Summary of Study ST000022

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000021. The data can be accessed directly via it's Project DOI: 10.21228/M8K01J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Perform statistical analysis  |  Show all samples  |  Download binned data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST000022
Study TitleBiomarker Discovery in Knee Osteoarthritis (II)
Study TypeBiomarker Discovery in Knee Osteoarthritis
Study SummaryThis metabolomics pilot and feasibility (P & F) study was conducted to provide data to be used to gain a better understanding of metabolic alterations in people with knee osteoarthritis (OA) and to discover novel biomarkers of the disease. The goal of the metabolomics study was to determine if metabolic differences, detected by a comprehensive metabolomics analysis, can be used to distinguish people who will develop symptomatic knee OA from those who will not. For this metabolomics study, individuals participating in T1 or T1* with 5-year follow-up at T2 were selected. At T2 subjects were on average 68.1(9.12) years old with an average BMI of 31.4(7.01) with 32% men and one-third African American. All had weight-bearing posterior-anterior knee films obtained with the Synaflexer positioning device at both time points and read paired for Kellgren-Lawrence grade and minimum joint space. Urine samples (second morning void) collected from 36 overweight or obese participants in the JoCo at T1 or T1* were selected from two subgroups (a group that developed radiographic osteoarthritis (n=16) and an age, race, sex, and BMI matched group that did not develop osteoarthritis (n=20). Radiographic knee OA was defined as Kellgren-Lawrence grade 2-4 at T2 in a person with Kellgren-Lawrence grade 0 or 1 at T1 or T1*.
Institute
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Emailsusan_sumner @unc.edu
Phone704-250-5066
Submit Date2014-03-04
Num Groups2
Total Subjects36
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2018-08-27
Release Version1
Susan Sumner Susan Sumner
https://dx.doi.org/10.21228/M8K01J
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Disease Status
SA001388E0225 Cases
SA001389E0195 Cases
SA001390E0004 Cases
SA001391E0487 Cases
SA001392F0036 Cases
SA001393C0559 Cases
SA001394F0108 Cases
SA001395D2090 Cases
SA001396E0309 Cases
SA001397C0835 Cases
SA001398C0640 Cases
SA001399D1158 Cases
SA001400D0613 Cases
SA001401C0629 Cases
SA001402D0762 Cases
SA001403D1113 Cases
SA001404D2404 Control
SA001405D2111 Control
SA001406D2079 Control
SA001407D2532 Control
SA001408D2062 Control
SA001409E0607 Control
SA001410F0035 Control
SA001411E2036 Control
SA001412D2054Control
SA001413E0546 Control
SA001414A0490 Control
SA001415C0586 Control
SA001416A2003 Control
SA001417A0233 Control
SA001418C2177 Control
SA001419D0177 Control
SA001420D0945 Control
SA001421D0909 Control
SA001422D0729 Control
SA001423D1174 Control
Showing results 1 to 36 of 36
  logo