Summary of project PR000338
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000338. The data can be accessed directly via it's Project DOI: 10.21228/M8X01N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000338 |
| Project DOI: | doi: 10.21228/M8X01N |
| Project Title: | Characterizing commonalities and differences between the breast and prostate cancer metabotypes in African-American cohorts |
| Project Type: | Identify Breast Cancer Progression and Prostate Cancer correlative Metabolite Markers |
| Project Summary: | Many attempts have been made to identify critical events responsible for the development and progression of breast cancer (BCa). In spite of this, the mechanisms underlying notably tumor invasion and BCa dissemination remain largely unclear. The pathological features of BCa follow a sequential progression from the transformation of a normal cell to benign proliferation, hyperplasia, atypical ductal hyperplasia (ADH), ductal carcinoma in-situ (DCIS) to invasive ductal carcinoma (IDC) and metastatic diseases. It has been reported that the disease phenotype is distinguishable in ADH and progresses along distinct pathways for each subtype. The genetic signature for disease heterogeneity across subtypes is greater than the heterogeneity of progression from DCIS to IDC within a subtype, suggesting that the disease subtypes have distinct progression pathways. Even so, genetics does not fully explain etiology nor progression. Additionally, a large population based study reported an increased risk of male BCa after prostate cancer (PCa). The two cancers share similarities with a wide heterogeneity of both phenotype and biology. A unique feature of PCa and BCa is that at least in the initial stages, they are hormone-dependent and have remarkable underlying biological similarities. Our recent study and others showed an increased level of common metabolites in BCa and PCa. Thus, understanding the metabolic profiles of breast and prostate cancer would pave the way for new biomarkers to improve diagnosis and treatment strategies. |
| Institute: | Howard University |
| Department: | Department of Microbiology and Cancer Center |
| Last Name: | Kanaan |
| First Name: | Yasmine |
| Address: | 1840 Seventh Street, NW Suite 309, Washington, DC 20001 |
| Email: | ymkanaan@Howard.edu |
| Phone: | 202 806 9540 |
Summary of all studies in project PR000338
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000438 | Characterizing commonalities and differences between the breast and prostate cancer metabotypes in African-American cohorts (part I) | Homo sapiens | University of North Carolina | NMR | 2016-09-23 | 1 | 48 | Uploaded data (38.1M)* |
| ST000439 | Characterizing commonalities and differences between the breast and prostate cancer metabotypes in African-American cohorts | Homo sapiens | University of North Carolina | NMR | 2016-09-23 | 1 | 66 | Uploaded data (19.1M)* |
