Summary of Study ST000465

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000357. The data can be accessed directly via it's Project DOI: 10.21228/M8WW32 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000465
Study TitleUniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response
Study TypeMetabolomic effect of Englerin A on renal cell carcinoma
Study SummaryThis targeted metabolomic analysis was performed on renal cell carcinoma A498 cells with or without anti-cancer drug Englerin treatment for 24 and 48 h.
University of California, San Diego
DepartmentDepartment of Pediatrics
Last NameBatova
First NameAyse
AddressLa Jolla, CA 92093
Submit Date2016-09-09
Num GroupsTwo groups for 24 h treatment (control and Eglerin treatment) and two groups for 48 h treatment. Each has 4 replicates
Total Subjects16
Analysis Type DetailLC-MS
Release Date2016-12-22
Release Version1
Ayse Batova Ayse Batova application/zip

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Collection ID:CO000480
Collection Summary:Cell extracts were obtained by the addition of 1 ml of ice-cold methanol:water (80:20) to each dish followed by scraping cells into 1.7ml Eppendorf tubes and vortexing vigorously for 30 sec. A 50 ul aliquot of sample was removed for the picogreen DNA assay for purposes of biomass normalization, and the remaining sample was kept at -80˚C until ready for metabolomic analysis.
Sample Type:Kidney