Summary of Study ST000054
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000051. The data can be accessed directly via it's Project DOI: 10.21228/M8MS3J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000054 |
| Study Title | Metabolic Microenvironments in Normal Breast and Breast Cancer (MS analysis) |
| Study Type | Metabolomic analysis of normal breast tissue |
| Study Summary | The purpose of this study was to understand the metabolomic changes in a breast tissue microenvironment at various stages of cancer development and progression (i.e. normal breast, DCIS, and invasive cancer). The goal of this metabolomics pilot and feasibility study was to apply a broad spectrum GC-MS metabolomics method to determine whether changes in normal tissue of women with cancer correlate with progression and or the subtype of the disease. |
| Institute | University of North Carolina |
| Department | Systems and Translational Sciences |
| Laboratory | Sumner Lab |
| Last Name | Sumner |
| First Name | Susan |
| Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
| susan_sumner @unc.edu | |
| Phone | 704-250-5066 |
| Submit Date | 2014-04-30 |
| Num Groups | 8 |
| Total Subjects | 192 |
| Study Comments | sample preparation and analysis randomized with data collection over multiple days |
| Publications | 1. Brauer HA, Makowski L, Hoadley KA, Casbas-Hernandez P, Lang LJ, Roman-Perez E, D’Arcy M, Freemerman AJ, Perou CM, Troester MA: Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res 2012;19:571-585. 2. J Budczies, C Denkert, B Muller, S Brockmoller, F Klauschen, B Gyorffy, M Dietel, C Richter-Ehrenstein, U Marten, R Salek, J Griffin, M Hilvo, M Oresic, G Wohlgemuth, O Fiehn: Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study. BMC Genomics 2012; 13:334. |
| Raw Data Available | Yes |
| Raw Data File Type(s) | cdf |
| Uploaded File Size | 8.4 G |
| Analysis Type Detail | GC-MS |
| Release Date | 2018-08-27 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | treatment | pool aliquot |
|---|---|---|---|
| SA002629 | 1402110jcsa35_1 | Basal | no |
| SA002630 | 140217ajcsa17_1 | Basal | no |
| SA002631 | 140214ajcsa10_1 | Basal | no |
| SA002632 | 140217ajcsa46_1 | Basal | no |
| SA002633 | 140219ajcsa08_1 | Basal | no |
| SA002634 | 140219ajcsa38_1 | Basal | no |
| SA002635 | 1402110jcsa37_1 | Basal | no |
| SA002636 | 140217ajcsa16_1 | Basal | no |
| SA002637 | 140214ajcsa40_1 | Basal | no |
| SA002638 | 140214ajcsa08_1 | Basal | no |
| SA002639 | 140214ajcsa44_1 | Basal | no |
| SA002640 | 140217ajcsa09_1 | Basal | no |
| SA002641 | 1402110jcsa42_1 | Basal | no |
| SA002642 | 1402110jcsa19_1 | Basal | no |
| SA002643 | 140214ajcsa28_1 | Basal | no |
| SA002644 | 140219ajcsa19_1 | Basal | no |
| SA002645 | 140219ajcsa24_1 | Basal | no |
| SA002646 | 1402110jcsa12_1 | Basal | no |
| SA002647 | 140219ajcsa22_1 | Basal | no |
| SA002648 | 140219ajcsa28_1 | Basal | no |
| SA002649 | 140219ajcsa36_1 | Basal | no |
| SA002650 | 140217ajcsa36_1 | Basal | yes |
| SA002651 | 1402110jcsa44_1 | Basal | yes |
| SA002652 | 140214ajcsa35_1 | Basal | yes |
| SA002653 | 140219ajcsa26_1 | Basal | yes |
| SA002654 | 140219ajcsa45_1 | DCIS | no |
