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MB Sample ID: SA174231

Local Sample ID:a8
Subject ID:SU001933
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
Genotype Strain:C57BL/6
Age Or Age Range:8 weeks
Weight Or Weight Range:20-25 g
Animal Animal Supplier:Model Animal Research Center of Nanjing University
Animal Housing:Standard specific pathogen free (SPF) conditions
Animal Light Cycle:12:12-h light/dark cycle
Animal Feed:food freely
Animal Water:water freely

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Treatment ID:TR001945
Treatment Summary:C57BL/6 mice were anesthetized using isoflurane. UIR was induced by clamping the right renal pedicle for 45 minutes and then releasing it to allow reperfusion, leaving the left kidney intact. Sham treated mice served as controls. Each mouse was located supine on a thermostatic pad (37 °C) to maintain its body temperature throughout the whole process. After 3 days of recovery, the mice received a daily intraperitoneal (i.p.) injection of FG4592 (10 mg/kg) or vehicle for 7 consecutive days. After treatment, the mice were sacrificed. Non-target metabolomics analysis was carried out using the kidney tissues of mice sacrificed at day 10 after UIR.
Treatment Compound:FG4592
Treatment Dosevolume:10 mg/kg