Summary of Study ST001270
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000855. The data can be accessed directly via it's Project DOI: 10.21228/M85H5H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001270 |
Study Title | Necrotizing soft-tissue infections (NSTIs) metabolomics |
Study Summary | Necrotizing soft-tissue infections (NSTIs) have multiple causes, risk factors, anatomical locations, and pathogenic mechanisms. In patients with NSTI, circulating metabolites may serve as substrate having impact on bacterial adaptation at the site of infection. Metabolic signatures associated with NSTI may reveal potential be useful as diagnostic and prognostic markers, as well as novel targets for therapy. This study used untargeted metabolomics analyses of plasma from NSTI patients (n=34) and healthy (non-infected) controls (n=24) to identify the metabolic signatures and connectivity patterns among metabolites associated with NSTI. |
Institute | Wageningen University & Research |
Last Name | Edoardo |
First Name | Saccenti |
Address | Stippeneng 4, 6708 Wageningen, the Netherlands |
edoardo.saccenti@wur.nl | |
Phone | +31644482628 |
Submit Date | 2019-10-28 |
Raw Data Available | Yes |
Raw Data File Type(s) | cdf |
Analysis Type Detail | GC-MS |
Release Date | 2020-01-06 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Collection:
Collection ID: | CO001332 |
Collection Summary: | EDTA plasma samples from 34 NSTI patients prospectively enrolled in the FP7 project, INFECT (Clinicaltrials.gov, NCT01790698)3 were included in this study. The patients were enrolled at 5 different clinical sites; Rigshospitalet (Copenhagen, Denmark), Karolinska University Hospital (Stockholm, Sweden), Blekingesjukhuset (Karlskrona, Sweden), Sahlgrenska University Hospital (Gothenburg, Sweden) and Haukeland University Hospital (Bergen, Norway). Sampling was done following standardized operating procedures as reported in Madsen, M. B.; Skrede, S.; Bruun, T.; Arnell, P.; Rosén, A.; Nekludov, M.; Karlsson, Y.; Bergey, F.; Saccenti, E.; Martins dos Santos, V. A. P.; et al. Necrotizing Soft Tissue Infections - a Multicentre, Prospective Observational Study (INFECT): Protocol and Statistical Analysis Plan. Acta Anaesthesiol. Scand. 2018, 62 (2), 272–279. https://doi.org/10.1111/aas.13024. |
Sample Type: | Blood (plasma) |