Summary of Study ST000149

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000130. The data can be accessed directly via it's Project DOI: 10.21228/M81P4M This work is supported by NIH grant, U2C- DK119886.


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Study IDST000149
Study TitleHigh Insulin Combined With Essential Amino Acids Stimulates Skeletal Muscle Mitochondrial Protein Synthesis While Decreasing Insulin Sensitivity in Healthy Humans
Study TypeHigh and low insulin with and without essential amino acids
Study SummaryThirty participants were randomized to 3 groups of 10 each with each participant studied twice. Study groups comprised (1) low and high insulin, (2) low insulin with and without EAAs, and (3) high insulin with and without EAAs.
Mayo Clinic
Last NameNair
First NameSreekumaran
Submit Date2015-03-05
Num Groups3
Raw Data AvailableNo
Analysis Type DetailLC-MS
Release Date2015-03-05
Release Version1
Sreekumaran Nair Sreekumaran Nair application/zip

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Collection ID:CO000154
Collection Summary:Percutaneous muscle biopsy specimens of the vastus lateralis (?300 mg) were performed at 180 and 480 minutes under local anesthesia (2% lidocaine). Muscle samples were blotted, were dissected free of fat and connective tissue, and then were frozen. Biopsy specimens were collected from the opposite legs on a single visit. Indirect calorimetry was performed at 11:00 am for 20 minutes using a ventilated hood (Parvo Medics). The final 10 minutes of steady-state oxygen consumption (Vo2) and carbon dioxide production (Vco2) determined the respiratory exchange ratio (RER = Vco2/Vo2). Urine was collected throughout the clamp and analyzed for urea content at a core laboratory.
Sample Type:Muscle