Summary of Study ST000649

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000460. The data can be accessed directly via it's Project DOI: 10.21228/M8M027 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000649
Study TitleEffects of NO Donor Therapy on the Dystrophic Mouse Muscle Non-Esterified Fatty Acids (part V)
Study SummaryFor this aim, we will only use male mdx mice. We will study three groups treated for 7 days with vehicle, naproxcinod (i.e., NO-naproxen), or naproxen (n = 10 each group). Two hours after the final treatment, half the mice in each group will be run to exhaustion on a treadmill. The heart and gastrocnemius, soleus, and quadriceps muscles of one hindlimb will be sent to the Mayo Clinic Metabolomics Resource Core. The heart and quadriceps muscle will be used for untargeted metabolomics profiling (LC/MS) while the gastrocnemius and soleus muscles will be used for targeted analyses of amino acids plus amino metabolites, non-esterified fatty acids, and citric acid cycle intermediates.
Institute
Mayo Clinic
Last NameThomas
First NameGail
AddressPenn State Hershey Heart and Vascular Institute Penn State College of Medicine 500 University Drive, MC H047 Hershey, PA 17033
Emailgthomas4@hmc.psu.edu
Phone717-531-0003, ext. 287087
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Gail Thomas Gail Thomas
https://dx.doi.org/10.21228/M8M027
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Time point Grouping
SA0365595863-6Post Run RUN-Naproxcinod
SA0365605863-8Post Run RUN-Naproxcinod
SA0365615863-10Post Run RUN-Naproxcinod
SA0365625863-7Post Run RUN-Naproxcinod
SA0365635863-9Post Run RUN-Naproxcinod
SA0365645863-18Post Run RUN-Naproxen
SA0365655863-20Post Run RUN-Naproxen
SA0365665863-19Post Run RUN-Naproxen
SA0365675863-17Post Run RUN-Naproxen
SA0365685863-16Post Run RUN-Naproxen
SA0365695863-30Post Run RUN-Vehicle
SA0365705863-27Post Run RUN-Vehicle
SA0365715863-29Post Run RUN-Vehicle
SA0365725863-28Post Run RUN-Vehicle
SA0365735863-26Post Run RUN-Vehicle
SA0365745863-3Sedentary SED-Naproxcinod
SA0365755863-2Sedentary SED-Naproxcinod
SA0365765863-4Sedentary SED-Naproxcinod
SA0365775863-5Sedentary SED-Naproxcinod
SA0365785863-1Sedentary SED-Naproxcinod
SA0365795863-13Sedentary SED-Naproxen
SA0365805863-14Sedentary SED-Naproxen
SA0365815863-15Sedentary SED-Naproxen
SA0365825863-12Sedentary SED-Naproxen
SA0365835863-11Sedentary SED-Naproxen
SA0365845863-21Sedentary SED-Vehicle
SA0365855863-22Sedentary SED-Vehicle
SA0365865863-23Sedentary SED-Vehicle
SA0365875863-24Sedentary SED-Vehicle
SA0365885863-25Sedentary SED-Vehicle
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