Summary of Study ST000879

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000610. The data can be accessed directly via it's Project DOI: 10.21228/M8TH6S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  |  Perform analysis on untargeted data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST000879
Study TitleDiet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma]
Study TypePlasma data
Study SummaryC57BL/6J mice (B6) and 129S1 mice (129J) were purchased from Jackson Laboratory (Bar Harbor, ME) and 129S6 mice (129T) were purchased from Taconic Farms (Germantown, NY). Mice were maintained on normal chow containing 22% calories from fat, 23% from protein and 55% from carbohydrates (Mouse Diet 9F 5020, PharmaServ, Framingham, MA) or a high fat diet (Open Source Diet, D12492, Research Diets, New Brunswick, NJ) containing 60% calories from fat, 20% from protein and 20% from carbohydrates. For antibiotic treatment, 6-week old mice were treated with either placebo, vancomycin (1g/L) or metronidazole (1g/L) (Sigma-Aldrich, St. Louis, MO) in drinking water then started on HFD from age 7 to 11 weeks. The mice were fasted for 2 hours and anesthetized with isoflurane before collecting cecum and plasma.
Institute
Broad Institute of MIT and Harvard
Last NameAvila-Pacheco
First NameJulian
Address415 Main Street
Emailjravilap@broadinstitute.org
Phone617-714-8264
Submit Date2017-10-02
Num Groups12
Total Subjects47
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2018-01-29
Release Version1
Julian Avila-Pacheco Julian Avila-Pacheco
https://dx.doi.org/10.21228/M8TH6S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Diet Treatment Strain
SA05104233_Chow_129JaxChow none 129Jax
SA05104336_Chow_129JaxChow none 129Jax
SA05104435_Chow_129JaxChow none 129Jax
SA05104534_Chow_129JaxChow none 129Jax
SA05104617_Chow_129TacChow none 129Tac
SA05104719_Chow_129TacChow none 129Tac
SA05104818_Chow_129TacChow none 129Tac
SA05104920_Chow_129TacChow none 129Tac
SA0510501_Chow_B6JaxChow none B6Jax
SA0510513_Chow_B6JaxChow none B6Jax
SA0510522_Chow_B6JaxChow none B6Jax
SA05105347_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05105448_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05105545_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05105646_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05105729_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05105831_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05105932_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05106030_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05106115_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05106216_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05106313_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05106414_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05106540_HFD Placebo_129JaxHFD placebo 129Jax
SA05106639_HFD Placebo_129JaxHFD placebo 129Jax
SA05106737_HFD Placebo_129JaxHFD placebo 129Jax
SA05106838_HFD Placebo_129JaxHFD placebo 129Jax
SA05106921_HFD Placebo_129TacHFD placebo 129Tac
SA05107022_HFD Placebo_129TacHFD placebo 129Tac
SA05107124_HFD Placebo_129TacHFD placebo 129Tac
SA05107223_HFD Placebo_129TacHFD placebo 129Tac
SA0510737_HFD Placebo_B6JaxHFD placebo B6Jax
SA0510748_HFD Placebo_B6JaxHFD placebo B6Jax
SA0510755_HFD Placebo_B6JaxHFD placebo B6Jax
SA0510766_HFD Placebo_B6JaxHFD placebo B6Jax
SA05107741_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05107842_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05107944_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05108043_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05108125_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA05108228_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA05108326_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA05108427_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA0510859_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
SA05108610_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
SA05108712_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
SA05108811_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
Showing results 1 to 47 of 47
  logo