Summary of Study ST002010

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001274. The data can be accessed directly via it's Project DOI: 10.21228/M81Q4Z This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002010
Study TitleChemoresistant Ovarian Cancer Global Metabolomics
Study SummaryChemoresistance remains the major barrier to effective ovarian cancer treatment. The molecular features and associated biological functions of this phenotype remain poorly understood. We developed carboplatin resistant cell line models using OVCAR5 and CaOV3 cell lines with the aim of identifying chemoresistance-specific molecular features. Mass spectrometry analysis was used to analyse the metabolome of these cell lines and was able to separate these populations based on their molecular features. It revealed signaling and metabolic perturbations in chemoresistant cell lines. A comprehensive analysis of a larger patient cohort, including advanced in vitro and in vivo models, promises to help better understand the molecular mechanisms of chemo-resistance and associated enhancement of migration and invasion.
University of South Australia
Last NameAcland
First NameMitchell
AddressCnr North Terrace and Morphett Street, Adelaide SA 5000
Submit Date2021-12-05
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-12-22
Release Version1
Mitchell Acland Mitchell Acland application/zip

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Collection ID:CO002084
Collection Summary:Two ovarian cancer cell lines were used to generate carboplatin resistant pairs. These were then grown in parallel before untargeted MS metabolomics analysis was applied in the pursuit of characterising metabolome mediated resistance mechanism
Sample Type:Cultured cells