Summary of Study ST001795

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001139. The data can be accessed directly via it's Project DOI: 10.21228/M8GH59 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001795
Study TitleChanges in mesenteric lymph lipid profile of mice upon high-fat diet with and without Celecoxib (part I)
Study TypeUntargeted lipidomics analysis
Study SummaryUntargeted lipid profiling of mesenteric mice lymph from mice fed with CHOW, HFD and HFD supplemented with COx-2 inhibitor drug Celecoxib. It is proposed that Celecoxib can protect from deleterious morphological changes in lymphatic system caused by obesity/HFD.
Institute
Monash Institute of Pharmaceutical Sciences
DepartmentDrug Delivery, Disposition and Dynamics
LaboratoryTrevaskis Lab, Creek Lab
Last NameAnderson
First NameDovile
Address6 Anderson
Emaildovile.anderson@gmail.com
Phone8671141
Submit Date2021-05-12
Num Groups3
Total Subjects26
Num Males26
PublicationsManuscript NATMETAB-A20022406A Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential novel treatment target in obesity
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-06-02
Release Version1
Dovile Anderson Dovile Anderson
https://dx.doi.org/10.21228/M8GH59
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO001865
Collection Summary:The efferent mesenteric lymphatic duct was cannulated in isoflurane anaesthetised non-fasted mice or rats and lymph fluid was collected for up to 4 h. For the lymphatic drug transport study, lymph was collected in mice that were fasted for 3-4 h. The mesenteric lymph duct cannulation was performed as described previously in rats4 and mice5 and mesenteric lymph fluid was collected continuously for up to 6 h.
Sample Type:Mesenteric lymph
Storage Conditions:-80℃
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