Summary of Study ST001079
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000722. The data can be accessed directly via it's Project DOI: 10.21228/M8BT3D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001079 |
| Study Title | Environmental exposures and inflammation in young children with cystic fibrosis |
| Study Type | Untargeted high-resolution mass spectrometry profiling |
| Study Summary | Secondhand smoke exposure (SHSe) is a common environmental factor known to increase asthma severity and respiratory infections in children, as well disrupt metabolic signals and host immune responses in patients with cystic fibrosis (CF). This study defines biomarkers and metabolic profiles of SHSe (includes ENDS exposure) in the young CF population and determines how SHSe impacts regulation of infection, inflammation, and respiratory health. |
| Institute | Emory University |
| Department | School of Medicine |
| Laboratory | Clincal Biomarkers Laboratory |
| Last Name | Ma |
| First Name | Chunyu |
| Address | 615 Michael St. Ste 225, Atlanta, GA, 30322, USA |
| chunyu.ma@emory.edu | |
| Phone | (404) 727 5091 |
| Submit Date | 2018-10-10 |
| Total Subjects | 92 |
| Study Comments | Both CHEAR and Clinical Biomarkers Laboratory pooled plasma samples were used for quality control. Study specific sample pools were not created |
| Chear Study | Yes |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-12-31 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO001160 |
| Collection Summary: | Children ages 3 months to <10 years with CF were recruited from outpatient CF clinics, and stratified according to age (infants <1 year, and children 1-10 years).The diagnosis of CF was defined by two disease-causing mutations or a sweat chloride test = 60 mmol/L. The study was approved by the Institutional Review Board at Nationwide Childrens Hospital (IRB 12-00084). A parent or guardian of the child participant provided informed consent on their behalf. Healthy, non-CF age-matched controls were recruited from primary care clinics. For each participant, plasma was collected during a state of baseline, non-fasting health as infants would not be able to fast for collection. Plasma was immediately flash frozen at -80C for metabolite preservation. |
| Sample Type: | Serum |
| Storage Conditions: | Described in summary |
