Summary of project PR001782
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001782. The data can be accessed directly via it's Project DOI: 10.21228/M8CB14 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001782 |
| Project DOI: | doi: 10.21228/M8CB14 |
| Project Title: | Targeting Pancreatic Cancer Metabolic Dependencies through Glutamine Antagonism. |
| Project Type: | Manuscript |
| Project Summary: | Pancreatic ductal adenocarcinoma (PDAC) cells utilize glutamine (Gln) to support proliferation and redox balance. Earlier attempts to inhibit Gln metabolism using glutaminase inhibitors resulted in rapid metabolic reprogramming and therapeutic resistance. We demonstrated that treating PDAC cells with a Gln antagonist, 6-Diazo-5-oxo-L-norleucine (DON), led to a metabolic crisis in vitro. In addition, we observed a profound decrease in tumor growth in various in vivo models using DRP-104 (sirpiglenastat), a pro-drug version of DON designed to circumvent DON-associated toxicity. |
| Institute: | New York University |
| Department: | Radiation Oncology |
| Laboratory: | Alec C Kimmelman |
| Last Name: | Encarnacion Rosado |
| First Name: | Joel |
| Address: | Smilow Research Building Room 907G New York, NY 10016 |
| Email: | jencarnacionrosado@salk.edu, Alec.Kimmelman@nyulangone.org |
| Phone: | 646-501-8984 |
Summary of all studies in project PR001782
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002847 | Targeting Pancreatic Cancer Metabolic Dependencies through Glutamine Antagonism. | Mus musculus | New York University | MS | 2024-09-08 | 1 | 9 | Uploaded data (329.5M)* |
| ST002853 | Targeting Pancreatic Cancer Metabolic Dependencies through Glutamine Antagonism (Lipidomics-human) | Homo sapiens | New York University | MS* | 2024-09-12 | 1 | 6 | Uploaded data (233.5M)* |
| ST002855 | Targeting Pancreatic Cancer Metabolic Dependencies through Glutamine Antagonism (Lipidomics mus musculus) | Mus musculus | New York University | MS* | 2024-09-12 | 1 | 6 | Uploaded data (108.9M)* |
