Summary of Study ST004391

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002783. The data can be accessed directly via it's Project DOI: 10.21228/M8XK1H This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST004391
Study TitlePolar metabolites profiling between Human Fragile X Syndrome (FXS) and typically developing (TD) human cerebellum.
Study SummaryPolar metabolites profiling in human FXS cerebellum compared to TD. ​​Human but not mouse brain shows Fragile X mental retardation protein (FMRP)-dependent metabolic changes. Therefore, polar metabolomics were performed to compare human cerebellum from patients with and without Fragile X Syndrome. Many metabolic changes relate to glutamine and glutamate metabolism.
Institute
UMass Chan Medical School
Last NameUMass Chan
First NameSpinelli Lab
Address55 Lake Avenue North, Worcester, Massachusetts, 01605, USA
Emailspinellilab@gmail.com
Phone(508) 856-8989 ext. 68148
Submit Date2025-11-12
Raw Data AvailableYes
Raw Data File Type(s)mzML, raw(Thermo)
Analysis Type DetailLC-MS
Release Date2025-12-02
Release Version1
Spinelli Lab UMass Chan Spinelli Lab UMass Chan
https://dx.doi.org/10.21228/M8XK1H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN007337 AN007338
Chromatography ID CH005567 CH005567
MS ID MS007031 MS007032
Analysis type MS MS
Chromatography type HILIC HILIC
Chromatography system Thermo Vanquish Thermo Vanquish
Column Merck SeQuant ZIC-HILIC (150 x 2.1mm,5um) Merck SeQuant ZIC-HILIC (150 x 2.1mm,5um)
MS Type ESI ESI
MS instrument type Orbitrap Orbitrap
MS instrument name Thermo Q Exactive Plus Orbitrap Thermo Q Exactive Plus Orbitrap
Ion Mode POSITIVE NEGATIVE
Units Peak area Peak area
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