Summary of Study ST001364

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000928. The data can be accessed directly via it's Project DOI: 10.21228/M8R094 This work is supported by NIH grant, U2C- DK119886.


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Study IDST001364
Study TitleCore Functional Nodes and Sex-Specific Pathways in Human Ischemic and Dilated Cardiomyopathy
Study SummaryRestricted access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a large human heart biobank of carefully procured, cryopreserved left ventricular myocardium to obtain direct molecular insights into ischaemic (ICM) and dilated cardiomyopathy (DCM), the most common causes of HF worldwide1. We performed unbiased, deep proteomic and metabolomic analyses of 51 left ventricular (LV) samples from 44 cryopreserved human ICM and DCM hearts, including age-matched, histopathologically normal, donor controls of both genders for comparison. For the first time, we report perturbed thyroid hormone signalling pathways in the myocardium of both types of HF, and unveil the interaction of gender with HF, including increased nitric oxide-related arginine metabolism in male hearts, and many gender-specific mitochondrial and X chromosome-linked protein and metabolite changes. We provide all raw data, in addition to an interactive online application, as a publicly-available resource.
University of Sydney
Last NameJohn
First NameO'Sullivan
AddressJohns Hopkins Dr, Camperdown NSW 2006, Australia
Submit Date2019-12-07
Raw Data AvailableYes
Analysis Type DetailAPI-MS
Release Date2020-04-30
O'Sullivan John O'Sullivan John application/zip

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Collection ID:CO001433
Collection Summary:Donor hearts were procured but not used for heart transplantation (reasons included transportation logistics, donor-recipient mismatch in size, and immune incompatibility), whilst heart failure samples comprised those patients undergoing heart transplantation.
Sample Type:Heart