Summary of study ST000450

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000348. The data can be accessed directly via it's Project DOI: 10.21228/M82K58 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000450
Study TitleMetabolic features of chronic fatigue syndrome
Study TypePlasma metabolomic profiling
Study SummaryThis targeted metabolomic analysis was performed on plasma samples from 39 normal controls (n=18 men and 21 women) and 45 subjects ((n = 22 men and 23 women) who met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria.
University of California, San Diego
DepartmentThe Mitochondrial and Metabolic Disease Center
Last NameNaviaux
First NameRobert
Address214 Dikinson Street, CTF-C102, San Diego, CA, 92103
Submit Date2016-08-11
Num Groups2 groups for men (control and CFS) and 2 groups for women (control and CFS)
Total Subjects84
Analysis Type DetailLC-MS
Release Date2016-12-22
Release Version1
Robert Naviaux Robert Naviaux application/zip

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Combined analysis:

Analysis ID AN000705 AN000706
Analysis type MS MS
Chromatography type HILIC HILIC
Chromatography system Shimadzu 20AD Shimadzu 20AD
Column Shodex NH2P-40 2E (250 mm × 2.0 mm) Shodex NH2P-40 2E (250 mm × 2.0 mm)
MS instrument type Triple quadrupole Triple quadrupole
MS instrument name ABI Sciex 5500 QTrap ABI Sciex 5500 QTrap


Chromatography ID:CH000510
Chromatography Summary:HILIC
Instrument Name:Shimadzu 20AD
Column Name:Shodex NH2P-40 2E (250 mm × 2.0 mm)
Column Pressure:920~2600 psi
Column Temperature:25C
Flow Gradient:0-3.5 min: 95%B, 3.6-8 min: 85% B, 8.1-13 min: 75% B, 13.5–35 min: 0% B, 36–46 min: 95% B, 46.1 min: end.
Flow Rate:0.2 ml/min
Solvent A:95% water with 20 mM (NH4)2CO3, 5% acetonitrile, and 38 mM NH4OH, final pH 9.75
Solvent B:100% acetonitrile
Analytical Time:46.1 min
Oven Temperature:25C
Sample Loop Size:10 ul
Sample Syringe Size:100 ul
Chromatography Type:HILIC