Summary of Study ST000365

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000290. The data can be accessed directly via it's Project DOI: 10.21228/M8JW2K This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000365
Study TitleZebrafish Metabolomics: Model for Environmental Metal Toxicity
Study SummaryThis metabolomics seed project will test the hypothesis that zebrafish can provide mechanistic insights into the human health effects of developmental exposure to Cd and Pb. We will use broad spectrum metabolomics of zebrafish larvae after exposure to Cd, Pb, and Cd and Pb compared to controls. Activity observed at 5 days post fertilization is will be used to determine if there is a correlation between biological pathways implicated by these metabolic profiles and cardiovascular, metabolic (obesity), and neurological phenotypes. The behavioral phenotypes have been quantified in zebrafish previously and have been measured in the Newborn Epigenetic STudy (NEST), a NIH-funded project that is investigating how environmental exposures and nutrition, in the womb and during childhood, affect how genes work and how these exposures developed into obesity and other diseases, disorders, and conditions. The results from this study will demonstrate the power of using zebrafish as a model for mechanism discovery in exposure using metabolomics to advance understanding of early life exposure to Cd and Pb and serve as preliminary data for opportunities.
Institute
University of North Carolina
DepartmentDiscovery Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Emailsusan_sumner @unc.edu
Phone704-250-5066
Submit Date2016-03-09
Raw Data AvailableYes
Raw Data File Type(s)1r
Analysis Type DetailNMR
Release Date2017-10-03
Release Version1
Susan Sumner Susan Sumner
https://dx.doi.org/10.21228/M8JW2K
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Zebrafish; Subject species: Danio rerio (Factor headings shown in green)

mb_sample_id local_sample_id Metal Exposure Exposure Level
SA016457CM_CdPool_1Cd -
SA016458CM_CdPool_2Cd -
SA016459CM_CdPool_3Cd -
SA016460CM_Cdhigh_1Cd high (1000 ppb)
SA016461CM_Cdhigh_3Cd high (1000 ppb)
SA016462CM_Cdhigh_2Cd high (1000 ppb)
SA016463CM_Cdlow_1Cd low (10 ppb)
SA016464CM_Cdlow_3Cd low (10 ppb)
SA016465CM_Cdlow_2Cd low (10 ppb)
SA016466CM_Cdmid_1Cd mid (100 ppb)
SA016467CM_Cdmid_3Cd mid (100 ppb)
SA016468CM_Cdmid_2Cd mid (100 ppb)
SA016445CM_CdPbPool_2Cd+Pb -
SA016446CM_CdPbPool_3-RCd+Pb -
SA016447CM_CdPbPool_1Cd+Pb -
SA016442CM_TotalPool_3CD+Pb -
SA016443CM_TotalPool_2CD+Pb -
SA016444CM_TotalPool_1CD+Pb -
SA016448CM_CdPbhigh_1Cd+Pb high (1000 ppb Cd and 1000 ppb Pb)
SA016449CM_CdPbhigh_3Cd+Pb high (1000 ppb Cd and 1000 ppb Pb)
SA016450CM_CdPbhigh_2Cd+Pb high (1000 ppb Cd and 1000 ppb Pb)
SA016451CM_CdPblow_1Cd+Pb low (10 ppb Cd and 10 ppb Pb)
SA016452CM_CdPblow_2Cd+Pb low (10 ppb Cd and 10 ppb Pb)
SA016453CM_CdPblow_3Cd+Pb low (10 ppb Cd and 10 ppb Pb)
SA016454CM_CdPBmid_2Cd+Pb mid (100 ppb Cd and 100 ppb Pb)
SA016455CM_CdPBmid_3Cd+Pb mid (100 ppb Cd and 100 ppb Pb)
SA016456CM_CdPBmid_1Cd+Pb mid (100 ppb Cd and 100 ppb Pb)
SA016481CM_NoExpPool_1control -
SA016482CM_NoExpPool_3control -
SA016483CM_NoExpPool_2control -
SA016484CM_NoExp_2control No
SA016485CM_NoExp_3control No
SA016486CM_NoExp_1control No
SA016469CM_PbPool_2Pb -
SA016470CM_PbPool_1Pb -
SA016471CM_PbPool_3-RPb -
SA016472CM_Pbhigh_2Pb high (1000 ppb)
SA016473CM_Pbhigh_3Pb high (1000 ppb)
SA016474CM_Pbhigh_1Pb high (1000 ppb)
SA016475CM_Pblow_2Pb low (10 ppb)
SA016476CM_Pblow_1Pb low (10 ppb)
SA016477CM_Pblow_3Pb low (10 ppb)
SA016478CM_Pbmid_3Pb mid (100 ppb)
SA016479CM_Pbmid_1Pb mid (100 ppb)
SA016480CM_Pbmid_2Pb mid (100 ppb)
Showing results 1 to 45 of 45
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