Summary of Study ST001202

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000809. The data can be accessed directly via it's Project DOI: 10.21228/M83X38 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST001202
Study TitlePeroxide antimalarial treatment timecourse on ring-stage P. falciparum parasites
Study SummaryRed blood cells (RBCs) infected with ring stage P. falciparum parasites (3D7 strain) at 10% parasitaemia and 2% haematocrit were treated with OZ277 (1 uM), OZ439 (1 uM), DHA (300 nM) or vehicle (0.03% DMSO). This was a 5-timepoint study, with samples taken 0, 1.5, 3, 6 and 9 h after drug or vehicle addition. Samples treated with vehicle acted as the untreated control. Samples from drug treated uninfected RBCs were also taken to ensure the observed drug effects were parasite specific.
Institute
Monash University
Last NameGiannangelo
First NameCarlo
Address381 Royal Parade, Parkville, Victoria, 3052, Australia
Emailcarlo.giannangelo@monash.edu
Phone99039282
Submit Date2019-06-24
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Carlo Giannangelo Carlo Giannangelo
https://dx.doi.org/10.21228/M83X38
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Plasmodium falciparum;Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id cell_type treatment treatment_duration_(h)
SA084070DHA_i0h_aiRBC DHA -
SA084071DHA_i0h_diRBC DHA -
SA084072DHA_i0h_biRBC DHA -
SA084073DHA_i0h_ciRBC DHA -
SA084074DHA_i1_5h_ciRBC DHA 1.5
SA084075DHA_i1_5h_biRBC DHA 1.5
SA084076DHA_i1_5h_diRBC DHA 1.5
SA084077DHA_i1_5h_aiRBC DHA 1.5
SA084078DHA_i3h_ciRBC DHA 3
SA084079DHA_i3h_biRBC DHA 3
SA084080DHA_i3h_aiRBC DHA 3
SA084081DHA_i3h_diRBC DHA 3
SA084082DHA_i6h_aiRBC DHA 6
SA084083DHA_i6h_biRBC DHA 6
SA084084DHA_i6h_ciRBC DHA 6
SA084085DHA_i6h_diRBC DHA 6
SA084086DMSO_i0h_diRBC DMSO -
SA084087DMSO_i0h_biRBC DMSO -
SA084088DMSO_i0h_aiRBC DMSO -
SA084089DMSO_i0h_ciRBC DMSO -
SA084090DMSO_i1_5h_aiRBC DMSO 1.5
SA084091DMSO_i1_5h_diRBC DMSO 1.5
SA084092DMSO_i1_5h_biRBC DMSO 1.5
SA084093DMSO_i1_5h_ciRBC DMSO 1.5
SA084094DMSO_i3h_ciRBC DMSO 3
SA084095DMSO_i3h_biRBC DMSO 3
SA084096DMSO_i3h_diRBC DMSO 3
SA084097DMSO_i3h_aiRBC DMSO 3
SA084098DMSO_i6h_diRBC DMSO 6
SA084099DMSO_i6h_aiRBC DMSO 6
SA084100DMSO_i6h_ciRBC DMSO 6
SA084101DMSO_i6h_biRBC DMSO 6
SA084102DMSO_i9h_ciRBC DMSO 9
SA084103DMSO_i9h_diRBC DMSO 9
SA084104DMSO_i9h_biRBC DMSO 9
SA084105DMSO_i9h_aiRBC DMSO 9
SA084106OZ277_i0h_aiRBC OZ277 -
SA084107OZ277_i0h_biRBC OZ277 -
SA084108OZ277_i0h_diRBC OZ277 -
SA084109OZ277_i0h_ciRBC OZ277 -
SA084110OZ277_i3h_diRBC OZ277 3
SA084111OZ277_i3h_biRBC OZ277 3
SA084112OZ277_i3h_ciRBC OZ277 3
SA084113OZ277_i3h_aiRBC OZ277 3
SA084114OZ277_i6h_aiRBC OZ277 6
SA084115OZ277_i6h_ciRBC OZ277 6
SA084116OZ277_i6h_diRBC OZ277 6
SA084117OZ277_i6h_biRBC OZ277 6
SA084118OZ277_i9h_diRBC OZ277 9
SA084119OZ277_i9h_ciRBC OZ277 9
SA084120OZ277_i9h_aiRBC OZ277 9
SA084121OZ277_i9h_biRBC OZ277 9
SA084122OZ439_i0h_aiRBC OZ439 -
SA084123OZ439_i0h_ciRBC OZ439 -
SA084124OZ439_i0h_diRBC OZ439 -
SA084125OZ439_i0h_biRBC OZ439 -
SA084126OZ439_i3h_aiRBC OZ439 3
SA084127OZ439_i3h_ciRBC OZ439 3
SA084128OZ439_i3h_biRBC OZ439 3
SA084129OZ439_i3h_diRBC OZ439 3
SA084130OZ439_i6h_ciRBC OZ439 6
SA084131OZ439_i6h_aiRBC OZ439 6
SA084132OZ439_i6h_biRBC OZ439 6
SA084133OZ439_i6h_diRBC OZ439 6
SA084134OZ439_i9h_ciRBC OZ439 9
SA084135OZ439_i9h_aiRBC OZ439 9
SA084136OZ439_i9h_biRBC OZ439 9
SA084137OZ439_i9h_diRBC OZ439 9
SA084138DHA_u0h_dunRBC DHA -
SA084139DHA_u0h_bunRBC DHA -
SA084140DHA_u0h_cunRBC DHA -
SA084141DHA_u0h_aunRBC DHA -
SA084142DHA_u1_5h_bunRBC DHA 1.5
SA084143DHA_u1_5h_cunRBC DHA 1.5
SA084144DHA_u1_5h_aunRBC DHA 1.5
SA084145DHA_u1_5h_dunRBC DHA 1.5
SA084146DHA_u3h_cunRBC DHA 3
SA084147DHA_u3h_aunRBC DHA 3
SA084148DHA_u3h_bunRBC DHA 3
SA084149DHA_u3h_dunRBC DHA 3
SA084150DHA_u6h_dunRBC DHA 6
SA084151DHA_u6h_aunRBC DHA 6
SA084152DHA_u6h_bunRBC DHA 6
SA084153DHA_u6h_cunRBC DHA 6
SA084154DMSO_u0h_dunRBC DMSO -
SA084155DMSO_u0h_cunRBC DMSO -
SA084156DMSO_u0h_aunRBC DMSO -
SA084157DMSO_u0h_bunRBC DMSO -
SA084158DMSO_u1_5h_aunRBC DMSO 1.5
SA084159DMSO_u1_5h_dunRBC DMSO 1.5
SA084160DMSO_u1_5h_cunRBC DMSO 1.5
SA084161DMSO_u1_5h_bunRBC DMSO 1.5
SA084162DMSO_u3h_dunRBC DMSO 3
SA084163DMSO_u3h_aunRBC DMSO 3
SA084164DMSO_u3h_bunRBC DMSO 3
SA084165DMSO_u3h_cunRBC DMSO 3
SA084166DMSO_u6h_bunRBC DMSO 6
SA084167DMSO_u6h_dunRBC DMSO 6
SA084168DMSO_u6h_aunRBC DMSO 6
SA084169DMSO_u6h_cunRBC DMSO 6
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