735 0.016539924 0.155088853 Nitrotyrosine 0.000335196 0 0.000203252 0 0 0.000111266 0 4.47427E-05 4.561E-05 0 8.86525E-05 4.09836E-05 6.54879E-06 0.000432292 0.051540914 5.39084E-05 9.19378E-05 0.001491409 9.30665E-05 0 2.4948E-05 6.54879E-05 4.06268E-05 3.63448E-05 1.37489E-05 0 1.90114E-05 0.090468498 Phenylethylamine 0.003072626 0 0 0 0 0.001029207 0.001003135 0 0.000752566 0 0 0.000336066 0 0.001677083 0 0 0.000360679 0.004536082 0.00033504 0 0 0 0.000290192 0 0.000256645 0 0 0 Putrescine 1.56424581 0.586206897 1.341463415 0.57660626 0.182488479 0.282336579 0.572100313 0.894854586 0.11391106 0.055077173 0.225177305 0.093442623 0.052586771 0.630208333 8.7141339 0.012830189 0.103960396 0.654982818 0.036761284 0.036949686 0.03018711 0.03994761 0.062100987 0.018172378 0.014436297 0.016280088 0.03269962 2.891760905 Symmetric dimethylarginine 0.130726257 0.063949843 0.089430894 0.027347611 0.007585253 0.01891516 0.017398119 0.023713647 0.010239453 0.005962632 0.025 0.003434426 0.003182711 0.002364583 0.050903294 0 0.000360679 0.045429553 0.001033039 0.002751572 0.001218295 0.001316306 0.000255369 0.00017134 0.000421632 0 0.001692015 0.505115778 Serotonine 0.005139665 0 0.00495935 0.002257002 0.002064516 0.003351878 0.00315047 0.003668904 0.00327252 0.004500406 0.006755319 0.004532787 0.004250164 0.004177083 0.010467588 0.00425876 0.008203678 0.00975945 0.003327129 0.00524109 0.002665281 0.006385069 0.003888566 0.008566978 0.008111824 0.006345733 0.00652725 0.073774906 Spermidine 13.01675978 9.21630094 10.56910569 4.546952224 2.221198157 2.80945758 3.463949843 6.487695749 3.112884835 2.177091795 3.439716312 1.43442623 1.434184676 0.296875 0.074388948 1.374663073 1.499292786 0.485223368 0.614239181 0.71278826 0.51975052 1.001964637 1.079512478 0.581516096 0.815765353 0.573304158 0.899873257 0.17447496 Spermine 0.230167598 0.019592476 0.336585366 0.059637562 0.004820276 0.030458971 0.007884013 0.008836689 0 0.013566206 0.040248227 0 0.004276359 0.016041667 0.006057386 0.003126685 0.006216407 0 0.022987436 0.006498952 0.018669439 0 0.019094602 0.009553479 0.003263061 0.028052516 0.014258555 0.004776521 trans-4-Hydroxyproline 0.798882682 0.978056426 1.304878049 0.321252059 0.156682028 0.278164117 0.21630094 0.304250559 0.160775371 0.131600325 0.205673759 0.086885246 0.082514735 0.0440625 0.458023379 0.039245283 0.057496464 0.071477663 0.036807818 0.048689727 0.038004158 0.038441388 0.041265235 0.027725857 0.022502291 0.018993435 0.014828897 0 Taurine 32.51396648 18.21316614 23.94308943 9.159802306 4.976958525 7.385257302 8.134796238 12.23713647 6.77309008 4.833468725 10.26595745 4.713114754 3.791748527 2.713541667 0 2.797843666 3.394625177 4.268041237 2.093997208 1.881551363 2.349272349 4.047151277 3.430063842 3.026998962 2.804766269 2.516411379 3.415716096 0 metabolite_name KEGG ID Alanine C00041 Arginine C00062 Asparagine C00152 Aspartate C00049 Citrulline C00327 Glutamine C00064 Glutamate C00025 Glycine C00037 Histidine C00135 Isoleucine C00407 Leucine C00123 Lysine C00047 Methionine C00073 Ornithine C00077 Phenylalanine C00079 Proline C00148 Serine C00065 Threonine C00188 Tryptophan C00078 Tyrosine C00082 Valine C00183 Acetylornithine C00437 Asymmetric dimethylarginine C03626 Alpha- Aminoadipic acid C00956 cis-4-Hydroxyproline C19706 Carnosine C00386 Creatinine C00791 Dihydroxyphenylalanine C00355 Dopamine C03758 Histamine C00388 Kynurenine C00328 Methioninesulfoxide C02989 Nitrotyrosine - Phenylethylamine C02455 Putrescine C00134 Symmetric dimethylarginine - Serotonine C00780 Spermidine C00315 Spermine C00750 trans-4-Hydroxyproline C01157 Taurine C00245