Summary of Study ST000880

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000610. The data can be accessed directly via it's Project DOI: 10.21228/M8TH6S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000880
Study TitleDiet, genetics and gut microbiome drive dynamic changes in plasma metabolites [cecal]
Study TypeCecal data
Study SummaryC57BL/6J mice (B6) and 129S1 mice (129J) were purchased from Jackson Laboratory (Bar Harbor, ME) and 129S6 mice (129T) were purchased from Taconic Farms (Germantown, NY). Mice were maintained on normal chow containing 22% calories from fat, 23% from protein and 55% from carbohydrates (Mouse Diet 9F 5020, PharmaServ, Framingham, MA) or a high fat diet (Open Source Diet, D12492, Research Diets, New Brunswick, NJ) containing 60% calories from fat, 20% from protein and 20% from carbohydrates. For antibiotic treatment, 6-week old mice were treated with either placebo, vancomycin (1g/L) or metronidazole (1g/L) (Sigma-Aldrich, St. Louis, MO) in drinking water then started on HFD from age 7 to 11 weeks. The mice were fasted for 2 hours and anesthetized with isoflurane before collecting cecum and plasma.
Institute
Broad Institute of MIT and Harvard
Last NameAvila-Pacheco
First NameJulian
Address415 Main Street
Emailjravilap@broadinstitute.org
Phone617-714-8264
Submit Date2017-10-03
Num Groups12
Total Subjects47
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2018-01-29
Release Version1
Julian Avila-Pacheco Julian Avila-Pacheco
https://dx.doi.org/10.21228/M8TH6S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Diet Treatment Strain
SA05108933_Chow_129JaxChow none 129Jax
SA05109036_Chow_129JaxChow none 129Jax
SA05109135_Chow_129JaxChow none 129Jax
SA05109234_Chow_129JaxChow none 129Jax
SA05109317_Chow_129TacChow none 129Tac
SA05109419_Chow_129TacChow none 129Tac
SA05109518_Chow_129TacChow none 129Tac
SA05109620_Chow_129TacChow none 129Tac
SA0510971_Chow_B6JaxChow none B6Jax
SA0510983_Chow_B6JaxChow none B6Jax
SA0510992_Chow_B6JaxChow none B6Jax
SA05110047_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05110148_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05110245_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05110346_HFD Metronidazole_129JaxHFD metronidazole 129Jax
SA05110429_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05110531_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05110632_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05110730_HFD Metronidazole_129TacHFD metronidazole 129Tac
SA05110815_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05110916_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05111013_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05111114_HFD Metronidazole_B6JaxHFD metronidazole B6Jax
SA05111240_HFD Placebo_129JaxHFD placebo 129Jax
SA05111339_HFD Placebo_129JaxHFD placebo 129Jax
SA05111437_HFD Placebo_129JaxHFD placebo 129Jax
SA05111538_HFD Placebo_129JaxHFD placebo 129Jax
SA05111621_HFD Placebo_129TacHFD placebo 129Tac
SA05111722_HFD Placebo_129TacHFD placebo 129Tac
SA05111824_HFD Placebo_129TacHFD placebo 129Tac
SA05111923_HFD Placebo_129TacHFD placebo 129Tac
SA0511207_HFD Placebo_B6JaxHFD placebo B6Jax
SA0511218_HFD Placebo_B6JaxHFD placebo B6Jax
SA0511225_HFD Placebo_B6JaxHFD placebo B6Jax
SA0511236_HFD Placebo_B6JaxHFD placebo B6Jax
SA05112441_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05112542_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05112644_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05112743_HFD Vancomycin_129JaxHFD vancomycin 129Jax
SA05112825_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA05112928_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA05113026_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA05113127_HFD Vancomycin_129TacHFD vancomycin 129Tac
SA0511329_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
SA05113310_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
SA05113412_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
SA05113511_HFD Vancomycin_B6JaxHFD vancomycin B6Jax
Showing results 1 to 47 of 47
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