Summary of Study ST001270

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000855. The data can be accessed directly via it's Project DOI: 10.21228/M85H5H This work is supported by NIH grant, U2C- DK119886.


Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001270
Study TitleNecrotizing soft-tissue infections (NSTIs) metabolomics
Study SummaryNecrotizing soft-tissue infections (NSTIs) have multiple causes, risk factors, anatomical locations, and pathogenic mechanisms. In patients with NSTI, circulating metabolites may serve as substrate having impact on bacterial adaptation at the site of infection. Metabolic signatures associated with NSTI may reveal potential be useful as diagnostic and prognostic markers, as well as novel targets for therapy. This study used untargeted metabolomics analyses of plasma from NSTI patients (n=34) and healthy (non-infected) controls (n=24) to identify the metabolic signatures and connectivity patterns among metabolites associated with NSTI.
Wageningen University & Research
Last NameEdoardo
First NameSaccenti
AddressStippeneng 4, 6708 Wageningen, the Netherlands
Submit Date2019-10-28
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailGC-MS
Release Date2020-01-06
Release Version1
Saccenti Edoardo Saccenti Edoardo application/zip

Select appropriate tab below to view additional metadata details:


Collection ID:CO001332
Collection Summary:EDTA plasma samples from 34 NSTI patients prospectively enrolled in the FP7 project, INFECT (, NCT01790698)3 were included in this study. The patients were enrolled at 5 different clinical sites; Rigshospitalet (Copenhagen, Denmark), Karolinska University Hospital (Stockholm, Sweden), Blekingesjukhuset (Karlskrona, Sweden), Sahlgrenska University Hospital (Gothenburg, Sweden) and Haukeland University Hospital (Bergen, Norway). Sampling was done following standardized operating procedures as reported in Madsen, M. B.; Skrede, S.; Bruun, T.; Arnell, P.; Rosén, A.; Nekludov, M.; Karlsson, Y.; Bergey, F.; Saccenti, E.; Martins dos Santos, V. A. P.; et al. Necrotizing Soft Tissue Infections - a Multicentre, Prospective Observational Study (INFECT): Protocol and Statistical Analysis Plan. Acta Anaesthesiol. Scand. 2018, 62 (2), 272–279.
Sample Type:Blood (plasma)