Summary of Study ST001237

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000828. The data can be accessed directly via it's Project DOI: 10.21228/M8NQ4J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Study ID	ST001237
Study Title	Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part III
Study Summary	Inhibition of immune-checkpoint targets including PD1 is clinically effective in a variety of cancers. However, only a subset of patients respond and complete response remains uncommon. Given the known role of metabolites in modulating immunity, we sought to understand how individual patients’ metabolic activities adapt to PD1 immune checkpoint blockade and how they associate with therapeutic benefits. To this end, we profiled metabolites in pre- and multiple on-treatment patient serum samples from three independent immunotherapy trials using hydrophilic interaction liquid chromatography coupled with either triple quadrupole MS multiple reaction monitoring or high resolution full scan MS detection. The study consisted of two Phase I trials (CA209-038, NCT01621490; CA209-009, NCT01358721) which included 78 patients with advanced melanoma and 91 patients with metastatic renal cell carcinoma (RCC) treated with nivolumab. To investigate the generalizability of our results, we also analyzed a large randomized Phase III trial (CheckMate 025, NCT01668784) with 743 RCC patients, among which 394 received nivolumab and 349 received everolimus.
Institute	Broad Institute of MIT and Harvard
Last Name	Clish
First Name	Clary
Address	415 Main St, Cambridge, MA 02142
Email	clary@broadinstitute.org
Phone	617-714-7654
Submit Date	2019-08-12
Num Groups	1
Total Subjects	743
Num Males	552
Num Females	191
Raw Data Available	Yes
Raw Data File Type(s)	raw(Thermo)
Analysis Type Detail	LC-MS
Release Date	2019-08-27
Release Version	1

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	Time point	OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)	CRF_MSKCC_Risk_Group	Treatment	Prior antiangiogenic regimens (≥2)
SA089169	CA209025-160-157_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089170	CA209025-141-730_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089171	CA209025-154-1019_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089172	CA209025-1-1048_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089173	CA209025-141-667_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089174	CA209025-114-56_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089175	CA209025-39-133_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089176	CA209025-1-96_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089177	CA209025-2-210_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089178	CA209025-20-946_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089179	CA209025-11-481_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089180	CA209025-2-792_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089181	CA209025-180-937_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089182	CA209025-12-216_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089183	CA209025-174-235_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089184	CA209025-159-994_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089185	CA209025-12-275_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089186	CA209025-1-110_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089187	CA209025-135-434_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089188	CA209025-139-827_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089189	CA209025-9-649_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089190	CA209025-154-125_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089191	CA209025-92-806_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089192	CA209025-93-212_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089193	CA209025-89-33_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089194	CA209025-87-548_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089195	CA209025-82-745_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089196	CA209025-82-690_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089197	CA209025-84-861_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089198	CA209025-50-281_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089199	CA209025-93-274_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089200	CA209025-43-787_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089201	CA209025-139-224_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089202	CA209025-14-943_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089203	CA209025-139-227_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089204	CA209025-65-579_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089205	CA209025-42-441_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089206	CA209025-159-812_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089207	CA209025-158-182_baseline	baseline	1	FAVORABLE	EVEROLIMUS	FALSE
SA089208	CA209025-87-229_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089209	CA209025-47-1037_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089210	CA209025-86-735_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089211	CA209025-158-77_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089212	CA209025-44-464_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089213	CA209025-139-775_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089214	CA209025-103-747_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089215	CA209025-1-1056_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089216	CA209025-139-741_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089217	CA209025-41-455_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089218	CA209025-138-699_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089219	CA209025-111-657_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089220	CA209025-2-67_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089221	CA209025-58-162_baseline	baseline	1	FAVORABLE	EVEROLIMUS	TRUE
SA089222	CA209025-41-979_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089223	CA209025-29-1002_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089224	CA209025-39-147_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089225	CA209025-97-765_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089226	CA209025-43-248_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089227	CA209025-65-329_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089228	CA209025-9-892_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089229	CA209025-90-105_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089230	CA209025-89-174_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089231	CA209025-9-756_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089232	CA209025-89-725_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089233	CA209025-82-338_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089234	CA209025-75-112_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089235	CA209025-44-643_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089236	CA209025-43-941_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089237	CA209025-6-586_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089238	CA209025-72-394_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089239	CA209025-73-511_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089240	CA209025-43-743_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089241	CA209025-174-1010_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089242	CA209025-169-660_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089243	CA209025-139-1006_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089244	CA209025-17-1044_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089245	CA209025-138-734_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089246	CA209025-13-181_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089247	CA209025-17-928_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089248	CA209025-162-171_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089249	CA209025-161-974_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089250	CA209025-15-99_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089251	CA209025-15-773_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089252	CA209025-154-929_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089253	CA209025-156-1017_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089254	CA209025-161-577_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089255	CA209025-24-840_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089256	CA209025-118-255_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089257	CA209025-170-221_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089258	CA209025-101-142_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089259	CA209025-22-1000_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089260	CA209025-21-1039_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089261	CA209025-21-849_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089262	CA209025-23-8_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089263	CA209025-173-757_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089264	CA209025-18-954_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089265	CA209025-2-10_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089266	CA209025-21-1027_baseline	baseline	1	FAVORABLE	NIVOLUMAB	FALSE
SA089267	CA209025-97-264_baseline	baseline	1	FAVORABLE	NIVOLUMAB	TRUE
SA089268	CA209025-95-167_baseline	baseline	1	FAVORABLE	NIVOLUMAB	TRUE