| SA002655 | 140214ajcsa45_1 | DCIS | no |
| SA002656 | 140214ajcsa17_1 | DCIS | no |
| SA002657 | 140217ajcsa10_1 | DCIS | no |
| SA002658 | 1402110jcsa07_1 | DCIS | no |
| SA002659 | 140217ajcsa11_1 | DCIS | no |
| SA002660 | 140219ajcsa32_1 | DCIS | no |
| SA002661 | 140219ajcsa51_1 | DCIS | no |
| SA002662 | 140214ajcsa39_1 | DCIS | no |
| SA002663 | 140219ajcsa17_1 | DCIS | no |
| SA002664 | 140219ajcsa54_1 | DCIS | no |
| SA002665 | 140214ajcsa43_1 | DCIS | no |
| SA002666 | 140219ajcsa50_1 | DCIS | no |
| SA002667 | 140217ajcsa45_1 | DCIS | no |
| SA002668 | 140217ajcsa12_1 | DCIS | no |
| SA002669 | 140219ajcsa14_1 | DCIS | no |
| SA002670 | 140214ajcsa22_1 | DCIS | no |
| SA002671 | 1402110jcsa32_1 | DCIS | no |
| SA002672 | 140217ajcsa26_1 | DCIS | no |
| SA002673 | 140214ajcsa16_1 | DCIS | no |
| SA002674 | 1402110jcsa17_1 | DCIS | no |
| SA002675 | 140214ajcsa33_1 | DCIS | no |
| SA002676 | 140214ajcsa31_1 | DCIS | no |
| SA002677 | 140219ajcsa29_1 | DCIS | no |
| SA002678 | 140219ajcsa40_1 | DCIS | no |
| SA002679 | 140214ajcsa36_1 | DCIS | yes |
| SA002680 | 140217ajcsa19_1 | DCIS | yes |
| SA002681 | 1402110jcsa23_1 | DCIS | yes |
| SA002682 | 140219ajcsa10_1 | DCIS | yes |
| SA002683 | 140214ajcsa23_1 | HER2 | no |
| SA002684 | 140217ajcsa21_1 | HER2 | no |
| SA002685 | 140219ajcsa21_1 | HER2 | no |
| SA002686 | 140219ajcsa31_1 | HER2 | no |
| SA002687 | 140219ajcsa18_1 | HER2 | no |
| SA002688 | 140217ajcsa33_1 | HER2 | no |
| SA002689 | 140217ajcsa15_1 | HER2 | no |
| SA002690 | 140217ajcsa28_1 | HER2 | no |
| SA002691 | 140217ajcsa14_1 | HER2 | no |
| SA002692 | 140214ajcsa42_1 | HER2 | no |
| SA002693 | 140214ajcsa12_1 | HER2 | no |
| SA002694 | 1402110jcsa36_1 | HER2 | no |
| SA002695 | 1402110jcsa45_1 | HER2 | no |
| SA002696 | 1402110jcsa46_1 | HER2 | no |
| SA002697 | 1402110jcsa43_1 | HER2 | no |
| SA002698 | 1402110jcsa28_1 | HER2 | no |
| SA002699 | 140214ajcsa21_1 | HER2 | yes |
| SA002700 | 140219ajcsa16_1 | HER2 | yes |
| SA002701 | 1402110jcsa47_1 | HER2 | yes |
| SA002702 | 140217ajcsa30_1 | HER2 | yes |
| SA002703 | 140217ajcsa37_1 | LumA | no |
| SA002704 | 140217ajcsa47_1 | LumA | no |
| SA002705 | 1402110jcsa10_1 | LumA | no |
| SA002706 | 140219ajcsa42_1 | LumA | no |
| SA002707 | 1402110jcsa26_1 | LumA | no |
| SA002708 | 140217ajcsa07_1 | LumA | no |
| SA002709 | 140217ajcsa18_1 | LumA | no |
| SA002710 | 1402110jcsa14_1 | LumA | no |
| SA002711 | 140217ajcsa29_1 | LumA | no |
| SA002712 | 1402110jcsa29_1 | LumA | no |
| SA002713 | 140217ajcsa24_1 | LumA | no |
| SA002714 | 1402110jcsa33_1 | LumA | no |
| SA002715 | 140214ajcsa47_1 | LumA | no |
| SA002716 | 140217ajcsa43_1 | LumA | no |
| SA002717 | 140219ajcsa23_1 | LumA | no |
| SA002718 | 1402110jcsa39_1 | LumA | no |
| SA002719 | 140219ajcsa43_1 | LumA | no |
| SA002720 | 140214ajcsa11_1 | LumA | no |
| SA002721 | 1402110jcsa25_1 | LumA | no |
| SA002722 | 1402110jcsa21_1 | LumA | no |
| SA002723 | 140219ajcsa12_1 | LumA | no |
| SA002724 | 1402110jcsa18_1 | LumA | no |
| SA002725 | 140219ajcsa55_1 | LumA | no |
| SA002726 | 140217ajcsa42_1 | LumA | yes |
| SA002727 | 140214ajcsa15_1 | LumA | yes |
| SA002728 | 140219ajcsa30_1 | LumA | yes |
