Summary of Study ST000903

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000627. The data can be accessed directly via it's Project DOI: 10.21228/M8MT2H This work is supported by NIH grant, U2C- DK119886.

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Study IDST000903
Study TitlePharmacometabolomic analysis of rat hippocampus and plasma in response to chronic stress and albiflorin treament
Study TypeAnimal study
Study SummaryMale Sprague-Dawley (SD) rats were exposed to one random stressor per day for 35 d. Following four weeks of stress exposure, rats with stress-induced depression-like behaviors were treated daily with either saline, fluoxetine or albiflorin for 7 days via intragastric gavage. Rat heparinized plasma was collected after drug treatment. After behavior tests, rats were sacrificed and the hippocampus was collected. Pharmacometabolomic analysis was conducted for both plasma and hippocampal samples
Institute
Beijing Wonner Biotech. Ltd. Co.
Last NameZhang
First NameZuoguang
AddressNo.9, Kexing Road, Fengtai, Beijing, Beijing, 101111, China
Emailleekefeng@hotmail.com
Phone86-10-65670787
Submit Date2017-11-16
Num Groups4
Study CommentsAnimal study
Analysis Type DetailLC-MS
Release Date2018-02-07
Release Version1
Zuoguang Zhang Zuoguang Zhang
https://dx.doi.org/10.21228/M8MT2H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN001469 AN001470
Analysis type MS MS
Chromatography type HILIC HILIC
Chromatography system Waters ACQUITY UPLC Waters ACQUITY UPLC
Column Luna NH2 aminopropyl HPLC column Luna NH2 aminopropyl HPLC column
MS Type ESI ESI
MS instrument type Triple quadrupole Triple quadrupole
MS instrument name ABI Sciex 6500 QTrap ABI Sciex 6500 QTrap
Ion Mode NEGATIVE POSITIVE
Units AUC AUC

Chromatography:

Chromatography ID:CH001033
Instrument Name:Waters ACQUITY UPLC
Column Name:Luna NH2 aminopropyl HPLC column
Column Pressure:2200 psi
Column Temperature:25 °C
Flow Rate:0.35 ml/min
Injection Temperature:4 °C
Sample Injection:12 µl
Solvent A:95% watrer+5% acetonitrile+20 mM ammonium hydroxide+20 mM ammonium acetate, pH 9.0
Solvent B:100% acetonitrile
Sample Loop Size:12
Randomization Order:Yes
Chromatography Type:HILIC
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