Summary of Study ST001219
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000818. The data can be accessed directly via it's Project DOI: 10.21228/M8Z68P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001219 |
| Study Title | Vitamin D regulates the microbiota to induce RORgt/FoxP3+ regulatory T cells |
| Study Summary | The active form of vitamin D (1,25(OH)2D) suppresses experimental models of inflammatory bowel disease in part by regulating the microbiota. In this study, the role of vitamin D in the regulation of microbe induced RORgt/FoxP3+ T regulatory (reg) cells in the colon was determined. Vitamin D sufficient (D+) mice had significantly higher frequencies of FoxP3+ and RORgt/FoxP3+ T reg cells in the colon compared to vitamin D deficient (D-) mice. The higher frequency of RORgt/FoxP3+ T reg cells in D+ colon correlated with higher numbers of bacteria from the Clostridium XIVa and Bacteroides in D+ compared to D- cecum. D- mice with fewer RORgt/FoxP3+ T reg cells were significantly more susceptible to colitis than D+ mice. Transfer of the cecal bacteria from D+ or D- mice to germfree recipients phenocopied the higher numbers of RORgt/FoxP3+ cells and reduced susceptibility to colitis in D+ versus D- recipient mice. 1,25(OH)2D treatment of the D- mice beginning at 3 weeks of age did not completely recover RORgt/FoxP3+ T reg cells or the Bacteriodes, Bacteriodes thetaiotaomicron, and Clostridium XIVa numbers to D+ values. Early vitamin D status shapes the microbiota to optimize the population of colonic RORgt/FoxP3+ T reg cells important for resistance to colitis. |
| Institute | Pennsylvania State University |
| Last Name | Nichols |
| First Name | Robert |
| Address | 917 Old Boalsburg Road, State College, Pennsylvania, 16801, USA |
| rgn5011@psu.edu | |
| Phone | 7247662694 |
| Submit Date | 2019-07-17 |
| Raw Data Available | Yes |
| Analysis Type Detail | NMR |
| Release Date | 2019-09-23 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Group |
|---|---|---|
| SA086187 | Sup_Fig4B-6 | Vitamin D - |
| SA086188 | Sup_Fig4B-7 | Vitamin D - |
| SA086189 | Sup_Fig4B-11 | Vitamin D - |
| SA086190 | Sup_Fig4B-9 | Vitamin D - |
| SA086191 | Sup_Fig4B-10 | Vitamin D - |
| SA086192 | Sup_Fig4B-8 | Vitamin D - |
| SA086218 | Sup_Fig4A-5 | Vitamin D- |
| SA086219 | Sup_Fig4A-6 | Vitamin D- |
| SA086220 | Sup_Fig4A-21 | Vitamin D- |
| SA086221 | Sup_Fig4A-4 | Vitamin D- |
| SA086222 | Sup_Fig4A-3 | Vitamin D- |
| SA086223 | Sup_Fig4A-2 | Vitamin D- |
| SA086224 | Sup_Fig4A-1 | Vitamin D- |
| SA086225 | Sup_Fig4A-22 | Vitamin D- |
| SA086226 | Sup_Fig4A-7 | Vitamin D- |
| SA086227 | Sup_Fig4A-27 | Vitamin D- |
| SA086228 | Sup_Fig4A-23 | Vitamin D- |
| SA086229 | Sup_Fig4A-20 | Vitamin D- |
| SA086230 | Sup_Fig4A-26 | Vitamin D- |
| SA086231 | Sup_Fig4A-28 | Vitamin D- |
| SA086232 | Sup_Fig4A-25 | Vitamin D- |
| SA086233 | Sup_Fig4A-24 | Vitamin D- |
| SA086193 | Sup_Fig4B-5 | Vitamin D+ |
| SA086194 | Sup_Fig4B-2 | Vitamin D+ |
| SA086195 | Sup_Fig4B-3 | Vitamin D+ |
| SA086196 | Sup_Fig4C-1 | Vitamin D+ |
| SA086197 | Sup_Fig4C-6 | Vitamin D+ |
| SA086198 | Sup_Fig4C-7 | Vitamin D+ |
| SA086199 | Sup_Fig4C-8 | Vitamin D+ |
| SA086200 | Sup_Fig4C-5 | Vitamin D+ |
| SA086201 | Sup_Fig4C-4 | Vitamin D+ |
| SA086202 | Sup_Fig4C-2 | Vitamin D+ |
| SA086203 | Sup_Fig4C-3 | Vitamin D+ |
| SA086204 | Sup_Fig4B-1 | Vitamin D+ |
| SA086205 | Sup_Fig4B-4 | Vitamin D+ |
| SA086206 | Sup_Fig4A-14 | Vitamin D+ |
| SA086207 | Sup_Fig4A-15 | Vitamin D+ |
| SA086208 | Sup_Fig4A-16 | Vitamin D+ |
| SA086209 | Sup_Fig4A-17 | Vitamin D+ |
| SA086210 | Sup_Fig4A-13 | Vitamin D+ |
| SA086211 | Sup_Fig4A-12 | Vitamin D+ |
| SA086212 | Sup_Fig4A-9 | Vitamin D+ |
| SA086213 | Sup_Fig4A-10 | Vitamin D+ |
| SA086214 | Sup_Fig4A-11 | Vitamin D+ |
| SA086215 | Sup_Fig4A-18 | Vitamin D+ |
| SA086216 | Sup_Fig4A-8 | Vitamin D+ |
| SA086217 | Sup_Fig4A-19 | Vitamin D+ |
| SA086234 | Sup_Fig4C-20 | Vitamin D-, +1,25D |
| SA086235 | Sup_Fig4C-19 | Vitamin D-, +1,25D |
| SA086236 | Sup_Fig4C-21 | Vitamin D-, +1,25D |
| SA086237 | Sup_Fig4C-23 | Vitamin D-, +1,25D |
| SA086238 | Sup_Fig4C-18 | Vitamin D-, +1,25D |
| SA086239 | Sup_Fig4C-24 | Vitamin D-, +1,25D |
| SA086240 | Sup_Fig4C-22 | Vitamin D-, +1,25D |
| SA086241 | Sup_Fig4C-9 | Vitamin D-, +1,25D |
| SA086242 | Sup_Fig4C-12 | Vitamin D-, +1,25D |
| SA086243 | Sup_Fig4C-11 | Vitamin D-, +1,25D |
| SA086244 | Sup_Fig4C-10 | Vitamin D-, +1,25D |
| SA086245 | Sup_Fig4C-13 | Vitamin D-, +1,25D |
| SA086246 | Sup_Fig4C-14 | Vitamin D-, +1,25D |
| SA086247 | Sup_Fig4C-16 | Vitamin D-, +1,25D |
| SA086248 | Sup_Fig4C-15 | Vitamin D-, +1,25D |
| SA086249 | Sup_Fig4C-17 | Vitamin D-, +1,25D |
| Showing results 1 to 63 of 63 |
