Summary of Study ST000946

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000651. The data can be accessed directly via it's Project DOI: 10.21228/M8HX17 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000946
Study TitleUntargeted Metabolomics of T1 Participants
Study TypeMS analysis
Study SummarySpecific Aims: (a) Identify sex differences in serum untargeted metabolomics profiles during late adolescence, (b) examine changes in metabolomics profiles between early and late adolescence in the same children, and (c) evaluate associations of exposure to prenatal and concurrent exposure to PAHs, metals, and EDCs with serum metabolite profiles among boys and girls, separately, during late adolescence.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2018-03-14
Num Groups2
Total Subjects207
Study CommentsThe overall objective of this project is to expand upon available data from Early Life Exposure in Mexico to ENvironental Toxicants (ELEMENT) Project to examine effects of toxicant exposures during three sensitive developmental timeframes – the prenatal period, early adolescence, and late adolescence – on adiposity and metabolic risk in adolescence with an emphasis on sex differences and the related molecular underpinnings. In addition to existing exposure data on BPA, metals and phthalates, we propose to add measures of polycyclic aromatic hydrocarbon (PAH) metabolites in archived urine samples from mothers and children. We also propose to assess the epigenome at three developmental periods (prenatal aka in utero, early and late adolescence) and the circulating metabolome during late adolescence. We will incorporate data on toxicant exposures and ‘omics, including untargeted metabolomics of 404 teenagers from the ELEMENT cohorts, to addressing several specific aims.
Raw Data AvailableYes
Raw Data File Type(s)d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8HX17
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN001552 AN001553
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent 6530 Agilent 6530
Column Waters Acquity HSS T3 (100 x 2.1mm,1.8um) Waters Acquity HSS T3 (100 x 2.1mm,1.8um)
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF
Ion Mode NEGATIVE POSITIVE
Units Counts Counts
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