Summary of study ST001620

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001041. The data can be accessed directly via it's Project DOI: 10.21228/M84M6M This work is supported by NIH grant, U2C- DK119886.

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Study IDST001620
Study TitleDietary composition analysis of chow diet and purified diet using untargeted metabonomics
Study SummaryDietary patterns and psychosocial factors, ubiquitous part of modern lifestyle, critically shape the gut microbiota and human health. However, it remains obscure how dietary and psychosocial inputs coordinately modulate the gut microbiota and host impact. Here, we show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cells (ISC) renewal and epithelial homeostasis. Chow diet (CD) and purified diet (PD) confer distinct vulnerability to gut epithelial injury, microbial alternation and ISC dysfunction in chronically restrained mice. CD preferably enriches Lactobacillus reuteri, and its colonization is sufficient to rescue stress-triggered epithelial injury.
Institute
China Pharmaceutical University
DepartmentSchool of Medicine
Laboratorymetabonomics
Last NameYuanlong
First NameHou
AddressNanjing, Jiangsu
Emailjian2103@163.com
Phone86-18851105337
Submit Date2020-12-09
Raw Data AvailableYes
Raw Data File Type(s).raw
Analysis Type DetailLC-MS
Release Date2020-12-16
Release Version1
Hou Yuanlong Hou Yuanlong
https://dx.doi.org/10.21228/M84M6M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN002655
Analysis type MS
Chromatography type Reversed phase
Chromatography system UltiMate 3000
Column Waters Acquity UPLC HSS T3 (150×2.1 mm,1.8 μm)
MS Type ESI
MS instrument type Orbitrap
MS instrument name Q Exactive Focus
Ion Mode UNSPECIFIED
Units peak area

Chromatography:

Chromatography ID:CH001958
Instrument Name:UltiMate 3000
Column Name:Waters Acquity UPLC HSS T3 (150×2.1 mm,1.8 μm)
Chromatography Type:Reversed phase
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