Summary of Study ST000913
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000631. The data can be accessed directly via it's Project DOI: 10.21228/M83T1G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000913 |
Study Title | Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part IV) |
Study Summary | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling illness characterized by six months or more of unexplained profound fatigue with post-exertional malaise, sleep abnormalities, cognitive dysfunction and autonomic disturbances. Focusing on the pathogenesis of central nervous system abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid (CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another fatiguing illness, and 19 healthy subjects with no neurological disease (ND). MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three untargeted metabolomic assays for primary metabolites, biogenic amines and complex lipids were performed with gas chromatography time-of-flight (GC-TOF) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS subjects with reduced levels in ME/CFS compared to both MS and ND subjects. Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher (cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with integration of both metabolomics and cytokine analyses (cross-validated AUC 0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of ME/CFS, and may enable new methods for diagnosis and insight into cognitive and autonomic disturbances in this syndrome. |
Institute | University of California, Davis |
Department | Genome and Biomedical Sciences Facility |
Laboratory | WCMC Metabolomics Core |
Last Name | Fiehn |
First Name | Oliver |
Address | 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616 |
ofiehn@ucdavis.edu | |
Phone | (530) 754-8258 |
Submit Date | 2017-12-12 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2018-08-27 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Diagnosis | Sex |
---|---|---|---|
SA053679 | Lipkin019_posHILIC_DPCSF3671_034.d | MECFS | FEMALE |
SA053680 | Lipkin048_posHILIC_DPCSF7598_086.d | MECFS | FEMALE |
SA053681 | Lipkin069_posHILIC_DPCSF3712_009.d | MECFS | FEMALE |
SA053682 | Lipkin081_posHILIC_DPCSF7638_068.d | MECFS | FEMALE |
SA053683 | Lipkin120_posHILIC_DPCSF3152_084.d | MECFS | FEMALE |
SA053684 | Lipkin028_posHILIC_DPCSF8065_085_2.d | MECFS | FEMALE |
SA053685 | Lipkin100_posHILIC_DPCSF6448_016.d | MECFS | FEMALE |
SA053686 | Lipkin016_posHILIC_DPCSF3752_069.d | MECFS | FEMALE |
SA053687 | Lipkin097_posHILIC_DPCSF4353_065.d | MECFS | FEMALE |
SA053688 | Lipkin004_posHILIC_DPCSF6529_083_2.d | MECFS | FEMALE |
SA053689 | Lipkin044_posHILIC_DPCSF6143_067.d | MECFS | FEMALE |
SA053690 | Lipkin078_posHILIC_DPCSF5981_073.d | MECFS | FEMALE |
SA053691 | Lipkin076_posHILIC_DPCSF5502_070.d | MECFS | FEMALE |
SA053692 | Lipkin093_posHILIC_DPCSF7263_094.d | MECFS | FEMALE |
SA053693 | Lipkin064_posHILIC_DPCSF5421_088.d | MECFS | FEMALE |
SA053694 | Lipkin003_posHILIC_DPCSF2216_007.d | MECFS | FEMALE |
SA053695 | Lipkin105_posHILIC_DPCSF7944_046.d | MECFS | FEMALE |
SA053696 | Lipkin109_posHILIC_DPCSF1870_082.d | MECFS | FEMALE |
SA053697 | Lipkin010_posHILIC_DPCSF9145_018.d | MECFS | FEMALE |
SA053698 | Lipkin096_posHILIC_DPCSF9226_039.d | MECFS | FEMALE |
SA053699 | Lipkin080_posHILIC_DPCSF8371_014.d | MECFS | FEMALE |
SA053700 | Lipkin074_posHILIC_DPCSF1495_036.d | MECFS | MALE |
SA053701 | Lipkin041_posHILIC_DPCSF6765_032.d | MECFS | MALE |
SA053702 | Lipkin077_posHILIC_DPCSF7476_001_2.d | MECFS | MALE |
SA053703 | Lipkin071_posHILIC_DPCSF1576_044.d | MECFS | MALE |
SA053704 | Lipkin107_posHILIC_DPCSF9012_005.d | MECFS | MALE |
SA053705 | Lipkin072_posHILIC_DPCSF7863_071.d | MECFS | MALE |
SA053706 | Lipkin001_posHILIC_DPCSF0426_003.d | MECFS | MALE |
SA053707 | Lipkin066_posHILIC_DPCSF2603_048.d | MECFS | MALE |
