Summary of Study ST000917

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000633. The data can be accessed directly via it's Project DOI: 10.21228/M8V961 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files
Study IDST000917
Study TitleBiomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 3:Urine
Study TypeLipidomics Study
Study SummaryThe spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibility and limitation of complications. Liver biopsy remains the clinical standard for definitive diagnosis. Diagnostic tools minimizing the need for invasive procedures or that add information to histologic data are important in novel management strategies for the growing epidemic of NAFLD. We describe an 'omics' approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples. Using linear discriminant analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, sphingolipids, sterols, and various aqueous small molecular weight components involved in cellular metabolic pathways, can be used to differentiate between NASH and steatosis. This identification of differential biomolecular signatures has the potential to improve clinical diagnosis and facilitate therapeutic intervention of NAFLD.
Institute
LIPID MAPS
DepartmentBioengineering
Last NameFahy
First NameEoin
Address9500 Gilman, La Jolla, CA, 92093, USA
Emailefahy@ucsd.edu
Phone858-534-4076
Submit Date2018-01-14
Publicationshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
Analysis Type DetailGC-MS/LC-MS
Release Date2018-04-05
Release Version1
Eoin Fahy Eoin Fahy
https://dx.doi.org/10.21228/M8V961
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Human clinical study; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Diagnosis
SA053978NASH055Cirrhosis
SA053979NASH049Cirrhosis
SA053980NASH048Cirrhosis
SA053981NASH064Cirrhosis
SA053982NASH068Cirrhosis
SA053983NASH005Cirrhosis
SA053984NASH069Cirrhosis
SA053985NASH047Cirrhosis
SA053986NASH065Cirrhosis
SA053987NASH052Cirrhosis
SA053988NASH016Cirrhosis
SA053989NASH013Cirrhosis
SA053990NASH040Cirrhosis
SA053991NASH007Cirrhosis
SA053992NASH022Cirrhosis
SA053993NASH009Cirrhosis
SA053994NASH026Cirrhosis
SA053995NASH029Cirrhosis
SA053996NASH028Cirrhosis
SA053997NASH027Cirrhosis
SA053998NASH072NASH
SA053999NASH057NASH
SA054000NASH044NASH
SA054001NASH074NASH
SA054002NASH088NASH
SA054003NASH039NASH
SA054004NASH090NASH
SA054005NASH087NASH
SA054006NASH084NASH
SA054007NASH031NASH
SA054008NASH018NASH
SA054009NASH012NASH
SA054010NASH038NASH
SA054011NASH010NASH
SA054012NASH019NASH
SA054013NASH015NASH
SA054014NASH037NASH
SA054015NASH035NASH
SA054016NASH030NASH
SA054017NASH021NASH
SA054018NASH067Normal
SA054019NASH070Normal
SA054020NASH066Normal
SA054021NASH060Normal
SA054022NASH077Normal
SA054023NASH053Normal
SA054024NASH054Normal
SA054025NASH086Normal
SA054026NASH091Normal
SA054027NASH051Normal
SA054028NASH089Normal
SA054029NASH085Normal
SA054030NASH080Normal
SA054031NASH082Normal
SA054032NASH078Normal
SA054033NASH014Normal
SA054034NASH017Normal
SA054035NASH020Normal
SA054036NASH006Normal
SA054037NASH004Normal
SA054038NASH050Normal
SA054039NASH003Normal
SA054040NASH024Normal
SA054041NASH011Normal
SA054042NASH043Normal
SA054043NASH045Normal
SA054044NASH034Normal
SA054045NASH042Normal
SA054046NASH046Normal
SA054047NASH041Normal
SA054048NASH036Normal
SA054049NASH075Steatosis
SA054050NASH073Steatosis
SA054051NASH071Steatosis
SA054052NASH076Steatosis
SA054053NASH081Steatosis
SA054054NASH083Steatosis
SA054055NASH062Steatosis
SA054056NASH079Steatosis
SA054057NASH002Steatosis
SA054058NASH032Steatosis
SA054059NASH023Steatosis
SA054060NASH001Steatosis
SA054061NASH033Steatosis
SA054062NASH056Steatosis
SA054063NASH059Steatosis
SA054064NASH058Steatosis
SA054065NASH061Steatosis
Showing results 1 to 88 of 88
  logo