Summary of project PR000842

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000842. The data can be accessed directly via it's Project DOI: 10.21228/M8V694 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000842
Project DOI:doi: 10.21228/M8V694
Project Title:Metabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens
Project Summary:Duchenne muscular dystrophy is caused by genetic defects in the gene encoding dystrophin and leads to progressive muscle degeneration. Glucocorticoid steroids are current mainstay pharmacological regimen to decrease muscle inflammation and prolong the ambulatory period in these patients, but daily intake of glucocorticoids like prednisone and deflazacort causes adverse side effects like osteoporosis, adrenal suppression, insulin resistance and obesity. Intermittent steroid dosing has been proposed as alternative to maintain benefits and limit side effects, but a detailed understanding of the mechanisms underpinning the regimen-specific effects in muscle is still missing. Here we explore how once-daily versus once-weekly prednisone (4 week-long treatment) affect the metabolomic landscape in mdx mouse muscle (genetic model of Duchenne muscular dystrophy; DBA/2J background) through metabolomics profiling.
Institute:Northwestern University
Department:Center for Genetic Medicine
Laboratory:McNally Laboratory
Last Name:Quattrocelli
First Name:Mattia
Address:303 East Superior St, SQBRC 5-500, Chicago, IL, 60611, USA
Funding Source:NIH, PPMD, MDA
Contributors:Quattrocelli, McNally

Summary of all studies in project PR000842

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001256 Metabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens Mus musculus Northwestern University MS 2020-01-06 1 9 Uploaded data (476.8M)*