Summary of Study ST000915

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000633. The data can be accessed directly via it's Project DOI: 10.21228/M8V961 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000915
Study TitleBiomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 1:Liver
Study TypeLipidomics Study
Study SummaryThe spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibility and limitation of complications. Liver biopsy remains the clinical standard for definitive diagnosis. Diagnostic tools minimizing the need for invasive procedures or that add information to histologic data are important in novel management strategies for the growing epidemic of NAFLD. We describe an 'omics' approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples. Using linear discriminant analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, sphingolipids, sterols, and various aqueous small molecular weight components involved in cellular metabolic pathways, can be used to differentiate between NASH and steatosis. This identification of differential biomolecular signatures has the potential to improve clinical diagnosis and facilitate therapeutic intervention of NAFLD.
Institute
LIPID MAPS
DepartmentBioengineering
Last NameFahy
First NameEoin
Address9500 Gilman, La Jolla, CA, 92093, USA
Emailefahy@ucsd.edu
Phone858-534-4076
Submit Date2018-01-14
Publicationshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
Analysis Type DetailGC-MS/LC-MS
Release Date2018-04-05
Release Version1
Eoin Fahy Eoin Fahy
https://dx.doi.org/10.21228/M8V961
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human clinical study; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Diagnosis
SA053802NASH055Cirrhosis
SA053803NASH049Cirrhosis
SA053804NASH048Cirrhosis
SA053805NASH064Cirrhosis
SA053806NASH068Cirrhosis
SA053807NASH005Cirrhosis
SA053808NASH069Cirrhosis
SA053809NASH047Cirrhosis
SA053810NASH065Cirrhosis
SA053811NASH052Cirrhosis
SA053812NASH016Cirrhosis
SA053813NASH013Cirrhosis
SA053814NASH040Cirrhosis
SA053815NASH007Cirrhosis
SA053816NASH022Cirrhosis
SA053817NASH009Cirrhosis
SA053818NASH026Cirrhosis
SA053819NASH029Cirrhosis
SA053820NASH028Cirrhosis
SA053821NASH027Cirrhosis
SA053822NASH072NASH
SA053823NASH057NASH
SA053824NASH044NASH
SA053825NASH074NASH
SA053826NASH088NASH
SA053827NASH039NASH
SA053828NASH090NASH
SA053829NASH087NASH
SA053830NASH084NASH
SA053831NASH031NASH
SA053832NASH018NASH
SA053833NASH012NASH
SA053834NASH038NASH
SA053835NASH010NASH
SA053836NASH019NASH
SA053837NASH015NASH
SA053838NASH037NASH
SA053839NASH035NASH
SA053840NASH030NASH
SA053841NASH021NASH
SA053842NASH067Normal
SA053843NASH070Normal
SA053844NASH066Normal
SA053845NASH060Normal
SA053846NASH077Normal
SA053847NASH053Normal
SA053848NASH054Normal
SA053849NASH086Normal
SA053850NASH091Normal
SA053851NASH051Normal
SA053852NASH089Normal
SA053853NASH085Normal
SA053854NASH080Normal
SA053855NASH082Normal
SA053856NASH078Normal
SA053857NASH014Normal
SA053858NASH017Normal
SA053859NASH020Normal
SA053860NASH006Normal
SA053861NASH004Normal
SA053862NASH050Normal
SA053863NASH003Normal
SA053864NASH024Normal
SA053865NASH011Normal
SA053866NASH043Normal
SA053867NASH045Normal
SA053868NASH034Normal
SA053869NASH042Normal
SA053870NASH046Normal
SA053871NASH041Normal
SA053872NASH036Normal
SA053873NASH075Steatosis
SA053874NASH073Steatosis
SA053875NASH071Steatosis
SA053876NASH076Steatosis
SA053877NASH081Steatosis
SA053878NASH083Steatosis
SA053879NASH062Steatosis
SA053880NASH079Steatosis
SA053881NASH002Steatosis
SA053882NASH032Steatosis
SA053883NASH023Steatosis
SA053884NASH001Steatosis
SA053885NASH033Steatosis
SA053886NASH056Steatosis
SA053887NASH059Steatosis
SA053888NASH058Steatosis
SA053889NASH061Steatosis
Showing results 1 to 88 of 88
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