SA053708 | Lipkin103_posHILIC_DPCSF9826_042.d | MECFS | MALE |
SA053709 | Lipkin110_posHILIC_DPCSF2938_066.d | MECFS | MALE |
SA053710 | Lipkin037_posHILIC_DPCSF3285_072.d | MECFS | MALE |
SA053711 | Lipkin011_posHILIC_DPCSF6890_090.d | MS | FEMALE |
SA053712 | Lipkin101_posHILIC_DPCSF9292_037.d | MS | FEMALE |
SA053713 | Lipkin075_posHILIC_DPCSF9627_092.d | MS | FEMALE |
SA053714 | Lipkin106_posHILIC_DPCSF6902_103.d | MS | FEMALE |
SA053715 | Lipkin023_posHILIC_DPCSF9506_013.d | MS | FEMALE |
SA053716 | Lipkin099_posHILIC_DPCSF6688_062.d | MS | FEMALE |
SA053717 | Lipkin068_posHILIC_DPCSF8824_081.d | MS | FEMALE |
SA053718 | Lipkin030_posHILIC_DPCSF7877_079.d | MS | FEMALE |
SA053719 | Lipkin053_posHILIC_DPCSF7970_102_2.d | MS | FEMALE |
SA053720 | Lipkin117_posHILIC_DPCSF8397_025.d | MS | FEMALE |
SA053721 | Lipkin032_posHILIC_DPCSF8478_008.d | MS | FEMALE |
SA053722 | Lipkin091_posHILIC_DPCSF8692_015.d | MS | FEMALE |
SA053723 | Lipkin090_posHILIC_DPCSF7410_043.d | MS | FEMALE |
SA053724 | Lipkin094_posHILIC_DPCSF8183_080.d | MS | FEMALE |
SA053725 | Lipkin029_posHILIC_DPCSF7318_087.d | MS | FEMALE |
SA053726 | Lipkin057_posHILIC_DPCSF6088_055.d | MS | FEMALE |
SA053727 | Lipkin046_posHILIC_DPCSF1896_029.d | MS | FEMALE |
SA053728 | Lipkin087_posHILIC_DPCSF3686_093.d | MS | FEMALE |
SA053729 | Lipkin119_posHILIC_DPCSF4165_101.d | MS | FEMALE |
SA053730 | Lipkin007_posHILIC_DPCSF4592_121.d | MS | FEMALE |
SA053731 | Lipkin014_posHILIC_DPCSF1815_122.d | MS | FEMALE |
SA053732 | Lipkin027_posHILIC_DPCSF1041_058.d | MS | FEMALE |
SA053733 | Lipkin089_posHILIC_DPCSF0614_035.d | MS | FEMALE |
SA053734 | Lipkin042_posHILIC_DPCSF0747_027.d | MS | FEMALE |
SA053735 | Lipkin104_posHILIC_DPCSF0868_089.d | MS | FEMALE |
SA053736 | Lipkin049_posHILIC_DPCSF4633_104.d | MS | FEMALE |
SA053737 | Lipkin063_posHILIC_DPCSF3137_060.d | MS | FEMALE |
SA053738 | Lipkin052_posHILIC_DPCSF5274_054.d | MS | FEMALE |
SA053739 | Lipkin118_posHILIC_DPCSF1174_023.d | MS | MALE |
SA053740 | Lipkin065_posHILIC_DPCSF8732_075.d | MS | MALE |
SA053741 | Lipkin033_posHILIC_DPCSF5395_077.d | MS | MALE |
SA053742 | Lipkin035_posHILIC_DPCSF5447_011.d | MS | MALE |
SA053743 | Lipkin031_posHILIC_DPCSF4927_074.d | MS | MALE |
SA053744 | Lipkin067_posHILIC_DPCSF6728_056.d | MS | MALE |
SA053745 | Lipkin102_posHILIC_DPCSF0909_078.d | MS | MALE |
SA053746 | Lipkin018_posHILIC_DPCSF9719_033.d | MS | MALE |
SA053747 | Lipkin020_posHILIC_DPCSF2029_041.d | MS | MALE |
SA053748 | Lipkin086_posHILIC_DPCSF7329_006.d | MS | MALE |
SA053749 | Lipkin050_posHILIC_DPCSF7664_076.d | MS | MALE |
SA053750 | Lipkin045_posHILIC_DPCSF7023_091.d | MS | MALE |
SA053751 | Lipkin036_posHILIC_DPCSF6128_115.d | ND | FEMALE |
SA053752 | Lipkin024_posHILIC_DPCSF0106_108.d | ND | FEMALE |
SA053753 | Lipkin034_posHILIC_DPCSF0828_031.d | ND | FEMALE |
SA053754 | Lipkin098_posHILIC_DPCSF7115_106_2.d | ND | FEMALE |
SA053755 | Lipkin005_posHILIC_DPCSF7756_002.d | ND | FEMALE |
SA053756 | Lipkin116_posHILIC_DPCSF6769_051.d | ND | FEMALE |
SA053757 | Lipkin113_posHILIC_DPCSF6555_107_2.d | ND | FEMALE |
SA053758 | Lipkin056_posHILIC_DPCSF0146_105.d | ND | FEMALE |
SA053759 | Lipkin108_posHILIC_DPCSF2710_064.d | ND | FEMALE |
SA053760 | Lipkin039_posHILIC_DPCSF3310_047.d | ND | FEMALE |
SA053761 | Lipkin009_posHILIC_DPCSF9332_017.d | ND | FEMALE |
SA053762 | Lipkin114_posHILIC_DPCSF7797_045.d | ND | FEMALE |
SA053763 | Lipkin084_posHILIC_DPCSF1281_053.d | ND | FEMALE |
SA053764 | Lipkin055_posHILIC_DPCSF1215_019.d | ND | MALE |
SA053765 | Lipkin059_posHILIC_DPCSF2924_118.d | ND | MALE |
SA053766 | Lipkin038_posHILIC_DPCSF2750_120_2.d | ND | MALE |
SA053767 | Lipkin092_posHILIC_DPCSF2110_119.d | ND | MALE |
SA053768 | Lipkin043_posHILIC_DPCSF8865_117.d | ND | MALE |
SA053769 | Lipkin051_posHILIC_DPCSF3605_116.d | ND | MALE |
Showing results 1 to 91 of 91 |