Summary of project PR002534
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002534. The data can be accessed directly via it's Project DOI: 10.21228/M83G11 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002534 |
| Project DOI: | doi: 10.21228/M83G11 |
| Project Title: | Untargeted metabolomics analysis on mouse hepatocytes |
| Project Summary: | To determine whether specific metabolites are associated with the induction of P2-HNF4α in liver disease and hepatocellular carcinoma (HCC), we performed untargeted metabolomics on hepatocytes isolated from wild-type mouse liver, which predominantly express the tumor-suppressive P1-HNF4α isoform. Using lentiviral transduction, we overexpressed the P2-HNF4α isoform and conducted metabolite profiling on cell lysates from both control and P2-HNF4α-overexpressing cells. Data analysis was performed using MetaboAnalyst (v5.0), resulting in a list of approximately 120 matched compounds representing significantly predicted metabolites. This study aims to uncover metabolic signatures associated with P2-HNF4α expression, offering insights into its potential role in liver pathogenesis and tumor progression. |
| Institute: | University of Texas Health Science Center at Houston |
| Department: | IMM |
| Laboratory: | Mahan Lab |
| Last Name: | Fekry |
| First Name: | Baharan |
| Address: | 1825 Pressler St, Houston TX 77030. USA, |
| Email: | Baharan.Fekry@uth.tmc.edu |
| Phone: | 7135002487 |
Summary of all studies in project PR002534
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004042 | Untargeted Metabolomics Identifies Oncometabolites Induced by P2-HNF4α Overexpression in Hepatocytes | Mus musculus | University of Tennessee Health Science Center | MS | 2025-08-05 | 1 | 6 | Not available |
