Summary of Study ST001205

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000809. The data can be accessed directly via it's Project DOI: 10.21228/M83X38 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001205
Study TitlePeroxide antimalarial treatment of K13-mutant and -wildtype P. falciparum parasites
Study SummaryRed blood cells (RBCs) infected with trophozoite stage P. falciparum parasites (Cam3.IIR539T or Cam3.IIrev lines) at 4% parasitaemia and 2% haematocrit were treated with 100 nM of DHA, OZ277 or OZ439 for a duration of 1, 3 and 5 h, respectively. The K13-mutant artemisinin resistant parasite line used was Cam3.IIR539T. The K13-wildtype artemisinin sensitive parasite line used was Cam3.IIrev. The Samples treated with vehicle (DMSO) acted as the untreated control.
Institute
Monash University
Last NameGiannangelo
First NameCarlo
Address381 Royal Parade, Parkville, Victoria, 3052, Australia
Emailcarlo.giannangelo@monash.edu
Phone99039282
Submit Date2019-06-26
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Carlo Giannangelo Carlo Giannangelo
https://dx.doi.org/10.21228/M83X38
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Plasmodium falciparum;Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id parasite_line treatment treatment_duration_(h)
SA0847421h_DHA_R1_troph_dCam3.IIR539T DHA 1
SA0847431h_DHA_R1_troph_bCam3.IIR539T DHA 1
SA0847441h_DHA_R1_troph_cCam3.IIR539T DHA 1
SA0847451h_DMSO_R1_troph_dCam3.IIR539T DMSO 1
SA0847461h_DMSO_R1_troph_cCam3.IIR539T DMSO 1
SA0847475h_DMSO_R1_troph_dCam3.IIR539T DMSO 5
SA0847485h_DMSO_R1_troph_bCam3.IIR539T DMSO 5
SA0847495h_DMSO_R1_troph_cCam3.IIR539T DMSO 5
SA0847503h_OZ277_R1_troph_bCam3.IIR539T OZ277 3
SA0847513h_OZ277_R1_troph_cCam3.IIR539T OZ277 3
SA0847523h_OZ277_R1_troph_dCam3.IIR539T OZ277 3
SA0847535h_OZ439_R1_troph_bCam3.IIR539T OZ439 5
SA0847545h_OZ439_R1_troph_cCam3.IIR539T OZ439 5
SA0847555h_OZ439_R1_troph_dCam3.IIR539T OZ439 5
SA0847561h_DHA_S_troph_bCam3.IIrev DHA 1
SA0847571h_DHA_S_troph_cCam3.IIrev DHA 1
SA0847581h_DHA_S_troph_dCam3.IIrev DHA 1
SA0847591h_DMSO_S_troph_dCam3.IIrev DMSO 1
SA0847601h_DMSO_S_troph_cCam3.IIrev DMSO 1
SA0847615h_DMSO_S_troph_cCam3.IIrev DMSO 5
SA0847625h_DMSO_S_troph_bCam3.IIrev DMSO 5
SA0847635h_DMSO_S_troph_dCam3.IIrev DMSO 5
SA0847643h_OZ277_S_troph_dCam3.IIrev OZ277 3
SA0847653h_OZ277_S_troph_cCam3.IIrev OZ277 3
SA0847663h_OZ277_S_troph_eCam3.IIrev OZ277 3
SA0847675h_OZ439_S_troph_eCam3.IIrev OZ439 5
SA0847685h_OZ439_S_troph_cCam3.IIrev OZ439 5
SA0847695h_OZ439_S_troph_dCam3.IIrev OZ439 5
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