Summary of Study ST000916

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000633. The data can be accessed directly via it's Project DOI: 10.21228/M8V961 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000916
Study TitleBiomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 2:Plasma
Study TypeLipidomics Study
Study SummaryThe spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibility and limitation of complications. Liver biopsy remains the clinical standard for definitive diagnosis. Diagnostic tools minimizing the need for invasive procedures or that add information to histologic data are important in novel management strategies for the growing epidemic of NAFLD. We describe an 'omics' approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples. Using linear discriminant analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, sphingolipids, sterols, and various aqueous small molecular weight components involved in cellular metabolic pathways, can be used to differentiate between NASH and steatosis. This identification of differential biomolecular signatures has the potential to improve clinical diagnosis and facilitate therapeutic intervention of NAFLD.
Institute
LIPID MAPS
DepartmentBioengineering
Last NameFahy
First NameEoin
Address9500 Gilman, La Jolla, CA, 92093, USA
Emailefahy@ucsd.edu
Phone858-534-4076
Submit Date2018-01-14
Publicationshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
Raw Data AvailableYes
Analysis Type DetailGC-MS/LC-MS
Release Date2018-04-05
Release Version1
Eoin Fahy Eoin Fahy
https://dx.doi.org/10.21228/M8V961
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human clinical study; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Diagnosis
SA053890NASH055Cirrhosis
SA053891NASH049Cirrhosis
SA053892NASH048Cirrhosis
SA053893NASH064Cirrhosis
SA053894NASH068Cirrhosis
SA053895NASH005Cirrhosis
SA053896NASH069Cirrhosis
SA053897NASH047Cirrhosis
SA053898NASH065Cirrhosis
SA053899NASH052Cirrhosis
SA053900NASH016Cirrhosis
SA053901NASH013Cirrhosis
SA053902NASH040Cirrhosis
SA053903NASH007Cirrhosis
SA053904NASH022Cirrhosis
SA053905NASH009Cirrhosis
SA053906NASH026Cirrhosis
SA053907NASH029Cirrhosis
SA053908NASH028Cirrhosis
SA053909NASH027Cirrhosis
SA053910NASH072NASH
SA053911NASH057NASH
SA053912NASH044NASH
SA053913NASH074NASH
SA053914NASH088NASH
SA053915NASH039NASH
SA053916NASH090NASH
SA053917NASH087NASH
SA053918NASH084NASH
SA053919NASH031NASH
SA053920NASH018NASH
SA053921NASH012NASH
SA053922NASH038NASH
SA053923NASH010NASH
SA053924NASH019NASH
SA053925NASH015NASH
SA053926NASH037NASH
SA053927NASH035NASH
SA053928NASH030NASH
SA053929NASH021NASH
SA053930NASH067Normal
SA053931NASH070Normal
SA053932NASH066Normal
SA053933NASH060Normal
SA053934NASH077Normal
SA053935NASH053Normal
SA053936NASH054Normal
SA053937NASH086Normal
SA053938NASH091Normal
SA053939NASH051Normal
SA053940NASH089Normal
SA053941NASH085Normal
SA053942NASH080Normal
SA053943NASH082Normal
SA053944NASH078Normal
SA053945NASH014Normal
SA053946NASH017Normal
SA053947NASH020Normal
SA053948NASH006Normal
SA053949NASH004Normal
SA053950NASH050Normal
SA053951NASH003Normal
SA053952NASH024Normal
SA053953NASH011Normal
SA053954NASH043Normal
SA053955NASH045Normal
SA053956NASH034Normal
SA053957NASH042Normal
SA053958NASH046Normal
SA053959NASH041Normal
SA053960NASH036Normal
SA053961NASH075Steatosis
SA053962NASH073Steatosis
SA053963NASH071Steatosis
SA053964NASH076Steatosis
SA053965NASH081Steatosis
SA053966NASH083Steatosis
SA053967NASH062Steatosis
SA053968NASH079Steatosis
SA053969NASH002Steatosis
SA053970NASH032Steatosis
SA053971NASH023Steatosis
SA053972NASH001Steatosis
SA053973NASH033Steatosis
SA053974NASH056Steatosis
SA053975NASH059Steatosis
SA053976NASH058Steatosis
SA053977NASH061Steatosis
Showing results 1 to 88 of 88
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