Summary of Study ST001929

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001218. The data can be accessed directly via it's Project DOI: 10.21228/M88H76 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001929
Study TitleMetabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype (Part 2)
Study SummaryUrinary O-desmethylangolensin (ODMA) concentrations provide a functional gut microbiome marker of dietary isoflavone daidzein metabolism to ODMA. Individuals who do not have gut microbial environments that produce ODMA have less favorable cardiometabolic and cancer risk profiles. Urinary metabolomics profiles were evaluated in relation to ODMA metabotypes within and between individuals over time. Secondary analysis was conducted of data from the BEAN2 trial, which was a cross-over study of premenopausal women consuming six months on a high- and a low-soy diet, each separated by a 1-month washout period. In all of the 672 samples in the study, 66 of the 84 women had the same ODMA metabotype at seven or all eight time points. Two or four urine samples per woman were selected based on temporal metabotypes in order to compare within and across individuals. Metabolomics assays for primary metabolism and biogenic amines were conducted in 60 urine samples from 20 women.
Institute
George Mason University
Last NameFrankenfeld
First NameCara
Address4400 University Drive, Fairfax, VA 22030
Emailprof.frankenfeld@gmail.com
Phone2062652563
Submit Date2021-08-23
Raw Data AvailableYes
Analysis Type DetailGC-MS
Release Date2021-11-02
Release Version1
Cara Frankenfeld Cara Frankenfeld
https://dx.doi.org/10.21228/M88H76
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003137
Analysis type MS
Chromatography type GC
Chromatography system Leco Pegasus IV GC
Column Restek Rtx-5Sil (30m x 0.25mm,0.25um)
MS Type EI
MS instrument type GC-TOF
MS instrument name Leco Pegasus IV TOF
Ion Mode POSITIVE
Units Peak height
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