Summary of study ST001256

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000842. The data can be accessed directly via it's Project DOI: 10.21228/M8V694 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001256
Study TitleMetabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens
Study SummaryDuchenne muscular dystrophy is caused by genetic defects in the gene encoding dystrophin and leads to progressive muscle degeneration. Glucocorticoid steroids are current mainstay pharmacological regimen to decrease muscle inflammation and prolong the ambulatory period in these patients, but daily intake of glucocorticoids like prednisone and deflazacort causes adverse side effects like osteoporosis, adrenal suppression, insulin resistance and obesity. Intermittent steroid dosing has been proposed as alternative to maintain benefits and limit side effects, but a detailed understanding of the mechanisms underpinning the regimen-specific effects in muscle is still missing. Here we explore how once-daily versus once-weekly prednisone (4 week-long treatment) affect the metabolomic landscape in mdx mouse muscle (genetic model of Duchenne muscular dystrophy; DBA/2J background) through metabolomics profiling.
Institute
Northwestern University
Last NameQuattrocelli
First NameMattia
Address303 East Superior St, SQBRC 5-500, Chicago, IL, 60611, USA
Emailmattia.quattrocelli@northwestern.edu
Phone3125037450
Submit Date2019-09-26
Num Groups3
Total Subjects9
Num Males9
Raw Data AvailableYes
Raw Data File Type(s).raw
Analysis Type DetailLC-MS
Release Date2020-01-06
Release Version1
Mattia Quattrocelli Mattia Quattrocelli
https://dx.doi.org/10.21228/M8V694
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN002085
Analysis type MS
Chromatography type HILIC
Chromatography system Thermo Ultimate3000
Column Waters XBridge Amide (100 x 4.6mm, 3.5um)
MS Type ESI
MS instrument type Orbitrap
MS instrument name Thermo Q-Exactive
Ion Mode UNSPECIFIED
Units peak area values
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