Summary of Study ST001448

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000995. The data can be accessed directly via it's Project DOI: 10.21228/M8311J This work is supported by NIH grant, U2C- DK119886.

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Study IDST001448
Study TitleMaternal Hypercortisolemia alters placental metabolism: NMR metabolomics
Study SummaryNMR metabolomic studies of placental tissue from sheep with excess maternal cortisol during late gestation
Institute
University of Florida
Last NameWalejko
First NameJacquelyn
Address300 N Duke St Durham NC 27701
Emailjacquelyn.walejko@duke.edu
Phone9194792304
Submit Date2020-08-18
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2020-09-16
Release Version1
Jacquelyn Walejko Jacquelyn Walejko
https://dx.doi.org/10.21228/M8311J
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO001517
Collection Summary:Placentomes were collected at necropsy from control ewes and ewes treated with cortisol (CORT: 1mg/kg/d from day 115 of pregnancy) at days 141-144 of gestation. CORT ewes received an intravenous infusion of cortisol (Solu-Cortef, hydrocortisone sodium succinate in sodium phosphate; Pfizer, New York, NY); control animals did not receive any treatment. Animals were sacrificed for collection of tissues at the first signs of labor, as evidenced by changes in uterine blood flow; placentomes were collected from sheep in early stages of labor at between 141-144 days and 142-144 days of gestation in the cortisol-treated and control groups, respectively. In this cohort of ewes, there were 7 control ewes, of which data were collected from placentomes of 7 live fetuses (including one set of twins); there was one lamb born, and that placenta was not collected. In this cohort there were 11 cortisol- treated ewes, from which we collected placentomes from 5 live fetuses. There was one live lamb born, and 5 stillborn lambs, from which placentas were not collected. Placentomes were classified as A-D placentomes, snap frozen in liquid nitrogen, and stored in -80C until metabolomic analysis.
Sample Type:Placenta
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