Summary of project PR000023
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000023. The data can be accessed directly via it's Project DOI: 10.21228/M89G6S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000023 |
| Project DOI: | doi: 10.21228/M89G6S |
| Project Title: | Diabetes and the Cori Cycle |
| Project Type: | Obesity/Diabetes Pathway Analysis |
| Project Summary: | Preliminary data generated by the Houmard lab indicates that the Cori Cycle may play a critical role in the hyperglycemia of type 2 diabetes mellitus (T2D). The Houmard lab hypothesizes that PDH activity is depressed in human skeletal muscle with severe obesity and T2D which increases lactate production and reduces flux through the TCA cycle; with gastric bypass, this inhibition of PDH is removed resulting in a greater flux of carbons through the TCA cycle, reduced lactate production and resolution of the lactate overproduction with obesity and the resolution of the hyperglycemic, diabetic state. Broad spectrum metabolomics will be used to better understand the pathways by which lactate production is elevated with obesity and obesity/diabetes and to produce preliminary data for an R01. |
| Institute: | East Carolina University |
| Department: | Department of Kinesiology |
| Laboratory: | Human Performance Laboratory |
| Last Name: | Houmard |
| First Name: | Joseph |
| Address: | Human Performance Laboratory, Ward Sports Medicine Building, East Carolina University, Greenville, NC 27858 |
| Email: | houmardj@ecu.edu |
| Phone: | 252-737-4617 |
Summary of all studies in project PR000023
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000024 (Availability TBA) | Metabolomics Analysis of Diabetes and the Cori Cycle (part I) | Homo sapiens | University of North Carolina | MS* | - | - | 8 | Not available |
| ST000219 (Availability TBA) | Metabolomics Analysis of Diabetes and the Cori Cycle (part II) | Homo sapiens | University of North Carolina | MS | - | - | 8 | Not available |
