Summary of Study ST001185

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000796. The data can be accessed directly via it's Project DOI: 10.21228/M8SM3C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001185
Study TitleGenetic and metabolic characterization of bioengineered human fatty liver tissue with modified SIRT1 expression
Study SummaryLipidomics and metabolomics was performed three types of tissue samples to compare human normal liver tissue against human NASH liver and the bioengineered human iPS-derived fatty liver tissue-iKD-SIRT1. The purpose of this study was to show that the global lipidomics profile of iPS-derived fatty liver tissue-iKD-SIRT1 was similar to that of patients with NASH
Institute
University of Pittsburgh
DepartmentDepartment of Pathology
Last NameSoto-Gutierrez
First NameAlejandro
Address200 Lothrop Street, 423 Biomedical Science Tower, Pittsburgh, PA 15261, USA
Emailals208@pitt.edu
Phone+14126480064
Submit Date2019-05-20
Num Groups3
Raw Data AvailableYes
Analysis Type DetailLC-MS
Release Date2020-01-06
Release Version1
Alejandro Soto-Gutierrez Alejandro Soto-Gutierrez
https://dx.doi.org/10.21228/M8SM3C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO001245
Collection Summary:De-identified tissues were obtained from Magee Women’s Hospital (Pittsburgh, PA) and the University of Washington Department of Pediatrics, Division of Genetic Medicine, Laboratory of Developmental Biology (Seattle, WA) after obtaining a written informed consent by a protocol approved by the Human Research Review Committee of the University of Pittsburgh (Honest broker approval number HB015 and HB000836). Human fetal liver tissue and/or cells were isolated and culture from fetal livers as previously described (26890260). The de-identified normal human liver tissue and/or cells were obtained through the Liver Tissue Cell Distribution System (Pittsburgh, PA) after obtaining a written informed consent by a protocol approved by the Human Research Review Committee of the University of Pittsburgh, which was funded by NIH Contract # HSN276201200017C. Adult human liver tissue and/or cells were also obtained from Ira J Fox Laboratory at Children’s Hospital of UPMC, after obtaining a written informed consent by a protocol approved by the Human Research Review Committee and the Institutional Review Board (IRB#: PRO12090466) of the University of Pittsburgh.
Sample Type:Liver
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